{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:33:59Z","timestamp":1790048039014,"version":"4.0.1"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-025-03309-3","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T02:07:50Z","timestamp":1743300470000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Blood transcriptomic signatures associated with depression, or the risk for depression, in pregnant women from the Psychiatry Research And Motherhood - Depression (PRAM-D) study"],"prefix":"10.1038","volume":"15","author":[{"given":"Maria Grazia","family":"Di Benedetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-2028","authenticated-orcid":false,"given":"Kristi M. S.","family":"Priestley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Cattane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1238-5440","authenticated-orcid":false,"given":"Patrizia","family":"Genini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Saleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Biaggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca H.","family":"Bind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Conroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9251-1534","authenticated-orcid":false,"given":"Andrea","family":"Du Preez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Hazelgrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Pawlby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaheshta","family":"Sethna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-5091","authenticated-orcid":false,"given":"Carmine M.","family":"Pariante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9963-848X","authenticated-orcid":false,"given":"Annamaria","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"3309_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1192\/bjp.bp.116.187179","volume":"210","author":"CL Dennis","year":"2017","unstructured":"Dennis CL, Falah-Hassani K, Shiri R. Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis. Br J Psychiatry. 2017;210:315\u201323.","journal-title":"Br J Psychiatry"},{"key":"3309_CR2","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00127-022-02386-9","volume":"58","author":"K Al-abri","year":"2023","unstructured":"Al-abri K, Edge D, Armitage CJ. Prevalence and correlates of perinatal depression. Soc Psychiatry Psychiatr Epidemiol. 2023;58:1581\u201390. https:\/\/doi.org\/10.1007\/s00127-022-02386-9.","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"3309_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.jad.2022.08.017","volume":"316","author":"V Mateus","year":"2022","unstructured":"Mateus V, Cruz S, Costa R, Mesquita A, Christoforou A, Wilson CA, et al. Rates of depressive and anxiety symptoms in the perinatal period during the COVID-19 pandemic: comparisons between countries and with pre-pandemic data. J Affect Disord. 2022;316:245\u201353.","journal-title":"J Affect Disord"},{"key":"3309_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1002\/ijgo.13593","volume":"153","author":"A Faisal-Cury","year":"2021","unstructured":"Faisal-Cury A, Levy RB, Azeredo CM, Matijasevich A. Prevalence and associated risk factors of prenatal depression underdiagnosis: a population-based study. Int J Gynaecol Obstet. 2021;153:469\u201375.","journal-title":"Int J Gynaecol Obstet"},{"key":"3309_CR5","doi-asserted-by":"publisher","unstructured":"American Psychiatric Association. American Psychiatric Association, 2013. Diagnostic and statistical manual of mental disorders (5th ed.). 2013 https:\/\/doi.org\/10.1176\/appi.books.9780890425596.744053.","DOI":"10.1176\/appi.books.9780890425596.744053"},{"key":"3309_CR6","doi-asserted-by":"publisher","first-page":"10.4088\/PCC.15f","DOI":"10.4088\/pcc.15f01776","volume":"17","author":"CL Wichman","year":"2015","unstructured":"Wichman CL, Stern TA. Diagnosing and treating depression during pregnancy. Prim Care Companion CNS Disord. 