{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:06:59Z","timestamp":1792033619698,"version":"4.4.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From a neurobiological perspective, diverse studies have associated emotional regulation with cognitive deficits. Structural and\/or metabolic changes in the frontal cortex are often inferred from dysfunction in cognitive-emotional processing. In addition, electroencephalographic findings support the idea that alpha band oscillations are responses to these same processes. Thus, the objective of this meta-analytical literature review is to verify whether the possible hemispheric lateralization attributed to frontal alpha asymmetry (FAA) correlates with emotional regulation and the cognitive deficits underlying depression. The data included in our meta-analysis are from articles published from 2009 to July 2020, which utilized DSM or ICD criteria to diagnose depression or anxiety disorders and included a control group. For statistical analysis, the measurements obtained through the 10\u201320 electroencephalography system were used. The frontal alpha asymmetry index was calculated from the difference between the logarithm of the absolute spectral values in the alpha rhythm observed from the F4 and F3 electrodes that were fixed to the scalp of the frontal region of the right and left hemispheres (ln\u2009\u00b5V\u00b2 RH\u2212ln\u2009\u00b5V\u00b2 LH)\u2009=\u2009(F4\u2212F3). Eighteen articles were included in the systematic review. Of these, 9 were homogeneous enough for statistical analyses (total <jats:italic>N<\/jats:italic>: 1061; <jats:italic>N<\/jats:italic><jats:sub>Dep<\/jats:sub>: 326; <jats:italic>N<\/jats:italic><jats:sub>cont<\/jats:sub>: 735). Nine others could not be statistically analyzed due to the absence of FAA measurements from the F4 and F3 electrodes. A random effects meta-analysis revealed low heterogeneity (Qt\u2009=\u200911,00<jats:italic>,<\/jats:italic> d<jats:italic>f<\/jats:italic>\u2009=\u20098, <jats:italic>p<\/jats:italic>\u2009=\u20090.20, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200927%) and an average effect size of the studies equal to \u22120.03 (CI\u2009=\u2009[\u22120.07 to 0.01]). The results, although not significant, suggested a slight tendency toward left lateralization in the depression group. Although the effects shown in these data did not confirm hemispherical lateralization in depressed patients, it was found that emotional regulation and cognitive processes share similar neural circuits. Therefore, future research on this complex relationship is encouraged, especially studies that are focused on the search for quantitative biological markers in depression.<\/jats:p>","DOI":"10.1038\/s41398-022-01927-9","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T07:26:23Z","timestamp":1650093983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["The relationship between emotional regulation and hemispheric lateralization in depression: a systematic review and a meta-analysis"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0883-2015","authenticated-orcid":false,"given":"Natia","family":"Horato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6928-5847","authenticated-orcid":false,"given":"Laiana A.","family":"Quagliato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4669","authenticated-orcid":false,"given":"Antonio E.","family":"Nardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"1927_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1590\/S1413-73722008000300014","volume":"13","author":"I Mocaiber","year":"2008","unstructured":"Mocaiber I, Oliveira L, Pereira M, Pinheiro W, Ventura P, Figueira I. et al. Neurobiologia da regula\u00e7\u00e3o emocional: implica\u00e7\u00f5es para a terapia cognitivo-comportamental. Psicol Estud. 