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We investigated pleiotropy amongst the common variant genomics of schizophrenia and seven other psychiatric disorders using a multimarker association test. Transcriptomic imputation was then leveraged to investigate the functional significance of variation mapped to these genes, prioritising several interesting functional candidates. Gene-based analysis of common variation revealed 67 schizophrenia-associated genes shared with other psychiatric phenotypes, including bipolar disorder, major depressive disorder, ADHD and autism-spectrum disorder. In addition, we uncovered 78 genes significantly enriched with common variant associations for schizophrenia that were not linked to any of these seven disorders (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05). Multivariable gene-set association suggested that common variation enrichment within biologically constrained genes observed for schizophrenia also occurs across several psychiatric phenotypes. Pairwise meta-analysis of schizophrenia and each psychiatric phenotype was implemented and identified 330 significantly associated genes (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>Meta<\/jats:sub>\n                    \u2009&lt;\u20092.7\u2009\u00d7\u200910\n                    <jats:sup>\u22126<\/jats:sup>\n                    ) that were only nominally associated with each disorder individually (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). These analyses consolidate the overlap between the genomic architecture of schizophrenia and other psychiatric disorders, uncovering several candidate pleiotropic genes which warrant further investigation.\n                  <\/jats:p>","DOI":"10.1038\/s41398-020-0817-7","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:04:49Z","timestamp":1589277889000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations"],"prefix":"10.1038","volume":"10","author":[{"given":"William R.","family":"Reay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-2538","authenticated-orcid":false,"given":"Murray J.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"817_CR1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41588-018-0059-2","volume":"50","author":"AF Pardi\u00f1as","year":"2018","unstructured":"Pardi\u00f1as, A. 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