{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:25:16Z","timestamp":1793316316909,"version":"4.5.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007543","name":"Grantov\u00e1 Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["1780218"],"award-info":[{"award-number":["1780218"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009532","name":"Ministerstvo Vnitra \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["VI20172020056"],"award-info":[{"award-number":["VI20172020056"]}],"id":[{"id":"10.13039\/100009532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009532","name":"Ministerstvo Vnitra \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["VI20172020056"],"award-info":[{"award-number":["VI20172020056"]}],"id":[{"id":"10.13039\/100009532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009532","name":"Ministerstvo Vnitra \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["VI20172020056"],"award-info":[{"award-number":["VI20172020056"]}],"id":[{"id":"10.13039\/100009532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009532","name":"Ministerstvo Vnitra \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["VI20172020056"],"award-info":[{"award-number":["VI20172020056"]}],"id":[{"id":"10.13039\/100009532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009532","name":"Ministerstvo Vnitra \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["VI20172020056"],"award-info":[{"award-number":["VI20172020056"]}],"id":[{"id":"10.13039\/100009532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00023752"],"award-info":[{"award-number":["00023752"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00023752"],"award-info":[{"award-number":["00023752"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00023752"],"award-info":[{"award-number":["00023752"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00023752"],"award-info":[{"award-number":["00023752"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["00023752"],"award-info":[{"award-number":["00023752"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LO1611"],"award-info":[{"award-number":["LO1611"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LO1611"],"award-info":[{"award-number":["LO1611"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LO1611"],"award-info":[{"award-number":["LO1611"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LO1611"],"award-info":[{"award-number":["LO1611"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LO1611"],"award-info":[{"award-number":["LO1611"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["18-16218"],"award-info":[{"award-number":["18-16218"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["20-25349S"],"award-info":[{"award-number":["20-25349S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["18-16218"],"award-info":[{"award-number":["18-16218"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["18-16218"],"award-info":[{"award-number":["18-16218"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serotonergic psychedelics are recently gaining a lot of attention as a potential treatment of several neuropsychiatric disorders. Broadband desynchronization of EEG activity and disconnection in humans have been repeatedly shown; however, translational data from animals are completely lacking. Therefore, the main aim of our study was to assess the effects of tryptamine and phenethylamine psychedelics (psilocin 4\u2009mg\/kg, LSD 0.2\u2009mg\/kg, mescaline 100\u2009mg\/kg, and DOB 5\u2009mg\/kg) on EEG in freely moving rats. A system consisting of 14 cortical EEG electrodes, co-registration of behavioral activity of animals with subsequent analysis only in segments corresponding to behavioral inactivity (resting-state-like EEG) was used in order to reach a high level of translational validity. Analyses of the mean power, topographic brain-mapping, and functional connectivity revealed that all of the psychedelics irrespective of the structural family induced overall and time-dependent global decrease\/desynchronization of EEG activity and disconnection within 1\u201340\u2009Hz. Major changes in activity were localized on the large areas of the frontal and sensorimotor cortex showing some subtle spatial patterns characterizing each substance. A rebound of occipital theta (4\u20138\u2009Hz) activity was detected at later stages after treatment with mescaline and LSD. Connectivity analyses showed an overall decrease in global connectivity for both the components of cross-spectral and phase-lagged coherence. Since our results show almost identical effects to those known from human EEG\/MEG studies, we conclude that our method has robust translational validity.