2008;13:531\u20138. https:\/\/doi.org\/10.1590\/S1413-73722008000300014.","journal-title":"Psicol Estud"},{"key":"1927_CR2","doi-asserted-by":"publisher","unstructured":"Davis E, Foland-Ross L, Gotlib I. Neural correlates of top-down regulation and generation of negative affect in major depressive disorder. Psychiatry Res: Neuroimaging. 2018. https:\/\/doi.org\/10.1016\/j.pscychresns.2018.04.001.","DOI":"10.1016\/j.pscychresns.2018.04.001"},{"key":"1927_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1037\/0021-843X.100.4.535","volume":"100","author":"J Henriques","year":"1991","unstructured":"Henriques J, Davidson R. Left frontal hypoactivation in depression. J Abnorm Psychol. 1991;100:535\u201345. https:\/\/doi.org\/10.1037\/0021-843X.100.4.535.","journal-title":"J Abnorm Psychol"},{"key":"1927_CR4","doi-asserted-by":"publisher","unstructured":"Jenkins L, Stange J, Bessette K, Chang Y, Corwin S, Skerrett K, et al. Differential engagement of cognitive control regions and subgenual cingulate based upon presence or absence of comorbid anxiety with depression. J Affect Disord 2018. https:\/\/doi.org\/10.1016\/j.jad.2018.07.082.","DOI":"10.1016\/j.jad.2018.07.082"},{"key":"1927_CR5","doi-asserted-by":"publisher","first-page":"22445","DOI":"10.1073\/pnas.0910651106","volume":"106","author":"A Heller","year":"2009","unstructured":"Heller A, Johnstone T, Shackman A, Light S, Peterson M, Kolden G, et al. Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation. PNAS. 2009;106:22445\u201350. https:\/\/doi.org\/10.1073\/pnas.0910651106.","journal-title":"PNAS"},{"key":"1927_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000503395","volume":"52","author":"R Ferreira-Garcia","year":"2019","unstructured":"Ferreira-Garcia R, Faria CGF, Nardi AE, Freire RC. Negative affect mediates impulsivity in generalized anxiety disorder psychopathology. Psychopathology. 2019;52:327\u201333.","journal-title":"Psychopathology"},{"key":"1927_CR7","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1002\/da.22541","volume":"33","author":"NA Crane","year":"2016","unstructured":"Crane NA, Jenkins LM, Dion C, Meyers KK, Weldon AL, Gabriel LB, et al. Comorbid anxiety increases cognitive control activation in major depressive disorder. Depress Anxiety. 2016;33:967\u201377. https:\/\/doi.org\/10.1002\/da.22541.","journal-title":"Depress Anxiety"},{"key":"1927_CR8","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1177\/070674370605101304","volume":"51","author":"M Fava","year":"2006","unstructured":"Fava M, Rush AJ, Alpert JE, Carmin CN, Balasubramani GK, Wisniewski SR, et al. What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extension. Can J Psychiatry. 2006;51:823\u201335. https:\/\/doi.org\/10.1177\/070674370605101304.","journal-title":"Can J Psychiatry"},{"key":"1927_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/1520-6394(2000)12:1","volume":"12","author":"KJ Ressler","year":"2000","unstructured":"Ressler KJ, Nemeroff CB. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress anxiety. 2000;12:2\u201319. https:\/\/doi.org\/10.1002\/1520-6394(2000)12:1.","journal-title":"Depress anxiety"},{"key":"1927_CR10","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ejphar.2007.12.032","volume":"583","author":"F Holsboer","year":"2008","unstructured":"Holsboer F, Ising M. Central CRH system in depression and anxiety\u2014evidence from clinical studies with CRH1 receptor antagonists. Eur J Pharmacol. 2008;583:350\u20137. https:\/\/doi.org\/10.1016\/j.ejphar.2007.12.032.","journal-title":"Eur J Pharmacol"},{"key":"1927_CR11","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1001\/jamapsychiatry.2013.2430","volume":"70","author":"AS Heller","year":"2013","unstructured":"Heller AS, Johnstone T, Peterson MJ, Kolden GG, Kalin NH, Davidson RJ. Increased prefrontal cortex activity during negative emotion regulation as a predictor of depression symptom severity trajectory over 6 months. JAMA Psychiatry. 