{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:45:30Z","timestamp":1791215130395,"version":"4.1.0"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["5R01MH071533-09"],"award-info":[{"award-number":["5R01MH071533-09"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["5F31MH117834-02"],"award-info":[{"award-number":["5F31MH117834-02"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["T32-MH018870"],"award-info":[{"award-number":["T32-MH018870"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["1R01MH118497-01A1"],"award-info":[{"award-number":["1R01MH118497-01A1"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-024-03181-7","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T05:45:36Z","timestamp":1733291136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-9742","authenticated-orcid":false,"given":"Emily M.","family":"Parker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan L.","family":"Kindja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"DeGiosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan B.","family":"Salisbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh M.","family":"Krivinko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E. J.","family":"Cheetham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-9709","authenticated-orcid":false,"given":"Robert A.","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"3181_CR1","doi-asserted-by":"crossref","unstructured":"Zamponi, GW. Voltage-gated calcium channels. New York: Springer; 2005.","DOI":"10.1007\/0-387-27526-6"},{"key":"3181_CR2","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1152\/physrev.00057.2009","volume":"90","author":"GW Buraei","year":"2010","unstructured":"Buraei GW, Yang J. The \u03b2 subunit of voltage-gated Ca 2+ channels. Physiol Rev. 2010;90:1461\u2013506.","journal-title":"Physiol Rev"},{"key":"3181_CR3","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.bbamem.2012.08.028","volume":"1828","author":"Z Buraei","year":"2013","unstructured":"Buraei Z, Yang J. Structure and function of the \u03b2 subunit of voltage-gated Ca2+ channels. Biochim Biophys Acta Biomembr. 2013;1828:1530\u201340.","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"3181_CR4","doi-asserted-by":"publisher","first-page":"5369","DOI":"10.1113\/JP272262","volume":"594","author":"AC Dolphin","year":"2016","unstructured":"Dolphin AC. Voltage\u2010gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol. 2016;594:5369\u201390.","journal-title":"J Physiol"},{"key":"3181_CR5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1042\/bst0220483","volume":"22","author":"A Castellano","year":"1994","unstructured":"Castellano A, Perez-Reyes E. Molecular diversity of Ca2+ channel \u03b2 subunits. Biochem Soc Trans. 1994;22:483\u20138.","journal-title":"Biochem Soc Trans"},{"key":"3181_CR6","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.neuroscience.2010.02.037","volume":"167","author":"B Schlick","year":"2010","unstructured":"Schlick B, Flucher B, Obermair G. Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Neuroscience. 2010;167:786\u201398.","journal-title":"Neuroscience"},{"key":"3181_CR7","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1523\/JNEUROSCI.3935-13.2014","volume":"34","author":"S Etemad","year":"2014","unstructured":"Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, et al. Differential neuronal targeting of a new and two known calcium channel \u03b24 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014;34:1446\u201361.","journal-title":"J Neurosci"},{"key":"3181_CR8","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1523\/JNEUROSCI.17-04-01339.1997","volume":"17","author":"A Ludwig","year":"1997","unstructured":"Ludwig A, Flockerzi V, Hofmann F. Regional expression and cellular localization of the \u03b11 and \u03b2 subunit of high voltage-activated calcium channels in rat brain. J Neurosci. 