<\/jats:p>","DOI":"10.1038\/s41398-021-01603-4","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T12:58:52Z","timestamp":1633352332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Psilocin, LSD, mescaline, and DOB all induce broadband desynchronization of EEG and disconnection in rats with robust translational validity"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-5978","authenticated-orcid":false,"given":"\u010cestm\u00edr","family":"Vejmola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-6999","authenticated-orcid":false,"given":"Filip","family":"Tyl\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clava","family":"Pioreck\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlastimil","family":"Koudelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk\u00e1\u0161","family":"Kade\u0159\u00e1bek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9156-9654","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Nov\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-9539","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"P\u00e1len\u00ed\u010dek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"1603_CR1","doi-asserted-by":"publisher","first-page":"e12412","DOI":"10.1371\/journal.pone.0012412","volume":"5","author":"E Studerus","year":"2010","unstructured":"Studerus E, Gamma A, Vollenweider FX. Psychometric evaluation of the altered states of consciousness rating scale (OAV). PLoS ONE. 2010;5:e12412.","journal-title":"PLoS ONE"},{"key":"1603_CR2","unstructured":"Shulgin, A. TiHKAL\u2014tryptamines I have known and loved; the continuation. Berkeley, CA: Transform Press; 1997."},{"key":"1603_CR3","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1007\/s00204-015-1513-x","volume":"89","author":"AM Ara\u00fajo","year":"2015","unstructured":"Ara\u00fajo AM, Carvalho F, Bastos MDL, Guedes de Pinho P, Carvalho M. The hallucinogenic world of tryptamines: an updated review. Arch Toxicol 2015;89:1151\u20131173.","journal-title":"Arch Toxicol"},{"key":"1603_CR4","unstructured":"Shulgin, A. PiHKAL\u2014phenethylamines I have known and loved; a chemical love story. Berkeley, CA: Transform Press; 1991."},{"key":"1603_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbr.2014.07.016","volume":"277","author":"AL Halberstadt","year":"2015","unstructured":"Halberstadt AL. Recent advances in the neuropsychopharmacology of serotonergic hallucinogens. Behav Brain Res. 2015;277:99\u2013120.","journal-title":"Behav Brain Res."},{"key":"1603_CR6","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1124\/pr.115.011478","volume":"68","author":"DE Nichols","year":"2016","unstructured":"Nichols DE. Psychedelics. Pharm Rev. 2016;68:264\u2013355.","journal-title":"Pharm Rev"},{"key":"1603_CR7","first-page":"642","volume":"11","author":"FX Vollenweider","year":"2010","unstructured":"Vollenweider FX, Kometer M. The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nature. 2010;11:642\u2013651.","journal-title":"Nature"},{"key":"1603_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1177\/2045125314527985","volume":"4","author":"D Baumeister","year":"2014","unstructured":"Baumeister D, Barnes G, Giaroli G, Tracy D. Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles. Ther Adv Psychopharmacol. 2014;4:156\u201369.","journal-title":"Ther Adv Psychopharmacol."},{"key":"1603_CR9","first-page":"11","volume":"0366","author":"RL Carhart-Harris","year":"2016","unstructured":"Carhart-Harris RL, Bolstridge M, Rucker J, Day CMJ, Erritzoe D, Kaelen M, et al. Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry. 2016;0366:11\u201313.","journal-title":"Lancet Psychiatry"},{"key":"1603_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-17546-0","volume":"7","author":"S Atasoy","year":"2017","unstructured":"Atasoy S, Roseman L, Kaelen M, Kringelbach ML, Deco G, Carhart-Harris RL. Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Sci Rep. 2017;7:1\u201318.","journal-title":"Sci Rep."