{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:39:04Z","timestamp":1792438744159,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Given our recent discovery of somatic mutations in autism spectrum disorder (ASD)\/intellectual disability (ID) genes in postmortem aged Alzheimer\u2019s disease brains correlating with increasing tauopathy, it is important to decipher if tauopathy is underlying brain imaging results of atrophy in ASD\/ID children. We concentrated on activity-dependent neuroprotective protein (ADNP), a prevalent autism gene. The unique availability of multiple postmortem brain sections of a 7-year-old male, heterozygous for ADNP de novo mutation c.2244Adup\/p.His559Glnfs*3 allowed exploration of tauopathy, reflecting on a general unexplored mechanism. The tested subject exhibited autism, fine motor delays, severe intellectual disability and seizures. The patient died after multiple organ failure following liver transplantation. To compare to other ADNP syndrome mutations, immortalized lymphoblastoid cell lines from three different patients (including ADNP p.Arg216*, p.Lys408Valfs*31, and p.Tyr719* heterozygous dominant mutations) and a control were subjected to RNA-seq. Immunohistochemistry, high-throughput gene expression profiles in numerous postmortem tissues followed. Comparisons to a control brain and to extensive datasets were used. Live cell imaging investigated Tau-microtubule interaction, protecting against tauopathy. Extensive child brain tauopathy paralleled by multiple gene expression changes was discovered. Tauopathy was explained by direct mutation effects on Tau-microtubule interaction and correction by the ADNP active snippet NAP. Significant pathway changes (empirical\n                    <jats:italic>P<\/jats:italic>\n                    value\u2009&lt;\u20090.05) included over 100 genes encompassing neuroactive ligand\u2013receptor and cytokine\u2013cytokine receptor interaction, MAPK and calcium signaling, axon guidance and Wnt signaling pathways. Changes were also seen in steroid biosynthesis genes, suggesting sex differences. Selecting the most affected genes by the ADNP mutations for gene expression analysis, in multiple postmortem tissues, identified Tau (MAPT)-gene-related expression changes compared with extensive normal gene expression (RNA-seq) databases.\n                    <jats:italic>ADNP<\/jats:italic>\n                    showed relatively reduced expression in the ADNP syndrome cerebellum, which was also observed for 25 additional genes (representing &gt;50% of the tested genes), including\n                    <jats:italic>NLGN1, NLGN2, PAX6, SMARCA4<\/jats:italic>\n                    , and\n                    <jats:italic>SNAP25<\/jats:italic>\n                    , converging on nervous system development and tauopathy. NAP provided protection against mutated ADNP disrupted Tau-microtubule association. In conclusion, tauopathy may explain brain-imaging findings in ADNP syndrome children and may provide a new direction for the development of tauopathy protecting drug candidates like NAP in ASD\/ID.\n                  <\/jats:p>","DOI":"10.1038\/s41398-020-00904-4","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T14:03:55Z","timestamp":1594649035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Tauopathy in the young autistic brain: novel biomarker and therapeutic target"],"prefix":"10.1038","volume":"10","author":[{"given":"Iris","family":"Grigg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanina","family":"Ivashko-Pachima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-8202","authenticated-orcid":false,"given":"Tom Aharon","family":"Hait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlasta","family":"Korenkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Touloumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Lagoudaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-2943","authenticated-orcid":false,"given":"Anke","family":"Van Dijck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatko","family":"Marusic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6789-617X","authenticated-orcid":false,"given":"Mirna","family":"Anicic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-9170","authenticated-orcid":false,"given":"Jurica","family":"Vukovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-0485","authenticated-orcid":false,"given":"R. Frank","family":"Kooy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Grigoriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-2430","authenticated-orcid":false,"given":"Illana","family":"Gozes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"904_CR1","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1046\/j.1471-4159.1999.0721283.x","volume":"72","author":"M Bassan","year":"1999","unstructured":"Bassan, M. et al. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J. Neurochem. 72, 1283\u20131293 (1999).","journal-title":"J. Neurochem."},{"key":"904_CR2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1074\/jbc.M007416200","volume":"276","author":"R Zamostiano","year":"2001","unstructured":"Zamostiano, R. et al. Cloning and characterization of the human activity-dependent neuroprotective protein. J. Biol. Chem. 276, 708\u2013714 (2001).","journal-title":"J. Biol. Chem."},{"key":"904_CR3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/ng.2899","volume":"46","author":"C Helsmoortel","year":"2014","unstructured":"Helsmoortel, C. et al. A SWI\/SNF-related autism syndrome caused by de novo mutations in ADNP. Nat. Genet. 46, 380\u2013384 (2014).","journal-title":"Nat. Genet."},{"key":"904_CR4","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature21062","volume":"542","author":"Deciphering Developmental Disorders S.","year":"2017","unstructured":"Deciphering Developmental Disorders S. Prevalence and architecture of de novo mutations in developmental disorders. Nature 542, 433\u2013438 (2017).","journal-title":"Nature"},{"key":"904_CR5","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/ng.3792","volume":"49","author":"HA Stessman","year":"2017","unstructured":"Stessman, H. A. et al. Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nat. Genet. 49, 515\u2013526 (2017).","journal-title":"Nat. Genet."},{"key":"904_CR6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.biopsych.2018.02.1173","volume":"85","author":"A Van Dijck","year":"2019","unstructured":"Van Dijck, A. et al. Clinical presentation of a complex neurodevelopmental disorder caused by mutations in ADNP. Biol. Psychiatry 85, 287\u2013297 (2019).","journal-title":"Biol. Psychiatry"},{"key":"904_CR7","doi-asserted-by":"crossref","unstructured":"Amram N. et al. Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory. Mol. Psychiatry 21, 1467\u20131476 (2016).","DOI":"10.1038\/mp.2015.208"},{"key":"904_CR8","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/mp.2013.174","volume":"20","author":"A Merenlender-Wagner","year":"2015","unstructured":"Merenlender-Wagner, A. et al. Autophagy has a key role in the pathophysiology of schizophrenia. Mol. Psychiatry 20, 126\u2013132 (2015).","journal-title":"Mol. Psychiatry"},{"key":"904_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12031-007-9013-y","volume":"35","author":"S Mandel","year":"2008","unstructured":"Mandel, S., Spivak-Pohis, I. & Gozes, I. ADNP differential nucleus\/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance. J. Mol. Neurosci. 35, 127\u2013141 (2008).","journal-title":"J. Mol. Neurosci."},{"key":"904_CR10","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1172\/JCI98199","volume":"128","author":"G Hacohen-Kleiman","year":"2018","unstructured":"Hacohen-Kleiman, G. et al. Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. J. Clin. Investig. 128, 4956\u20134969 (2018).","journal-title":"J. Clin. Investig."},{"key":"904_CR11","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/mp.2014.97","volume":"19","author":"S Oz","year":"2014","unstructured":"Oz, S. et al. The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins. Mol. Psychiatry 19, 1115\u20131124 (2014).","journal-title":"Mol. Psychiatry"},{"key":"904_CR12","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/mp.2016.255","volume":"22","author":"Y Ivashko-Pachima","year":"2017","unstructured":"Ivashko-Pachima, Y., Sayas, C. L., Malishkevich, A. & Gozes, I. ADNP\/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy. Mol. Psychiatry 22, 1335\u20131344 (2017).","journal-title":"Mol. Psychiatry"},{"key":"904_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051458","volume":"7","author":"S Oz","year":"2012","unstructured":"Oz, S., Ivashko-Pachima, Y. & Gozes, I. The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities. PLoS ONE 7, e51458 (2012).","journal-title":"PLoS ONE"},{"key":"904_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.nbd.2013.04.012","volume":"56","author":"Y Jouroukhin","year":"2013","unstructured":"Jouroukhin, Y. et al. NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport. Neurobiol. Dis. 56, 79\u201394 (2013).","journal-title":"Neurobiol. Dis."},{"key":"904_CR15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1124\/jpet.107.129551","volume":"323","author":"I Vulih-Shultzman","year":"2007","unstructured":"Vulih-Shultzman, I. et al. Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. J. Pharmacol. Exp. Ther. 323, 438\u2013449 (2007).