1997;17:1339\u201349.","journal-title":"J Neurosci"},{"key":"3181_CR9","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/j.1471-4159.2012.07853.x","volume":"122","author":"C Ferr\u00e1ndiz\u2010Huertas","year":"2012","unstructured":"Ferr\u00e1ndiz\u2010Huertas C, Gil\u2010M\u00ednguez M, Luj\u00e1n R. Regional expression and subcellular localization of the voltage\u2010gated calcium channel \u03b2 subunits in the developing mouse brain. J Neurochem. 2012;122:1095\u2013107.","journal-title":"J Neurochem"},{"key":"3181_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0169-328X(94)00265-G","volume":"30","author":"O Tanaka","year":"1995","unstructured":"Tanaka O, Sakagami H, Kondo H. Localization of mRNAs of voltage-dependent Ca2+-channels: four subtypes of \u03b11-and \u03b2-subunits in developing and mature rat brain. Mol Brain Res. 1995;30:1\u201316.","journal-title":"Mol Brain Res"},{"key":"3181_CR11","doi-asserted-by":"publisher","first-page":"37807","DOI":"10.1074\/jbc.M004653200","volume":"275","author":"S Wittemann","year":"2000","unstructured":"Wittemann S, Mark MD, Rettig J, Herlitze S. Synaptic localization and presynaptic function of calcium channel \u03b24-subunits in cultured hippocampal neurons. J Biol Chem. 2000;275:37807\u201314.","journal-title":"J Biol Chem"},{"key":"3181_CR12","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1074\/jbc.271.6.3207","volume":"271","author":"VE Scott","year":"1996","unstructured":"Scott VE, De Waard M, Liu H, Gurnett CA, Venzke DP, Lennon VA, et al. Beta subunit heterogeneity in N-type Ca2+ channels. J Biol Chem. 1996;271:3207\u201312.","journal-title":"J Biol Chem"},{"key":"3181_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1023\/A:1021997924473","volume":"30","author":"MW McEnery","year":"1998","unstructured":"McEnery MW, Vance CL, Begg CM, Lee WL, Choi Y, Dubel SJ. Differential expression and association of calcium channel subunits in development and disease. J Bioenerg Biomembr. 1998;30:409\u201318.","journal-title":"J Bioenerg Biomembr"},{"key":"3181_CR14","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jprot.2008.10.005","volume":"72","author":"P Klemmer","year":"2009","unstructured":"Klemmer P, Smit AB, Li KW. Proteomics analysis of immuno-precipitated synaptic protein complexes. J Proteom. 2009;72:82\u201390.","journal-title":"J Proteom"},{"key":"3181_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1085\/jgp.200709901","volume":"132","author":"G Gonzalez-Gutierrez","year":"2008","unstructured":"Gonzalez-Gutierrez G, Miranda-Laferte E, Naranjo D, Hidalgo P, Neely A. Mutations of nonconserved residues within the calcium channel \u03b11-interaction domain inhibit \u03b2-subunit potentiation. J Gen Physiol. 2008;132:383\u201395.","journal-title":"J Gen Physiol"},{"key":"3181_CR16","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nsmb909","volume":"12","author":"JM Maltez","year":"2005","unstructured":"Maltez JM, Nunziato DA, Kim J, Pitt GS. Essential Ca v \u03b2 modulatory properties are AID-independent. Nat Struct Mol Biol. 2005;12:372\u20137.","journal-title":"Nat Struct Mol Biol"},{"key":"3181_CR17","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/S0006-3495(96)79685-6","volume":"70","author":"IR Josephson","year":"1996","unstructured":"Josephson IR, Varadi G. The beta subunit increases Ca2+ currents and gating charge movements of human cardiac L-type Ca2+ channels. Biophys J. 1996;70:1285\u201393.","journal-title":"Biophys J"},{"key":"3181_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1085\/jgp.112.2.125","volume":"112","author":"LP Jones","year":"1998","unstructured":"Jones LP, Wei S-K, Yue DT. Mechanism of auxiliary subunit modulation of neuronal \u03b11E calcium channels. J Gen Physiol. 1998;112:125\u201343.","journal-title":"J Gen Physiol"},{"key":"3181_CR19","doi-asserted-by":"publisher","first-page":"a005686","DOI":"10.1101\/cshperspect.a005686","volume":"4","author":"MJ Higley","year":"2012","unstructured":"Higley MJ, Sabatini BL. Calcium signaling in dendritic spines. Cold Spring Harb Perspect Biol. 2012;4:a005686.","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3181_CR20","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/35046076","volume":"408","author":"BL Sabatini","year":"2000","unstructured":"Sabatini BL, Svoboda K. Analysis of calcium channels in single spines using optical fluctuation analysis. Nature. 