2013;70:1181\u20139. https:\/\/doi.org\/10.1001\/jamapsychiatry.2013.2430.","journal-title":"JAMA Psychiatry"},{"key":"1927_CR12","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1093\/scan\/nsu084","volume":"10","author":"JP Hamilton","year":"2015","unstructured":"Hamilton JP, Chen MC, Waugh CE, Joormann J, Gotlib IH. Distinctive and common neural underpinnings of major depression, social anxiety, and their comorbidity. Soc Cogn Affect Neurosci. 2015;10:552\u201360. https:\/\/doi.org\/10.1093\/scan\/nsu084.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"1927_CR13","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.biopsych.2005.10.012","volume":"60","author":"F Sotres-Bayon","year":"2006","unstructured":"Sotres-Bayon F, Cain CK, LeDoux JE. Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex. Biol Psychiatry. 2006;60:329\u201336. https:\/\/doi.org\/10.1016\/j.biopsych.2005.10.012.","journal-title":"Biol Psychiatry"},{"key":"1927_CR14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1469-8986.2003.00149.x","volume":"41","author":"JJ Allen","year":"2004","unstructured":"Allen JJ, Urry HL, Hitt SK, Coan JA. The stability of resting frontal electroencephalographic asymmetry in depression. Psychophysiology. 2004;41:269\u201380. https:\/\/doi.org\/10.1111\/j.1469-8986.2003.00149.x.","journal-title":"Psychophysiology"},{"key":"1927_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1117\/155005941104200110","volume":"42","author":"R Segrave","year":"2011","unstructured":"Segrave R, Cooper N, Thomson R, Croft R, Sheppard D, Fitzgerald P. Individualized Alpha activity and frontal asymmetry in major depression. Clin EEG Neurosci. 2011;42:45\u201352. https:\/\/doi.org\/10.1117\/155005941104200110.","journal-title":"Clin EEG Neurosci"},{"key":"1927_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10484-015-9315-8","volume":"41","author":"EJ Cheon","year":"2016","unstructured":"Cheon EJ, Koo BH, Choi JH. The efficacy of neurofeedback in patients with major depressive disorder: an open labeled prospective study. Appl Psychophysiol Biofeedback. 2016;41:103\u201310. https:\/\/doi.org\/10.1007\/s10484-015-9315-8.","journal-title":"Appl Psychophysiol Biofeedback"},{"key":"1927_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","volume":"24","author":"E Miller","year":"2001","unstructured":"Miller E, Cohen J. An integrative theory of prefrontal cortex function. Rev Neurosci 2001;24:167\u2013202. https:\/\/doi.org\/10.1146\/annurev.neuro.24.1.167.","journal-title":"Rev Neurosci"},{"key":"1927_CR18","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jad.2010.08.023","volume":"129","author":"A Carvalho","year":"2011","unstructured":"Carvalho A, Moraes H, Silveira H, Ribeiro P, Piedade R, Deslandes A, et al. EEG frontal asymmetry in the depressed and remitted elderly: is it related to the trait or to the state of depression? J Affect Disord. 2011;129:143\u20138. https:\/\/doi.org\/10.1016\/j.jad.2010.08.023.","journal-title":"J Affect Disord"},{"key":"1927_CR19","doi-asserted-by":"publisher","first-page":"250","DOI":"10.4103\/jnrp.jnrp_293_18","volume":"10","author":"AS Dharmadhikari","year":"2019","unstructured":"Dharmadhikari AS, Jaiswal SV, Tandle AL, Sinha D, Jog N. Study of frontal alpha asymmetry in mild depression: a potential biomarker or not? J Neurosci Rural Pract. 2019;10:250\u201355. https:\/\/doi.org\/10.4103\/jnrp.jnrp_293_18.","journal-title":"J Neurosci Rural Pract"},{"key":"1927_CR20","doi-asserted-by":"publisher","unstructured":"Gollan J, Hoxha D, Chihade D, Pflieger M, Rosebrock L, Cacioppo J. Frontal alpha EEG asymmetry before and after behavioral activation treatment for depression. Biol Psychol. 2014. https:\/\/doi.org\/10.1016\/j.biopsycho.2014.03.003.","DOI":"10.1016\/j.biopsycho.2014.03.003"},{"key":"1927_CR21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1097\/WNP.0b013e3181c298fe","volume":"26","author":"V Grin-Yatsenko","year":"2009","unstructured":"Grin-Yatsenko V, Baas I, Ponomarev V, Kropotov J. EEG power spectra at early stages of depressive disorders. J Clin Neurophysiol. 