{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:44:15Z","timestamp":1789382655662,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2014M3C7A1046049"],"award-info":[{"award-number":["2014M3C7A1046049"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF2014M3C7A1046042"],"award-info":[{"award-number":["NRF2014M3C7A1046042"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. Besides the apolipoprotein E \u03b54 (<jats:italic>APOE<\/jats:italic> \u03b54) allele, a few dozen other genetic loci associated with AD have been identified through genome-wide association studies (GWAS) conducted mainly in individuals of European ancestry. Recently, several GWAS performed in other ethnic groups have shown the importance of replicating studies that identify previously established risk loci and searching for novel risk loci. <jats:italic>APOE<\/jats:italic>-stratified GWAS have yielded novel AD risk loci that might be masked by, or be dependent on, <jats:italic>APOE<\/jats:italic> alleles. We performed whole-genome sequencing (WGS) on DNA from blood samples of 331 AD patients and 169 elderly controls of Korean ethnicity who were <jats:italic>APOE<\/jats:italic> \u03b54 carriers. Based on WGS data, we designed a customized AD chip (cAD chip) for further analysis on an independent set of 543 AD patients and 894 elderly controls of the same ethnicity, regardless of their <jats:italic>APOE<\/jats:italic> \u03b54 allele status. Combined analysis of WGS and cAD chip data revealed that SNPs rs1890078 (<jats:italic>P<\/jats:italic>\u2009=\u20096.64E\u221207) and rs12594991 (<jats:italic>P<\/jats:italic>\u2009=\u20092.03E\u221207) in <jats:italic>SORCS1<\/jats:italic> and <jats:italic>CHD2<\/jats:italic> genes, respectively, are novel genetic variants among <jats:italic>APOE<\/jats:italic> \u03b54 carriers in the Korean population. In addition, nine possible novel variants that were rare in individuals of European ancestry but common in East Asia were identified. This study demonstrates that <jats:italic>APOE<\/jats:italic>-stratified analysis is important for understanding the genetic background of AD in different populations.<\/jats:p>","DOI":"10.1038\/s41398-021-01412-9","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T20:02:26Z","timestamp":1621454546000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Novel Alzheimer\u2019s disease risk variants identified based on whole-genome sequencing of APOE \u03b54 carriers"],"prefix":"10.1038","volume":"11","author":[{"given":"Jong-Ho","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia Moonkyung","family":"Youm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sejoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-5154","authenticated-orcid":false,"given":"Jun Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahyun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Ju","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nari","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Yoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-4611","authenticated-orcid":false,"given":"Hoyoung","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki woong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hye","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyang","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8908-0884","authenticated-orcid":false,"given":"Junehawk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younghoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung Alice","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-9242","authenticated-orcid":false,"given":"Jong-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"1412_CR1","doi-asserted-by":"crossref","unstructured":"Holtzman D. M., Morris J. C. & Goate A. M. Alzheimer\u2019s disease: the challenge of the second century. Sci. Transl. Med. 3, 77sr71 (2011).","DOI":"10.1126\/scitranslmed.3002369"},{"key":"1412_CR2","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","volume":"80","author":"LE Hebert","year":"2013","unstructured":"Hebert, L. E., Weuve, J., Scherr, P. A. & Evans, D. A. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology 80, 1778\u20131783 (2013).","journal-title":"Neurology"},{"key":"1412_CR3","doi-asserted-by":"publisher","unstructured":"Alzheimer\u2019s Association Report. Alzheimer\u2019s disease facts and figures. Alzheimers Dement. 