2000;408:589\u201393.","journal-title":"Nature"},{"key":"3181_CR21","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/nn1112","volume":"6","author":"R Yasuda","year":"2003","unstructured":"Yasuda R, Sabatini BL, Svoboda K. Plasticity of calcium channels in dendritic spines. Nat Neurosci. 2003;6:948\u201355.","journal-title":"Nat Neurosci"},{"key":"3181_CR22","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/76609","volume":"3","author":"R Yuste","year":"2000","unstructured":"Yuste R, Majewska A, Holthoff K. From form to function: calcium compartmentalization in dendritic spines. Nat Neurosci. 2000;3:653\u20139.","journal-title":"Nat Neurosci"},{"key":"3181_CR23","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S0166-2236(03)00162-0","volume":"26","author":"H Kasai","year":"2003","unstructured":"Kasai H, Matsuzaki M, Noguchi J, Yasumatsu N, Nakahara H. Structure\u2013stability\u2013function relationships of dendritic spines. Trends Neurosci. 2003;26:360\u20138.","journal-title":"Trends Neurosci"},{"key":"3181_CR24","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/ng.2742","volume":"45","author":"S Ripke","year":"2013","unstructured":"Ripke S, O'Dushlaine C, Chambert K, Moran JL, K\u00e4hler AK, Akterin S, et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45:1150\u20139.","journal-title":"Nat Genet"},{"key":"3181_CR25","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature13595","volume":"511","author":"R Stephan","year":"2014","unstructured":"Stephan R, Benjamin MN, Aiden C, James TRW, Kai-How F, et al. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421\u20137.","journal-title":"Nature"},{"key":"3181_CR26","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/npp.2008.67","volume":"34","author":"RA Sweet","year":"2009","unstructured":"Sweet RA, Henteleff RA, Zhang W, Sampson AR, Lewis DA. Reduced dendritic spine density in auditory cortex of subjects with schizophrenia. Neuropsychopharmacology. 2009;34:374\u201389.","journal-title":"Neuropsychopharmacology"},{"key":"3181_CR27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neulet.2014.11.042","volume":"601","author":"CE Moyer","year":"2015","unstructured":"Moyer CE, Shelton MA, Sweet RA. Dendritic spine alterations in schizophrenia. Neurosci Lett. 2015;601:46\u201353.","journal-title":"Neurosci Lett"},{"key":"3181_CR28","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.biopsych.2014.12.029","volume":"78","author":"MA Shelton","year":"2015","unstructured":"Shelton MA, Newman JT, Gu H, Sampson AR, Fish KN, MacDonald ML, et al. Loss of microtubule-associated protein 2 immunoreactivity linked to dendritic spine loss in schizophrenia. Biol Psychiatry. 2015;78:374\u201385.","journal-title":"Biol Psychiatry"},{"key":"3181_CR29","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/s41386-019-0350-7","volume":"44","author":"BC McKinney","year":"2019","unstructured":"McKinney BC, MacDonald ML, Newman JT, Shelton MA, DeGiosio RA, Kelly RM, et al. Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia. Neuropsychopharmacology. 2019;44:1055\u201361.","journal-title":"Neuropsychopharmacology"},{"key":"3181_CR30","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1176\/appi.ajp.2017.16070814","volume":"174","author":"ML MacDonald","year":"2017","unstructured":"MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, et al. Selective loss of smaller spines in schizophrenia. Am J Psychiatry. 2017;174:586\u201394.","journal-title":"Am J Psychiatry"},{"key":"3181_CR31","doi-asserted-by":"publisher","first-page":"eaat8127","DOI":"10.1126\/science.aat8127","volume":"362","author":"MJ Gandal","year":"2018","unstructured":"Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018;362:eaat8127.","journal-title":"Science"},{"key":"3181_CR32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1089\/hgtb.2013.076","volume":"24","author":"S Gholizadeh","year":"2013","unstructured":"Gholizadeh S, Tharmalingam S, MacAldaz ME, Hampson DR. Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice. Hum Gene Ther Methods. 2013;24:205\u201313.","journal-title":"Hum Gene Ther Methods"},{"key":"3181_CR33","first-page":"Unit 14D.15","volume":"Chapter 14","author":"L Stoica","year":"2013","unstructured":"Stoica L, Ahmed SS, Gao G, Esteves MS. AAV-mediated gene transfer to the mouse CNS. Curr Protoc Microbiol. 2013;Chapter 14:Unit 14D.15.","journal-title":"Curr Protoc Microbiol"},{"key":"3181_CR34","doi-asserted-by":"crossref","unstructured":"Cheetham CEJ, Grier BD, Belluscio L. Bulk regional viral injection in neonatal mice enables structural and functional interrogation of defined neuronal populations throughout targeted brain areas. Front Neural Circuits. 2015;9:72.","DOI":"10.3389\/fncir.2015.00072"},{"key":"3181_CR35","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0031-9384(86)90058-2","volume":"38","author":"CB Phifer","year":"1986","unstructured":"Phifer CB, Terry LM. Use of hypothermia for general anesthesia in preweaning rodents. J Physiol Behav. 1986;38:887\u201390.","journal-title":"J Physiol Behav"},{"key":"3181_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56847-4","volume":"10","author":"EM Parker","year":"2020","unstructured":"Parker EM, Kindja NL, Cheetham CEJ, Sweet RA. Sex differences in dendritic spine density and morphology in auditory and visual cortices in adolescence and adulthood. Sci Rep. 2020;10:1\u201311.","journal-title":"Sci Rep"},{"key":"3181_CR37","unstructured":"Franklin KBJ, Paxinos G. The mouse brain in stereotaxic coordinates. Orlando: Gulf Professional Publishing; 2004."},{"key":"3181_CR38","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1523\/JNEUROSCI.2557-16.2017","volume":"37","author":"R Bopp","year":"2017","unstructured":"Bopp R, Holler-Rickauer S, Martin KAC, Schuhknecht GFP. An ultrastructural study of the thalamic input to layer 4 of primary motor and primary somatosensory cortex in the mouse. J Neurosci. 2017;37:2435\u201348.","journal-title":"J Neurosci"},{"key":"3181_CR39","doi-asserted-by":"publisher","first-page":"2754","DOI":"10.1523\/JNEUROSCI.4900-12.2014","volume":"34","author":"W Zhang","year":"2014","unstructured":"Zhang W, Peterson M, Beyer B, Frankel WN, Zhang Z. Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures. J Neurosci. 2014;34:2754\u201363.","journal-title":"J Neurosci"},{"key":"3181_CR40","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/S0896-6273(03)00755-4","volume":"40","author":"H-S Li","year":"2003","unstructured":"Li H-S, Wang D, Shen Q, Schonemann MD, Gorski JA, Jones KR, et al. Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron. 2003;40:1105\u201318.","journal-title":"Neuron"},{"key":"3181_CR41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3389\/neuro.01.1.1.010.2007","volume":"1","author":"JI Arellano","year":"2007","unstructured":"Arellano JI, Benavides-Piccione R, DeFelipe J, Yuste R. Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies. Front Neurosci. 2007;1:131\u201343.","journal-title":"Front Neurosci"},{"key":"3181_CR42","doi-asserted-by":"publisher","first-page":"107591","DOI":"10.1371\/journal.pone.0107591","volume":"9","author":"WC Risher","year":"2014","unstructured":"Risher WC, Ustunkaya T, Alvarado JS, Eroglu C. Rapid Golgi analysis method for efficient and unbiased classification of dendritic spines. PLoS One. 2014;9:107591.","journal-title":"PLoS One"},{"key":"3181_CR43","doi-asserted-by":"publisher","first-page":"Appendix-4I","DOI":"10.1002\/0471142301.nsa04is48","volume":"48","author":"CS Caligioni","year":"2009","unstructured":"Caligioni CS. Assessing reproductive status\/stages in mice. Curr Protoc Neurosci. 2009;48:Appendix-4I.","journal-title":"Curr Protoc Neurosci"},{"key":"3181_CR44","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1093\/cercor\/bhv040","volume":"26","author":"CE Moyer","year":"2015","unstructured":"Moyer CE, Erickson SL, Fish KN, Thiels E, Penzes P, Sweet RA. Developmental trajectories of auditory cortex synaptic structures and gap-prepulse inhibition of acoustic startle between early adolescence and young adulthood in mice. Cereb Cortex. 