2015;17:10.4088\/PCC.15f01776 https:\/\/doi.org\/10.4088\/pcc.15f01776.","journal-title":"Prim Care Companion CNS Disord"},{"key":"3309_CR7","doi-asserted-by":"publisher","first-page":"107720","DOI":"10.1016\/j.biopsycho.2019.107720","volume":"147","author":"IS Yim","year":"2019","unstructured":"Yim IS, Dunkel Schetter C. Biopsychosocial predictors of perinatal depressive symptoms: moving toward an integrative approach. Biol Psychol. 2019;147:107720 https:\/\/doi.org\/10.1016\/j.biopsycho.2019.107720.","journal-title":"Biol Psychol"},{"key":"3309_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-clinpsy-101414-020426","volume":"11","author":"IS Yim","year":"2015","unstructured":"Yim IS, Stapleton LRT, Guardino CM, Hahn- J, Schetter CD, Behavior S, et al. Biological and psychosocial predictors of postpartum depression: systematic review and call for integration. Annu Rev Clin Psychol. 2015;11:99\u2013137.","journal-title":"Annu Rev Clin Psychol"},{"key":"3309_CR9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jad.2015.11.014","volume":"191","author":"A Biaggi","year":"2016","unstructured":"Biaggi A, Conroy S, Pawlby S, Pariante CM. Identifying the women at risk of antenatal anxiety and depression: a systematic review. J Affect Disord. 2016;191:62\u201377.","journal-title":"J Affect Disord"},{"key":"3309_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12888-021-03684-3","volume":"22","author":"K Yang","year":"2022","unstructured":"Yang K, Wu J, Chen X. Risk factors of perinatal depression in women: a systematic review and meta-analysis. BMC Psychiatry. 2022;22:1\u201311.","journal-title":"BMC Psychiatry"},{"key":"3309_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jad.2016.01.027","volume":"193","author":"M Serati","year":"2016","unstructured":"Serati M, Redaelli M, Buoli M, Altamura AC. Perinatal major depression biomarkers: a systematic review. J Affect Disord. 2016;193:391\u2013404.","journal-title":"J Affect Disord"},{"key":"3309_CR12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.5830\/CVJA-2016-021","volume":"27","author":"P Soma-Pillay","year":"2016","unstructured":"Soma-Pillay P, Nelson-Piercy C, Tolppanen H, Mebazaa A. Physiological changes in pregnancy. Cardiovasc J Afr. 2016;27:89\u201394.","journal-title":"Cardiovasc J Afr"},{"key":"3309_CR13","doi-asserted-by":"publisher","first-page":"3737","DOI":"10.1210\/en.2018-00677","volume":"159","author":"MJ Dickens","year":"2018","unstructured":"Dickens MJ, Pawluski JL. The HPA axis during the perinatal period: implications for perinatal depression. Endocrinology. 2018;159:3737\u201346.","journal-title":"Endocrinology"},{"key":"3309_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0915-y","volume":"16","author":"S Seth","year":"2016","unstructured":"Seth S, Lewis AJ, Galbally M. Perinatal maternal depression and cortisol function in pregnancy and the postpartum period: a systematic literature review. BMC Pregnancy Childbirth. 2016;16:124 https:\/\/doi.org\/10.1186\/s12884-016-0915-y.","journal-title":"BMC Pregnancy Childbirth"},{"key":"3309_CR15","first-page":"149","volume":"21","author":"MJ Szpunar","year":"2018","unstructured":"Szpunar MJ, Parry BL. A systematic review of cortisol, thyroid stimulating hormone and prolactin in peripartum women with major depression. Arch Womens Ment Health. 2018;21:149\u201361.","journal-title":"Arch Womens Ment Health"},{"key":"3309_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00737-017-0777-y","volume":"21","author":"OR Orta","year":"2018","unstructured":"Orta OR, Gelaye B, Bain PA, Williams MA. The association between maternal cortisol and depression during pregnancy, a systematic review. Arch Womens Ment Health. 2018;21:43\u201353.","journal-title":"Arch Womens Ment Health"},{"key":"3309_CR17","doi-asserted-by":"publisher","first-page":"105969","DOI":"10.1016\/j.psyneuen.2022.105969","volume":"147","author":"JE Khoury","year":"2023","unstructured":"Khoury JE, Giles L, Kaur H, Johnson D, Gonzalez A, Atkinson L. Associations between psychological distress and hair cortisol during pregnancy and the early postpartum: a meta-analysis. Psychoneuroendocrinology. 