{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:55:02Z","timestamp":1781088902780,"version":"3.54.1"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain pathological features during manic\/hypomanic and depressive episodes in the same patients with bipolar disorder (BPD) have not been described precisely. The study aimed to investigate depressive and manic-phase-specific brain neural activity patterns of BPD in the same murine model to provide information guiding investigation of the mechanism of phase switching and tailored prevention and treatment for patients with BPD. In vivo two-photon imaging was used to observe brain activity alterations in the depressive and manic phases in the same murine model of BPD. Two-photon imaging showed significantly reduced Ca<jats:sup>2+<\/jats:sup> activity in temporal cortex pyramidal neurons in the depression phase in mice exposed to chronic unpredictable mild stress (CUMS), but not in the manic phase in mice exposed to CUMS and ketamine. Total integrated calcium values correlated significantly with immobility times. Brain Ca<jats:sup>2+<\/jats:sup> hypoactivity was observed in the depression and manic phases in the same mice exposed to CUMS and ketamine relative to na\u00efve controls. The novel object recognition preference ratio correlated negatively with the immobility time in the depression phase and the total distance traveled in the manic phase. With recognition of its limitations, this study revealed brain neural activity impairment indicating that intrinsic emotional network disturbance is a mechanism of BPD and that brain neural activity is associated with cognitive impairment in the depressive and manic phases of this disorder. These findings are consistent with those from macro-imaging studies of patients with BPD. The observed correlation of brain neural activity with the severity of depressive, but not manic, symptoms need to be investigated further.<\/jats:p>","DOI":"10.1038\/s41398-021-01750-8","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T19:02:38Z","timestamp":1638903758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study"],"prefix":"10.1038","volume":"11","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaungdong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Langlang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deguo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongguang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-550X","authenticated-orcid":false,"given":"Chuanjun","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"1750_CR1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","volume":"387","author":"I Grande","year":"2016","unstructured":"Grande I, Berk M, Birmaher B, Vieta E. Bipolar disorder. Lancet. 2016;387:1561\u201372.","journal-title":"Lancet"},{"key":"1750_CR2","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","volume":"35","author":"M Berk","year":"2011","unstructured":"Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 2011;35:804\u201317.","journal-title":"Neurosci Biobehav Rev"},{"key":"1750_CR3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1017\/S1461145708009498","volume":"12","author":"M Berk","year":"2009","unstructured":"Berk M. Neuroprogression: pathways to progressive brain changes in bipolar disorder. Int J Neuropsychopharmacol. 2009;12:441\u20135.","journal-title":"Int J Neuropsychopharmacol"},{"key":"1750_CR4","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1111\/bdi.12099","volume":"16","author":"M Berk","year":"2014","unstructured":"Berk M, Berk L, Dodd S, Cotton S, Macneil C, Daglas R, et al. Stage managing bipolar disorder. Bipolar Disord. 2014;16:471\u20137.","journal-title":"Bipolar Disord"},{"key":"1750_CR5","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s11920-012-0319-2","volume":"14","author":"GR Fries","year":"2012","unstructured":"Fries GR, Pfaffenseller B, Stertz L, Paz AV, Darg\u00e9l AA, Kunz M, et al. Staging and neuroprogression in bipolar disorder. Curr Psychiatry Rep. 2012;14:667\u201375.","journal-title":"Curr Psychiatry Rep"},{"key":"1750_CR6","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/j.1399-5618.2012.01024.x","volume":"14","author":"MR Schneider","year":"2012","unstructured":"Schneider MR, DelBello MP, McNamara RK, Strakowski SM, Adler CM. Neuroprogression in bipolar disorder. Bipolar Disord. 2012;14:356\u201374.","journal-title":"Bipolar Disord"},{"key":"1750_CR7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1399-5618.2006.00284.x","volume":"8","author":"IK Lyoo","year":"2006","unstructured":"Lyoo IK, Sung YH, Dager SR, Friedman SD, Lee JY, Kim SJ, et al. Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord. 2006;8:65\u201374.","journal-title":"Bipolar Disord"},{"key":"1750_CR8","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1176\/appi.ajp.159.11.1841","volume":"159","author":"SM Strakowski","year":"2002","unstructured":"Strakowski SM, DelBello MP, Zimmerman ME, Getz GE, Mills NP, Ret J, et al. Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder. Am J Psychiatry. 