2009;26:401\u20136. https:\/\/doi.org\/10.1097\/WNP.0b013e3181c298fe.","journal-title":"J Clin Neurophysiol"},{"key":"1927_CR22","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.jpsychires.2012.08.003","volume":"46","author":"N Jaworska","year":"2012","unstructured":"Jaworska N, Blier P, Fusee W, Knott V. Alpha power, alpha asymmetry and anterior cingulate cortex activity in depressed males and females. J Psychiatr Res. 2012;46:1483\u201391. https:\/\/doi.org\/10.1016\/j.jpsychires.2012.08.003.","journal-title":"J Psychiatr Res"},{"key":"1927_CR23","doi-asserted-by":"publisher","unstructured":"Kaiser A, Doppelmayr M, Iglseder B. Electroencephalogram alpha asymmetry in geriatric depression valid or vanished? Z Gerontol Geriat. 2016;51. https:\/\/doi.org\/10.1007\/s00391-016-1108-z.","DOI":"10.1007\/s00391-016-1108-z"},{"key":"1927_CR24","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.biopsycho.2010.08.001","volume":"85","author":"A Kemp","year":"2010","unstructured":"Kemp A, Griffiths K, Felmingham K, Shankmand S, Drinkenburge W, Arns M, et al. Disorder specificity despite comorbidity: resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder. Biol Psychol. 2010;85:350\u20134. https:\/\/doi.org\/10.1016\/j.biopsycho.2010.08.001.","journal-title":"Biol Psychol"},{"key":"1927_CR25","doi-asserted-by":"publisher","first-page":"58","DOI":"10.9758\/cpn.2020.18.1.58","volume":"18","author":"S Roh","year":"2020","unstructured":"Roh S, Kim J, Kim S, Kim Y, Lee S. Frontal alpha asymmetry moderated by suicidal ideation in patients with major depressive disorder: a comparison with healthy individuals. Clin Psychopharmacol Neurosci. 2020;18:58\u201366A. https:\/\/doi.org\/10.9758\/cpn.2020.18.1.58.","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"1927_CR26","unstructured":"Horato N, Quagliato L, Nardi AE. The relationship between emotional regulation and executive control: a meta-analysis. PROSPERO 2020. CRD42020150815."},{"key":"1927_CR27","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s11517-009-0554-9","volume":"47","author":"H Hinrikus","year":"2009","unstructured":"Hinrikus H, Suhhova A, Bachmann M, Aadamsoo K, Vohma U, Lass J, et al. Electroencephalographic spectral asymmetry index for detection of depression. Med Biol Eng Comput. 2009;47:1291\u20139. https:\/\/doi.org\/10.1007\/s11517-009-0554-9.","journal-title":"Med Biol Eng Comput"},{"key":"1927_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.pscychresns.2014.02.010","volume":"222","author":"S Olbrich","year":"2014","unstructured":"Olbrich S, Tr\u00e4nkner A, Chittka T, Hegerl U, Sch\u00f6nknecht P. Functional connectivity in major depression: increased phase synchronization between frontal cortical EEG-source estimates. Psychiatry Res: Neuroimaging. 2014;222:91\u201399. https:\/\/doi.org\/10.1016\/j.pscychresns.2014.02.010.","journal-title":"Psychiatry Res: Neuroimaging"},{"key":"1927_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jpsychires.2014.01.018","volume":"53","author":"I Cook","year":"2014","unstructured":"Cook I, Hunter A, Korb A, Leuchter A. Do prefrontal midline electrodes provide unique neurophysiologic information in major depressive disorder? J Psychiatr Res. 2014;53:69\u201375. https:\/\/doi.org\/10.1016\/j.jpsychires.2014.01.018.","journal-title":"J Psychiatr Res"},{"key":"1927_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0917-3","volume":"16","author":"Y Wang","year":"2016","unstructured":"Wang Y, Chai F, Zhang H, Liu X, Xie P, Zheng L, et al. Cortical functional activity in patients with generalized. BMC Psychiatry. 