2015;26:2115\u201326.","journal-title":"Cereb Cortex"},{"key":"3181_CR45","unstructured":"Grubisha MJ et al. MAP2 is hyperphosphorylated in schizophrenia and alters its function. bioRxiv:683912 [Preprint]. 2019."},{"key":"3181_CR46","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","volume":"26","author":"B MacLean","year":"2010","unstructured":"MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B, et al. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics. 2010;26:966\u20138.","journal-title":"Bioinformatics"},{"key":"3181_CR47","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/nn.3917","volume":"18","author":"KD Harris","year":"2015","unstructured":"Harris KD, Shepherd GMG. The neocortical circuit: themes and variations. Nat Neurosci. 2015;18:170\u201381.","journal-title":"Nat Neurosci"},{"key":"3181_CR48","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1023\/A:1024134312173","volume":"31","author":"R Benavides-Piccione","year":"2002","unstructured":"Benavides-Piccione R, Ballesteros-Y\u00e1\u00f1ez I, DeFelipe J, Yuste R. Cortical area and species differences in dendritic spine morphology. J Neurocytol. 2002;31:337\u201346.","journal-title":"J Neurocytol"},{"key":"3181_CR49","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1002\/cne.24196","volume":"525","author":"A Hsu","year":"2017","unstructured":"Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017;525:2175\u201391.","journal-title":"J Comp Neurol"},{"key":"3181_CR50","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fnana.2017.00011","volume":"11","author":"JI Luebke","year":"2017","unstructured":"Luebke JI. Pyramidal neurons are not generalizable building blocks of cortical networks. Front Neuroanat. 2017;11:11.","journal-title":"Front Neuroanat"},{"key":"3181_CR51","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3389\/fnmol.2018.00083","volume":"11","author":"BH Alexander","year":"2018","unstructured":"Alexander BH, Barnes HM, Trimmer E, Davidson AM, Ogola BO, Lindsey SH, Mostany R. Stable density and dynamics of dendritic spines of cortical neurons across the estrous cycle while expressing differential levels of sensory-evoked plasticity. Front Mol Neurosci. 2018;11:83.","journal-title":"Front Mol Neurosci"},{"key":"3181_CR52","doi-asserted-by":"publisher","first-page":"4035","DOI":"10.1523\/JNEUROSCI.10-12-04035.1990","volume":"10","author":"CS Woolley","year":"1990","unstructured":"Woolley CS, Gould E, Frankfurt M, McEwen BS. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci. 1990;10:4035\u20139.","journal-title":"J Neurosci"},{"key":"3181_CR53","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1523\/JNEUROSCI.12-07-02549.1992","volume":"12","author":"CS Woolley","year":"1992","unstructured":"Woolley CS, McEwen BS. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992;12:2549\u201354.","journal-title":"J Neurosci"},{"key":"3181_CR54","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fncir.2013.00149","volume":"7","author":"A Kato","year":"2013","unstructured":"Kato A, Hojo Y, Higo S, Komatsuzaki Y, Murakami G, Yoshino H, et al. Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines. Front Neural Circuits. 2013;7:149.","journal-title":"Front Neural Circuits"},{"key":"3181_CR55","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.dcn.2018.01.007","volume":"30","author":"JR Boivin","year":"2018","unstructured":"Boivin JR, Piekarski DJ, Thomas AW, Wilbrecht L. Adolescent pruning and stabilization of dendritic spines on cortical layer 5 pyramidal neurons do not depend on gonadal hormones. Dev Cogn Neurosci. 