2002;159:1841\u20137.","journal-title":"Am J Psychiatry"},{"key":"1750_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1034\/j.1399-5618.2001.030206.x","volume":"3","author":"SM El-Badri","year":"2001","unstructured":"El-Badri SM, Ashton CH, Moore PB, Marsh VR, Ferrier IN. Electrophysiological and cognitive function in young euthymic patients with bipolar affective disorder. Bipolar Disord. 2001;3:79\u201387.","journal-title":"Bipolar Disord"},{"key":"1750_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1399-5618.2006.00277.x","volume":"8","author":"LJ Robinson","year":"2006","unstructured":"Robinson LJ, Ferrier IN. Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence. Bipolar Disord. 2006;8:103\u201316.","journal-title":"Bipolar Disord"},{"key":"1750_CR11","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ceca.2007.11.005","volume":"44","author":"T Kato","year":"2008","unstructured":"Kato T. Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder. Cell Calcium. 2008;44:92\u2013102.","journal-title":"Cell Calcium"},{"key":"1750_CR12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/gbb.12371","volume":"16","author":"CE Terrillion","year":"2017","unstructured":"Terrillion CE, Dao DT, Cachope R, Lobo MK, Puche AC, Cheer JF, et al. Reduced levels of Cacna1c attenuate mesolimbic dopamine system function. Genes Brain Behav. 2017;16:495\u2013505.","journal-title":"Genes Brain Behav"},{"key":"1750_CR13","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.biopsych.2010.06.019","volume":"68","author":"DT Dao","year":"2010","unstructured":"Dao DT, Mahon PB, Cai X, Kovacsics CE, Blackwell RA, Arad M, et al. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol Psychiatry. 2010;68:801\u201310.","journal-title":"Biol Psychiatry"},{"key":"1750_CR14","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.biopsych.2012.10.016","volume":"73","author":"MP Leussis","year":"2013","unstructured":"Leussis MP, Berry-Scott EM, Saito M, Jhuang H, de Haan G, Alkan O, et al. The ANK3 bipolar disorder gene regulates psychiatric-related behaviors that are modulated by lithium and stress. Biol Psychiatry. 2013;73:683\u201390.","journal-title":"Biol Psychiatry"},{"key":"1750_CR15","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/mp.2012.104","volume":"18","author":"EH Rueckert","year":"2013","unstructured":"Rueckert EH, Barker D, Ruderfer D, Bergen SE, O'dushlaine C, Luce CJ, et al. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. Mol Psychiatry. 2013;18:922\u20139.","journal-title":"Mol Psychiatry"},{"key":"1750_CR16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.ajhg.2018.07.011","volume":"103","author":"JHT Song","year":"2018","unstructured":"Song JHT, Lowe CB, Kingsley DM. Characterization of a human-specific tandem repeat associated with bipolar disorder and schizophrenia. Am J Hum Genet. 2018;103:421\u201330.","journal-title":"Am J Hum Genet"},{"key":"1750_CR17","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1038\/s41380-018-0308-x","volume":"25","author":"AD Nelson","year":"2020","unstructured":"Nelson AD, Caballero-Flor\u00e1n RN, Rodr\u00edguez D\u00edaz JC, Hull JM, Yuan Y, Li J, et al. Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. Mol Psychiatry. 2020;25:2800\u201317.","journal-title":"Mol Psychiatry"},{"key":"1750_CR18","doi-asserted-by":"publisher","first-page":"10479","DOI":"10.1073\/pnas.1700689114","volume":"114","author":"S Zhu","year":"2017","unstructured":"Zhu S, Cordner ZA, Xiong J, Chiu CT, Artola A, Zuo Y, et al. Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder. Proc Natl Acad Sci USA. 2017;114:10479\u201384.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1750_CR19","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.biopsych.2020.09.024","volume":"1","author":"J Chen","year":"2021","unstructured":"Chen J, M\u00fcller VI, Dukart J, Hoffstaedter F, Baker JT, Holmes AJ, et al. Intrinsic connectivity patterns of task-defined brain networks allow individual prediction of cognitive symptom dimension of schizophrenia and are linked to molecular architecture. Biol Psychiatry. 2021;1:308\u201319.","journal-title":"Biol Psychiatry"},{"key":"1750_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00972-6","volume":"10","author":"SY Wei","year":"2020","unstructured":"Wei SY, Tseng HH, Chang HH, Lu TH, Chang WH, Chiu NT, et al. Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder. Transl Psychiatry. 2020;10:281.","journal-title":"Transl Psychiatry"},{"key":"1750_CR21","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.neubiorev.2016.06.010","volume":"68","author":"GR Fries","year":"2016","unstructured":"Fries GR, Li Q, McAlpin B, Rein T, Walss-Bass C, Soares JC, et al. The role of DNA methylation in the pathophysiology and treatment of bipolar disorder. Neurosci Biobehav Rev. 2016;68:474\u201388.","journal-title":"Neurosci Biobehav Rev"},{"key":"1750_CR22","doi-asserted-by":"publisher","first-page":"343","DOI":"10.2217\/epi.15.5","volume":"7","author":"KJ Burghardt","year":"2015","unstructured":"Burghardt KJ, Goodrich JM, Dolinoy DC, Ellingrod VL. DNA methylation, insulin resistance and second-generation antipsychotics in bipolar disorder. Epigenomics. 2015;7:343\u201352.","journal-title":"Epigenomics"},{"key":"1750_CR23","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature14192","volume":"517","author":"D Schubeler","year":"2015","unstructured":"Schubeler D. Function and information content of DNA methylation. Nature. 