},{"key":"1603_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fnhum.2014.00020","volume":"8","author":"RL Carhart-Harris","year":"2014","unstructured":"Carhart-Harris RL, Leech R, Hellyer PJ, Shanahan M, Feilding A, Tagliazucchi E, et al. The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs. Front Hum Neurosci. 2014;8:20.","journal-title":"Front Hum Neurosci."},{"key":"1603_CR12","doi-asserted-by":"publisher","unstructured":"Daws R, Timmerman C, Giribaldi B, Sexton J, Wall M, Erritzoe D, et al. Decreased brain modularity after psilocybin therapy for depression. 2021:1\u201319. https:\/\/doi.org\/10.21203\/rs.3.rs-513323\/v1.","DOI":"10.21203\/rs.3.rs-513323\/v1"},{"key":"1603_CR13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/0014-2999(75)90278-2","volume":"32","author":"T Yamamoto","year":"1975","unstructured":"Yamamoto T, Ueki S. Behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rats and mice. Eur J Pharmacol. 1975;32:156\u201362.","journal-title":"Eur J Pharmacol."},{"key":"1603_CR14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0028-3908(94)90074-4","volume":"33","author":"TA Sipes","year":"1994","unstructured":"Sipes TA, Geyer MA. Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology. 1994;33:441\u20138.","journal-title":"Neuropharmacology"},{"key":"1603_CR15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0893-133X(97)00164-4","volume":"18","author":"K Krebs-Thomson","year":"1998","unstructured":"Krebs-Thomson K, Paulus MP, Geyer MA. Effects of hallucinogens on locomotor and investigatory activity and patterns: Influence of 5-HT(2A) and 5-HT(2C) receptors. Neuropsychopharmacology. 1998;18:339\u201351.","journal-title":"Neuropsychopharmacology"},{"key":"1603_CR16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0893-133X(01)00282-2","volume":"25","author":"A Ouagazzal","year":"2001","unstructured":"Ouagazzal A, Grottick AJ, Moreau J, Higgins GA. Effect of LSD on prepulse inhibition and spontaneous behavior in the rat. A pharmacological analysis and comparison between two rat strains. Neuropsychopharmacology. 2001;25:565\u201375.","journal-title":"Neuropsychopharmacology"},{"key":"1603_CR17","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/00008877-200312000-00004","volume":"14","author":"S Body","year":"2003","unstructured":"Body S, Kheramin S, Ho MY, Miranda F, Bradshaw CM, Szabadi E. Effects of a 5-HT2 receptor agonist, DOI (2,5-dimethoxy-4-iodoamphetamine), and antagonist, ketanserin, on the performance of rats on a free-operant timing schedule. Behav Pharmacol. 2003;14:599\u2013607.","journal-title":"Behav Pharmacol."},{"key":"1603_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/01.fbp.0000189810.69425.89","volume":"17","author":"K Asgari","year":"2006","unstructured":"Asgari K, Body S, Bak VK, Zhang ZQ, Rickard JF, Glennon JC, et al. Effects of 5-HT2A receptor stimulation on the discrimination of durations by rats. Behav Pharmacol. 2006;17:51\u201359.","journal-title":"Behav Pharmacol."},{"key":"1603_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00213-007-0926-5","volume":"196","author":"T P\u00e1len\u00ed\u010dek","year":"2008","unstructured":"P\u00e1len\u00ed\u010dek T, Bal\u00edkov\u00e1 M, Buben\u00edkov\u00e1-Vale\u0161ov\u00e1 V, Hor\u00e1\u010dek J. Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose. Psychopharmacology. 2008;196:51\u201362.","journal-title":"Psychopharmacology"},{"key":"1603_CR20","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00213-003-1640-6","volume":"172","author":"F Hasler","year":"2004","unstructured":"Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX. Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study. Psychopharmacology. 2004;172:145\u201356.","journal-title":"Psychopharmacology"},{"key":"1603_CR21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1146\/annurev.pa.09.040169.001325","volume":"9","author":"M Fink","year":"1969","unstructured":"Fink M. EEG and human psychopharmacology. Annu Rev Pharmacol. 1969;9:241\u201358.","journal-title":"Annu Rev Pharmacol."},{"key":"1603_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000077946","volume":"50","author":"J Riba","year":"2004","unstructured":"Riba J, Anderer P, Jan\u00e9 F, Saletu B, Barbanoj MJ. Effects of the South American psychoactive beverage Ayahuasca on regional brain electrical activity in humans: a functional neuroimaging study using low-resolution electromagnetic tomography. Neuropsychobiology. 