2016;16:217. https:\/\/doi.org\/10.1186\/s12888-016-0917-3.","journal-title":"BMC Psychiatry"},{"key":"1927_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neulet.2019.03.047","volume":"703","author":"J Liu","year":"2019","unstructured":"Liu J, Lia J, Peng W, Fenga M, Luo Y. EEG correlates of math anxiety during arithmetic problem solving: implication for attention deficits. Neurosci Lett. 2019;703:191\u20137. https:\/\/doi.org\/10.1016\/j.neulet.2019.03.047.","journal-title":"Neurosci Lett"},{"key":"1927_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18306-w","volume":"7","author":"Y Li","year":"2017","unstructured":"Li Y, Kang C, Wei Z, Qu X, Liu T, Zhou Y, et al. Beta oscillations in major depression\u2014signalling a new cortical circuit for central executive function. Sci Rep. 2017;7:18021. https:\/\/doi.org\/10.1038\/s41598-017-18306-w.","journal-title":"Sci Rep"},{"key":"1927_CR33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.euroneuro.2017.02.002","volume":"27","author":"T Iseger","year":"2017","unstructured":"Iseger T, Korgaonkarc M, Kenemansa J, Grievec S, Baekenf C, Fitzgeraldg P, et al. EEG connectivity between the subgenual anterior cingulate and prefrontal cortices in response to antidepressant medication. Eur Neuropsychofarmacol. 2017;27:301\u201312. https:\/\/doi.org\/10.1016\/j.euroneuro.2017.02.002.","journal-title":"Eur Neuropsychofarmacol"},{"key":"1927_CR34","doi-asserted-by":"publisher","unstructured":"Kan D, Lee P. Decrease alpha waves in depression: an electroencephalogram (EEG) study. In BioSignal Analysis Processing and Systems (ICBAPS), 2015 International Conference on, IEEE (2015), p. 156\u2013161. https:\/\/doi.org\/10.1109\/ICBAPS.2015.7292237.","DOI":"10.1109\/ICBAPS.2015.7292237"},{"key":"1927_CR35","first-page":"355","volume":"23","author":"D Begi\u0107","year":"2011","unstructured":"Begi\u0107 D, Popovi\u0107-Knapi\u0107 V, Grubi\u0161in J, Kosanovi\u0107-Raja\u010di\u0107 B, Filip\u010di\u0107 I, Telarovi\u0107 I, et al. Quantitative electroencephalography in schizophrenia and depression. Psychiatr Danubina. 2011;23:355\u201362.","journal-title":"Psychiatr Danubina"},{"key":"1927_CR36","doi-asserted-by":"publisher","first-page":"12341","DOI":"10.1523\/jneurosci.2324-08.2008","volume":"28","author":"M Koenigs","year":"2008","unstructured":"Koenigs M, Huey E, Calamia M, Raymont V, Tranel D, Grafman J. Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression. J Neurosci. 2008;28:12341\u20138. https:\/\/doi.org\/10.1523\/jneurosci.2324-08.2008.","journal-title":"J Neurosci"},{"key":"1927_CR37","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1590\/S0004-282X1999000100026","volume":"2","author":"F Luccas","year":"1996","unstructured":"Luccas F, Braga O, Fonseca C, Frochtgarten L. Recomenda\u00e7\u00f5es para o registro e interpreta\u00e7\u00e3o do mapeamento topogr\u00e1fico do eletroencefalograma (EEG) e potenciais evocados sensoriais (PES). Braz J Epilepsy Clin Neurophysiol 1996;2:82\u201375. https:\/\/doi.org\/10.1590\/S0004-282X1999000100026.","journal-title":"Braz J Epilepsy Clin Neurophysiol"},{"key":"1927_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnhum.2012.00127","volume":"127","author":"R Nenert","year":"2012","unstructured":"Nenert R, Viswanathan S, Dubuc D, Visscher K. Modulations of ongoing alpha ocillations predict successful short-term visual memory encoding. Front Hum Neurosci. 2012;127:1\u201310. https:\/\/doi.org\/10.3389\/fnhum.2012.00127.","journal-title":"Front Hum Neurosci"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-022-01927-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-022-01927-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-022-01927-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T19:26:14Z","timestamp":1669231574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-022-01927-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["1927"],"URL":"https:\/\/doi.org\/10.1038\/s41398-022-01927-9","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,16]]},"assertion":[{"value":"7 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"162"}}