2015;517:321\u20136.","journal-title":"Nature"},{"key":"1750_CR24","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jad.2019.02.034","volume":"249","author":"A Sayad","year":"2019","unstructured":"Sayad A, Taheri M, Omrani MD, Fallah H, Oskooei VK, Ghafouri Fard S. Peripheral expression of long non-coding RNAs in bipolar patients. J Affect Disord. 2019;249:169\u201374.","journal-title":"J Affect Disord"},{"key":"1750_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/978-1-4939-7601-0_6","volume":"1733","author":"GR Fries","year":"2018","unstructured":"Fries GR, Quevedo J. Exosomal microRNAs as potential biomarkers in neuropsychiatric disorders. Methods Mol Biol. 2018;1733:79\u201385.","journal-title":"Methods Mol Biol"},{"key":"1750_CR26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jad.2019.05.020","volume":"255","author":"GR Fries","year":"2019","unstructured":"Fries GR, Lima CN, Valvassori SS, Zunta-Soares G, Soares JC, Quevedo J. Preliminary investigation of peripheral extracellular vesicles\u2019 microRNAs in bipolar disorder. J Affect Disord. 2019;255:10\u20134.","journal-title":"J Affect Disord"},{"key":"1750_CR27","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1001\/archpsyc.65.9.1017","volume":"65","author":"MJ Kempton","year":"2008","unstructured":"Kempton MJ, Geddes JR, Ettinger U, Williams SC, Grasby PM. Metaanalysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder. Arch Gen Psychiatry. 2008;65:1017\u201332.","journal-title":"Arch Gen Psychiatry"},{"key":"1750_CR28","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/386824a0","volume":"386","author":"WC Drevets","year":"1997","unstructured":"Drevets WC, Price JL, Simpson JR JR Jr, Todd RD, Reich T, Vannier M, et al. Subgenual prefrontal cortex bnormalities in mood disorders. Nature. 1997;386:824\u20137.","journal-title":"Nature"},{"key":"1750_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.schres.2009.12.022","volume":"117","author":"I Ellison-Wright","year":"2010","unstructured":"Ellison-Wright I, Bullmore E. Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophr Res. 2010;117:1\u201312.","journal-title":"Schizophr Res"},{"key":"1750_CR30","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.biopsych.2010.01.020","volume":"67","author":"E Bora","year":"2010","unstructured":"Bora E, Fornito A, Yucel M, Pantelis C. Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biol Psychiatry. 2010;67:1097\u2013105.","journal-title":"Biol Psychiatry"},{"key":"1750_CR31","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/cercor\/bhx319","volume":"29","author":"K Matsuo","year":"2019","unstructured":"Matsuo K, Harada K, Fujita Y, Okamoto Y, Ota M, Narita H, et al. Distinctive neuroanatomical substrates for depression in bipolar disorder versus major depressive disorder. Cereb Cortex. 2019;29:202\u201314.","journal-title":"Cereb Cortex"},{"key":"1750_CR32","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/mp.2017.73","volume":"23","author":"DP Hibar","year":"2018","unstructured":"Hibar DP, Westlye LT, Doan NT, Jahanshad N, Cheung JW, Ching CRK, et al. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018;23:932\u201342. https:\/\/doi.org\/10.1038\/mp.2017.73.","journal-title":"Mol Psychiatry"},{"key":"1750_CR33","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jad.2013.05.034","volume":"150","author":"G Nortje","year":"2013","unstructured":"Nortje G, Stein DJ, Radua J, Mataix-Cols D, Horn N. Systematic review and voxel-based meta-analysis of diffusion tensor imaging studies in bipolar disorder. J Affect Disord. 2013;150:192\u2013200.","journal-title":"J Affect Disord"},{"key":"1750_CR34","doi-asserted-by":"publisher","unstructured":"Harrison PJ, Hall N, Mould A, Al-Juffali N, Tunbridge EM. Cellular calcium in bipolar disorder: systematic review and meta-analysis. Mol Psychiatry. 2019. https:\/\/doi.org\/10.1038\/s41380-019-0622-y.","DOI":"10.1038\/s41380-019-0622-y"},{"key":"1750_CR35","unstructured":"Francis MM. Bipolar disorder: a guide for you and your loved ones (A Johns Hopkins Press Health Book). Johns Hopkins University Press; 2020."},{"key":"1750_CR36","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.biopsych.2017.10.030","volume":"83","author":"J Hiser","year":"2018","unstructured":"Hiser J, Koenigs M. The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology. Biol Psychiatry. 2018;83:638\u201347.","journal-title":"Biol Psychiatry"},{"key":"1750_CR37","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s12264-014-1502-8","volume":"31","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Fan L, Qiu C, Jiang T. Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia. Neurosci Bull. 2015;31:207\u201319.","journal-title":"Neurosci Bull"},{"key":"1750_CR38","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.biopsych.2018.09.031","volume":"85","author":"EL Belleau","year":"2019","unstructured":"Belleau EL, Treadway MT, Pizzagalli DA. The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology. Biol Psychiatry. 