2023;147:105969.","journal-title":"Psychoneuroendocrinology"},{"key":"3309_CR18","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/00045391-200211000-00008","volume":"9","author":"S Grigoriadis","year":"2002","unstructured":"Grigoriadis S, Kennedy SH. Role of estrogen in the treatment of depression. Am J Ther. 2002;9:503\u20139.","journal-title":"Am J Ther"},{"key":"3309_CR19","doi-asserted-by":"publisher","first-page":"e9851","DOI":"10.1371\/journal.pone.0009851","volume":"5","author":"LC Yang","year":"2010","unstructured":"Yang LC, Zhang QG, Zhou CF, Yang F, Zhang YD, Wang RM, et al. Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus. PLoS ONE. 2010;5:e9851 https:\/\/doi.org\/10.1371\/journal.pone.0009851.","journal-title":"PLoS ONE"},{"key":"3309_CR20","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1210\/en.2008-1247","volume":"150","author":"PK Jodhka","year":"2009","unstructured":"Jodhka PK, Kaur P, Underwood W, Lydon JP, Singh M. The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression. Endocrinology. 2009;150:3162\u20138. https:\/\/doi.org\/10.1210\/en.2008-1247","journal-title":"Endocrinology"},{"key":"3309_CR21","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.yhbeh.2012.06.003","volume":"63","author":"M Singh","year":"2013","unstructured":"Singh M, Su C. Progesterone-induced neuroprotection. Horm Behav. 2013;63:284\u201390.","journal-title":"Horm Behav"},{"key":"3309_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-016-0937-5","volume":"16","author":"H Schock","year":"2016","unstructured":"Schock H, Zeleniuch-Jacquotte A, Lundin E, Grankvist K, Lakso H\u00c5, Idahl A, et al. Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study. BMC Pregnancy Childbirth. 2016;16:1\u201311.","journal-title":"BMC Pregnancy Childbirth"},{"key":"3309_CR23","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1017\/S1092852914000480","volume":"20","author":"CE Schiller","year":"2015","unstructured":"Schiller CE, Meltzer-Brody S, Rubinow DR. The role of reproductive hormones in postpartum depression. CNS Spectr. 2015;20:48\u201359.","journal-title":"CNS Spectr"},{"key":"3309_CR24","doi-asserted-by":"publisher","first-page":"543","DOI":"10.3109\/09513590.2010.501886","volume":"27","author":"C Chatzicharalampous","year":"2011","unstructured":"Chatzicharalampous C, Rizos D, Pliatsika P, Leonardou A, Hasiakos D, Zervas I, et al. Reproductive hormones and postpartum mood disturbances in Greek women. Gynecol Endocrinol. 2011;27:543\u201350. https:\/\/doi.org\/10.3109\/09513590.2010.501886","journal-title":"Gynecol Endocrinol"},{"key":"3309_CR25","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jpsychires.2006.09.002","volume":"41","author":"CM Klier","year":"2007","unstructured":"Klier CM, Muzik M, Dervic K, Mossaheb N, Benesch T, Ulm B, et al. The role of estrogen and progesterone in depression after birth. J Psychiatr Res. 2007;41:273\u20139. https:\/\/doi.org\/10.1016\/j.jpsychires.2006.09.002","journal-title":"J Psychiatr Res"},{"key":"3309_CR26","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1176\/appi.ajp.157.6.924","volume":"157","author":"M Bloch","year":"2000","unstructured":"Bloch M, Schmidt PJ, Danaceau M, Murphy J, Nieman L, Rubinow DR. Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry. 2000;157:924\u201330.","journal-title":"Am J Psychiatry"},{"key":"3309_CR27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3389\/fendo.2014.00106","volume":"5","author":"B Polese","year":"2014","unstructured":"Polese B, Gridelet V, Araklioti E, Martens H, d\u2019Hauterive SP, Geenen V. The endocrine milieu and CD4 T-lymphocyte polarization during pregnancy. Front Endocrinol. 2014;5:106 https:\/\/doi.org\/10.3389\/fendo.2014.00106","journal-title":"Front Endocrinol"},{"key":"3309_CR28","doi-asserted-by":"publisher","first-page":"967629","DOI":"10.1155\/2012\/967629","volume":"2012","author":"L Sykes","year":"2012","unstructured":"Sykes L, MacIntyre DA, Yap XJ, Teoh TG, Bennett PR. The Th1:Th2 dichotomy of pregnancy and preterm labour. Mediators Inflamm. 