{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:30:40Z","timestamp":1792071040895,"version":"4.4.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-024-03220-3","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T11:36:45Z","timestamp":1736163405000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"15","author":[{"given":"Yong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxue","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-8296","authenticated-orcid":false,"given":"Wen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-5322","authenticated-orcid":false,"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"3220_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack","year":"2018","unstructured":"Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA\u2010AA research framework: toward a biological definition of Alzheimer\u2019s disease. Alzheimers Dement. 2018;14:535\u201362.","journal-title":"Alzheimers Dement"},{"key":"3220_CR2","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jalz.2016.09.014","volume":"13","author":"SE O\u2019Bryant","year":"2017","unstructured":"O\u2019Bryant SE, Mielke MM, Rissman RA, Lista S, Vanderstichele H, Zetterberg H, et al. Blood\u2010based biomarkers in Alzheimer disease: current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers Dement. 2017;13:45\u201358.","journal-title":"Alzheimers Dement"},{"key":"3220_CR3","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/S1474-4422(21)00361-6","volume":"21","author":"CE Teunissen","year":"2022","unstructured":"Teunissen CE, Verberk IMW, Thijssen EH, Vermunt L, Hansson O, Zetterberg H, et al. Blood-based biomarkers for Alzheimer\u2019s disease: towards clinical implementation. Lancet Neurol. 2022;21:66\u201377.","journal-title":"Lancet Neurol"},{"key":"3220_CR4","doi-asserted-by":"publisher","first-page":"4729","DOI":"10.1002\/alz.13084","volume":"19","author":"BP Imbimbo","year":"2023","unstructured":"Imbimbo BP, Watling M, Imbimbo C, Nistic\u00f2 R. Plasma ATN(I) classification and precision pharmacology in Alzheimer\u2019s disease. Alzheimers Dement. 2023;19:4729\u201334.","journal-title":"Alzheimers Dement"},{"key":"3220_CR5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","volume":"19","author":"TK Karikari","year":"2020","unstructured":"Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, et al. Blood phosphorylated tau 181 as a biomarker for Alzheimer\u2019s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol. 2020;19:422\u201333.","journal-title":"Lancet Neurol"},{"key":"3220_CR6","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1001\/jamaneurol.2019.0765","volume":"76","author":"N Mattsson","year":"2019","unstructured":"Mattsson N, Cullen NC, Andreasson U, Zetterberg H, Blennow K. Association between longitudinal plasma neurofilament light and neurodegeneration in patients with Alzheimer disease. JAMA Neurol. 2019;76:791\u20139.","journal-title":"JAMA Neurol"},{"key":"3220_CR7","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1212\/WNL.0000000000003246","volume":"87","author":"N Mattsson","year":"2016","unstructured":"Mattsson N, Zetterberg H, Janelidze S, Insel PS, Andreasson U, Stomrud E, et al. Plasma tau in Alzheimer disease. Neurology. 2016;87:1827\u201335.","journal-title":"Neurology"},{"key":"3220_CR8","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/clinchem\/hvad018","volume":"69","author":"X-N Shen","year":"2023","unstructured":"Shen X-N, Huang S-Y, Cui M, Zhao Q-H, Guo Y, Huang Y-Y, et al. Plasma glial fibrillary acidic protein in the Alzheimer disease continuum: relationship to other biomarkers, differential diagnosis, and prediction of clinical progression. Clin Chem. 2023;69:411\u201321.","journal-title":"Clin Chem"},{"key":"3220_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.arr.2023.101911","volume":"87","author":"Y Chen","year":"2023","unstructured":"Chen Y, Wang Y, Song Z, Fan Y, Gao T, Tang X. Abnormal white matter changes in Alzheimer\u2019s disease based on diffusion tensor imaging: a systematic review. Ageing Res Rev. 2023;87:17.","journal-title":"Ageing Res Rev"},{"key":"3220_CR10","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1007\/s00415-019-09429-3","volume":"266","author":"K Brueggen","year":"2019","unstructured":"Brueggen K, Dyrba M, Cardenas-Blanco A, Schneider A, Fliessbach K, Buerger K, et al. Structural integrity in subjective cognitive decline, mild cognitive impairment and Alzheimer\u2019s disease based on multicenter diffusion tensor imaging. J Neurol. 