2019;85:443\u201353.","journal-title":"Biol Psychiatry"},{"key":"1750_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01297-8","volume":"11","author":"D Sasabayashi","year":"2021","unstructured":"Sasabayashi D, Takahashi T, Takayanagi Y, Suzuki M. Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration. Transl Psychiatry. 2021;11:176.","journal-title":"Transl Psychiatry"},{"key":"1750_CR40","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1038\/s41386-021-01038-x","volume":"46","author":"G Rey","year":"2021","unstructured":"Rey G, Bolton TAW, Gaviria J, Piguet C, Preti MG, Favre S, et al. Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states. Neuropsychopharmacology. 2021;46:1693\u2013701.","journal-title":"Neuropsychopharmacology"},{"key":"1750_CR41","first-page":"bhab356","volume":"5","author":"L Nabulsi","year":"2021","unstructured":"Nabulsi L, McPhilemy G, O\u2019donoghue S, Cannon DM, Kilmartin L, O\u2019hora D, et al. Aberrant subnetwork and hub dysconnectivity in adult bipolar disorder: a multicenter graph theory analysis. Cereb Cortex. 2021;5:bhab356.","journal-title":"Cereb Cortex"},{"key":"1750_CR42","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41586-021-03778-8","volume":"596","author":"D Witvliet","year":"2021","unstructured":"Witvliet D, Mulcahy B, Mitchell JK, Meirovitch Y, Berger DR, Wu Y, et al. Connectomes across development reveal principles of brain maturation. Nature. 2021;596:257\u201361.","journal-title":"Nature"},{"key":"1750_CR43","first-page":"bhab281","volume":"5","author":"H Lu","year":"2021","unstructured":"Lu H, Gallinaro JV, Normann C, Rotter S, Yalcin I. Time course of homeostatic structural plasticity in response to optogenetic stimulation in mouse anterior cingulate cortex. Cereb Cortex. 2021;5:bhab281.","journal-title":"Cereb Cortex"},{"key":"1750_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/YPG.0000000000000267","volume":"31","author":"A Legrand","year":"2021","unstructured":"Legrand A, Iftimovici A, Khayachi A, Chaumette B. Epigenetics in bipolar disorder: a critical review of the literature. Psychiatr Genet. 2021;31:1\u201312.","journal-title":"Psychiatr Genet"},{"key":"1750_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neubiorev.2020.03.005","volume":"113","author":"\u00c7 G\u00fcrel","year":"2020","unstructured":"G\u00fcrel \u00c7, Ku\u015f\u00e7u GC, Yava\u015fo\u011flu A, Biray Avc\u0131 \u00c7. The clues in solving the mystery of major psychosis: the epigenetic basis of schizophrenia and bipolar disorder. Neurosci Biobehav Rev. 2020;113:51\u201361.","journal-title":"Neurosci Biobehav Rev"},{"key":"1750_CR46","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41380-020-0831-4","volume":"26","author":"SJ Haggarty","year":"2021","unstructured":"Haggarty SJ, Karmacharya R, Perlis RH. Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Mol Psychiatry. 2021;26:168\u201385.","journal-title":"Mol Psychiatry"},{"key":"1750_CR47","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1038\/s41380-021-01061-w","volume":"26","author":"H Le-Niculescu","year":"2021","unstructured":"Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, et al. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Mol Psychiatry. 2021;26:2776\u2013804.","journal-title":"Mol Psychiatry"},{"key":"1750_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-020-00218-w","volume":"9","author":"RM Post","year":"2021","unstructured":"Post RM, Altshuler LL, Kupka R, McElroy SL, Frye MA, Grunze H, et al. 25 years of the International Bipolar Collaborative Network (BCN). Int J Bipolar Disord. 2021;9:13.","journal-title":"Int J Bipolar Disord"},{"key":"1750_CR49","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.euroneuro.2020.05.006","volume":"36","author":"M Manchia","year":"2020","unstructured":"Manchia M, Vieta E, Smeland OB, Altimus C, Bechdolf A, Bellivier F, et al. European College of Neuropsychopharmacology (ECNP) bipolar disorders network. Translating big data to better treatment in bipolar disorder\u2014a manifesto for coordinated action. Eur Neuropsychopharmacol. 2020;36:121\u201336.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1750_CR50","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jad.2021.08.127","volume":"295","author":"LS Rotenberg","year":"2021","unstructured":"Rotenberg LS, Borges-J\u00fanior RG, Lafer B, Salvini R, Dias RDS. Exploring machine learning to predict depressive relapses of bipolar disorder patients. J Affect Disord. 2021;295:681\u201387.","journal-title":"J Affect Disord"},{"key":"1750_CR51","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/978-981-32-9721-0_10","volume":"1192","author":"J Lydiard","year":"2019","unstructured":"Lydiard J, Nemeroff CB. Biomarker-guided tailored therapy. Adv Exp Med Biol. 2019;1192:199\u2013224.","journal-title":"Adv Exp Med Biol"},{"key":"1750_CR52","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1001\/jamapsychiatry.2018.1415","volume":"75","author":"N Hemager","year":"2018","unstructured":"Hemager N, Plessen KJ, Thorup A, Christiani C, Ellersgaard D, Spang KS, et al. Assessment of neurocognitive functions in 7-year-old children at familial high risk for schizophrenia or bipolar disorder: The Danish High Risk and Resilience Study VIA 7. JAMA Psychiatry. 