2012;2012:967629 https:\/\/doi.org\/10.1155\/2012\/967629","journal-title":"Mediators Inflamm"},{"key":"3309_CR29","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/j.psyneuen.2013.03.019","volume":"38","author":"LM Osborne","year":"2013","unstructured":"Osborne LM, Monk C. Perinatal depression \u2013 the fourth inflammatory morbidity of pregnancy? Theory and literature review. Psychoneuroendocrinology. 2013;38:1929\u201352.","journal-title":"Psychoneuroendocrinology"},{"key":"3309_CR30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00737-016-0672-y","volume":"20","author":"L Karlsson","year":"2017","unstructured":"Karlsson L, Nousiainen N, Scheinin NM, Maksimow M, Salmi M, Lehto SM, et al. Cytokine profile and maternal depression and anxiety symptoms in mid-pregnancy \u2014 the FinnBrain Birth Cohort Study. Arch Womens Ment Health. 2017;20:39\u201348.","journal-title":"Arch Womens Ment Health"},{"key":"3309_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12888-019-2087-6","volume":"19","author":"P Leff Gelman","year":"2019","unstructured":"Leff Gelman P, Mancilla-Herrera I, Flores-Ramos M, Saravia Takashima MF, Cruz Coronel FM, Cruz Fientes C, et al. The cytokine profile of women with severe anxiety and depression during pregnancy. BMC Psychiatry. 2019;19:1\u201311.","journal-title":"BMC Psychiatry"},{"key":"3309_CR32","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.psyneuen.2017.02.029","volume":"79","author":"E Br\u00e4nn","year":"2017","unstructured":"Br\u00e4nn E, Papadopoulos F, Fransson E, White R, Edvinsson \u00c5, Hellgren C, et al. Inflammatory markers in late pregnancy in association with postpartum depression\u2014A nested case-control study. Psychoneuroendocrinology. 2017;79:146\u201359.","journal-title":"Psychoneuroendocrinology"},{"key":"3309_CR33","first-page":"167","volume":"1","author":"DA Scrandis","year":"2008","unstructured":"Scrandis DA, Langenberg P, Tonelli LH, Sheikh TM, Manogura AC, Alberico LA, et al. Prepartum depressive symptoms correlate positively with C-Reactive protein levels and negatively with tryptophan levels: a preliminary report. Int J Child Health Hum Dev. 2008;1:167\u201374.","journal-title":"Int J Child Health Hum Dev"},{"key":"3309_CR34","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jri.2012.01.007","volume":"94","author":"AE Cassidy-Bushrow","year":"2012","unstructured":"Cassidy-Bushrow AE, Peters RM, Johnson DA, Templin TN. Association of depressive symptoms with inflammatory biomarkers among pregnant African-American women. J Reprod Immunol. 2012;94:202\u20139.","journal-title":"J Reprod Immunol"},{"key":"3309_CR35","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbi.2021.09.020","volume":"99","author":"S Osborne","year":"2022","unstructured":"Osborne S, Biaggi A, Hazelgrove K, Preez AD, Nikkheslat N, Sethna V, et al. Increased maternal inflammation and poorer infant neurobehavioural competencies in women with a history of major depressive disorder from the psychiatry research and motherhood \u2013 depression (PRAM-D) study. Brain Behav Immun. 2022;99:223\u201330.","journal-title":"Brain Behav Immun"},{"key":"3309_CR36","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.psyneuen.2018.06.017","volume":"98","author":"S Osborne","year":"2018","unstructured":"Osborne S, Biaggi A, Chua TE, Du Preez A, Hazelgrove K, Nikkheslat N, et al. Antenatal depression programs cortisol stress reactivity in offspring through increased maternal inflammation and cortisol in pregnancy: the psychiatry research and motherhood \u2013 depression (PRAM-D) study. Psychoneuroendocrinology. 2018;98:211\u201321.","journal-title":"Psychoneuroendocrinology"},{"key":"3309_CR37","doi-asserted-by":"publisher","first-page":"271.e1","DOI":"10.1016\/j.ajog.2018.12.015","volume":"220","author":"ES Miller","year":"2019","unstructured":"Miller ES, Sakowicz A, Roy A, Yang A, Sullivan JT, Grobman WA, et al. Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression. Am J Obstet Gynecol. 