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In order to identify susceptible gene and drug-response-related markers, 2413 subjects in our research were chosen for determining drug-response-related markers in schizophrenia. The rs1516569 variant (OR\u2009=\u20090.95, <jats:italic>P<\/jats:italic>\u2009&lt;\u20093.47\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>) was a significant risk factor, and a single-nucleotide polymorphism of <jats:italic>GRM7<\/jats:italic> gene- rs9883258 (OR\u2009=\u20090.84, <jats:italic>P<\/jats:italic>\u2009=\u20092.18\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>) has been determined as potential biomarkers for therapeutic responses of seven commonly used antipsychotic drugs (aripiprazole, haloperidol, olanzapine, perphenazine, quetiapine, risperidone and ziprasidone) in Chinese Han population; Significant associations with treatment response for several single-nucleotide polymorphisms in every antipsychotic drugs, such as rs779746 (OR\u2009=\u20091.39, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), rs480409 (OR\u2009=\u20090.73, <jats:italic>P<\/jats:italic>\u2009=\u20090.04), rs78137319 (OR\u2009=\u20093.09, <jats:italic>P<\/jats:italic>\u2009=\u20090.04), rs1154370 (OR\u2009=\u20091.51, <jats:italic>P<\/jats:italic>\u2009=\u20090.006) have been identified in our study. Hence our research elucidates that <jats:italic>GRM7<\/jats:italic> variants play the critical role of predicting the risk of schizophrenia and antipsychotic effect of seven common drugs.<\/jats:p>","DOI":"10.1038\/s41398-020-0763-4","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T12:03:54Z","timestamp":1583237034000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia"],"prefix":"10.1038","volume":"10","author":[{"given":"Wei","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-8489","authenticated-orcid":false,"given":"Hao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-9037","authenticated-orcid":false,"given":"Hao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-8465","authenticated-orcid":false,"given":"Weihua","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"763_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0140-6736(95)91325-4","volume":"346","author":"NC Andreasen","year":"1995","unstructured":"Andreasen, N. 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