2019;266:2465\u201374.","journal-title":"J Neurol"},{"key":"3220_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00401-020-02215-w","volume":"140","author":"N Korte","year":"2020","unstructured":"Korte N, Nortley R, Attwell D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer\u2019s disease. Acta Neuropathol. 2020;140:793\u2013810.","journal-title":"Acta Neuropathol"},{"key":"3220_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.arr.2021.101450","volume":"71","author":"H Zhang","year":"2021","unstructured":"Zhang H, Wang Y, Lyu D, Li Y, Li W, Wang Q, et al. Cerebral blood flow in mild cognitive impairment and Alzheimer\u2019s disease: a systematic review and meta-analysis. Ageing Res Rev. 2021;71:9.","journal-title":"Ageing Res Rev"},{"key":"3220_CR13","doi-asserted-by":"publisher","first-page":"S411","DOI":"10.3233\/JAD-141467","volume":"42","author":"CE Wierenga","year":"2014","unstructured":"Wierenga CE, Hays CC, Zlatar ZZ. Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer\u2019s disease. J Alzheimers Dis. 2014;42:S411\u20139.","journal-title":"J Alzheimers Dis"},{"key":"3220_CR14","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1017\/S1041610213002317","volume":"26","author":"J O\u2019Donovan","year":"2014","unstructured":"O\u2019Donovan J, Watson R, Colloby SJ, Blamire AM, O\u2019Brien JT. Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer\u2019s disease. Int Psychogeriatr. 2014;26:627\u201335.","journal-title":"Int Psychogeriatr"},{"key":"3220_CR15","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.bbadis.2011.08.002","volume":"1822","author":"Y Wang","year":"2012","unstructured":"Wang Y, West JD, Flashman LA, Wishart HA, Santulli RB, Rabin LA, et al. Selective changes in white matter integrity in MCI and older adults with cognitive complaints. Biochim Biophys Acta Mol Basis Dis. 2012;1822:423\u201330.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"3220_CR16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jalz.2016.08.013","volume":"13","author":"AE Leeuwis","year":"2017","unstructured":"Leeuwis AE, Benedictus MR, Kuijer JPA, Binnewijzend MAA, Hooghiemstra AM, Verfaillie SCJ, et al. Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer\u2019s disease. Alzheimers Dement. 2017;13:531\u201340.","journal-title":"Alzheimers Dement"},{"key":"3220_CR17","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/alz.12666","volume":"19","author":"RWJ Weijs","year":"2023","unstructured":"Weijs RWJ, Shkredova DA, Brekelmans ACM, Thijssen DHJ, Claassen JAHR. Longitudinal changes in cerebral blood flow and their relation with cognitive decline in patients with dementia: current knowledge and future directions. Alzheimers Dement. 2023;19:532\u201348.","journal-title":"Alzheimers Dement"},{"key":"3220_CR18","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s11011-022-00908-7","volume":"37","author":"F Nabizadeh","year":"2022","unstructured":"Nabizadeh F, Pourhamzeh M, Khani S, Rezaei A, Ranjbaran F, Deravi N, et al. Plasma phosphorylated-tau181 levels reflect white matter microstructural changes across Alzheimer\u2019s disease progression. Metab Brain Dis. 2022;37:761\u201371.","journal-title":"Metab Brain Dis"},{"key":"3220_CR19","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1007\/s40520-022-02095-y","volume":"34","author":"F Nabizadeh","year":"2022","unstructured":"Nabizadeh F, Balabandian M, Rostami MR, Kankam SB, Ranjbaran F, Pourhamzeh M, et al. Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer\u2019s disease: results from ADNI. Aging Clin Exp Res. 2022;34:2363\u201372.","journal-title":"Aging Clin Exp Res"},{"key":"3220_CR20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2021.02.012","volume":"103","author":"BM Bettcher","year":"2021","unstructured":"Bettcher BM, Olson KE, Carlson NE, McConnell BV, Boyd T, Adame V, et al. Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer\u2019s disease. Neurobiol Aging. 