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Previous studies showed that deletion of\n                    <jats:italic>Ank3-1b<\/jats:italic>\n                    , a BD-associated variant of\n                    <jats:italic>Ank3<\/jats:italic>\n                    in mice leads to increased firing threshold and diminished action potential dynamic range of parvalbumin (PV) interneurons and absence epilepsy, thus providing a biological mechanism linking epilepsy and BD. To explore the behavioral overlap of these disorders, we characterized behavioral patterns of\n                    <jats:italic>Ank3-1b<\/jats:italic>\n                    KO mice during overnight home-cage activity and examined network activity during these behaviors using paired video and EEG recordings. Since PV interneurons contribute to the generation of high-frequency gamma oscillations, we anticipated changes in the power of neocortical EEG signals in the gamma frequency range (&gt; 25\u2009Hz) during behavioral states related to human BD symptoms, including abnormal sleep, hyperactivity, and repetitive behaviors.\n                    <jats:italic>Ank3-1b<\/jats:italic>\n                    KO mice exhibited an overall increase in slow gamma (~25-45\u2009Hz) power compared to controls, and slow gamma power correlated with seizure phenotype severity across behaviors. During sleep, increased slow gamma power correlated with decreased time spent in the rapid eye movement (REM) stage of sleep. Seizures were more common during REM sleep compared to non-REM (NREM) sleep. We also found that\n                    <jats:italic>Ank3-1b<\/jats:italic>\n                    KO mice were hyperactive and exhibited a repetitive behavior phenotype that co-occurred with increased slow gamma power. Our results identify a novel EEG biomarker associating\n                    <jats:italic>Ank3<\/jats:italic>\n                    genetic variation with BD and epilepsy and suggest modulation of gamma oscillations as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1038\/s41398-023-02700-2","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T13:02:01Z","timestamp":1703077321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-2247","authenticated-orcid":false,"given":"Juan E.","family":"Villacres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2791-4155","authenticated-orcid":false,"given":"Nicholas","family":"Riveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-5466","authenticated-orcid":false,"given":"Sohmee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4853-8913","authenticated-orcid":false,"given":"Laura L.","family":"Colgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Noebels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-2681","authenticated-orcid":false,"given":"Angel Y.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"2700_CR1","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1111\/j.1528-1167.2011.03372.x","volume":"53","author":"C Lau","year":"2012","unstructured":"Lau C, Ettinger AB, Hamberger S, Fanning K, Reed ML. 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