2018;75:844\u201352.","journal-title":"JAMA Psychiatry"},{"key":"1750_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-021-00228-2","volume":"9","author":"A Cooper","year":"2021","unstructured":"Cooper A, Horrocks J, Goodday S, Keown-Stoneman C, Duffy A. Predicting the risk and timing of major mood disorder in offspring of bipolar parents: exploring the utility of a neural network approach. Int J Bipolar Disord. 2021;9:22.","journal-title":"Int J Bipolar Disord"},{"key":"1750_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S0033291720003153","volume":"7","author":"G Roberts","year":"2020","unstructured":"Roberts G, Lenroot R, Overs B, Fullerton J, Leung V, Ridgway K, et al. Accelerated cortical thinning and volume reduction over time in young people at high genetic risk for bipolar disorder. Psychol Med. 2020;7:1\u201312. https:\/\/doi.org\/10.1017\/S0033291720003153.","journal-title":"Psychol Med"},{"key":"1750_CR55","doi-asserted-by":"publisher","first-page":"101598","DOI":"10.1016\/j.nicl.2018.11.008","volume":"21","author":"I Meluken","year":"2019","unstructured":"Meluken I, Ottesen NM, Phan KL, Goldin PR, Di Simplicio M, Macoveanu J, et al. Neural response during emotion regulation in monozygotic twins at high familial risk of affective disorders. Neuroimage Clin. 2019;21:101598.","journal-title":"Neuroimage Clin"},{"key":"1750_CR56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/mp.2016.216","volume":"23","author":"G Roberts","year":"2018","unstructured":"Roberts G, Perry A, Lord A, Frankland A, Leung V, Holmes-Preston E, et al. Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder. Mol Psychiatry. 2018;23:413\u201321.","journal-title":"Mol Psychiatry"},{"key":"1750_CR57","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","volume":"99","author":"S Antoniuk","year":"2019","unstructured":"Antoniuk S, Bijata M, Ponimaskin E, Wlodarczyk J. Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability. Neurosci Biobehav Rev. 2019;99:101\u201316.","journal-title":"Neurosci Biobehav Rev"},{"key":"1750_CR58","doi-asserted-by":"publisher","first-page":"20l02811","DOI":"10.4088\/PCC.20l02811","volume":"23","author":"K Bhatt","year":"2021","unstructured":"Bhatt K, Yoo J, Bridges A. Ketamine-induced manic episode. Prim Care Companion CNS Disord. 2021;23:20l02811.","journal-title":"Prim Care Companion CNS Disord"},{"key":"1750_CR59","doi-asserted-by":"publisher","first-page":"454","DOI":"10.4103\/0253-7613.161277","volume":"47","author":"G Banwari","year":"2015","unstructured":"Banwari G, Desai P, Patidar P. Ketamine-induced affective switch in a patient with treatment-resistant depression. Indian J Pharmacol. 2015;47:454\u201355.","journal-title":"Indian J Pharmacol"},{"key":"1750_CR60","doi-asserted-by":"publisher","first-page":"173108","DOI":"10.1016\/j.pbb.2021.173108","volume":"202","author":"TH Gao","year":"2021","unstructured":"Gao TH, Ni RJ, Liu S, Tian Y, Wei J, Zhao L, et al. Chronic lithium exposure attenuates ketamine-induced mania-like behavior and c-Fos expression in the forebrain of mice. Pharmacol Biochem Behav. 2021;202:173108.","journal-title":"Pharmacol Biochem Behav"},{"key":"1750_CR61","doi-asserted-by":"publisher","first-page":"e578","DOI":"10.4088\/JCP.13r08905","volume":"75","author":"AF Carvalho","year":"2014","unstructured":"Carvalho AF, Dimellis D, Gonda X, Vieta E, Mclntyre RS, Fountoulakis KN. Rapid cycling in bipolar disorder: a systematic review. J Clin Psychiatry. 2014;75:e578\u201386.","journal-title":"J Clin Psychiatry"},{"key":"1750_CR62","first-page":"363","volume":"39","author":"JK M\u00fcller","year":"2016","unstructured":"M\u00fcller JK, Leweke FM. Bipolar disorder: clinical overview. Med Monatsschr Pharm. 2016;39:363\u201369.","journal-title":"Med Monatsschr Pharm"},{"key":"1750_CR63","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3390\/biom11030343","volume":"11","author":"ES Li","year":"2021","unstructured":"Li ES, Saha MS. Optimizing calcium detection methods in animal systems: a sandbox for synthetic biology. Biomolecules. 2021;11:343.","journal-title":"Biomolecules"},{"key":"1750_CR64","doi-asserted-by":"publisher","first-page":"118998","DOI":"10.1016\/j.bbamcr.2021.118998","volume":"1868","author":"M Calvo-Rodriguez","year":"2021","unstructured":"Calvo-Rodriguez M, Kharitonova EK, Bacskai BJ. In vivo brain imaging of mitochondrial Ca(2+) in neurodegenerative diseases with multiphoton microscopy. Biochim Biophys Acta Mol Cell Res. 2021;1868:118998.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"1750_CR65","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fnins.2020.00517","volume":"14","author":"C Zhou","year":"2020","unstructured":"Zhou C, Kong D, Xue R, Chen M, Li G, Xu Y, et al. Metformin enhances antidepressant\/antipsychotic combination therapy of schizophrenia with comorbid depression in a murine model. Front Neurosci. 2020;14:517.","journal-title":"Front Neurosci"},{"key":"1750_CR66","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3389\/fnins.2020.00115","volume":"14","author":"C Zhou","year":"2020","unstructured":"Zhou C, Kong D, Zhu X, Wu W, Xue R, Li G, et al. Rethinking schizophrenia and depression comorbidity as one psychiatric disorder entity: evidence from mouse model. Front Neurosci. 