2019;220:271.e1\u2013271.e10.","journal-title":"Am J Obstet Gynecol"},{"key":"3309_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/7854_2016_6","volume":"31","author":"R Dantzer","year":"2017","unstructured":"Dantzer R. Role of the kynurenine metabolism pathway in inflammation- induced depression \u2013 preclinical approaches robert. Curr Top Behav Neurosci. 2017;31:117\u201338.","journal-title":"Curr Top Behav Neurosci"},{"key":"3309_CR39","doi-asserted-by":"publisher","first-page":"e01566","DOI":"10.1002\/brb3.1566","volume":"10","author":"C Quan","year":"2020","unstructured":"Quan C, Wang S, Duan K, Ma J, Yu H, Yang M, et al. The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women. Brain Behav. 2020;10:e01566 https:\/\/doi.org\/10.1002\/brb3.1566","journal-title":"Brain Behav"},{"key":"3309_CR40","first-page":"725","volume":"43","author":"S Wang","year":"2018","unstructured":"Wang S, Quan C, Tan Y, Wen S, Zhang J, Duan K. Duan K. Correlation between kynurenine metabolites and postpartum depression. J Cent South Univ (Medical Sci. 2018;43:725\u201331.","journal-title":"J Cent South Univ (Medical Sci."},{"key":"3309_CR41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jad.2020.10.052","volume":"281","author":"Q Sha","year":"2021","unstructured":"Sha Q, Achtyes E, Nagalla M, Keaton S, Smart LA, Leach R, et al. Associations between estrogen and progesterone, the kynurenine pathway, and inflammation in the post-partum. J Affect Disord. 2021;281:9\u201312.","journal-title":"J Affect Disord"},{"key":"3309_CR42","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jad.2010.10.004","volume":"130","author":"V O\u2019Keane","year":"2011","unstructured":"O\u2019Keane V, Lightman S, Marsh M, Pawlby S, Papadopoulos AS, Taylor A, et al. Increased pituitary-adrenal activation and shortened gestation in a sample of depressed pregnant women: a pilot study. J Affect Disord. 2011;130:300\u20135.","journal-title":"J Affect Disord"},{"key":"3309_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1192\/bjo.2021.52","volume":"7","author":"RH Bind","year":"2021","unstructured":"Bind RH, Biaggi A, Bairead A, Du Preez A, Hazelgrove K, Waites F, et al. Mother\u2013infant interaction in women with depression in pregnancy and in women with a history of depression: the psychiatry research and motherhood \u2013 depression (PRAM-D) study. BJPsych Open. 2021;7:1\u201310.","journal-title":"BJPsych Open"},{"key":"3309_CR44","doi-asserted-by":"publisher","first-page":"W782","DOI":"10.1093\/nar\/gkac392","volume":"50","author":"Y Dai","year":"2022","unstructured":"Dai Y, Hu R, Liu A, Cho KS, Manuel AM, Li X, et al. WebCSEA: web-based cell-type-specific enrichment analysis of genes. Nucleic Acids Res. 2022;50:W782\u2013W790.","journal-title":"Nucleic Acids Res"},{"key":"3309_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01270-5","volume":"11","author":"D Mehta","year":"2021","unstructured":"Mehta D, Grewen K, Pearson B, Wani S, Wallace L, Henders AK, et al. Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape. Transl Psychiatry. 2021;11:155 https:\/\/doi.org\/10.1038\/s41398-021-01270-5","journal-title":"Transl Psychiatry"},{"key":"3309_CR46","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1038\/s41380-022-01525-7","volume":"27","author":"J Guintivano","year":"2022","unstructured":"Guintivano J, Aberg KA, Clark SL, Rubinow DR, Sullivan PF, Meltzer-brody S, et al. Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance. Mol Psychiatry. 2022;27:2858\u201367.","journal-title":"Mol Psychiatry"},{"key":"3309_CR47","first-page":"2055","volume":"18","author":"M Petralia","year":"2019","unstructured":"Petralia M, Mazzon E, Fagone P, Falzone L, Bramanti P, Nicoletti F, et al. Retrospective follow-up analysis of the transcriptomic patterns of cytokines, cytokine receptors and chemokines at preconception and during pregnancy, in women with post-partum depression. Exp Ther Med. 2019;18:2055\u201362.","journal-title":"Exp Ther Med"},{"key":"3309_CR48","doi-asserted-by":"publisher","first-page":"868936","DOI":"10.3389\/fpsyt.2022.868936","volume":"13","author":"M Ravi","year":"2022","unstructured":"Ravi M, Bernabe B, Michopoulos V. Stress-related mental health disorders and inflammation in pregnancy: the current landscape and the need for further investigation. Front Psychiatry. 