2018;30:100\u20137.","journal-title":"Dev Cogn Neurosci"},{"key":"3181_CR56","first-page":"5013","volume":"24","author":"QZ Lao","year":"2010","unstructured":"Lao QZ, Kobrinsky E, Liu Z, Soldatov NM. Oligomerization of Cav\u03b2 subunits is an essential correlate of Ca2+ channel activity. FASEB J. 2010;24:5013\u201323.","journal-title":"FASEB J"},{"key":"3181_CR57","doi-asserted-by":"publisher","first-page":"e292","DOI":"10.1371\/journal.pone.0000292","volume":"2","author":"R Hullin","year":"2007","unstructured":"Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, et al. Increased expression of the auxiliary \u03b22-subunit of ventricular L-type Ca2+ channels leads to single-channel activity characteristic of heart failure. PLoS One. 2007;2:e292.","journal-title":"PLoS One"},{"key":"3181_CR58","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1161\/01.RES.0000189270.72915.D1","volume":"97","author":"X Chen","year":"2005","unstructured":"Chen X, Zhang X, Kubo H, Harris DM, Mills GD, Moyer J, et al. Ca2+ influx\u2013induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes. Circ. Res. 2005;97:1009\u201317.","journal-title":"Circ. Res"},{"key":"3181_CR59","doi-asserted-by":"publisher","first-page":"10349","DOI":"10.1523\/JNEUROSCI.1409-18.2018","volume":"38","author":"T Rush","year":"2018","unstructured":"Rush T, Martinez-Hernandez J, Dollmeyer M, Frandemiche ML, Borel E, Boisseau S, et al. Synaptotoxicity in Alzheimer\u2019s disease involved a dysregulation of actin cytoskeleton dynamics through cofilin 1 phosphorylation. J Neurosci. 2018;38:10349\u201361.","journal-title":"J Neurosci"},{"key":"3181_CR60","doi-asserted-by":"publisher","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","volume":"24","author":"PN Lacor","year":"2004","unstructured":"Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, et al. Synaptic targeting by Alzheimer\u2019s-related amyloid \u03b2 oligomers. J Neurosci. 2004;24:10191\u2013200.","journal-title":"J Neurosci"},{"key":"3181_CR61","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1523\/JNEUROSCI.3501-06.2007","volume":"27","author":"PN Lacor","year":"2007","unstructured":"Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, et al. A\u03b2 oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer\u2019s disease. J Neurosci. 2007;27:796\u2013807.","journal-title":"J Neurosci"},{"key":"3181_CR62","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3233\/JAD-2012-120394","volume":"32","author":"M Kervern","year":"2012","unstructured":"Kervern M, Angeli A, Nicole O, L\u00e9veill\u00e9 F, Parent B, Villette V, et al. Selective impairment of some forms of synaptic plasticity by oligomeric amyloid-\u03b2 peptide in the mouse hippocampus: implication of extrasynaptic NMDA receptors. J Alzheimer\u2019s Dis. 2012;32:183\u201396.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"3181_CR63","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1111\/j.1582-4934.2009.00861.x","volume":"13","author":"KN Green","year":"2009","unstructured":"Green KN. Calcium in the initiation, progression and as an effector of Alzheimer\u2019s disease pathology. J Cell Mol Med. 2009;13:2787\u201399.","journal-title":"J Cell Mol Med"},{"key":"3181_CR64","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.neulet.2013.02.001","volume":"538","author":"D Min","year":"2013","unstructured":"Min D, Guo F, Zhu S, Xu X, Mao X, Cao Y, et al. The alterations of Ca2+\/calmodulin\/CaMKII\/CaV1. 2 signaling in experimental models of Alzheimer\u2019s disease and vascular dementia. Neurosci Lett. 2013;538:60\u201365.","journal-title":"Neurosci Lett"},{"key":"3181_CR65","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10059-011-0075-x","volume":"32","author":"S Kim","year":"2011","unstructured":"Kim S, Rhim H. Effects of amyloid-\u03b2 peptides on voltage-gated L-type Cav1.2 and Cav1.3 Ca2+ channels. Mol cells. 2011;32:289\u201394.","journal-title":"Mol cells"},{"key":"3181_CR66","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1046\/j.1471-4159.1997.68010265.x","volume":"68","author":"K Ueda","year":"1997","unstructured":"Ueda K, Shinohara S, Yagami T, Asakura K, Kawasaki K. Amyloid \u03b2 protein potentiates Ca2+ influx through L-type voltage-sensitive Ca2+ channels: a possible involvement of free radicals. J Neurochem. 