{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:31:24Z","timestamp":1790829084990,"version":"4.1.0"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010571","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft, Forschung und Technologie","doi-asserted-by":"publisher","award":["GoBIO miRassay"],"award-info":[{"award-number":["GoBIO miRassay"]}],"id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language difficulties, and cognitive decline. In this study, smallRNA sequencing was conducted on postmortem brain tissues obtained from the frontal and temporal of FTD patients with\n                    <jats:italic>GRN<\/jats:italic>\n                    ,\n                    <jats:italic>MAPT<\/jats:italic>\n                    , or\n                    <jats:italic>C9ORF72<\/jats:italic>\n                    mutations. Our analysis identified miR-129-5p as consistently deregulated across all analyzed mutation conditions and brain regions. Functional investigations in in-vitro models revealed a novel role of miR-129-5p in astrocytes, where its loss led to neuroinflammation and impaired neuronal support functions, including reduced glutamate uptake. Depletion of miR-129-5p in astrocytes also resulted in the loss of neuronal spines and altered neuronal network activity in a cell culture system. These findings highlight miR-129-5p as a potential therapeutic target in neurodegenerative diseases and also sheds light on the role of astrocytes in Frontotemporal dementia pathogenesis.\n                  <\/jats:p>","DOI":"10.1038\/s41398-025-03338-y","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T06:57:36Z","timestamp":1744354656000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A role for astrocytic miR-129-5p in frontotemporal dementia"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-6111","authenticated-orcid":false,"given":"Lalit","family":"Kaurani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7589-657X","authenticated-orcid":false,"given":"Sophie","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Burkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lena","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-9547","authenticated-orcid":false,"given":"Dennis M.","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9329-8912","authenticated-orcid":false,"given":"Tonatiuh","family":"Pena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-1737","authenticated-orcid":false,"given":"Peter","family":"Heutink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Sananbenesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8546-1161","authenticated-orcid":false,"given":"Andre","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"3338_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.psc.2020.02.006","volume":"43","author":"K Younes","year":"2020","unstructured":"Younes K, Miller BL. Frontotemporal dementia: neuropathology, genetics, neuroimaging, and treatments. Psychiatr Clin North Am. 2020;43:331\u201344.","journal-title":"Psychiatr Clin North Am"},{"key":"3338_CR2","doi-asserted-by":"publisher","first-page":"5824","DOI":"10.1038\/s41380-021-01271-2","volume":"26","author":"M Wagner","year":"2021","unstructured":"Wagner M, Lorenz G, Volk AE, Brunet T, Edbauer D, Berutti R, et al. linico-genetic findings in 509 frontotemporal dementia patients. Mol Psychiatry. 2021;26:5824\u201332.","journal-title":"Mol Psychiatry"},{"key":"3338_CR3","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1212\/WNL.58.11.1615","volume":"58","author":"E Ratnavalli","year":"2002","unstructured":"Ratnavalli E, Brayne C, Dawson K, Hodges JR. The prevalence of frontotemporal dementia. Neurology. 2002;58:1615\u201321.","journal-title":"Neurology"},{"key":"3338_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/jnc.13588","volume":"138","author":"IR Mackenzie","year":"2016","unstructured":"Mackenzie IR, Neumann M. Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies. J Neurochem. 2016;138:54\u201357.","journal-title":"J Neurochem"},{"key":"3338_CR5","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","volume":"266","author":"CV Greaves","year":"2019","unstructured":"Greaves CV, Rohrer JD. An update on genetic frontotemporal dementia. J Neurol. 