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Hallmark psychotic symptoms can be considered as existing on a continuum from non-clinical to clinical populations. Assessing genetic risk and psychotic-like experiences (PLEs) in non-clinical populations and their associated neurobiological underpinnings can offer valuable insights into symptom-associated brain mechanisms without the potential confounds of the effects of schizophrenia and its treatment. We leveraged a large population-based cohort (UKBiobank,\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20093875) including information on PLEs (obtained from the Mental Health Questionnaire (MHQ); UKBiobank Category: 144;\n                    <jats:italic>N<\/jats:italic>\n                    auditory hallucinations\u2009=\u200955,\n                    <jats:italic>N<\/jats:italic>\n                    visual hallucinations\u2009=\u200979,\n                    <jats:italic>N<\/jats:italic>\n                    persecutory delusions\u2009=\u200916,\n                    <jats:italic>N<\/jats:italic>\n                    delusions of reference\u2009=\u200913), polygenic risk scores for schizophrenia (PRS\n                    <jats:sub>SZ<\/jats:sub>\n                    ) and multi-modal brain imaging in combination with network neuroscience. Morphometric (cortical thickness, volume) and water diffusion (fractional anisotropy) properties of the regions and pathways belonging to the salience, default-mode, and central-executive networks were computed. We hypothesized that these anatomical concomitants of functional dysconnectivity would be negatively associated with PRS\n                    <jats:sub>SZ<\/jats:sub>\n                    and PLEs. PRS\n                    <jats:sub>SZ<\/jats:sub>\n                    was significantly associated with a latent measure of cortical thickness across the salience network (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.069,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010) and PLEs showed a number of significant associations, both negative and positive, with properties of the salience and default mode networks (involving the insular cortex, supramarginal gyrus, and pars orbitalis,\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>FDR<\/jats:sub>\n                    \u2009&lt;\u20090.050); with the cortical thickness of the insula largely mediating the relationship between PRS\n                    <jats:sub>SZ<\/jats:sub>\n                    and auditory hallucinations. Generally, these results are consistent with the hypothesis that higher genetic liability for schizophrenia is related to subtle disruptions in brain structure and may predispose to PLEs even among healthy participants. In addition, our study suggests that networks engaged during auditory hallucinations show structural associations with PLEs in the general population.\n                  <\/jats:p>","DOI":"10.1038\/s41398-020-0794-x","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T12:56:37Z","timestamp":1587992197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-8055","authenticated-orcid":false,"given":"C.","family":"Alloza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blesa-C\u00e1bez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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In the last 3 years, S.M.L. has received research support from Janssen, and personal fees from Janssen and Sunovion. A.M.M. has previously received financial support from Janssen and Lilly. A.M.M., H.C.W., and S.M.L. have previously received financial support from Pfizer (formerly Wyeth) in relation to imaging studies of people with schizophrenia and bipolar disorder. All other authors report no biomedical financial interests or potential conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"122"}}