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In addition to standard measures of cortical GM thickness and WM volume, we analyzed tissue-specific profiles of brain metabolites using multivoxel proton magnetic resonance spectroscopy, T1 relaxation time as a proxy of myelin content leveraging advanced quantitative MRI methods and serum NF-L concentrations in a sample of 30 female, predominately adolescent patients with AN and 30 age-matched female healthy control participants. In patients with AN, we found a reduction in GM cortical thickness and GM total N-acetyl aspartate. The latter predicted higher NF-L levels, which were elevated in AN. Furthermore, GM total choline was elevated. In WM, there were no group differences in either imaging markers, choline levels or N-acetyl aspartate levels. The current study provides evidence for neuronal damage processes as well as for increased membrane lipid catabolism and turnover in GM in acute AN but no evidence for WM pathology. Our results illustrate the potential of multimodal research including tissue-specific proton magnetic resonance spectroscopy analyses to shed light on brain changes in psychiatric and neurological conditions, which may ultimately lead to better treatments.<\/jats:p>","DOI":"10.1038\/s41398-023-02580-6","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T10:01:51Z","timestamp":1691834511000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers"],"prefix":"10.1038","volume":"13","author":[{"given":"Arne","family":"Doose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike I.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Hellerhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Gottloeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Raschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Bartnik-Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Akg\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Roessner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Linn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-4445","authenticated-orcid":false,"given":"Stefan","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"2580_CR1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopsych.2017.08.011","volume":"83","author":"JA King","year":"2018","unstructured":"King JA, Frank GKW, Thompson PM, Ehrlich S. 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F.I.T. has received funding from the Medical Faculty of the Technische Universit\u00e4t Dresden (\u201cHabilitation Funding for Women\u201d). V.R. has received payment for consulting and writing activities from Eli Lilly and Co., Novartis and Shire Pharmaceuticals\/Takeda, lecture honoraria from Eli Lilly and Co., Novartis, Shire Pharmaceuticals\/Takeda, and Medice Pharma, and support for research from Shire Pharmaceuticals\/Takeda and Novartis. V.R. has carried out (and is currently carrying out) clinical trials in cooperation with Novartis, Shire Pharmaceuticals\/Takeda and Otsuka. V.R. has no financial relationship with the organizations that sponsored the research. V.R. has received lecture honoraria from Infectopharm and Medice companies. He has carried out clinical trials in cooperation with Servier and Shire Pharmaceuticals\/Takeda companies. K.A. received personal compensation from Novartis, Biogen Idec, Teva, Sanofi, and Roche for consulting service. J.L. serves as advisory boardmember for Biogen GmbH and Mediaire GmbH. A.P.L. is a consultant for Agios Pharmaceuticals, Biomarin Pharmaceuticals, and Moncton MRI; is co-founder of BrainSpec; and receives research funding from NINDS, NIA, the Department of Defense, and the Alzheimer\u2019s Association. A.D., I.H., J.K, I.B, K.G, H.W., A.W., F.R., and B.B. declare no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"277"}}