2019;266:2075\u201386.","journal-title":"J Neurol"},{"key":"3338_CR6","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1176\/appi.neuropsych.21060166","volume":"34","author":"N Magrath Guimet","year":"2022","unstructured":"Magrath Guimet N, Zapata-Restrepo LM, Miller BL. Advances in treatment of frontotemporal dementia. J Neuropsychiatry Clin Neurosci. 2022;34:316\u201327.","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"3338_CR7","doi-asserted-by":"publisher","first-page":"101664","DOI":"10.1016\/j.pneurobio.2019.101664","volume":"182","author":"CAS Ju\u017awik","year":"2019","unstructured":"Ju\u017awik CAS, Drake S, Zhang Y, Paradis-Isler N, Sylvester A, Amar-Zifkin A, et al. microRNA dysregulation in neurodegenerative diseases: a systematic review. Prog Neurobiol. 2019;182:101664. https:\/\/doi.org\/10.1016\/j.pneurobio.2019.101664","journal-title":"Prog Neurobiol"},{"key":"3338_CR8","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1016\/j.jmb.2013.03.007","volume":"425","author":"AM Gurtan","year":"2013","unstructured":"Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks. J Mol Biol. 2013;425:3582\u2013600.","journal-title":"J Mol Biol"},{"key":"3338_CR9","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1002\/1878-0261.12144","volume":"11","author":"R Bayraktar","year":"2017","unstructured":"Bayraktar R, Van Roosbroeck K, Calin GA. Cell-to-cell communication: microRNAs as hormones. Mol Oncol. 2017;11:1673\u201386.","journal-title":"Mol Oncol"},{"key":"3338_CR10","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/dvg.22871","volume":"53","author":"AM Jose","year":"2015","unstructured":"Jose AM. Movement of regulatory RNA between animal cells. Genesis. 2015;53:395\u2013416.","journal-title":"Genesis"},{"key":"3338_CR11","doi-asserted-by":"publisher","first-page":"278","DOI":"10.3389\/fnins.2017.00278","volume":"11","author":"M Mustapic","year":"2017","unstructured":"Mustapic M, Eitan E, Werner JKJ, Berkowitz ST, Lazaropoulos MP, Tran J, et al. Plasma extracellular vesicles enriched for neuronal origin: a potential window into brain pathologic processes. Front Neurosci. 2017;11:278. https:\/\/doi.org\/10.3389\/fnins.2017.00278","journal-title":"Front Neurosci"},{"key":"3338_CR12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","volume":"8","author":"MA Cortez","year":"2011","unstructured":"Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA. MicroRNAs in body fluids-the mix of hormones and biomarkers. Nat Rev Clin Oncol. 2011;8:467\u201377.","journal-title":"Nat Rev Clin Oncol"},{"key":"3338_CR13","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nm.3582","volume":"20","author":"JP Lopez","year":"2014","unstructured":"Lopez JP, Lim R, Cruceanu C, Crapper L, Fasano C, Labonte B, et al. miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment. Nat Med. 2014;20:764\u20138.","journal-title":"Nat Med"},{"key":"3338_CR14","doi-asserted-by":"publisher","first-page":"e13659","DOI":"10.15252\/emmm.202013659","volume":"13","author":"MR Islam","year":"2021","unstructured":"Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, et al. A microRNA-signature that correlates with cognition and is a target against cognitive decline. EMBO Mol Med. 2021;13:e13659. https:\/\/doi.org\/10.15252\/emmm.202013659","journal-title":"EMBO Mol Med"},{"key":"3338_CR15","doi-asserted-by":"crossref","unstructured":"Magen I, Coenen-Stass A, Yacovzada N, Grosskreutz J, Lu C-H, Greensmith L, et al. Circulating miR-181a-5p is a prognostic biomarker for amyotrophic lateral sclerosis. Nat neurosci. 2021;24:1534\u201341.","DOI":"10.1038\/s41593-021-00936-z"},{"key":"3338_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac274","volume":"4","author":"V Dobricic","year":"2022","unstructured":"Dobricic V, Schilling M, Farkas I, Gveric DO, Ohlei O, Schulz J, et al. Common signatures of differential microRNA expression in Parkinson\u2019s and Alzheimer\u2019s disease brains. Brain Commun. 