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Remote assessments were used to acquire an extensive range of phenotypes, including mood state, transdiagnostic symptom severity, task-based measures of cognition, environmental exposures, personality traits. In this paper we describe the study design, and the demographic and clinical characteristics of the cohort. In addition we report genetic ancestry, SNP heritability, and genetic correlations with other large cohorts of mood disorders.<\/jats:p><jats:p>A total of 48,467 participants were enrolled: 14,768 with MD, 9864 with BD, and 23,835 controls. Upon enrollment, 47% of participants with MD and 27% with BD indicated being in an active mood episode. Cases reported early ages of onset (mean\u2009=\u200913.2 and 14.3 years for MD and BD, respectively), and high levels of recurrence (78.6% and 84.9% with &gt;5 episodes), psychotherapy, and psychotropic medication use. SNP heritability on the liability scale for the ascertained MD participants (0.19\u20130.21) was consistent with the high level of disease severity in this cohort, while BD heritability estimates (0.16\u20130.22) were comparable to reports in other large scale genomic studies of mood disorders. Genetic correlations between the AFFECT cohort and other large-scale cohorts were high for MD but not for BD. By incorporating transdiagnostic symptom assessments, repeated measures, and genomic data, the AFFECT study represents a unique resource for dissecting the structure of mood disorders across multiple levels of analysis. In addition, the fully remote nature of the study provides valuable insights for future virtual and decentralized clinical trials within mood disorders.<\/jats:p>","DOI":"10.1038\/s41398-022-01877-2","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T14:11:39Z","timestamp":1648217499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the 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