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We previously identified a genetic risk variant for cocaine addiction in the\n                    <jats:italic>PLCB1<\/jats:italic>\n                    gene and found this gene upregulated in postmortem brains of cocaine abusers and in human dopaminergic neuron-like cells after an acute cocaine exposure. Here, we functionally tested the contribution of the\n                    <jats:italic>PLCB1<\/jats:italic>\n                    gene to cocaine addictive properties using\n                    <jats:italic>Plcb1<\/jats:italic>\n                    +\/\u2212\u2009mice. First, we performed a general phenotypic characterization and found that\n                    <jats:italic>Plcb1<\/jats:italic>\n                    +\/\u2212\u2009mice showed normal behavior, although they had increased anxiety and impaired short-term memory. Subsequently, mice were trained for operant conditioning, self-administered cocaine for 10 days, and were tested for cocaine motivation. After extinction, we found a reduction in the cue-induced reinstatement of cocaine-seeking behavior in\n                    <jats:italic>Plcb1<\/jats:italic>\n                    +\/\u2212\u2009mice. After reinstatement, we identified transcriptomic alterations in the medial prefrontal cortex of\n                    <jats:italic>Plcb1<\/jats:italic>\n                    +\/\u2212\u2009mice, mostly related to pathways relevant to addiction like the dopaminergic synapse and long-term potentiation. To conclude, we found that heterozygous deletion of the\n                    <jats:italic>Plcb1<\/jats:italic>\n                    gene decreases cue-induced reinstatement of cocaine-seeking, pointing at PLCB1 as a possible therapeutic target for preventing relapse and treating cocaine addiction.\n                  <\/jats:p>","DOI":"10.1038\/s41398-021-01396-6","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T11:47:27Z","timestamp":1633952847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1\u2009+\/\u2212\u2009mice"],"prefix":"10.1038","volume":"11","author":[{"given":"Judit","family":"Cabana-Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mart\u00edn-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gallego-Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-8773","authenticated-orcid":false,"given":"Rafael","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e8lia","family":"Fern\u00e0ndez-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-4382","authenticated-orcid":false,"given":"Bru","family":"Cormand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"1396_CR1","doi-asserted-by":"publisher","unstructured":"UNODC. 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