16, 391\u2013460 https:\/\/doi.org\/10.1002\/alz.12068 (2020).","DOI":"10.1002\/alz.12068"},{"key":"1412_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3233\/JAD-2010-101221","volume":"23","author":"KW Kim","year":"2011","unstructured":"Kim, K. W. et al. A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea. J. Alzheimers Dis. 23, 281\u2013291 (2011).","journal-title":"J. Alzheimers Dis."},{"key":"1412_CR5","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S1474-4422(16)00127-7","volume":"15","author":"E Cuyvers","year":"2016","unstructured":"Cuyvers, E. & Sleegers, K. Genetic variations underlying Alzheimer\u2019s disease: evidence from genome-wide association studies and beyond. Lancet Neurol. 15, 857\u2013868 (2016).","journal-title":"Lancet Neurol."},{"key":"1412_CR6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","volume":"63","author":"M Gatz","year":"2006","unstructured":"Gatz, M. et al. Role of genes and environments for explaining Alzheimer disease. Arch. Gen. Psychiatry 63, 168\u2013174 (2006).","journal-title":"Arch. Gen. Psychiatry"},{"key":"1412_CR7","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/gim.2015.117","volume":"18","author":"C Van Cauwenberghe","year":"2016","unstructured":"Van Cauwenberghe, C., Van Broeckhoven, C. & Sleegers, K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genet. Med. 18, 421\u2013430 (2016).","journal-title":"Genet. Med."},{"key":"1412_CR8","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/ng.2802","volume":"45","author":"JC Lambert","year":"2013","unstructured":"Lambert, J. C. et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat. Genet. 45, 1452\u20131458 (2013).","journal-title":"Nat. Genet."},{"key":"1412_CR9","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41588-018-0311-9","volume":"51","author":"IE Jansen","year":"2019","unstructured":"Jansen, I. E. et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer\u2019s disease risk. Nat. Genet. 51, 404\u2013413 (2019).","journal-title":"Nat. Genet."},{"key":"1412_CR10","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","volume":"51","author":"BW Kunkle","year":"2019","unstructured":"Kunkle, B. W. et al. Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing. Nat. Genet. 51, 414\u2013430 (2019).","journal-title":"Nat. Genet."},{"key":"1412_CR11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S1474-4422(19)30435-1","volume":"19","author":"SJ Andrews","year":"2020","unstructured":"Andrews, S. J., Fulton-Howard, B. & Goate, A. Interpretation of risk loci from genome-wide association studies of Alzheimer\u2019s disease. Lancet Neurol. 19, 326\u2013335 (2020).","journal-title":"Lancet Neurol."},{"key":"1412_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41398-018-0150-6","volume":"8","author":"RE Marioni","year":"2018","unstructured":"Marioni, R. E. et al. GWAS on family history of Alzheimer\u2019s disease. Transl. Psychiatry 8, 99 (2018).","journal-title":"Transl. Psychiatry"},{"key":"1412_CR13","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1001\/jama.2013.2973","volume":"309","author":"C Reitz","year":"2013","unstructured":"Reitz, C. et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans. JAMA 309, 1483\u20131492 (2013).","journal-title":"JAMA"},{"key":"1412_CR14","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1086\/503687","volume":"78","author":"Y Meng","year":"2006","unstructured":"Meng, Y. et al. Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community. Am. J. Hum. Genet. 78, 871\u2013877 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"1412_CR15","doi-asserted-by":"publisher","first-page":"e58618","DOI":"10.1371\/journal.pone.0058618","volume":"8","author":"A Miyashita","year":"2013","unstructured":"Miyashita, A. et al. SORL1 is genetically associated with late-onset Alzheimer\u2019s disease in Japanese, Koreans and Caucasians. PLoS ONE 8, e58618 (2013).","journal-title":"PLoS ONE"},{"key":"1412_CR16","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1001\/jamaneurol.2018.4249","volume":"76","author":"JC Morris","year":"2019","unstructured":"Morris, J. C. et al. Assessment of racial disparities in biomarkers for Alzheimer disease. JAMA Neurol. 76, 264\u2013273 (2019).","journal-title":"JAMA Neurol."