2004;50:89\u2013101.","journal-title":"Neuropsychobiology"},{"key":"1603_CR23","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1007\/s00213-015-4026-7","volume":"232","author":"M Kometer","year":"2015","unstructured":"Kometer M, Pokorny T, Seifritz E, Volleinweider FX. Psilocybin-induced spiritual experiences and insightfulness are associated with synchronization of neuronal oscillations. Psychopharmacology. 2015;232:3663\u201376.","journal-title":"Psychopharmacology"},{"key":"1603_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neuroimage.2019.06.053","volume":"200","author":"C Pallavicini","year":"2019","unstructured":"Pallavicini C, Vilas MG, Villarreal M, Zamberlan F, Muthukumaraswamy S, Nutt D, et al. Spectral signatures of serotonergic psychedelics and glutamatergic dissociatives. Neuroimage. 2019;200:281\u201391.","journal-title":"Neuroimage"},{"key":"1603_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-51974-4","volume":"9","author":"C Timmermann","year":"2019","unstructured":"Timmermann C, Roseman L, Schartner M, Milliere R, Williams L, Erritzoe D, et al. Neural correlates of the DMT experience assessed with multivariate EEG. Sci Rep. 2019;9:1\u201313.","journal-title":"Sci Rep."},{"key":"1603_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/02791072.2005.10399798","volume":"37","author":"DE Stuckey","year":"2005","unstructured":"Stuckey DE, Lawson R, Luna LE. EEG gamma coherence and other correlates of subjective reports during ayahuasca experiences. J Psychoact Drugs. 2005;37:163\u201378.","journal-title":"J Psychoact Drugs"},{"key":"1603_CR27","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0944-7113(98)80003-2","volume":"5","author":"NS Don","year":"1998","unstructured":"Don NS, McDonough BE, Moura G, Warren CA, Kawanishi K, Tomita H, et al. Effects of Ayahuasca on the human EEG. Phytomedicine. 1998;5:87\u201396.","journal-title":"Phytomedicine"},{"key":"1603_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0137202","volume":"10","author":"EE Schenberg","year":"2015","unstructured":"Schenberg EE, Alexandre JFM, Filev R, Cravo AM, Sato JR, Muthukumaraswamy SD, et al. Acute biphasic effects of ayahuasca. PLoS ONE. 2015;10:1\u201327.","journal-title":"PLoS ONE"},{"key":"1603_CR29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1046\/j.1365-2125.2002.01609.x","volume":"53","author":"J Riba","year":"2002","unstructured":"Riba J, Anderer P, Morte A, Urbano G, Jan\u00e9 F, Saletu B, et al. Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers. Br J Clin Pharmacol. 2002;53:613\u201328.","journal-title":"Br J Clin Pharmacol."},{"key":"1603_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnhum.2013.00138","volume":"7","author":"SD Muthukumaraswamy","year":"2013","unstructured":"Muthukumaraswamy SD. High-frequency brain activity and muscle artifacts in MEG\/EEG: a review and recommendations. Front Hum Neurosci. 2013;7:1\u201311.","journal-title":"Front Hum Neurosci."},{"key":"1603_CR31","doi-asserted-by":"publisher","first-page":"15171","DOI":"10.1523\/JNEUROSCI.2063-13.2013","volume":"33","author":"SD Muthukumaraswamy","year":"2013","unstructured":"Muthukumaraswamy SD, Carhart-Harris RL, Moran RJ, Brookes MJ, Williams TM, Errtizoe D, et al. Broadband cortical desynchronization underlies the human psychedelic state. J Neurosci. 2013;33:15171\u201383.","journal-title":"J Neurosci."},{"key":"1603_CR32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1212\/WNL.7.8.559","volume":"7","author":"M Vogt","year":"1957","unstructured":"Vogt M, Gunn CG, Sawyer CH. Electroencephalographic effects of intraventricular 5-HT and LSD in the cat. Neurology. 1957;7:559\u201366.","journal-title":"Neurology"},{"key":"1603_CR33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/brain\/80.1.77","volume":"80","author":"PB Bradley","year":"1957","unstructured":"Bradley PB, Elkes J. The effects of some drugs on the electrical activity of the brain. Brain. 1957;80:77\u2013117.","journal-title":"Brain"},{"key":"1603_CR34","first-page":"201","volume":"122","author":"LB Speck","year":"1958","unstructured":"Speck LB. Electroencephalographic changes in the rat with mescaline intoxication. J Pharmacol Exp Therapeut. 