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"904_CR16","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/mp.2013.32","volume":"18","author":"S Quraishe","year":"2013","unstructured":"Quraishe, S., Cowan, C. M. & Mudher, A. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol. Psychiatry 18, 834\u2013842 (2013).","journal-title":"Mol. Psychiatry"},{"key":"904_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213666","volume":"14","author":"Y Ivashko-Pachima","year":"2019","unstructured":"Ivashko-Pachima, Y., Maor-Nof, M. & Gozes, I. NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathies. PLoS ONE 14, e0213666 (2019).","journal-title":"PLoS ONE"},{"key":"904_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.128","volume":"7","author":"I Gozes","year":"2017","unstructured":"Gozes, I. et al. Premature primary tooth eruption in cognitive\/motor-delayed ADNP-mutated children. Transl. Psychiatry 7, e1166 (2017).","journal-title":"Transl. Psychiatry"},{"key":"904_CR19","doi-asserted-by":"crossref","unstructured":"Ivashko-Pachima Y. et al. Discovery of autism\/intellectual disability somatic mutations in Alzheimer\u2019s brains: mutated ADNP cytoskeletal impairments and repair as a case study. Mol. Psychiatry (2019). (EPUB)","DOI":"10.1038\/s41380-019-0563-5"},{"key":"904_CR20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/bio.2015.0032","volume":"13","author":"LJ Carithers","year":"2015","unstructured":"Carithers, L. J. et al. A novel approach to high-quality postmortem tissue procurement: the GTEx project. Biopreserv. Biobank. 13, 311\u2013319 (2015).","journal-title":"Biopreserv. Biobank."},{"key":"904_CR21","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"904_CR22","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1016\/j.jmb.2019.05.013","volume":"431","author":"TA Hait","year":"2019","unstructured":"Hait, T. A. et al. The EXPANDER integrated platform for transcriptome analysis. J. Mol. Biol. 431, 2398\u20132406 (2019).","journal-title":"J. Mol. Biol."},{"key":"904_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"904_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","volume":"1","author":"A Liberzon","year":"2015","unstructured":"Liberzon, A. et al. The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst. 1, 417\u2013425 (2015).","journal-title":"Cell Syst."},{"key":"904_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1556\/1886.2018.00006","volume":"8","author":"U Escher","year":"2018","unstructured":"Escher, U. et al. Anti-inflammatory effects of the octapeptide NAP in human microbiota-associated mice suffering from Subacute Ileitis. Eur. J. Microbiol. Immunol. 8, 34\u201340 (2018).","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"904_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.peptides.2017.12.023","volume":"101","author":"MM Heimesaat","year":"2018","unstructured":"Heimesaat, M. M., Giladi, E., Kuhl, A. A., Bereswill, S. & Gozes, I. The octapetide NAP alleviates intestinal and extra-intestinal anti-inflammatory sequelae of acute experimental colitis. Peptides 101, 1\u20139 (2018).","journal-title":"Peptides"},{"key":"904_CR27","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.ydbio.2006.11.039","volume":"303","author":"S Mandel","year":"2007","unstructured":"Mandel, S., Rechavi, G. & Gozes, I. Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev. Biol. 303, 814\u2013824 (2007).","journal-title":"Dev. Biol."},{"key":"904_CR28","doi-asserted-by":"publisher","first-page":"9057","DOI":"10.1523\/JNEUROSCI.4385-15.2016","volume":"36","author":"J Yeung","year":"2016","unstructured":"Yeung, J., Ha, T. J., Swanson, D. J. & Goldowitz, D. A novel and multivalent role of Pax6 in cerebellar development. J. Neurosci. 36, 9057\u20139069 (2016).","journal-title":"J. Neurosci."},{"key":"904_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0357-6","volume":"9","author":"S Sragovich","year":"2019","unstructured":"Sragovich, S. et al. The autism\/neuroprotection-linked ADNP\/NAP regulate the excitatory glutamatergic synapse. Transl. Psychiatry 9, 2 (2019).","journal-title":"Transl. Psychiatry"},{"key":"904_CR30","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/ng0894-463","volume":"7","author":"T Glaser","year":"1994","unstructured":"Glaser, T. et al. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat. Genet. 7, 463\u2013471 (1994).","journal-title":"Nat. Genet."},{"key":"904_CR31","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/nn828","volume":"5","author":"N Heins","year":"2002","unstructured":"Heins, N. et al. Glial cells generate neurons: the role of the transcription factor Pax6. Nat. Neurosci. 