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A total of 460 COVID-19 patients from 13 medical centers in Hubei province were investigated for their mental health status using online questionnaires (including Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Patient Health Questionnaire-15, and Insomnia Severity Index scales). Among all 460 COVID-19 patients, 187 (40.65%) of them were healthcare workers (HCWs). 297 (64.57%) of them were females. The most common psychological problems were somatization symptoms (66.09%, <jats:italic>n<\/jats:italic>\u2009=\u2009304), followed by depression (53.48%, <jats:italic>n<\/jats:italic>\u2009=\u2009246), anxiety (46.30%, <jats:italic>n<\/jats:italic>\u2009=\u2009213), problems of insomnia (42.01%, <jats:italic>n<\/jats:italic>\u2009=\u2009171), and then self-mutilating or suicidal thoughts (23.26%, <jats:italic>n<\/jats:italic>\u2009=\u2009107). Of all the patients, 15.65% (<jats:italic>n<\/jats:italic>\u2009=\u200972) had severe somatization symptoms, and 2.83% (<jats:italic>n<\/jats:italic>\u2009=\u200913) had severe (almost every day) self-mutilating or suicidal thoughts. The most common psychological problems for HCWs were somatization symptoms (67.84%, <jats:italic>n<\/jats:italic>\u2009=\u2009125), followed by depression (51.87%, <jats:italic>n<\/jats:italic>\u2009=\u200997), anxiety (44.92%, <jats:italic>n<\/jats:italic>\u2009=\u200984), problems of insomnia (36.18%, <jats:italic>n<\/jats:italic>\u2009=\u200955), and then self-mutilating or suicidal thoughts (20.86%, <jats:italic>n<\/jats:italic>\u2009=\u200939). Patients with lower education levels were found to be associated with higher incidence of self-mutilating or suicidal thoughts (odds ratio [OR], 2.68, 95% confidence interval [95% CI], 1.66\u20134.33 [<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001]). Patients with abnormal body temperature were found to be associated with higher incidence of self-mutilating or suicidal thoughts (OR, 3.97, 95% CI, 2.07\u20137.63 [<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001]), somatic symptoms (OR, 2.06, 95% CI, 1.20\u20133.55 [<jats:italic>P<\/jats:italic>\u2009=\u20090.009]) and insomnia (OR, 1.66, 95% CI, 1.04\u20132.65 [<jats:italic>P<\/jats:italic>\u2009=\u20090.033]). Those with suspected infected family members displayed a higher prevalence of anxiety than those without infected family members (OR, 1.61, 95% CI, 1.1\u20132.37 [<jats:italic>P<\/jats:italic>\u2009=\u20090.015]). Patients at the age of 18\u201344 years old had fewer somatic symptoms than those aged over 45 years old (OR, 1.91, 95% CI, 1.3\u20132.81 [<jats:italic>P<\/jats:italic>\u2009=\u20090.001]). In conclusion, COVID-19 patients tended to have a high prevalence of adverse psychological events. Early identification and intervention should be conducted to avoid extreme events such as self-mutilating or suicidal impulsivity for COVID-19 patients, especially for those with low education levels and females who have undergone divorce or bereavement.<\/jats:p>","DOI":"10.1038\/s41398-021-01259-0","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T09:06:15Z","timestamp":1613811975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Acute psychological impact on COVID-19 patients in Hubei: a multicenter observational study"],"prefix":"10.1038","volume":"11","author":[{"given":"Minghuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canshou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfa","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiyan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia Jiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suiqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4511-8083","authenticated-orcid":false,"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"1259_CR1","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.ijid.2020.01.009","volume":"91","author":"DS Hui","year":"2020","unstructured":"Hui, D. 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