2022;4:fcac274.","journal-title":"Brain Commun"},{"key":"3338_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02108-4","volume":"12","author":"V Dobricic","year":"2022","unstructured":"Dobricic V, Schilling M, Schulz J, Zhu LS, Zhou CW, Fu\u00df J, et al. Differential microRNA expression analyses across two brain regions in Alzheimer\u2019s disease. Transl Psychiatry. 2022;12:352.","journal-title":"Transl Psychiatry"},{"key":"3338_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02582-4","volume":"13","author":"L Kaurani","year":"2023","unstructured":"Kaurani L, Besse M, Methfessel I, Methi A, Zhou J, Pradhan R, et al. Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression. Transl Psychiatry. 2023;13:294.","journal-title":"Transl Psychiatry"},{"key":"3338_CR19","doi-asserted-by":"publisher","first-page":"5628","DOI":"10.1007\/s12035-023-03869-9","volume":"61","author":"A Methi","year":"2024","unstructured":"Methi A, Islam MR, Kaurani L, Sakib MS, Kr\u00fcger DM, Pena T, et al. A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exercise. Mol Neurobiol. 2024;61:5628\u201345.","journal-title":"Mol Neurobiol"},{"key":"3338_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/nar\/gky1141","volume":"47","author":"A Kozomara","year":"2019","unstructured":"Kozomara A, Birgaoanu M, Griffiths-Jones S. miRBase: from microRNA sequences to function. Nucleic Acids Res. 2019;47:155\u201362.","journal-title":"Nucleic Acids Res"},{"key":"3338_CR21","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1093\/cvr\/cvr266","volume":"93","author":"A Zampetaki","year":"2012","unstructured":"Zampetaki A, Willeit P, Drozdov I, Kiechl S, Mayr M. Profiling of circulating microRNAs: from single biomarkers to re-wired networks. Cardiovasc Res. 2012;93:555\u201362.","journal-title":"Cardiovasc Res"},{"key":"3338_CR22","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1002\/embj.201387637","volume":"33","author":"A Fischer","year":"2014","unstructured":"Fischer A. Epigenetic memory: the Lamarckian brain. EMBO J. 2014;33:945\u201367.","journal-title":"EMBO J"},{"key":"3338_CR23","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/cells9020276","volume":"9","author":"CE Condrat","year":"2020","unstructured":"Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, et al. miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis. Cells. 2020;9:276.","journal-title":"Cells"},{"key":"3338_CR24","doi-asserted-by":"publisher","first-page":"e10551","DOI":"10.1371\/journal.pone.0010551","volume":"10","author":"J Jiao","year":"2010","unstructured":"Jiao J, Herl LD, Farese RV, Gao FB. MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. PLoS ONE. 2010;10:e10551.","journal-title":"PLoS ONE"},{"key":"3338_CR25","doi-asserted-by":"publisher","first-page":"334","DOI":"10.2353\/ajpath.2010.091202","volume":"177","author":"WX Wang","year":"2010","unstructured":"Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, et al. miR-107 regulates granulin\/progranulin with implications for traumatic brain injury and neurodegenerative disease. Am J Pathol. 2010;177:334\u201345.","journal-title":"Am J Pathol"},{"key":"3338_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3389\/fnmol.2016.00031","volume":"9","author":"P Piscopo","year":"2016","unstructured":"Piscopo P, Grasso M, Fontana F, Crestini A, Puopolo M, Del Vescovo V, et al. Reduced miR-659-3p levels correlate with progranulin increase in hypoxic conditions: implications for frontotemporal dementia. Front Mol Neurosci. 2016;9:31. https:\/\/doi.org\/10.3389\/fnmol.2016.00031","journal-title":"Front Mol Neurosci"},{"key":"3338_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1038\/s41591-018-0223-3","volume":"25","author":"V Swarup","year":"2018","unstructured":"Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, et al. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nat Med. 2018;25:152\u201364.","journal-title":"Nat Med"},{"key":"3338_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/nar\/gkr688","volume":"40","author":"MR Friedl\u00e4nder","year":"2012","unstructured":"Friedl\u00e4nder MR, Mackowiak SD, Li N, Chen W, Rajewsky N. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res. 2012;40:37\u201352.","journal-title":"Nucleic Acids Res"},{"key":"3338_CR29","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/s44318-44024-00067-44318","volume":"43","author":"L Kaurani","year":"2024","unstructured":"Kaurani L, Islam MR, Heilbronner U, Kr\u00fcger DM, Zhou J, Methi A, et al. Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice. EMBO J. 2024;43:1420\u201344. https:\/\/doi.org\/10.1038\/s44318-44024-00067-44318","journal-title":"EMBO J"},{"key":"3338_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27293-5","volume":"8","author":"AT McKenzie","year":"2018","unstructured":"McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A, et al. Brain cell type specific gene expression and Co-expression network architectures. Sci Rep. 2018;8:8868.","journal-title":"Sci Rep"},{"key":"3338_CR31","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41586-019-1374-1","volume":"571","author":"RJ Ries","year":"2019","unstructured":"Ries RJ, Zaccara S, Klein P, Olarerin-George A, Namkoong S, Pickering BF, et al. m6A enhances the phase separation potential of mRNA. Nature. 2019;571:424\u20138.","journal-title":"Nature"},{"key":"3338_CR32","doi-asserted-by":"publisher","first-page":"11732","DOI":"10.3390\/ijms241411732","volume":"24","author":"A Antonioni","year":"2023","unstructured":"Antonioni A, Raho EM, Lopriore P, Pace AP, Latino RR, Assogna M, et al. Frontotemporal dementia, where do we stand? A narrative review. Int J Mol Sci. 2023;24:11732.","journal-title":"Int J Mol Sci"},{"key":"3338_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-023-02598-x","volume":"10","author":"K Menden","year":"2023","unstructured":"Menden K, Francescatto M, Nyima T, Blauwendraat C, Dhingra A, Castillo-Lizardo M, et al. A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes. Sci Data. 2023;10:849.","journal-title":"Sci Data"},{"key":"3338_CR34","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bbr.2015.03.032","volume":"1","author":"J Hernandez-Rapp","year":"2015","unstructured":"Hernandez-Rapp J, Smith PY, Filali M, Goupil C, Planel E, Magill ST, et al. Memory formation and retention are affected in adult miR-132\/212 knockout mice. Behav Brain Res. 2015;1:15\u201326.","journal-title":"Behav Brain Res"},{"key":"3338_CR35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13195-023-01366-8","volume":"16","author":"SW Han","year":"2024","unstructured":"Han SW, Pyun JM, Bice PJ, Bennett DA, Saykin AJ, Kim SY, et al. miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer\u2019s disease. Alzheimer\u2019s Res Ther. 2024;16:5.","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"3338_CR36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13024-017-0191-y","volume":"12","author":"E Patrick","year":"2017","unstructured":"Patrick E, Rajagopal S, Wong HA, McCabe C, Xu J, Tang A, et al. Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer\u2019s disease. Mol Neurodegener. 2017;12:51.","journal-title":"Mol Neurodegener"},{"key":"3338_CR37","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1242\/dev.144337","volume":"44","author":"M Rajman","year":"2017","unstructured":"Rajman M, Schratt G. MicroRNAs in neural development: from master regulators to fine-tuners. Development. 2017;44:2310\u201322.","journal-title":"Development"},{"key":"3338_CR38","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giac083","volume":"11","author":"AH Patil","year":"2022","unstructured":"Patil AH, Baran A, Brehm ZP, McCall MN, Halushka MK. A curated human cellular microRNAome based on 196 primary cell types. Gigascience. 2022;11:giac083.","journal-title":"Gigascience"},{"key":"3338_CR39","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.3390\/cells12111450","volume":"12","author":"CF Valori","year":"2023","unstructured":"Valori CF, Sulmona C, Brambilla L, Rossi D. Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia. Cells. 