},{"key":"1412_CR17","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/mp.2015.23","volume":"21","author":"G Jun","year":"2016","unstructured":"Jun, G. et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Mol. Psychiatry 21, 108\u2013117 (2016).","journal-title":"Mol. Psychiatry"},{"key":"1412_CR18","doi-asserted-by":"publisher","first-page":"160.e1","DOI":"10.1016\/j.neurobiolaging.2018.03.006","volume":"68","author":"B Wang","year":"2018","unstructured":"Wang, B. et al. A rare variant in MLKL confers susceptibility to ApoE varepsilon4-negative Alzheimer\u2019s disease in Hong Kong Chinese population. Neurobiol Aging 68, 160.e1\u2013160.e7 (2018).","journal-title":"Neurobiol Aging"},{"key":"1412_CR19","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1001\/jamaneurol.2019.1456","volume":"76","author":"Y Ma","year":"2019","unstructured":"Ma, Y. et al. Analysis of Whole-exome sequencing data for Alzheimer disease stratified by APOE genotype. JAMA Neurol. 76, 1099\u20131108 (2019).","journal-title":"JAMA Neurol."},{"key":"1412_CR20","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754\u20131760 (2009).","journal-title":"Bioinformatics"},{"key":"1412_CR21","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna, A. et al. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297\u20131303 (2010).","journal-title":"Genome Res."},{"key":"1412_CR22","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang, K., Li, M. & Hakonarson, H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res. 38, e164 (2010).","journal-title":"Nucleic Acids Res."},{"key":"1412_CR23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature19057","volume":"536","author":"M Lek","year":"2016","unstructured":"Lek, M. et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 536, 285\u2013291 (2016).","journal-title":"Nature"},{"key":"1412_CR24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng1934","volume":"39","author":"L Bertram","year":"2007","unstructured":"Bertram, L., McQueen, M. B., Mullin, K., Blacker, D. & Tanzi, R. E. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39, 17\u201323 (2007).","journal-title":"Nat. Genet."},{"key":"1412_CR25","doi-asserted-by":"publisher","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","volume":"42","author":"D Welter","year":"2014","unstructured":"Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res 42, D1001\u2013D1006 (2014).","journal-title":"Nucleic Acids Res"},{"key":"1412_CR26","doi-asserted-by":"publisher","first-page":"D877","DOI":"10.1093\/nar\/gkv1340","volume":"44","author":"LD Ward","year":"2016","unstructured":"Ward, L. D. & Kellis, M. HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease. Nucleic Acids Res. 44, D877\u2013D881 (2016).","journal-title":"Nucleic Acids Res."},{"key":"1412_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","volume":"4","author":"CC Chang","year":"2015","unstructured":"Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience 4, 7 (2015).","journal-title":"Gigascience"},{"key":"1412_CR28","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","volume":"26","author":"RJ Pruim","year":"2010","unstructured":"Pruim, R. J. et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336\u20132337 (2010).","journal-title":"Bioinformatics"},{"key":"1412_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.jalz.2016.12.012","volume":"13","author":"GR Jun","year":"2017","unstructured":"Jun, G. R. et al. Transethnic genome-wide scan identifies novel Alzheimer\u2019s disease loci. Alzheimers Dement. 13, 727\u2013738 (2017).","journal-title":"Alzheimers Dement."},{"key":"1412_CR30","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1093\/brain\/awv052","volume":"138","author":"EC Galizia","year":"2015","unstructured":"Galizia, E. C. et al. CHD2 variants are a risk factor for photosensitivity in epilepsy. Brain 138, 1198\u20131207 (2015).","journal-title":"Brain"},{"key":"1412_CR31","unstructured":"Carvill, G., Helbig I. & Mefford, H. CHD2-related neurodevelopmental disorders. (ed Adam, M. P. et al.). GeneReviews(R) (1993)."