{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:06:10Z","timestamp":1777295170408,"version":"3.51.4"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The oxytocin (OXT) and dopamine systems synergistically facilitate striatal reactivity. Abnormal striatal activation has repeatedly been observed in patients with bipolar disorder (BD); however, such abnormality remains unclear in BD II. Here we aimed to investigate whether the corticostriatal connectivity was altered and the possible relationships among corticostriatal connectivity, OXT, and dopamine systems in BD II. Twenty-five BD II patients, as defined by the DSM-V, and 29 healthy controls (HC) were enrolled in this study. Plasma OXT was measured and striatal dopamine transporter (DAT) availability was assessed using [<jats:sup>99m<\/jats:sup>Tc]TRODAT-1 single-photon emission computed tomography (SPECT). Brain network functional connectivity (FC) was measured during the resting-state using functional magnetic resonance imaging, and the dorsal caudate (DC) was selected as the seed region. The results showed that the OXT level was significantly lower in the BD II patients, while the striatal DAT availability was not significantly different between the BD II and HC groups. The BD II patients exhibited significantly lower FC between the DC and the executive control network (dorsolateral prefrontal, anterior cingulate cortex, and posterior parietal cortex) as compared with the HC. Only observed in HC, the DC-posterior parietal cortex FC was negatively correlated with the OXT level and striatal DAT availability. Our findings in the HC support a model in which the OXT and dopamine systems act in tandem to regulate corticostriatal circuitry, while the synergistic interaction was perturbed in BD II. Taken together, these results implied a maladaptive neuroplasticity in BD II.<\/jats:p>","DOI":"10.1038\/s41398-020-00972-6","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T12:03:44Z","timestamp":1597233824000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder"],"prefix":"10.1038","volume":"10","author":[{"given":"Shyh-Yuh","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5213-1585","authenticated-orcid":false,"given":"Huai-Hsuan","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-5481","authenticated-orcid":false,"given":"Hui Hua","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Hua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Hung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan Tsing","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4963-578X","authenticated-orcid":false,"given":"Po See","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"972_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.neuron.2017.07.002","volume":"95","author":"A Charlet","year":"2017","unstructured":"Charlet, A. & Grinevich, V. Oxytocin mobilizes midbrain dopamine toward sociality. Neuron 95, 235\u2013237 (2017).","journal-title":"Neuron"},{"key":"972_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.pbb.2013.07.015","volume":"119","author":"M Tops","year":"2014","unstructured":"Tops, M., Koole, S. L., H, I. J. & Buisman-Pijlman, F. T. Why social attachment and oxytocin protect against addiction and stress: Insights from the dynamics between ventral and dorsal corticostriatal systems. Pharmacol. Biochem. Behav. 119, 39\u201348 (2014).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"972_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.72","volume":"7","author":"RAI Bethlehem","year":"2017","unstructured":"Bethlehem, R. A. I. et al. Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women. Transl. Psychiatry 7, e1099 (2017).","journal-title":"Transl. Psychiatry"},{"key":"972_CR4","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1073\/pnas.1612233114","volume":"114","author":"S Atzil","year":"2017","unstructured":"Atzil, S. et al. Dopamine in the medial amygdala network mediates human bonding. Proc. Natl Acad. Sci. USA 114, 2361\u20132366 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"972_CR5","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.neuroscience.2014.10.008","volume":"282","author":"SN Haber","year":"2014","unstructured":"Haber, S. N. The place of dopamine in the cortico-basal ganglia circuit. Neuroscience 282, 248\u2013257 (2014).","journal-title":"Neuroscience"},{"key":"972_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/nature22381","volume":"546","author":"EA Amadei","year":"2017","unstructured":"Amadei, E. A. et al. Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles. Nature 546, 297\u2013301 (2017).","journal-title":"Nature"},{"key":"972_CR7","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1038\/npp.2017.71","volume":"42","author":"E Abraham","year":"2017","unstructured":"Abraham, E. et al. The human coparental bond implicates distinct corticostriatal pathways: longitudinal impact on family formation and child well-being. Neuropsychopharmacology 42, 2301\u20132313 (2017).","journal-title":"Neuropsychopharmacology"},{"key":"972_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.31887\/DCNS.2016.18.1\/shaber","volume":"18","author":"SN Haber","year":"2016","unstructured":"Haber, S. N. Corticostriatal circuitry. Dialogues Clin. Neurosci. 18, 7\u201321 (2016).","journal-title":"Dialogues Clin. Neurosci."},{"key":"972_CR9","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.tins.2010.07.002","volume":"33","author":"P Krack","year":"2010","unstructured":"Krack, P., Hariz, M. I., Baunez, C., Guridi, J. & Obeso, J. A. Deep brain stimulation: from neurology to psychiatry? Trends Neurosci. 33, 474\u2013484 (2010).","journal-title":"Trends Neurosci."},{"key":"972_CR10","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1111\/j.1399-5618.2010.00874.x","volume":"12","author":"WR Marchand","year":"2010","unstructured":"Marchand, W. R. & Yurgelun-Todd, D. Striatal structure and function in mood disorders: a comprehensive review. Bipolar Disord. 12, 764\u2013785 (2010).","journal-title":"Bipolar Disord."},{"key":"972_CR11","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/nrn3469","volume":"14","author":"GM Shepherd","year":"2013","unstructured":"Shepherd, G. M. Corticostriatal connectivity and its role in disease. Nat. Rev. Neurosci. 14, 278\u2013291 (2013).","journal-title":"Nat. Rev. Neurosci."},{"key":"972_CR12","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1017\/S0033291716000143","volume":"46","author":"J Stoddard","year":"2016","unstructured":"Stoddard, J. et al. Aberrant intrinsic functional connectivity within and between corticostriatal and temporal-parietal networks in adults and youth with bipolar disorder. Psychol. Med. 46, 1509\u20131522 (2016).","journal-title":"Psychol. Med."},{"key":"972_CR13","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.1399-5618.2012.01018.x","volume":"14","author":"J Liu","year":"2012","unstructured":"Liu, J. et al. Trait and state corticostriatal dysfunction in bipolar disorder during emotional face processing. Bipolar Disord. 14, 432\u2013441 (2012).","journal-title":"Bipolar Disord."},{"key":"972_CR14","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s12264-018-0315-6","volume":"35","author":"Y Zhong","year":"2019","unstructured":"Zhong, Y. et al. Aberrant resting-state functional connectivity in the default mode network in pediatric bipolar disorder patients with and without psychotic symptoms. Neurosci. Bull. 35, 581\u2013590 (2019).","journal-title":"Neurosci. Bull."},{"key":"972_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.pnpbp.2018.11.009","volume":"90","author":"Z He","year":"2019","unstructured":"He, Z. et al. Altered resting-state cerebral blood flow and functional connectivity of striatum in bipolar disorder and major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 90, 177\u2013185 (2019).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"972_CR16","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.jad.2018.12.068","volume":"246","author":"SA Thomas","year":"2019","unstructured":"Thomas, S. A. et al. Preliminary analysis of resting state functional connectivity in young adults with subtypes of bipolar disorder. J. Affect. Disord. 246, 716\u2013726 (2019).","journal-title":"J. Affect. Disord."},{"key":"972_CR17","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3758\/s13415-011-0083-5","volume":"12","author":"TA Niendam","year":"2012","unstructured":"Niendam, T. A. et al. Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions. Cogn. Affect. Behav. Neurosci. 12, 241\u2013268 (2012).","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"972_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0433-6","volume":"9","author":"M Ernst","year":"2019","unstructured":"Ernst, M. et al. Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation. Transl. Psychiatry 9, 103 (2019).","journal-title":"Transl. Psychiatry"},{"key":"972_CR19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.pnpbp.2018.03.022","volume":"91","author":"KM Han","year":"2019","unstructured":"Han, K. M., De Berardis, D., Fornaro, M. & Kim, Y. K. Differentiating between bipolar and unipolar depression in functional and structural MRI studies. Prog. Neuropsychopharmacol. Biol. Psychiatry 91, 20\u201327 (2019).