5, 308\u2013315 (2002).","journal-title":"Nat. Neurosci."},{"key":"904_CR32","doi-asserted-by":"publisher","first-page":"34448","DOI":"10.1074\/jbc.M704756200","volume":"282","author":"S Mandel","year":"2007","unstructured":"Mandel, S. & Gozes, I. Activity-dependent neuroprotective protein constitutes a novel element in the SWI\/SNF chromatin remodeling complex. J. Biol. Chem. 282, 34448\u201334456 (2007).","journal-title":"J. Biol. Chem."},{"key":"904_CR33","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1007\/s11064-019-02723-6","volume":"44","author":"G Hacohen-Kleiman","year":"2019","unstructured":"Hacohen-Kleiman, G. et al. Atypical auditory brainstem response and protein expression aberrations related to ASD and hearing loss in the adnp haploinsufficient mouse brain. Neurochem. Res. 44, 1494\u20131507 (2019).","journal-title":"Neurochem. Res."},{"key":"904_CR34","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ng1194-269","volume":"8","author":"M Muenke","year":"1994","unstructured":"Muenke, M. et al. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat. Genet. 8, 269\u2013274 (1994).","journal-title":"Nat. Genet."},{"key":"904_CR35","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000312693","volume":"39","author":"C Villanueva","year":"2010","unstructured":"Villanueva, C. & de Roux, N. FGFR1 mutations in Kallmann syndrome. Front. Horm. Res. 39, 51\u201361 (2010).","journal-title":"Front. Horm. Res."},{"key":"904_CR36","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1101\/gad.250703","volume":"17","author":"N Trokovic","year":"2003","unstructured":"Trokovic, N., Trokovic, R., Mai, P. & Partanen, J. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev. 17, 141\u2013153 (2003).","journal-title":"Genes Dev."},{"key":"904_CR37","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.neuron.2020.01.038","volume":"106","author":"C Tai","year":"2020","unstructured":"Tai, C. et al. Tau reduction prevents key features of autism in mouse models. Neuorn 106, 421\u2013437 (2020).","journal-title":"Neuorn"},{"key":"904_CR38","doi-asserted-by":"crossref","unstructured":"La Joie R. et al. Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET. Sci. Transl. Med. 12, eaau5732 (2020).","DOI":"10.1126\/scitranslmed.aau5732"},{"key":"904_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3136","volume":"4","author":"R Tomasoni","year":"2013","unstructured":"Tomasoni, R. et al. SNAP-25 regulates spine formation through postsynaptic binding to p140Cap. Nat. Commun. 4, 2136 (2013).","journal-title":"Nat. Commun."},{"key":"904_CR40","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s12031-015-0640-4","volume":"57","author":"A Malishkevich","year":"2015","unstructured":"Malishkevich, A., Leyk, J., Goldbaum, O., Richter-Landsberg, C. & Gozes, I. ADNP\/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment. J. Mol. Neurosci. 57, 304\u2013313 (2015).","journal-title":"J. Mol. Neurosci."},{"key":"904_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.138","volume":"5","author":"A Malishkevich","year":"2015","unstructured":"Malishkevich, A. et al. Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer\u2019s pathologies. Transl. Psychiatry 5, e501 (2015).","journal-title":"Transl. Psychiatry"},{"key":"904_CR42","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0165-3806(03)00162-7","volume":"144","author":"A Pinhasov","year":"2003","unstructured":"Pinhasov, A. et al. Activity-dependent neuroprotective protein: a novel gene essential for brain formation. Dev. Brain Res. 144, 83\u201390 (2003).","journal-title":"Dev. Brain Res."},{"key":"904_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/srep16300","volume":"5","author":"S Vaisburd","year":"2015","unstructured":"Vaisburd, S., Shemer, Z., Yeheskel, A., Giladi, E. & Gozes, I. Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model. Sci. Rep. 5, 16300 (2015).","journal-title":"Sci. Rep."}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00904-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00904-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00904-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T09:12:06Z","timestamp":1670231526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00904-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["904"],"URL":"https:\/\/doi.org\/10.1038\/s41398-020-00904-4","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]},"assertion":[{"value":"5 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Professor I. Gozes serves as the Chief Scientific Officer of Coronis Neurosciences developing CP201 for the ADNP syndrome.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"228"}}