2020;14:115.","journal-title":"Front Neurosci"},{"key":"1750_CR67","doi-asserted-by":"publisher","first-page":"192","DOI":"10.21307\/ane-2017-019","volume":"76","author":"FC Arslan","year":"2016","unstructured":"Arslan FC, Tiryaki A, Y\u0131ld\u0131r\u0131m M, \u00d6zkorumak E, Alver A, Altun \u0130K, et al. The effects of edaravone in ketamine-induced model of mania in rats. Acta Neurobiol Exp (Wars). 2016;76:192\u201398.","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"1750_CR68","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.pbb.2019.01.003","volume":"179","author":"JT Krug","year":"2019","unstructured":"Krug JT, Klein AK, Purvis EM, Ayala K, Mayes MS, Collins L, et al. Effects of chronic lithium exposure in a modified rodent ketamine-induced hyperactivity model of mania. Pharm Biochem Behav. 2019;179:150\u201355.","journal-title":"Pharm Biochem Behav"},{"key":"1750_CR69","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3109\/15622975.2013.830775","volume":"15","author":"R Machado-Vieira","year":"2014","unstructured":"Machado-Vieira R, Soeiro-De-Souza MG, Richards EM, Teixeira AL, Zarate CA Jr. Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: developing treatments using an integrated translational approach. World J Biol Psychiatry. 2014;15:84\u201395.","journal-title":"World J Biol Psychiatry"},{"key":"1750_CR70","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.jpsychires.2012.08.010","volume":"46","author":"FV Ghedim","year":"2012","unstructured":"Ghedim FV, Fraga Dde B, Deroza PF, Oliveira MB, Valvassori SS, Steckert AV, et al. Evaluation of behavioral and neurochemical changes induced by ketamine in rats: implications as an animal model of mania. J Psychiatr Res. 2012;46:1569\u201375.","journal-title":"J Psychiatr Res"},{"key":"1750_CR71","doi-asserted-by":"publisher","first-page":"172875","DOI":"10.1016\/j.pbb.2020.172875","volume":"190","author":"A Ettenberg","year":"2020","unstructured":"Ettenberg A, Ayala K, Krug JT, Collins L, Mayes MS, Fisher MPA. Differential effects of lithium isotopes in a ketamine-induced hyperactivity model of mania. Pharm Biochem Behav. 2020;190:172875.","journal-title":"Pharm Biochem Behav"},{"key":"1750_CR72","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/978-1-4939-6352-2_10","volume":"1474","author":"GB Smith","year":"2016","unstructured":"Smith GB, Fitzpatrick D. Viral injection and cranial window implantation for in vivo two-photon imaging. Methods Mol Biol. 2016;1474:171\u201385.","journal-title":"Methods Mol Biol"},{"key":"1750_CR73","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1101\/pdb.prot068551","volume":"2012","author":"SD Brenowitz","year":"2012","unstructured":"Brenowitz SD, Regehr WG. Presynaptic imaging of projection fibers by in vivo injection of dextran-conjugated calcium indicators. Cold Spring Harb Protoc. 2012;2012:465\u201371.","journal-title":"Cold Spring Harb Protoc"},{"key":"1750_CR74","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1365-2982.2004.00538.x","volume":"16","author":"R De Giorgio","year":"2004","unstructured":"De Giorgio R, Camilleri M. Human enteric neuropathies: morphology and molecular pathology. Neurogastroenterol Motil. 2004;16:515\u201331.","journal-title":"Neurogastroenterol Motil"},{"key":"1750_CR75","doi-asserted-by":"publisher","first-page":"e12900","DOI":"10.1111\/nmo.12900","volume":"29","author":"JE Cooper","year":"2017","unstructured":"Cooper JE, Natarajan D, McCann CJ, Choudhury S, Godwin H, Burns AJ, et al. In vivo transplantation of fetal human gut-derived enteric neural crest cells. Neurogastroenterol Motil. 2017;29:e12900.","journal-title":"Neurogastroenterol Motil"},{"key":"1750_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.85","volume":"7","author":"LA Feldcamp","year":"2017","unstructured":"Feldcamp LA, Boutros PC, Raymond R, Fletcher PJ, Nobrega JN, Wong AHC. Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse. Transl Psychiatry. 2017;7:e1125.","journal-title":"Transl Psychiatry"},{"key":"1750_CR77","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.schres.2015.04.044","volume":"168","author":"R Frau","year":"2015","unstructured":"Frau R, Abbiati F, Bini V, Casti A, Caruso D, Devoto P, et al. Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress. Schizophr Res. 2015;168:640\u201348.","journal-title":"Schizophr Res"},{"key":"1750_CR78","first-page":"1","volume":"20","author":"B Kaygisiz","year":"2021","unstructured":"Kaygisiz B, Aydin S, Yildirim E, Musmul A, Erol K, Kilic FS. The effects of galangin in prepulse inhibition test and experimental schizophrenia models. Acta Neuropsychiatr. 2021;20:1\u201327.","journal-title":"Acta Neuropsychiatr"},{"key":"1750_CR79","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98167-6","volume":"11","author":"N Wake","year":"2021","unstructured":"Wake N, Ishizu K, Abe T, Takahashi H. Prepulse inhibition predicts subjective hearing in rats. Sci Rep. 2021;11:18902.","journal-title":"Sci Rep"},{"key":"1750_CR80","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1016\/j.clinph.2021.08.005","volume":"132","author":"J Valls-Sole","year":"2021","unstructured":"Valls-Sole J. Prepulse inhibition on the spot. Clin Neurophysiol. 