},{"key":"1412_CR32","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.neuron.2018.09.049","volume":"100","author":"YJ Kim","year":"2018","unstructured":"Kim, Y. J. et al. Chd2 is necessary for neural circuit development and long-term memory. Neuron 100, 1180\u20131193 e1186 (2018).","journal-title":"Neuron"},{"key":"1412_CR33","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.neuron.2018.11.036","volume":"100","author":"V Nieto-Estevez","year":"2018","unstructured":"Nieto-Estevez, V. & Hsieh, J. CHD2: one gene, many roles. Neuron 100, 1014\u20131016 (2018).","journal-title":"Neuron"},{"key":"1412_CR34","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1002\/stem.2001","volume":"33","author":"TJ Shen","year":"2015","unstructured":"Shen, T. J., Ji, F., Yuan, Z. Q. & Jiao, J. W. CHD2 is required for embryonic neurogenesis in the developing cerebral cortex. Stem Cells 33, 1794\u20131806 (2015).","journal-title":"Stem Cells"},{"key":"1412_CR35","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1038\/ng.2756","volume":"45","author":"HJ Westra","year":"2013","unstructured":"Westra, H. J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238\u20131243 (2013).","journal-title":"Nat. Genet."},{"key":"1412_CR36","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhlen","year":"2015","unstructured":"Uhlen, M. et al. Proteomics. Tissue-based map of the human proteome. Science 347, 1260419 (2015).","journal-title":"Science"},{"key":"1412_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jnc.13231","volume":"135","author":"EJ Coulson","year":"2015","unstructured":"Coulson, E. J. & Andersen, O. M. The A-B-C for SORting APP. J. Neurochemistry 135, 1\u20133 (2015).","journal-title":"J. Neurochemistry"},{"key":"1412_CR38","doi-asserted-by":"publisher","first-page":"e63621","DOI":"10.1371\/journal.pone.0063621","volume":"8","author":"W Xu","year":"2013","unstructured":"Xu, W. et al. The genetic variation of SORCS1 is associated with late-onset Alzheimer\u2019s disease in Chinese Han population. PLoS ONE 8, e63621 (2013).","journal-title":"PLoS ONE"},{"key":"1412_CR39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.brainres.2012.01.067","volume":"1448","author":"HF Wang","year":"2012","unstructured":"Wang, H. F. et al. SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer\u2019s disease in a Northern Han Chinese population. Brain Res. 1448, 111\u2013116 (2012).","journal-title":"Brain Res."},{"key":"1412_CR40","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13040-014-0035-z","volume":"7","author":"CS Floudas","year":"2014","unstructured":"Floudas, C. S., Um, N., Kamboh, M. I., Barmada, M. M. & Visweswaran, S. Identifying genetic interactions associated with late-onset Alzheimer\u2019s disease. BioData Min. 7, 35 (2014).","journal-title":"BioData Min."},{"key":"1412_CR41","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1074\/mcp.M114.041533","volume":"14","author":"B Dislich","year":"2015","unstructured":"Dislich, B. et al. Label-free quantitative proteomics of mouse cerebrospinal fluid detects beta-site APP Cleaving enzyme (BACE1) protease substrates in vivo. Mol. Cell Proteom. 14, 2550\u20132563 (2015).","journal-title":"Mol. Cell Proteom."},{"key":"1412_CR42","doi-asserted-by":"publisher","first-page":"2476","DOI":"10.1093\/cercor\/bht101","volume":"24","author":"M Hokama","year":"2014","unstructured":"Hokama, M. et al. Altered expression of diabetes-related genes in Alzheimer\u2019s disease brains: the Hisayama study. Cereb. Cortex 24, 2476\u20132488 (2014).","journal-title":"Cereb. Cortex"},{"key":"1412_CR43","doi-asserted-by":"publisher","first-page":"14134","DOI":"10.1523\/JNEUROSCI.1711-10.2010","volume":"30","author":"D Oh","year":"2010","unstructured":"Oh, D. et al. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J. Neurosci. 30, 14134\u201314144 (2010).","journal-title":"J. Neurosci."}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01412-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01412-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01412-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:48:29Z","timestamp":1747147709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01412-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["1412"],"URL":"https:\/\/doi.org\/10.1038\/s41398-021-01412-9","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"8 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In this article the affiliation details for Jong-Won Kim were incorrectly given as 'Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea' but should have been 'Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea'.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"296"}}