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"972_CR20","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1111\/j.1524-4733.2010.00768.x","volume":"13","author":"AR Rosa","year":"2010","unstructured":"Rosa, A. R. et al. Functional impairment and disability across mood states in bipolar disorder. Value Health 13, 984\u2013988 (2010).","journal-title":"Value Health"},{"key":"972_CR21","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.bbi.2019.05.011","volume":"80","author":"L Yin","year":"2019","unstructured":"Yin, L. et al. Inflammation and decreased functional connectivity in a widely-distributed network in depression: centralized effects in the ventral medial prefrontal cortex. Brain. Behav. Immun. 80, 657\u2013666 (2019).","journal-title":"Brain. Behav. Immun."},{"key":"972_CR22","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/mp.2017.16","volume":"22","author":"AH Ashok","year":"2017","unstructured":"Ashok, A. H. et al. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Mol. Psychiatry 22, 666\u2013679 (2017).","journal-title":"Mol. Psychiatry"},{"key":"972_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.tips.2013.07.005","volume":"34","author":"RA Vaughan","year":"2013","unstructured":"Vaughan, R. A. & Foster, J. D. Mechanisms of dopamine transporter regulation in normal and disease states. Trends Pharmacol. Sci. 34, 489\u2013496 (2013).","journal-title":"Trends Pharmacol. Sci."},{"key":"972_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00406-014-0570-0","volume":"265","author":"CC Huang","year":"2015","unstructured":"Huang, C. C. et al. Dopamine transporter gene may be associated with bipolar disorder and its personality traits. Eur. Arch. Psychiatry Clin. Neurosci. 265, 281\u2013290 (2015).","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"972_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0316-2","volume":"8","author":"JP Hamilton","year":"2018","unstructured":"Hamilton, J. P. et al. Striatal dopamine deficits predict reductions in striatal functional connectivity in major depression: a concurrent (11)C-raclopride positron emission tomography and functional magnetic resonance imaging investigation. Transl. Psychiatry 8, 264 (2018).","journal-title":"Transl. Psychiatry"},{"key":"972_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.psychres.2017.08.080","volume":"258","author":"YJ Lien","year":"2017","unstructured":"Lien, Y. J. et al. Plasma oxytocin levels in major depressive and bipolar II disorders. Psychiatry Res. 258, 402\u2013406 (2017).","journal-title":"Psychiatry Res."},{"key":"972_CR27","first-page":"34","volume":"59","author":"DV Sheehan","year":"1998","unstructured":"Sheehan, D. V. et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 34\u201357 (1998).","journal-title":"J. Clin. Psychiatry"},{"key":"972_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/YIC.0000000000000067","volume":"30","author":"LT Lee","year":"2015","unstructured":"Lee, L. T. et al. Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study. Int. Clin. Psychopharmacol. 30, 175\u2013178 (2015).","journal-title":"Int. Clin. Psychopharmacol."},{"key":"972_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/JCP.0000000000000632","volume":"37","author":"WH Chang","year":"2017","unstructured":"Chang, W. H. et al. Unaltered dopamine transporter availability in drug-naive patients with schizophrenia after 6 months of antipsychotics treatment: a naturalistic study. J. Clin. Psychopharmacol. 37, 21\u201326 (2017).","journal-title":"J. Clin. Psychopharmacol."},{"key":"972_CR30","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1177\/1087054716654570","volume":"23","author":"YC Tai","year":"2019","unstructured":"Tai, Y. C. et al. Availability of striatal dopamine transporter in healthy individuals with and without a family history of ADHD. J. Atten. Disord. 23, 665\u2013670 (2019).","journal-title":"J. Atten. Disord."},{"key":"972_CR31","first-page":"207","volume":"45","author":"WJ Hwang","year":"2004","unstructured":"Hwang, W. J., Yao, W. J., Wey, S. P. & Ting, G. Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson\u2019s disease. J. Nucl. Med. 45, 207\u2013213 (2004).","journal-title":"J. Nucl. Med."