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The Italian Ministry of Health and the Istituto Superiore di Sanit\u00e0 had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (ClinicalTrials.gov Identifier: NCT00021528) and the Combining Medications to Enhance Depression outcomes (CO-MED) study (ClinicalTrials.gov Identifier: NCT00590863) analyzed in the present paper received ethical approval and enrolled participants provided written informed consent. In addition, we confirmed that all methods were performed in accordance with current guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"32"}}