1958;122:201\u2013206.","journal-title":"J Pharmacol Exp Therapeut"},{"key":"1603_CR35","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1212\/WNL.12.9.591","volume":"12","author":"RW Adey","year":"1962","unstructured":"Adey RW, Bell FR, Dennis BJ. Effects of LSD-25, psilocybin, and psilocin on temporal lobe EEG patterns and learned behavior in the cat. Neurology. 1962;12:591\u2013602.","journal-title":"Neurology"},{"key":"1603_CR36","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/jps.2600540125","volume":"54","author":"ZP Horovitz","year":"1965","unstructured":"Horovitz ZP, Mulroy MI, Waldron T, Leaf R. Behavioral and electroencephalographic effects of LSD. J Pharm Sci. 1965;54:108\u201310.","journal-title":"J Pharm Sci"},{"key":"1603_CR37","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.biopsych.2008.03.013","volume":"64","author":"P Celada","year":"2008","unstructured":"Celada P, Puig MV, D\u00edaz-Mataix L, Artigas F. The hallucinogen DOI reduces low-frequency oscillations in rat prefrontal cortex: reversal by antipsychotic drugs. Biol Psychiatry. 2008;64:392\u2013400.","journal-title":"Biol Psychiatry"},{"key":"1603_CR38","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1017\/S1461145714000261","volume":"17","author":"MS Riga","year":"2014","unstructured":"Riga MS, Soria G, Tudela R, Artigas F, Celada P. The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs. Int J Neuropsychopharmacol. 2014;17:1269\u201382.","journal-title":"Int J Neuropsychopharmacol."},{"key":"1603_CR39","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1523\/JNEUROSCI.6377-11.2012","volume":"32","author":"J Wood","year":"2012","unstructured":"Wood J, Kim Y, Moghaddam B. Disruption of prefrontal cortex large scale neuronal activity by different classes of psychotomimetic drugs. J Neurosci. 2012;32:3022\u201331.","journal-title":"J Neurosci"},{"key":"1603_CR40","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00213-013-3057-1","volume":"228","author":"SA Goda","year":"2013","unstructured":"Goda SA, Piasecka J, Olszewski M, Kasicki S, Hunt MJ. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology. 2013;228:271\u201382.","journal-title":"Psychopharmacology"},{"key":"1603_CR41","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00213-012-2797-7","volume":"225","author":"T P\u00e1len\u00ed\u010dek","year":"2013","unstructured":"P\u00e1len\u00ed\u010dek T, Fuj\u00e1kov\u00e1 M, Brunovsk\u00fd M, Hor\u00e1\u010dek J, Gorman I, Bal\u00edkov\u00e1 M, et al. Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats. Psychopharmacology. 2013;225:75\u201393.","journal-title":"Psychopharmacology"},{"key":"1603_CR42","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.pbb.2014.03.001","volume":"122","author":"M Fuj\u00e1kov\u00e1","year":"2014","unstructured":"Fuj\u00e1kov\u00e1 M, P\u00e1len\u00ed\u010dek T, Brunovsk\u00fd M, Gorman I, Tyl\u0161 F, Kube\u0161ov\u00e1 A, et al. The effect of ((-)-2-oxa-4-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY379268), an mGlu2\/3 receptor agonist, on EEG power spectra and coherence in ketamine model of psychosis. Pharmacol Biochem Behav. 2014;122:212\u201321.","journal-title":"Pharmacol Biochem Behav"},{"key":"1603_CR43","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.pharmthera.2003.11.002","volume":"101","author":"DE Nichols","year":"2004","unstructured":"Nichols DE. Hallucinogens. Pharmacol Ther. 2004;101:131\u201381.","journal-title":"Pharmacol Ther."},{"key":"1603_CR44","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.pnpbp.2010.02.008","volume":"34","author":"T P\u00e1len\u00ed\u010dek","year":"2010","unstructured":"P\u00e1len\u00ed\u010dek T, Hli\u0148\u00e1k Z, Buben\u00edkov\u00e1-Vale\u0161ov\u00e1 V, Nov\u00e1k T, Hor\u00e1\u010dek J. Sex differences in the effects of N,N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition. Prog Neuro-Psychopharmacology Biol Psychiatry. 2010;34:588\u201396.","journal-title":"Prog Neuro-Psychopharmacology Biol Psychiatry"},{"key":"1603_CR45","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/FBP.0000000000000198","volume":"27","author":"F Tyl\u0161","year":"2016","unstructured":"Tyl\u0161 F, P\u00e1len\u00ed\u010dek T, Kade\u0159\u00e1bek L, Lipski M, Kube\u0161ov\u00e1 A, Hor\u00e1\u010dek J. Sex differences and serotonergic mechanisms in the behavioural effects of psilocin. Behav Pharmacol. 2016;27:309\u201320.","journal-title":"Behav Pharmacol."