2022;13:868936 https:\/\/doi.org\/10.3389\/fpsyt.2022.868936","journal-title":"Front Psychiatry"},{"key":"3309_CR49","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s12264-016-0048-3","volume":"32","author":"P Leff-Gelman","year":"2016","unstructured":"Leff-Gelman P, Mancilla-Herrera I, Flores-Ramos M, Carlos C, Reyes-Grajeda JP, Garc\u00eda-Cu\u00e9tara Mdel P, et al. The immune system and the role of inflammation in perinatal depression. Neurosci Bull. 2016;32:398\u2013420.","journal-title":"Neurosci Bull"},{"key":"3309_CR50","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41584-020-00544-4","volume":"17","author":"S Fillatreau","year":"2021","unstructured":"Fillatreau S, Manfroi B, D\u00f6rner T. Toll-like receptor signalling in B cells during systemic lupus erythematosus. Nat Rev Rheumatol. 2021;17:98\u2013108.","journal-title":"Nat Rev Rheumatol"},{"key":"3309_CR51","doi-asserted-by":"publisher","first-page":"145","DOI":"10.4049\/jimmunol.1301901","volume":"192","author":"CM Buchta","year":"2014","unstructured":"Buchta CM, Bishop GA. TRAF5 negatively regulates Toll-like receptor signaling in B lymphocytes. J Immunol. 2014;192:145\u201350. https:\/\/doi.org\/10.4049\/jimmunol.1301901","journal-title":"J Immunol"},{"key":"3309_CR52","doi-asserted-by":"publisher","first-page":"e99882","DOI":"10.1371\/journal.pone.0099882","volume":"9","author":"AJNM Bastiaansen","year":"2014","unstructured":"Bastiaansen AJNM, Karper JC, Wezel A, De Boer HC, Welten SMJ, De Jong RCM, et al. TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. PLoS ONE. 2014;9:e99882 https:\/\/doi.org\/10.1371\/journal.pone.0099882","journal-title":"PLoS ONE"},{"key":"3309_CR53","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.bbi.2017.03.002","volume":"64","author":"FN Kaufmann","year":"2017","unstructured":"Kaufmann FN, Costa AP, Ghisleni G, Diaz AP, Rodrigues ALS, Peluffo H, et al. NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings. Brain Behav Immun. 2017;64:367\u201383.","journal-title":"Brain Behav Immun"},{"key":"3309_CR54","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","volume":"36","author":"E Alcocer-G\u00f3mez","year":"2014","unstructured":"Alcocer-G\u00f3mez E, de Miguel M, Casas-Barquero N, N\u00fa\u00f1ez-Vasco J, S\u00e1nchez-Alcazar JA, Fern\u00e1ndez-Rodr\u00edguez A, et al. NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav Immun. 2014;36:111\u20137.","journal-title":"Brain Behav Immun"},{"key":"3309_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0001-8","volume":"6","author":"PJ Wu","year":"2016","unstructured":"Wu PJ, Liu HY, Huang TN, Hsueh YP. AIM 2 inflammasomes regulate neuronal morphology and influence anxiety and memory in mice. Sci Rep. 2016;6:1\u201312.","journal-title":"Sci Rep"},{"key":"3309_CR56","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3109\/08039488.2015.1100328","volume":"70","author":"M Momeni","year":"2016","unstructured":"Momeni M, Ghorban K, Dadmanesh M, Khodadadi H, Bidaki R, Kazemi Arababadi M, et al. ASC provides a potential link between depression and inflammatory disorders: a clinical study of depressed Iranian medical students. Nord J Psychiatry. 2016;70:280\u20134.","journal-title":"Nord J Psychiatry"},{"key":"3309_CR57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B978-0-12-398314-5.00002-7","volume":"88","author":"G Anderson","year":"2012","unstructured":"Anderson G, Maes M, Berk M. Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization. Adv Protein Chem Struct Biol. 2012;88:27\u201348.","journal-title":"Adv Protein Chem Struct Biol"},{"key":"3309_CR58","first-page":"47","volume":"2021","author":"P Wigner","year":"2021","unstructured":"Wigner P, Galecki P, Sliwinski T. Molecular basis of tryptophan metabolism disorders associated with depression. Neurosci Depress Genet Cell Biol Neurol Behav Diet. 2021;2021:47\u201357.","journal-title":"Neurosci Depress Genet Cell Biol Neurol Behav Diet"},{"key":"3309_CR59","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.bbi.2019.10.017","volume":"83","author":"E Achtyes","year":"2020","unstructured":"Achtyes E, Keaton SA, Smart L, Burmeister AR, Heilman PL, Krzyzanowski S, et al. Inflammation and kynurenine pathway dysregulation in post- partum women with severe and suicidal depression. Brain Behav Immun. 2020;83:239\u201347.","journal-title":"Brain Behav Immun"},{"key":"3309_CR60","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jad.2019.05.028","volume":"255","author":"T Teshigawara","year":"2019","unstructured":"Teshigawara T, Mouri A, Kubo H, Nakamura Y, Shiino T, Okada T, et al. Changes in tryptophan metabolism during pregnancy and postpartum periods: potential involvement in postpartum depressive symptoms. J Affect Disord. 2019;255:168\u201376.","journal-title":"J Affect Disord"},{"key":"3309_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01801-8","volume":"12","author":"Q Sha","year":"2022","unstructured":"Sha Q, Madaj Z, Keaton S, Escobar Galvis ML, Smart LA, Krzyzanowski S, et al. Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy. Transl Psychiatry. 2022;12:35 https:\/\/doi.org\/10.1038\/s41398-022-01801-8","journal-title":"Transl Psychiatry"},{"key":"3309_CR62","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41586-019-1537-0","volume":"573","author":"D Dong","year":"2019","unstructured":"Dong D, Zheng L, Lin J, Zhang B, Zhu Y, Li N, et al. Structural basis of assembly of the human T cell receptor\u2013CD3 complex. Nature. 2019;573:546\u201352.","journal-title":"Nature"},{"key":"3309_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.00291","volume":"9","author":"K Patas","year":"2018","unstructured":"Patas K, Willing A, Demiralay C, Engler JB, Lupu A, Ramien C, et al. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder. Front Immunol. 2018;9:1\u201312.","journal-title":"Front Immunol"},{"key":"3309_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2009.09.009","volume":"24","author":"AH Miller","year":"2010","unstructured":"Miller AH. Depression and immunity: a role for T cells? Brain Behav Immun. 2010;24:1\u20138.","journal-title":"Brain Behav Immun"},{"key":"3309_CR65","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.humimm.2006.04.007","volume":"67","author":"JR Wilczy\u0144ski","year":"2006","unstructured":"Wilczy\u0144ski JR. Immunological analogy between allograft rejection, recurrent abortion and pre-eclampsia - the same basic mechanism? Hum Immunol. 2006;67:492\u2013511.","journal-title":"Hum Immunol"},{"key":"3309_CR66","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1034\/j.1600-0897.2002.01094.x","volume":"48","author":"RM Gorczynski","year":"2002","unstructured":"Gorczynski RM, Hadidi S, Yu G, Clark DA. The same immunoregulatory molecules contribute to successful pregnancy and transplantation. Am J Reprod Immunol. 2002;48:18\u201326.","journal-title":"Am J Reprod Immunol"},{"key":"3309_CR67","first-page":"1","volume":"12","author":"JY Sun","year":"2021","unstructured":"Sun JY, Wu R, Xu J, Xue HY, Lu XJ, Ji J. Placental immune tolerance and organ transplantation: underlying interconnections and clinical implications. Front Immunol. 2021;12:1\u201310.","journal-title":"Front Immunol"},{"key":"3309_CR68","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1002\/eji.200526122","volume":"35","author":"K Bratke","year":"2005","unstructured":"Bratke K, Kuepper M, Bade B, Virchow JC, Luttmann W. Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur J Immunol. 2005;35:2608\u201316.","journal-title":"Eur J Immunol"},{"key":"3309_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2017.00195","volume":"8","author":"I Broadley","year":"2017","unstructured":"Broadley I, Pera A, Morrow G, Davies KA, Kern F. Expansions of cytotoxic CD4+CD28- T cells drive excess cardiovascular mortality in rheumatoid arthritis and other chronic inflammatory conditions and are triggered by CMV infection. Front Immunol. 