2021;103:68\u201377.","journal-title":"Neurobiol Aging"},{"key":"3220_CR21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neurobiolaging.2023.06.014","volume":"130","author":"CG Swinford","year":"2023","unstructured":"Swinford CG, Risacher SL, Vosmeier A, Deardorff R, Chumin EJ, Dzemidzic M, et al. Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer\u2019s disease. Neurobiol Aging. 2023;130:103\u201313.","journal-title":"Neurobiol Aging"},{"key":"3220_CR22","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1212\/WNL.0000000000000721","volume":"83","author":"E McDade","year":"2014","unstructured":"McDade E, Kim A, James J, Sheu LK, Kuan DC-H, Minhas D, et al. Cerebral perfusion alterations and cerebral amyloid in autosomal dominant Alzheimer disease. Neurology. 2014;83:710\u20137.","journal-title":"Neurology"},{"key":"3220_CR23","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/2051-5960-1-75","volume":"1","author":"A ElAli","year":"2013","unstructured":"ElAli A, Th\u00e9riault P, Pr\u00e9fontaine P, Rivest S. Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation. Acta Neuropathol Commun. 2013;1:75.","journal-title":"Acta Neuropathol Commun"},{"key":"3220_CR24","doi-asserted-by":"publisher","first-page":"300","DOI":"10.2353\/ajpath.2010.090750","volume":"177","author":"MA Koike","year":"2010","unstructured":"Koike MA, Green KN, Blurton-Jones M, LaFerla FM. Oligemic hypoperfusion differentially affects tau and amyloid-\u03b2. Am J Pathol. 2010;177:300\u201310.","journal-title":"Am J Pathol"},{"key":"3220_CR25","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","volume":"13","author":"B Dubois","year":"2014","unstructured":"Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, et al. Advancing research diagnostic criteria for Alzheimer\u2019s disease: the IWG-2 criteria. Lancet Neurol. 2014;13:614\u201329.","journal-title":"Lancet Neurol"},{"key":"3220_CR26","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1192\/bjp.140.6.566","volume":"140","author":"CP Hughes","year":"1982","unstructured":"Hughes CP, Berg L, Danziger W, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140:566\u201372.","journal-title":"Br J Psychiatry"},{"key":"3220_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189\u201398.","journal-title":"J Psychiatr Res"},{"key":"3220_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnagi.2023.1129051","volume":"15","author":"H Dong","year":"2023","unstructured":"Dong H, Guo L, Yang H, Zhu W, Liu F, Xie Y, et al. Association between gray matter atrophy, cerebral hypoperfusion, and cognitive impairment in Alzheimer\u2019s disease. Front Aging Neurosci. 2023;15:10.","journal-title":"Front Aging Neurosci"},{"key":"3220_CR29","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","volume":"31","author":"SM Smith","year":"2006","unstructured":"Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage. 2006;31:1487\u2013505.","journal-title":"NeuroImage"},{"key":"3220_CR30","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.neuroimage.2007.12.035","volume":"40","author":"S Mori","year":"2008","unstructured":"Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, et al. Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. NeuroImage. 2008;40:570\u201382.","journal-title":"NeuroImage"},{"key":"3220_CR31","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","volume":"26","author":"H Hampel","year":"2021","unstructured":"Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, et al. The amyloid-\u03b2 pathway in Alzheimer\u2019s disease. Mol Psychiatry. 2021;26:5481\u2013503.","journal-title":"Mol Psychiatry"},{"key":"3220_CR32","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nrd3505","volume":"10","author":"E Karran","year":"2011","unstructured":"Karran E, Mercken M, Strooper BD. The amyloid cascade hypothesis for Alzheimer\u2019s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov. 2011;10:698\u2013712.","journal-title":"Nat Rev Drug Discov"},{"key":"3220_CR33","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1016\/j.scib.2023.07.009","volume":"68","author":"F Gao","year":"2023","unstructured":"Gao F, Dai L, Wang Q, Liu C, Deng K, Cheng Z, et al. Blood-based biomarkers for Alzheimer\u2019s disease a multicenter-based cross-sectional and longitudinal study in China. Sci Bull 2023;68:1800\u20138.","journal-title":"Sci Bull"},{"key":"3220_CR34","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.jalz.2014.04.521","volume":"11","author":"BS Ye","year":"2015","unstructured":"Ye BS, Seo SW, Kim GH, Noh Y, Cho H, Yoon CW. et al. Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients. Alzheimers Dement. 2015;11:494","journal-title":"Alzheimers Dement"},{"key":"3220_CR35","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/brain\/awu043","volume":"137","author":"N Mattsson","year":"2014","unstructured":"Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, et al. Association of brain amyloid-\u03b2 with cerebral perfusion and structure in Alzheimer\u2019s disease and mild cognitive impairment. Brain. 2014;137:1550\u201361.","journal-title":"Brain"},{"key":"3220_CR36","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1038\/nm.3734","volume":"20","author":"FC Maier","year":"2014","unstructured":"Maier FC, Wehrl HF, Schmid AM, Mannheim JG, Wiehr S, Lerdkrai C, et al. Longitudinal PET-MRI reveals \u03b2-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion. Nat Med. 2014;20:1485\u201392.","journal-title":"Nat Med"},{"key":"3220_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50681-4","volume":"9","author":"J-H Park","year":"2019","unstructured":"Park J-H, Hong J-H, Lee S-W, Ji HD, Jung J-A, Yoon K-W, et al. The effect of chronic cerebral hypoperfusion on the pathology of Alzheimer\u2019s disease: a positron emission tomography study in rats. Sci Rep. 2019;9:14102.","journal-title":"Sci Rep"},{"key":"3220_CR38","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","volume":"26","author":"S Janelidze","year":"2020","unstructured":"Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE, et al. Plasma P-tau181 in Alzheimer\u2019s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer\u2019s dementia. Nat Med. 2020;26:379\u201386.","journal-title":"Nat Med"},{"key":"3220_CR39","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/acn3.51253","volume":"8","author":"O Hansson","year":"2021","unstructured":"Hansson O, Cullen N, Zetterberg H, Blennow K, Mattsson\u2010Carlgren N.The Alzheimer\u2019s disease neuroimaging initiative Plasma phosphorylated tau181 and neurodegeneration in Alzheimer\u2019s disease. Ann Clin Transl Neurol. 2021;8:259\u201365.","journal-title":"Ann Clin Transl Neurol"},{"key":"3220_CR40","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13195-021-00802-x","volume":"13","author":"C Tissot","year":"2021","unstructured":"Tissot C, Benedet AL, Therriault J, Pascoal TA, Lussier FZ, Saha-Chaudhuri P, et al. Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer\u2019s disease. Alzheimers Res Ther. 2021;13:11.","journal-title":"Alzheimers Res Ther"},{"key":"3220_CR41","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1001\/jamaneurol.2020.4986","volume":"78","author":"A Moscoso","year":"2021","unstructured":"Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Lantero Rodr\u00edguez J, Snellman A, et al. Longitudinal associations of blood phosphorylated tau181 and neurofilament light chain with neurodegeneration in Alzheimer disease. JAMA Neurol. 2021;78:396.","journal-title":"JAMA Neurol"},{"key":"3220_CR42","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3233\/JAD-180325","volume":"67","author":"P Oeckl","year":"2019","unstructured":"Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, et al. Glial fibrillary acidic protein in serum is increased in Alzheimer\u2019s disease and correlates with cognitive impairment. J Alzheimers Dis. 2019;67:481\u20138.","journal-title":"J Alzheimers Dis"},{"key":"3220_CR43","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","volume":"78","author":"AL Benedet","year":"2021","unstructured":"Benedet AL, Mil\u00e0-Alom\u00e0 M, Vrillon A, Ashton NJ, Pascoal TA, Lussier F, et al. Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum. JAMA Neurol. 2021;78:1471.","journal-title":"JAMA Neurol"},{"key":"3220_CR44","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3390\/cells10030540","volume":"10","author":"P Preman","year":"2021","unstructured":"Preman P, Alfonso-Triguero M, Alberdi E, Verkhratsky A, Arranz AM. Astrocytes in Alzheimer\u2019s disease: pathological significance and molecular pathways. Cells. 