},{"key":"1603_CR46","unstructured":"Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Amsterdam: Academic Press\/Elsevier Inc.; 2014."},{"key":"1603_CR47","doi-asserted-by":"crossref","unstructured":"Vejmola \u010c, Tyl\u0161 F, Kade\u0159\u00e1bek L, Lipski M, P\u00e1len\u00ed\u010dek T. Poster, Quantitative EEG study of serotonergic hallucinogens in rats\u2014the relationship of brain activity and behavior. In: 29th ECNP Congress. Vienna: ECNP Congress; 2016, P.1.g.080., Vieta E.","DOI":"10.26226\/morressier.5785edc6d462b80296c9930b"},{"key":"1603_CR48","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1111\/ejn.14373","volume":"50","author":"IH Hansen","year":"2019","unstructured":"Hansen IH, Agerskov C, Arvastson L, Bastlund JF, S\u00f8rensen H, Herrik KF. Pharmaco-electroencephalographic responses in the rat differ between active and inactive locomotor states. Eur J Neurosci. 2019;50:1948\u201371.","journal-title":"Eur J Neurosci."},{"key":"1603_CR49","first-page":"39","volume":"34","author":"RW Thatcher","year":"2003","unstructured":"Thatcher RW, Biver CJ, North DM. Quantitative EEG and the Frye and Daubert standards of admissibility. Clin EEG Neurosci. 2003;34:39\u201353.","journal-title":"Clin EEG Neurosci."},{"key":"1603_CR50","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1016\/j.clinph.2004.04.029","volume":"115","author":"G Nolte","year":"2004","unstructured":"Nolte G, Bai O, Wheaton L, Mari Z, Vorbach S, Hallett M. Identifying true brain interaction from EEG data using the imaginary part of coherency. Clin Neurophysiol. 2004;115:2292\u2013307.","journal-title":"Clin Neurophysiol."},{"key":"1603_CR51","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/hbm.20346","volume":"28","author":"CJ Stam","year":"2007","unstructured":"Stam CJ, Nolte G, Daffertshofer A. Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources. Hum Brain Mapp. 2007;28:1178\u201393.","journal-title":"Hum Brain Mapp."},{"key":"1603_CR52","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.schres.2013.12.008","volume":"152","author":"C Andreou","year":"2014","unstructured":"Andreou C, Faber PL, Leicht G, Schoettle D, Polomac N, Hanganu-Opatz IL, et al. Resting-state connectivity in the prodromal phase of schizophrenia: Insights from EEG microstates. Schizophr Res. 2014;152:513\u201320.","journal-title":"Schizophr Res."},{"key":"1603_CR53","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1080\/87565641.2011.619241","volume":"37","author":"RW Thatcher","year":"2012","unstructured":"Thatcher RW. Coherence, phase differences, phase shift, and phase lock in EEG\/ERP analyses. Dev Neuropsychol. 2012;37:476\u201396.","journal-title":"Dev Neuropsychol."},{"key":"1603_CR54","first-page":"1","volume":"11","author":"RG Erra","year":"2017","unstructured":"Erra RG, Velazquez JLP, Rosenblum M. Neural synchronization from the perspective of non-linear dynamics. Front Comput Neurosci. 2017;11:1\u20134.","journal-title":"Front Comput Neurosci."},{"key":"1603_CR55","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.neuron.2013.10.002","volume":"80","author":"G Buzs\u00e1ki","year":"2013","unstructured":"Buzs\u00e1ki G, Logothetis N, Singer W. Scaling brain size, keeping timing: evolutionary preservation of brain rhythms. Neuron. 2013;80:751\u201364.","journal-title":"Neuron"},{"key":"1603_CR56","first-page":"190","volume":"29","author":"JA John","year":"1980","unstructured":"John JA, Draper NR. An alternative family of transformations. J R Stat Soc. 1980;29:190\u2013197.","journal-title":"J R Stat Soc"},{"key":"1603_CR57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1159\/000119258","volume":"33","author":"PAR Koopman","year":"1996","unstructured":"Koopman PAR, Wouters PAWM, Krijzer FNC. Mean power spectra from pharmaco-electrocorticographic studies: Relative baseline correction and log transformation for a proper analysis of variance to assess drug effects. Neuropsychobiology. 1996;33:100\u2013105.","journal-title":"Neuropsychobiology"},{"key":"1603_CR58","doi-asserted-by":"publisher","first-page":"806","DOI":"10.13164\/re.2018.0806","volume":"27","author":"V Pioreck\u00e1","year":"2018","unstructured":"Pioreck\u00e1 V, Kraj\u010da V, Tyl\u0161 F, P\u00e1len\u00ed\u010dek T. Methods for animal brain mapping. Radioengineering. 