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Clinical studies show an association between CD and depression and preclinical evidence suggests that depressive-like behaviors in <jats:italic>T. cruzi<\/jats:italic> infected mice are due, at least partially, to immune dysregulation. However, mechanistic studies regarding this issue are still lacking. Herein, we present and discuss the state of art of data on CD and depression, and revise the mechanisms that may explain the development of depression in CD. We also discuss how the knowledge generated by current and future data may contribute to the discovery of new mechanisms underlying depressive symptoms associated with CD and, hence, to the identification of new therapeutic targets, which ultimately may change the way we see and treat CD and its psychiatric comorbidities.<\/jats:p>","DOI":"10.1038\/s41398-020-01105-9","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T20:03:42Z","timestamp":1606939422000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Shared neuroimmune and oxidative pathways underpinning Chagas disease and major depressive disorder"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-7090","authenticated-orcid":false,"given":"Eduardo","family":"Duarte-Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-5930","authenticated-orcid":false,"given":"Christina Alves","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"1105_CR1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1038\/nature09220","volume":"465","author":"J Clayton","year":"2010","unstructured":"Clayton, J. 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