2017;8:1\u201310.","journal-title":"Front Immunol"},{"key":"3309_CR70","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/cdd.2009.161","volume":"17","author":"JC Choy","year":"2010","unstructured":"Choy JC. Granzymes and perforin in solid organ transplant rejection. Cell Death Differ. 2010;17:567\u201376.","journal-title":"Cell Death Differ"},{"key":"3309_CR71","first-page":"3341","volume":"41","author":"S Hegde","year":"2000","unstructured":"Hegde S, Niederkorn JY. The role of cytotoxic T lymphocytes in corneal allograft rejection. Invest Ophthalmol Vis Sci. 2000;41:3341\u20137.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3309_CR72","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/ki.2010.274","volume":"78","author":"SM Van Ham","year":"2010","unstructured":"Van Ham SM, Heutinck KM, Jorritsma T, Bemelman FJ, Strik MCM, Vos W, et al. Urinary granzyme A mRNA is a biomarker to diagnose subclinical and acute cellular rejection in kidney transplant recipients. Kidney Int. 2010;78:1033\u201340.","journal-title":"Kidney Int"},{"key":"3309_CR73","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/humupd\/dmt056","volume":"20","author":"S Seshadri","year":"2014","unstructured":"Seshadri S, Sunkara SK. Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis. Hum Reprod Update. 2014;20:429\u201338.","journal-title":"Hum Reprod Update"},{"key":"3309_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12955-021-01703-1","volume":"19","author":"Y Wang","year":"2021","unstructured":"Wang Y, Meng Z, Pei J, Qian L, Mao B, Li Y, et al. Anxiety and depression are risk factors for recurrent pregnancy loss: a nested case\u2013control study. Health Qual Life Outcomes. 2021;19:1\u20139.","journal-title":"Health Qual Life Outcomes"},{"key":"3309_CR75","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1093\/humrep\/17.10.2580","volume":"17","author":"M Sugiura-Ogasawara","year":"2002","unstructured":"Sugiura-Ogasawara M, Furukawa TA, Nakano Y, Hori S, Aoki K, Kitamura T. Depression as a potential causal factor in subsequent miscarriage in recurrent spontaneous aborters. Hum Reprod. 2002;17:2580\u20134.","journal-title":"Hum Reprod"},{"key":"3309_CR76","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.8755-8920.2001.460201.x","volume":"46","author":"PC Arck","year":"2001","unstructured":"Arck PC. Stress and pregnancy loss: Role of immune mediators, hormones and neurotransmitters. Am J Reprod Immunol. 2001;46:117\u201323.","journal-title":"Am J Reprod Immunol"},{"key":"3309_CR77","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1600-0897.1999.tb00101.x","volume":"42","author":"M Makhseed","year":"1999","unstructured":"Makhseed M, Raghupathy R, Azizieh F, Al-Azemi MMK, Hassan NA, Bandar A. Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-type bias in normal pregnancy and pregnancy failure. Am J Reprod Immunol. 1999;42:273\u201381.","journal-title":"Am J Reprod Immunol"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03309-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03309-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03309-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:39:31Z","timestamp":1743467971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03309-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3309"],"URL":"https:\/\/doi.org\/10.1038\/s41398-025-03309-3","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,29]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"For CMP: less than 10% of his support in the last 10 years derives from commercial collaborations, including consultation and speaker\u2019s fees from Boehringer Ingelheim, Eli Lilly, Compass, Eleusis, GH Research, Lundbeck, and V\u00e4rde Partners. All other authors have no conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"110"}}