2021;10:540.","journal-title":"Cells"},{"key":"3220_CR45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","volume":"131","author":"M Pekny","year":"2016","unstructured":"Pekny M, Pekna M, Messing A, Steinh\u00e4user C, Lee J-M, Parpura V, et al. Astrocytes: a central element in neurological diseases. Acta Neuropathol. 2016;131:323\u201345.","journal-title":"Acta Neuropathol"},{"key":"3220_CR46","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","volume":"93","author":"J Middeldorp","year":"2011","unstructured":"Middeldorp J, Hol EM. GFAP in health and disease. Prog Neurobiol. 2011;93:421\u201343.","journal-title":"Prog Neurobiol"},{"key":"3220_CR47","first-page":"9","volume":"14","author":"D Shir","year":"2022","unstructured":"Shir D, Graff-Radford J, Hofrenning EI, Lesnick TG, Przybelski SA, Lowe VJ, et al. Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer\u2019s disease and vascular pathology. Alzheimers Dement Diagn Assess Dis Monit. 2022;14:9.","journal-title":"Alzheimers Dement Diagn Assess Dis Monit"},{"key":"3220_CR48","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1093\/brain\/awaa342","volume":"143","author":"AL Benedet","year":"2020","unstructured":"Benedet AL, Leuzy A, Pascoal TA, Ashton NJ, Mathotaarachchi S, Savard M, et al. Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer\u2019s disease. Brain 2020;143:3793\u2013804.","journal-title":"Brain"},{"key":"3220_CR49","first-page":"E671","volume":"96","author":"I Ill\u00e1n-Gaia","year":"2021","unstructured":"Ill\u00e1n-Gaia I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, et al. Plasma tau and neurofilament light in frontotemporal lobar degeneration and Alzheimer disease. Neurology. 2021;96:E671\u201383.","journal-title":"Neurology"},{"key":"3220_CR50","doi-asserted-by":"publisher","first-page":"E252","DOI":"10.1212\/WNL.0000000000007767","volume":"93","author":"MM Mielke","year":"2019","unstructured":"Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Vemuri P, Skoog I, et al. Plasma and CSF neurofilament light Relation to longitudinal neuroimaging and cognitive measures. Neurology. 2019;93:E252\u201360.","journal-title":"Neurology"},{"key":"3220_CR51","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1093\/brain\/awy264","volume":"141","author":"M Ten Kate","year":"2018","unstructured":"Ten Kate M, Dicks E, Visser PJ, Van Der Flier WM, Teunissen CE, Barkhof F, et al. Atrophy subtypes in prodromal Alzheimer\u2019s disease are associated with cognitive decline. Brain. 2018;141:3443\u201356.","journal-title":"Brain"},{"key":"3220_CR52","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3233\/JAD-161114","volume":"58","author":"KD Deters","year":"2017","unstructured":"Deters KD, Shannon LRB, Kim S, Nhoa K, West JD, Blennow K, et al. Plasma tau association with brain atrophy in mild cognitive impairment and Alzheimer\u2019s disease. J Alzheimers Dis. 2017;58:1245\u201354.","journal-title":"J Alzheimers Dis"},{"key":"3220_CR53","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13195-021-00944-y","volume":"13","author":"JD Marks","year":"2021","unstructured":"Marks JD, Syrjanen JA, Graff-Radford J, Petersen RC, Machulda MM, Campbell MR, et al. Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes. Alzheimers Res Ther. 2021;13:14.","journal-title":"Alzheimers Res Ther"},{"key":"3220_CR54","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1001\/archneurol.2011.167","volume":"68","author":"MR Sabuncu","year":"2011","unstructured":"Sabuncu MR, Desikan RS, Sepulcre J, Yeo BTT, Liu HS, Schmansky NJ, et al. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011;68:1040\u20138.","journal-title":"Arch Neurol"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03220-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03220-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03220-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T12:02:25Z","timestamp":1736164945000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-024-03220-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3220"],"URL":"https:\/\/doi.org\/10.1038\/s41398-024-03220-3","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"15 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethics Committee of Tianjin Medical University General Hospital approved this study. Written informed consent was obtained from all participants. The present study was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"2"}}