},{"key":"972_CR32","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1093\/cercor\/bhn041","volume":"18","author":"A Di Martino","year":"2008","unstructured":"Di Martino, A. et al. Functional connectivity of human striatum: a resting state FMRI study. Cereb. Cortex 18, 2735\u20132747 (2008).","journal-title":"Cereb. Cortex"},{"key":"972_CR33","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1038\/mp.2015.168","volume":"21","author":"JC Felger","year":"2016","unstructured":"Felger, J. C. et al. Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Mol. Psychiatry 21, 1358\u20131365 (2016).","journal-title":"Mol. Psychiatry"},{"key":"972_CR34","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1097\/WNR.0b013e328310af58","volume":"19","author":"WD Killgore","year":"2008","unstructured":"Killgore, W. D., Gruber, S. A. & Yurgelun-Todd, D. A. Abnormal corticostriatal activity during fear perception in bipolar disorder. Neuroreport 19, 1523\u20131527 (2008).","journal-title":"Neuroreport"},{"key":"972_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-017-0083-7","volume":"5","author":"A Vaskinn","year":"2017","unstructured":"Vaskinn, A. et al. Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity. Int. J. Bipolar Disord. 5, 13 (2017).","journal-title":"Int. J. Bipolar Disord."},{"key":"972_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0670-8","volume":"9","author":"N Petersen","year":"2019","unstructured":"Petersen, N. et al. Resting-state functional connectivity in women with PMDD. Transl. Psychiatry 9, 339 (2019).","journal-title":"Transl. Psychiatry"},{"key":"972_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0560-0","volume":"9","author":"DM Lydon-Staley","year":"2019","unstructured":"Lydon-Staley, D. M. et al. Repetitive negative thinking in daily life and functional connectivity among default mode, fronto-parietal, and salience networks. Transl. Psychiatry 9, 234 (2019).","journal-title":"Transl. Psychiatry"},{"key":"972_CR38","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/pcn.12189","volume":"68","author":"CH Ko","year":"2014","unstructured":"Ko, C. H. et al. Gonadotrophic hormone and reinforcement sensitivity systems in women with premenstrual dysphoric disorder. Psychiatry Clin. Neurosci. 68, 785\u2013794 (2014).","journal-title":"Psychiatry Clin. Neurosci."},{"key":"972_CR39","doi-asserted-by":"publisher","first-page":"103850","DOI":"10.1016\/j.jesp.2019.103850","volume":"85","author":"J Allaert","year":"2019","unstructured":"Allaert, J., De Raedt, R. & Vanderhasselt, M.-A. When choosing means losing: Regret enhances repetitive negative thinking in high brooders. J. Exp. Soc. Psychol. 85, 103850 (2019).","journal-title":"J. Exp. Soc. Psychol."},{"key":"972_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2144","volume":"3","author":"JC Patel","year":"2012","unstructured":"Patel, J. C., Rossignol, E., Rice, M. E. & Machold, R. P. Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits. Nat. Commun. 3, 1172 (2012).","journal-title":"Nat. Commun."},{"key":"972_CR41","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroimage.2011.12.010","volume":"60","author":"JL Robinson","year":"2012","unstructured":"Robinson, J. L. et al. The functional connectivity of the human caudate: an application of meta-analytic connectivity modeling with behavioral filtering. Neuroimage 60, 117\u2013129 (2012).","journal-title":"Neuroimage"},{"key":"972_CR42","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.neuroimage.2006.02.047","volume":"32","author":"AL Krain","year":"2006","unstructured":"Krain, A. L., Wilson, A. M., Arbuckle, R., Castellanos, F. X. & Milham, M. P. Distinct neural mechanisms of risk and ambiguity: a meta-analysis of decision-making. Neuroimage 32, 477\u2013484 (2006).","journal-title":"Neuroimage"},{"key":"972_CR43","first-page":"923","volume":"14","author":"SP Verney","year":"2003","unstructured":"Verney, S. P., Brown, G. G., Frank, L. & Paulus, M. P. Error-rate-related caudate and parietal cortex activation during decision making. Neuroreport 14, 923\u2013928 (2003).","journal-title":"Neuroreport"},{"key":"972_CR44","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.biopsych.2005.06.004","volume":"58","author":"M Ernst","year":"2005","unstructured":"Ernst, M. & Paulus, M. P. Neurobiology of decision making: a selective review from a neurocognitive and clinical perspective. Biol. Psychiatry 58, 597\u2013604 (2005).","journal-title":"Biol. Psychiatry"},{"key":"972_CR45","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.psyneuen.2013.09.026","volume":"39","author":"N Striepens","year":"2014","unstructured":"Striepens, N. et al. Oxytocin enhances attractiveness of unfamiliar female faces independent of the dopamine reward system. Psychoneuroendocrinology 39, 74\u201387 (2014).","journal-title":"Psychoneuroendocrinology"},{"key":"972_CR46","first-page":"35","volume":"36","author":"D Denny-Brown","year":"1958","unstructured":"Denny-Brown, D. & Chambers, R. A. The parietal lobe and behavior. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 36, 35\u2013117 (1958).","journal-title":"Res. Publ. Assoc. Res. Nerv. Ment. Dis."},{"key":"972_CR47","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0166-4328(05)80118-4","volume":"47","author":"E Save","year":"1992","unstructured":"Save, E., Buhot, M. C., Foreman, N. & Thinus-Blanc, C. Exploratory activity and response to a spatial change in rats with hippocampal or posterior parietal cortical lesions. Behav. Brain Res. 47, 113\u2013127 (1992).","journal-title":"Behav. Brain Res."},{"key":"972_CR48","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s12311-015-0706-4","volume":"15","author":"M Diano","year":"2016","unstructured":"Diano, M. et al. Cerebellar clustering and functional connectivity during pain processing. Cerebellum 15, 343\u2013356 (2016).","journal-title":"Cerebellum"},{"key":"972_CR49","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.nicl.2017.03.001","volume":"14","author":"JA Bernard","year":"2017","unstructured":"Bernard, J. A., Orr, J. M. & Mittal, V. A. Cerebello-thalamo-cortical networks predict positive symptom progression in individuals at ultra-high risk for psychosis. Neuroimage Clin. 14, 622\u2013628 (2017).","journal-title":"Neuroimage Clin."},{"key":"972_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0531-5","volume":"9","author":"H Cao","year":"2019","unstructured":"Cao, H., Ingvar, M., Hultman, C. M. & Cannon, T. Evidence for cerebello-thalamo-cortical hyperconnectivity as a heritable trait for schizophrenia. Transl. Psychiatry 9, 192 (2019).","journal-title":"Transl. Psychiatry"},{"key":"972_CR51","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.neubiorev.2013.04.018","volume":"37","author":"ME McCullough","year":"2013","unstructured":"McCullough, M. E., Churchland, P. S. & Mendez, A. J. Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted? Neurosci. Biobehav. Rev. 37, 1485\u20131492 (2013).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"972_CR52","doi-asserted-by":"crossref","unstructured":"Leng, G. & Sabatier, N. Measuring oxytocin and vasopressin: bioassays, immunoassays and random numbers. J. Neuroendocrinol. 28, 12413 (2016).","DOI":"10.1111\/jne.12413"},{"key":"972_CR53","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jneumeth.2014.01.019","volume":"226","author":"KJ Robinson","year":"2014","unstructured":"Robinson, K. J., Hazon, N., Lonergan, M. & Pomeroy, P. P. Validation of an enzyme-linked immunoassay (ELISA) for plasma oxytocin in a novel mammal species reveals potential errors induced by sampling procedure. J. Neurosci. Methods 226, 73\u201379 (2014).","journal-title":"J. Neurosci. Methods"},{"key":"972_CR54","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nrendo.2017.115","volume":"13","author":"EA Lawson","year":"2017","unstructured":"Lawson, E. A. The effects of oxytocin on eating behaviour and metabolism in humans. Nat. Rev. Endocrinol. 13, 700\u2013709 (2017).","journal-title":"Nat. Rev. Endocrinol."},{"key":"972_CR55","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.psyneuen.2011.07.013","volume":"37","author":"JK Rilling","year":"2012","unstructured":"Rilling, J. K. et al. Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men. Psychoneuroendocrinology 37, 447\u2013461 (2012).","journal-title":"Psychoneuroendocrinology"},{"key":"972_CR56","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1503\/jpn.170175","volume":"43","author":"SK Syan","year":"2018","unstructured":"Syan, S. K. et al. Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review. J. Psychiatry Neurosci. 43, 298\u2013316 (2018).","journal-title":"J. Psychiatry Neurosci."}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00972-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00972-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00972-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T14:32:19Z","timestamp":1670250739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-020-00972-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,12]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["972"],"URL":"https:\/\/doi.org\/10.1038\/s41398-020-00972-6","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,12]]},"assertion":[{"value":"18 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"281"}}