2018;27:806\u201312.","journal-title":"Radioengineering"},{"key":"1603_CR59","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.aca.2004.08.071","volume":"527","author":"K Saito","year":"2004","unstructured":"Saito K, Toyo\u2019oka T, Fukushima T, Kato M, Shirota O, Goda Y. Determination of psilocin in magic mushrooms and rat plasma by liquid chromatography with fluorimetry and electrospray ionization mass spectrometry. Anal Chim Acta. 2004;527:149\u201356.","journal-title":"Anal Chim Acta"},{"key":"1603_CR60","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1093\/jat\/20.5.323","volume":"20","author":"Y Nakahara","year":"1996","unstructured":"Nakahara Y, Kikura R, Takahashi K, Foltz RL, Mieczkowski T. Detection of LSD and metabolite in rat hair and human hair. J Anal Toxicol. 1996;20:323\u2013329.","journal-title":"J Anal Toxicol."},{"key":"1603_CR61","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.forsciint.2007.03.023","volume":"170","author":"K Ber\u00e1nkov\u00e1","year":"2007","unstructured":"Ber\u00e1nkov\u00e1 K, Szkutov\u00e1 M, Bal\u00edkov\u00e1 M. Distribution profile of 2,5-dimethoxy-4-bromoamphetamine (DOB) in rats after oral and subcutaneous doses. Forensic Sci Int. 2007;170:94\u201399.","journal-title":"Forensic Sci Int."},{"key":"1603_CR62","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000442210","volume":"72","author":"WHIM Drinkenburg","year":"2016","unstructured":"Drinkenburg WHIM, Ruigt GSF, Ahnaou A. Pharmaco-EEG studies in animals: an overview of contemporary translational applications. Neuropsychobiology. 2016;72:151\u201364.","journal-title":"Neuropsychobiology."},{"key":"1603_CR63","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0091-3057(88)90485-6","volume":"30","author":"GA Young","year":"1988","unstructured":"Young GA. Relationship between amphetamine-induced effects on EEG power spectra and motor activity in rats. Pharmacol Biochem Behav. 1988;30:489\u201392.","journal-title":"Pharmacol Biochem Behav."},{"key":"1603_CR64","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.neuropharm.2014.08.015","volume":"86","author":"A Ahnaou","year":"2014","unstructured":"Ahnaou A, Huysmans H, Jacobs T, Drinkenburg WHIM. Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential. Neuropharmacology. 2014;86:362\u201377.","journal-title":"Neuropharmacology"},{"key":"1603_CR65","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00213-005-2183-9","volume":"180","author":"D Marona-Lewicka","year":"2005","unstructured":"Marona-Lewicka D, Thisted RA, Nichols DE. Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Psychopharmacology. 2005;180:427\u201335.","journal-title":"Psychopharmacology"},{"key":"1603_CR66","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.pbb.2007.06.001","volume":"87","author":"D Marona-Lewicka","year":"2007","unstructured":"Marona-Lewicka D, Nichols DE. Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacol Biochem Behav. 2007;87:453\u201361.","journal-title":"Pharmacol Biochem Behav."},{"key":"1603_CR67","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00213-008-1238-0","volume":"203","author":"D Marona-Lewicka","year":"2009","unstructured":"Marona-Lewicka D, Chemel BR, Nichols DE. Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology. 2009;203:265\u201377.","journal-title":"Psychopharmacology"},{"key":"1603_CR68","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1007\/BF00169680","volume":"340","author":"W Kropf","year":"1989","unstructured":"Kropf W, Kuschinsky K, Krieglstein J. Apomorphine-induced alterations in cortical EEG activity of rats: involvement of D-1 and D-2 dopamine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989;340:718\u201325.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"1603_CR69","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4196\/kjpp.2009.13.3.147","volume":"13","author":"SJ Hwan","year":"2009","unstructured":"Hwan SJ, Ji YK, Sang HK, Lee MG. Role of dopamine receptors on electroencephalographic changes produced by repetitive apomorphine treatments in rats. Korean J Physiol Pharmacol. 2009;13:147\u201351.","journal-title":"Korean J Physiol Pharmacol."},{"key":"1603_CR70","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.disamonth.2014.01.001","volume":"60","author":"ME Nelson","year":"2014","unstructured":"Nelson ME, Bryant SM, Aks SE. Emerging drugs of abuse. Dis-a-Mon. 2014;60:110\u201332.","journal-title":"Dis-a-Mon"},{"key":"1603_CR71","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/BF00451678","volume":"98","author":"W Dimpfel","year":"1989","unstructured":"Dimpfel W, Sp\u00fcler M, Nichols DE. Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG). Psychopharmacology. 1989;98:297\u2013303.","journal-title":"Psychopharmacology"},{"key":"1603_CR72","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1016\/0006-2952(87)90643-5","volume":"36","author":"M Titeler","year":"1987","unstructured":"Titeler M, Lyon RA, Davis KH, Glennon RA. Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), A 5-HT2 agonist radioligand. Biochem Pharmacol. 1987;36:3265\u201371.","journal-title":"Biochem Pharmacol."},{"key":"1603_CR73","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.euroneuro.2016.05.001","volume":"26","author":"A Rickli","year":"2016","unstructured":"Rickli A, Moning OD, Hoener MC, Liechti ME. Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. Eur Neuropsychopharmacol. 2016;26:1327\u201337.","journal-title":"Eur Neuropsychopharmacol."},{"key":"1603_CR74","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1523\/JNEUROSCI.3335-09.2010","volume":"30","author":"MV Puig","year":"2010","unstructured":"Puig MV, Watakabe A, Ushimaru M, Yamamori T, Kawaguchi Y. Serotonin modulates fast-spiking interneuron and synchronous activity in the rat prefrontal cortex through 5-HT1A and 5-HT2A receptors. J Neurosci. 2010;30:2211\u201322.","journal-title":"J Neurosci."},{"key":"1603_CR75","first-page":"1379","volume":"46","author":"RL Carhart-Harris","year":"2016","unstructured":"Carhart-Harris RL, Kaelen M, Bolstridge M, Williams TM, Williams LT, Underwood R, et al. Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proc Natl Acad Sci USA. 2016;46:1379\u201390.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1603_CR76","doi-asserted-by":"publisher","first-page":"10544","DOI":"10.1523\/JNEUROSCI.3007-12.2013","volume":"33","author":"M Kometer","year":"2013","unstructured":"Kometer M, Schmidt A, J\u00e4ncke L, Vollenweider FX. Activation of serotonin 2A receptors underlies the psilocybin-induced effects on \u03b1 oscillations, N170 visual-evoked potentials, and visual hallucinations. J Neurosci. 2013;33:10544\u201351.","journal-title":"J Neurosci."},{"key":"1603_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.applanim.2008.02.007","volume":"112","author":"CC Burn","year":"2008","unstructured":"Burn CC. What is it like to be a rat? Rat sensory perception and its implications for experimental design and rat welfare. Appl Anim Behav Sci. 2008;112:1\u201332.","journal-title":"Appl Anim Behav Sci."},{"key":"1603_CR78","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fninf.2020.589228","volume":"14","author":"S Jiricek","year":"2021","unstructured":"Jiricek S, Koudelka V, Lacik J, Vejmola C, Kuratko D, W\u00f3jcik DK, et al. Electrical source imaging in freely moving rats: evaluation of twelve-electrode cortical EEG system. Front Neuroinform. 2021;14:68.","journal-title":"Front Neuroinform."}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01603-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01603-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01603-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T15:19:40Z","timestamp":1669907980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01603-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,2]]},"references-count":78,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["1603"],"URL":"https:\/\/doi.org\/10.1038\/s41398-021-01603-4","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,2]]},"assertion":[{"value":"2 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. TP and FT declare to have shares in \u201cPsychedelick\u00e1 klinika s.r.o\u201d and are involved in Compass Pathways trials with psilocybin and MAPS clinical trial with MDMA outside the submitted work. Dr. TP has founded \u201cPSYRES - Psychedelic Research Foundation\u201d, has shares in \u201cSpole\u010dnost pro podporu neurov\u011bdn\u00edho v\u00fdzkumu s.r.o\u201d and reports consulting fees from GH Research and CB21-Pharma outside the submitted work. Dr. FT is the head of PSYRES scientific committee. The remaining authors declare no potential conflict of interest with regard to this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"506"}}