2021;132:2679\u201380.","journal-title":"Clin Neurophysiol"},{"key":"1750_CR81","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/FBP.0000000000000643","volume":"32","author":"W Du","year":"2021","unstructured":"Du W, Li M, Zhou H, Shao F, Wang W. Alteration of the PKA-CREB cascade in the mPFC accompanying prepulse inhibition deficits: evidence from adolescent social isolation and chronic SKF38393 injection during early adolescence. Behav Pharmacol. 2021;32:487\u201396.","journal-title":"Behav Pharmacol"},{"key":"1750_CR82","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/bdi.12225","volume":"16","author":"MA Cerullo","year":"2014","unstructured":"Cerullo MA, Eliassen JC, Smith CT, Fleck DE, Nelson EB, Strawn JR, et al. Bipolar I disorder and major depressive disorder show similar brain activation during depression. Bipolar Disord. 2014;16:703\u201312.","journal-title":"Bipolar Disord"},{"key":"1750_CR83","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s11682-019-00117-4","volume":"13","author":"Q Xiao","year":"2019","unstructured":"Xiao Q, Cui D, Jiao Q, Zhong Y, Cao W, Lu G, et al. Altered regional homogeneity in bipolar disorder during manic and euthymic state: a resting-state fMRI study. Brain Imaging Behav. 2019;13:1789\u201398.","journal-title":"Brain Imaging Behav"},{"key":"1750_CR84","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jad.2021.05.052","volume":"292","author":"J Gong","year":"2021","unstructured":"Gong J, Wang J, Chen P, Qi Z, Luo Z, Wang J, et al. Large-scale network abnormality in bipolar disorder: a multimodal meta-analysis of resting-state functional and structural magnetic resonance imaging studies. J Affect Disord. 2021;292:9\u201320.","journal-title":"J Affect Disord"},{"key":"1750_CR85","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jad.2021.04.051","volume":"291","author":"AJ Cahn","year":"2021","unstructured":"Cahn AJ, Keramatian K, Frysch C, Yatham LN, Chakrabarty T. Longitudinal grey matter changes following first episode mania in bipolar I disorder: a systematic review. J Affect Disord. 2021;291:198\u2013208.","journal-title":"J Affect Disord"},{"key":"1750_CR86","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jad.2021.04.090","volume":"291","author":"I Angelescu","year":"2021","unstructured":"Angelescu I, Brugger SP, Borgan F, Kaar SJ, Howes OD. The magnitude and variability of brain structural alterations in bipolar disorder: a double meta-analysis of 5534 patients and 6651 healthy controls. J Affect Disord. 2021;291:171\u201376.","journal-title":"J Affect Disord"},{"key":"1750_CR87","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01036-5","volume":"10","author":"J Gong","year":"2020","unstructured":"Gong J, Wang J, Qiu S, Chen P, Luo Z, Wang J, et al. Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis. Transl Psychiatry. 2020;10:353.","journal-title":"Transl Psychiatry"},{"key":"1750_CR88","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/bdi.12995","volume":"23","author":"K Keramatian","year":"2021","unstructured":"Keramatian K, Chakrabarty T, Saraf G, Pinto JV, Yatham LN. Grey matter abnormalities in first-episode mania: a systematic review and meta-analysis of voxel-based morphometry studies. Bipolar Disord. 2021;23:228\u201340.","journal-title":"Bipolar Disord"},{"key":"1750_CR89","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/14737175.2019.1562338","volume":"19","author":"B Vai","year":"2019","unstructured":"Vai B, Bertocchi C, Benedetti F. Cortico-limbic connectivity as a possible biomarker for bipolar disorder: where are we now? Expert Rev Neurother. 2019;19:159\u201372.","journal-title":"Expert Rev Neurother"},{"key":"1750_CR90","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-020-00304-4","volume":"19","author":"KN Fountoulakis","year":"2020","unstructured":"Fountoulakis KN. Neurocognitive impairment and evidence-based treatment options in bipolar disorder. Ann Gen Psychiatry. 2020;19:54.","journal-title":"Ann Gen Psychiatry"},{"key":"1750_CR91","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/bdi.12821","volume":"22","author":"TE Van Rheenen","year":"2020","unstructured":"Van Rheenen TE, Lewandowski KE, Bauer IE, Kapczinski F, Miskowiak K, Burdick KE, et al. Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: an overview of evidence. Bipolar Disord. 2020;22:13\u201327.","journal-title":"Bipolar Disord"},{"key":"1750_CR92","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jad.2017.12.057","volume":"229","author":"E Bora","year":"2018","unstructured":"Bora E. Neurocognitive features in clinical subgroups of bipolar disorder: a meta-analysis. J Affect Disord. 2018;229:125\u201334.","journal-title":"J Affect Disord"},{"key":"1750_CR93","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/ijnp\/pyx032","volume":"20","author":"B Sol\u00e9","year":"2017","unstructured":"Sol\u00e9 B, Jim\u00e9nez E, Torrent C, Reinares M, Bonnin CDM, Torres I, et al. Cognitive impairment in bipolar disorder: treatment and prevention strategies. Int J Neuropsychopharmacol. 2017;20:670\u201380.","journal-title":"Int J Neuropsychopharmacol"},{"key":"1750_CR94","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.neubiorev.2016.08.002","volume":"69","author":"SA Cardenas","year":"2016","unstructured":"Cardenas SA, Kassem L, Brotman MA, Leibenluft E, McMahon FJ. Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: a review of the literature. Neurosci Biobehav Rev. 2016;69:193\u2013215.","journal-title":"Neurosci Biobehav Rev"},{"key":"1750_CR95","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jpsychires.2021.08.025","volume":"143","author":"L Kuang","year":"2021","unstructured":"Kuang L, Gao W, Wang L, Guo Y, Cao W, Cui D, et al. Increased resting-state brain entropy of parahippocampal gyrus and dorsolateral prefrontal cortex in manic and euthymic adolescent bipolar disorder. J Psychiatr Res. 2021;143:106\u201312.","journal-title":"J Psychiatr Res"},{"key":"1750_CR96","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/acps.13303","volume":"144","author":"MJ Lomastro","year":"2021","unstructured":"Lomastro MJ, Valerio MP, Szmulewicz AG, Martino DJ. Manic morbidity and executive function impairment as determinants of long-term psychosocial dysfunction in bipolar disorder. Acta Psychiatr Scand. 2021;144:72\u201381.","journal-title":"Acta Psychiatr Scand"},{"key":"1750_CR97","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/WNN.0000000000000231","volume":"33","author":"SMS Sarmento","year":"2020","unstructured":"Sarmento SMS, Bittencourt L, de Mendon\u00e7a Filho EJ, Abreu N, Tavares de Lacerda AL, Miranda-Scippa \u00c2. Neurocognitive impairment in bipolar disorder and associated factors: using population-based norms and a strict criterion for impairment definition. Cogn Behav Neurol. 2020;33:103\u201312.","journal-title":"Cogn Behav Neurol"},{"key":"1750_CR98","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/bdi.12786","volume":"22","author":"JW Young","year":"2020","unstructured":"Young JW, Geyer MA, Halberstadt AL, van Enkhuizen J, Minassian A, Khan A, et al. Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT. Bipolar Disord. 2020;22:46\u201358.","journal-title":"Bipolar Disord"},{"key":"1750_CR99","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jpsychires.2015.05.006","volume":"68","author":"GR Fries","year":"2015","unstructured":"Fries GR, Valvassori SS, Bock H, Stertz L, Magalh\u00e3es PV, Mariot E, et al. Memory and brain-derived neurotrophic factor after subchronic or chronic amphetamine treatment in an animal model of mania. J Psychiatr Res. 2015;68:329\u201336.","journal-title":"J Psychiatr Res"},{"key":"1750_CR100","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01576-4","volume":"11","author":"G Hindley","year":"2021","unstructured":"Hindley G, Bahrami S, Steen NE. Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking. Transl Psychiatry. 2021;11:466.","journal-title":"Transl Psychiatry"},{"key":"1750_CR101","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41398-020-0737-6","volume":"10","author":"R Zhang","year":"2020","unstructured":"Zhang R, Song J, Isgren A, Jakobsson J, Blennow K, Sellgren CM, Zetterberg H, Bergen SE, Land\u00e9n M. Genome wide study of immune biomarkers in cerebrospinal fluid and serum from patients with bipolar disorder and controls. Transl Psychiatry. 2020;10:58. https:\/\/doi.org\/10.1038\/s41398-020-0737-6.","journal-title":"Transl Psychiatry"},{"key":"1750_CR102","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/brainsci11020276","volume":"11","author":"G Serafini","year":"2021","unstructured":"Serafini G, Pardini M, Monacelli F, Orso B, Girtler N, Brugnolo A, et al. Neuroprogression as an illness trajectory in bipolar disorder: a selective review of the current literature. Brain Sci. 2021;11:276.","journal-title":"Brain Sci"},{"key":"1750_CR103","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1038\/mp.2014.167","volume":"20","author":"MM Sidor","year":"2015","unstructured":"Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, et al. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015;20:1406\u201319.","journal-title":"Mol Psychiatry"},{"key":"1750_CR104","doi-asserted-by":"publisher","first-page":"9484","DOI":"10.1523\/JNEUROSCI.1114-14.2014","volume":"16","author":"S Mastwal","year":"2014","unstructured":"Mastwal S, Ye Y, Ren M, Jimenez DV, Martinowich K, Gerfen CR, et al. Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence. J Neurosci. 2014;16:9484\u201396.","journal-title":"J Neurosci"},{"key":"1750_CR105","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S0006-3223(03)00069-6","volume":"53","author":"E Leibenluft","year":"2003","unstructured":"Leibenluft E, Charney DS, Pine DS. Researching the pathophysiology of pediatric bipolar disorder. Biol Psychiatry. 2003;53:1009\u201320.","journal-title":"Biol Psychiatry"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01750-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01750-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01750-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T12:08:31Z","timestamp":1676030911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-021-01750-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":105,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["1750"],"URL":"https:\/\/doi.org\/10.1038\/s41398-021-01750-8","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"1 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"619"}}