1997;68:265\u201371.","journal-title":"J Neurochem"},{"key":"3181_CR67","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.nbd.2010.08.020","volume":"41","author":"TS Anekonda","year":"2011","unstructured":"Anekonda TS, et al. L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer\u2019s disease. Neurobiol Dis 2011;41:62\u201370.","journal-title":"Neurobiol Dis"},{"key":"3181_CR68","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neulet.2017.08.004","volume":"663","author":"AM Mata","year":"2018","unstructured":"Mata AM. Functional interplay between plasma membrane Ca2+-ATPase, amyloid \u03b2-peptide and tau. Neurosci Lett. 2018;663:55\u201359.","journal-title":"Neurosci Lett"},{"key":"3181_CR69","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/00001756-199901180-00022","volume":"10","author":"H-S Kim","year":"1999","unstructured":"Kim H-S, Lee J-H, Suh Y-H. C-terminal fragment of Alzheimer\u2019s amyloid precursor protein inhibits sodium\/calcium exchanger activity in SK\u2013N\u2013SH cell. Neuroreport. 1999;10:113\u20136.","journal-title":"Neuroreport"},{"key":"3181_CR70","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/0006-8993(94)91338-2","volume":"665","author":"RA Colvin","year":"1994","unstructured":"Colvin RA, Davis N, Wu A, Murphy CA, Levengood J. Studies of the mechanism underlying increased Na+\/Ca2+ exchange activity in Alzheimer\u2019s disease brain. Brain Res. 1994;665:192\u2013200.","journal-title":"Brain Res"},{"key":"3181_CR71","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.neuropharm.2017.12.037","volume":"131","author":"S Moriguchi","year":"2018","unstructured":"Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, et al. Reduced expression of Na+\/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer\u2019s disease model mice. Neuropharmacology. 2018;131:291\u2013303.","journal-title":"Neuropharmacology"},{"key":"3181_CR72","doi-asserted-by":"publisher","first-page":"e11820","DOI":"10.1371\/journal.pone.0011820","volume":"5","author":"FJ Sepulveda","year":"2010","unstructured":"Sepulveda FJ, Parodi J, Peoples RW, Opazo C, Aguayo LG. Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property. PLoS One. 2010;5:e11820.","journal-title":"PLoS One"},{"key":"3181_CR73","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/jnc.13060","volume":"132","author":"CR Pacheco","year":"2015","unstructured":"Pacheco CR, Morales CN, Ram\u00edrez AE, Mu\u00f1oz FJ, Gallegos SS, Caviedes PA, et al. Extracellular \u03b1-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. J Neurochem. 2015;132:731\u201341.","journal-title":"J Neurochem"},{"key":"3181_CR74","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nn1632","volume":"9","author":"M Day","year":"2006","unstructured":"Day M, Wang Z, Ding J, An X, Ingham CA, Shering AF, et al. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat Neurosci. 2006;9:251\u20139.","journal-title":"Nat Neurosci"},{"key":"3181_CR75","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.ceca.2005.01.016","volume":"37","author":"TG Oertner","year":"2005","unstructured":"Oertner TG, Matus A. Calcium regulation of actin dynamics in dendritic spines. Cell Calcium. 2005;37:477\u201382.","journal-title":"Cell Calcium"},{"key":"3181_CR76","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3389\/fnana.2017.00131","volume":"11","author":"EM Parker","year":"2018","unstructured":"Parker EM, Sweet RA. Stereological assessments of neuronal pathology in auditory cortex in schizophrenia. Front Neuroanat. 2018;11:131.","journal-title":"Front Neuroanat"},{"key":"3181_CR77","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.schres.2010.10.022","volume":"126","author":"TB Ziermans","year":"2011","unstructured":"Ziermans TB, Schothorst PF, Sprong M, van Engeland H. Transition and remission in adolescents at ultra-high risk for psychosis. Schizophr Res. 2011;126:58\u201364.","journal-title":"Schizophr Res"},{"key":"3181_CR78","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nn.2741","volume":"14","author":"P Penzes","year":"2011","unstructured":"Penzes P, Cahill ME, Jones KA, VanLeeuwen J-E, Woolfrey KM. Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci. 2011;14:285\u201393.","journal-title":"Nat Neurosci"},{"key":"3181_CR79","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/dneu.22417","volume":"77","author":"V Mart\u00ednez-Cerde\u00f1o","year":"2017","unstructured":"Mart\u00ednez-Cerde\u00f1o V. Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models. Dev Neurobiol. 2017;77:393\u2013404.","journal-title":"Dev Neurobiol"},{"key":"3181_CR80","doi-asserted-by":"publisher","first-page":"12997","DOI":"10.1523\/JNEUROSCI.5284-12.2013","volume":"33","author":"RP Murmu","year":"2013","unstructured":"Murmu RP, Li W, Holtmaat A, Li J-Y. Dendritic spine instability leads to progressive neocortical spine loss in a mouse model of Huntington\u2019s disease. J Neurosci. 2013;33:12997\u20133009.","journal-title":"J Neurosci"},{"key":"3181_CR81","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nrn2699","volume":"10","author":"A Holtmaat","year":"2009","unstructured":"Holtmaat A, Svoboda K. Experience-dependent structural synaptic plasticity in the mammalian brain. Nat Rev Neurosci. 2009;10:647.","journal-title":"Nat Rev Neurosci"},{"key":"3181_CR82","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neuron.2005.01.003","volume":"45","author":"AJ Holtmaat","year":"2005","unstructured":"Holtmaat AJ, Trachtenberg JT, Wilbrecht L, Shepherd GM, Zhang X, Knott GW, et al. Transient and persistent dendritic spines in the neocortex in vivo. Neuron. 2005;45:279\u201391.","journal-title":"Neuron"},{"key":"3181_CR83","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1085\/jgp.201812261","volume":"151","author":"M Bell","year":"2019","unstructured":"Bell M, Bartol T, Sejnowski T, Rangamani P. Dendritic spine geometry and spine apparatus organization govern the spatiotemporal dynamics of calcium. J Gen Physiol. 2019;151:1017\u201334.","journal-title":"J Gen Physiol"},{"key":"3181_CR84","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.neubiorev.2010.07.002","volume":"35","author":"AK Beery","year":"2011","unstructured":"Beery AK, Zucker I. Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev. 2011;35:565\u201372.","journal-title":"Neurosci Biobehav Rev"},{"key":"3181_CR85","doi-asserted-by":"publisher","first-page":"343","DOI":"10.4161\/chan.3.5.9696","volume":"3","author":"P Subramanyam","year":"2009","unstructured":"Subramanyam P, Obermair GJ, Baumgartner S, Gebhart M, Striessnig J, Kaufmann WA, et al. Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells. Channels. 2009;3:343\u201355.","journal-title":"Channels"},{"key":"3181_CR86","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1111\/j.0953-816X.2004.03272.x","volume":"19","author":"GJ Obermair","year":"2004","unstructured":"Obermair GJ, Szabo Z, Bourinet E, Flucher BE. Differential targeting of the L-type Ca2+ channel \u03b11C (CaV1. 2) to synaptic and extrasynaptic compartments in hippocampal neurons. Eur J Neurosci. 2004;19:2109\u201322.","journal-title":"Eur J Neurosci"},{"key":"3181_CR87","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature12975","volume":"506","author":"SM Purcell","year":"2014","unstructured":"Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014;506:185\u201390.","journal-title":"Nature"},{"key":"3181_CR88","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/ajmg.10100","volume":"105","author":"R Freedman","year":"2001","unstructured":"Freedman R, Leonard S, Olincy A, Kaufmann CA, Malaspina D, Cloninger CR, et al. Evidence for the multigenic inheritance of schizophrenia. Am J Med Genet 2001;105:794\u2013800.","journal-title":"Am J Med Genet"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03181-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03181-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03181-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T07:08:55Z","timestamp":1733296135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03181-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":88,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3181"],"URL":"https:\/\/doi.org\/10.1038\/s41398-024-03181-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2014698\/v1","asserted-by":"object"}]},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"30 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"484"}}