2023;12:1450.","journal-title":"Cells"},{"key":"3338_CR40","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1002\/glia.23013","volume":"64","author":"VT Cheli","year":"2016","unstructured":"Cheli VT, Santiago Gonz\u00e1lez DA, Smith J, Spreuer V, Murphy GG, Paez PM. L-type voltage-operated calcium channels contribute to astrocyte activation in vitro. Glia. 2016;64:1396\u2013415.","journal-title":"Glia"},{"key":"3338_CR41","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000357383","volume":"93","author":"N Daschil","year":"2014","unstructured":"Daschil N, Geisler S, Obermair GJ, Humpel C. Short- and long-term treatment of mouse cortical primary astrocytes with \u03b2-amyloid differentially regulates the mRNA expression of L-type calcium channels. Pharmacology. 2014;93:24\u201331.","journal-title":"Pharmacology"},{"key":"3338_CR42","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/nm.3717","volume":"20","author":"E Gascon","year":"2014","unstructured":"Gascon E, Lynch K, Ruan H, Almeida S, Verheyden JM, Seeley WW, et al. Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nat Med. 2014;20:1444\u201351.","journal-title":"Nat Med"},{"key":"3338_CR43","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1136\/jnnp-2017-317492","volume":"89","author":"R Schneider","year":"2018","unstructured":"Schneider R, McKeever P, Kim T, Graff C, van Swieten JC, Karydas A, et al. Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. J Neurol Neurosurg Psychiatry. 2018;89:851\u20138.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"3338_CR44","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3233\/JAD-122350","volume":"35","author":"SS H\u00e9bert","year":"2013","unstructured":"H\u00e9bert SS, Wang WX, Zhu Q, Nelson PT. A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer\u2019s disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimer\u2019s Dis. 2013;35:335\u201348.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"3338_CR45","doi-asserted-by":"publisher","first-page":"11213","DOI":"10.1523\/JNEUROSCI.0521-12.2012","volume":"32","author":"AS Chen-Plotkin","year":"2012","unstructured":"Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, et al. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132\/212 cluster and affects progranulin pathways. J Neurosci. 2012;32:11213\u201327.","journal-title":"J Neurosci"},{"key":"3338_CR46","doi-asserted-by":"publisher","first-page":"805","DOI":"10.3233\/ADR-210311","volume":"5","author":"YJ Tan","year":"2021","unstructured":"Tan YJ, Wong BYX, Vaidyanathan R, Sreejith S, Chia SY, Kandiah N, et al. Altered cerebrospinal fluid exosomal microRNA levels in young-onset Alzheimer\u2019s disease and frontotemporal dementia. J Alzheimer\u2019s Dis Rep. 2021;5:805\u201313.","journal-title":"J Alzheimer\u2019s Dis Rep"},{"key":"3338_CR47","doi-asserted-by":"publisher","first-page":"e30854","DOI":"10.1097\/MD.0000000000030854","volume":"101","author":"J Pounders","year":"2022","unstructured":"Pounders J, Hill EJ, Hooper D, Zhang X, Biesiada J, Kuhnell D, et al. MicroRNA expression within neuronal-derived small extracellular vesicles in frontotemporal degeneration. Medicine. 2022;101:e30854.","journal-title":"Medicine"},{"key":"3338_CR48","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202320220750","volume":"95","author":"Y Hu","year":"2023","unstructured":"Hu Y, Hu C, Yin J, Zhong J, Deng Y, Yang G. MiR-181c-5p ameliorates learning and memory in sleep-deprived mice via HMGB1\/TLR4\/NF-\u03baB pathway. An Acad Bras Cienc. 2023;95:e20220750.","journal-title":"An Acad Bras Cienc"},{"key":"3338_CR49","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1007\/s00018-016-2179-0","volume":"73","author":"A Kos","year":"2016","unstructured":"Kos A, Olde Loohuis N, Meinhardt J, van Bokhoven H, Kaplan BB, Martens GJ, et al. MicroRNA-181 promotes synaptogenesis and attenuates axonal outgrowth in cortical neurons. Cell Mol Life Sci. 2016;73:3555\u201367.","journal-title":"Cell Mol Life Sci"},{"key":"3338_CR50","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.neuron.2009.05.029","volume":"63","author":"P Rajasethupathy","year":"2009","unstructured":"Rajasethupathy P, Fiumara F, Sheridan R, Betel D, Puthanveettil SV, Russo JJ, et al. Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron. 2009;63:803\u201317.","journal-title":"Neuron"},{"key":"3338_CR51","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nm.2266","volume":"17","author":"ED Ponomarev","year":"2011","unstructured":"Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C\/EBP-\u03b1-PU.1. Nat Med. 2011;17:64\u201370.","journal-title":"Nat Med"},{"key":"3338_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02299-5","volume":"18","author":"T Lan","year":"2021","unstructured":"Lan T, Li Y, Fan C, Wang L, Wang W, Chen S, et al. MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway. J Neuroinflammation. 2021;18:243.","journal-title":"J Neuroinflammation"},{"key":"3338_CR53","doi-asserted-by":"publisher","first-page":"151","DOI":"10.15586\/aei.v51i2.767","volume":"51","author":"J Gao","year":"2023","unstructured":"Gao J, Wu XL. MiR-328-3p promotes TGF-\u03b21-induced proliferation, migration, and inflammation of airway smooth muscle cells by regulating the PTEN\/Akt pathway. Allergol Immunopathol (Madr). 2023;51:151\u20139. https:\/\/doi.org\/10.15586\/aei.v51i2.767","journal-title":"Allergol Immunopathol (Madr)"},{"key":"3338_CR54","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1177\/1535370217734492","volume":"242","author":"L Geng","year":"2017","unstructured":"Geng L, Liu W, Chen Y. miR-124-3p attenuates MPP+-induced neuronal injury by targeting STAT3 in SH-SY5Y cells. Exp Biol Med. 2017;242:1757\u201364. https:\/\/doi.org\/10.1177\/1535370217734492","journal-title":"Exp Biol Med"},{"key":"3338_CR55","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s10020-021-00305-3","volume":"27","author":"M Min","year":"2021","unstructured":"Min M, Hu J, Peng Y, Li J, Ren R. CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Mol Med. 2021;27:45.","journal-title":"Mol Med"},{"key":"3338_CR56","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1021\/acschemneuro.3c00047","volume":"14","author":"CS Shi","year":"2023","unstructured":"Shi CS, Hu Q, Fang SL, Sun CX, Shao DH. icroRNA-204-5p ameliorates neurological injury via the EphA4\/PI3K\/AKT signaling pathway in ischemic stroke. ACS Chem Neurosci. 2023;14:2060\u201373.","journal-title":"ACS Chem Neurosci"},{"key":"3338_CR57","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.15252\/embj.201695748","volume":"36","author":"M Rajman","year":"2017","unstructured":"Rajman M, Metge F, Fiore R, Khudayberdiev S, Aksoy-Aksel A, Bicker S, et al. A microRNA-129-5p\/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses. EMBO J. 2017;36:1770\u201387.","journal-title":"EMBO J"},{"key":"3338_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0977-4","volume":"14","author":"XQ Li","year":"2017","unstructured":"Li XQ, Chen FS, Tan WF, Fang B, Zhang ZL, Ma H. Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway. J Neuroinflammation. 2017;14:205.","journal-title":"J Neuroinflammation"},{"key":"3338_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107016","volume":"89","author":"X Huang","year":"2020","unstructured":"Huang X, Hou X, Chuan L, Wei S, Wang J, Yang X, et al. miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1\/TLRs\/NF-kappaB pathway. Int Immunopharmacol. 2020;89:107016.","journal-title":"Int Immunopharmacol"},{"key":"3338_CR60","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s10020-021-00305-3","volume":"27","author":"M Li","year":"2021","unstructured":"Li M, Hu J, Peng Y, Li J, Ren R. ircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Mol Med. 2021;27:45.","journal-title":"Mol Med"},{"key":"3338_CR61","doi-asserted-by":"publisher","first-page":"e62509","DOI":"10.1371\/journal.pone.0062509","volume":"8","author":"J Remenyi","year":"2013","unstructured":"Remenyi J, van den Bosch MW, Palygin O, Mistry RB, McKenzie C, Macdonald A, et al. miR-132\/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS ONE. 2013;8:e62509.","journal-title":"PLoS ONE"},{"key":"3338_CR62","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1096\/fj.201700447rr","volume":"32","author":"Q Huang","year":"2018","unstructured":"Huang Q, Voloudakis G, Ren Y, Yoon Y, Zhang E, Kajiwara Y, et al. Presenilin1\/\u03b3-secretase protects neurons from glucose deprivation-induced death by regulating miR-212 and PEA15. FASEB J. 2018;32:243\u201353.","journal-title":"FASEB J"},{"key":"3338_CR63","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3389\/fnmol.2018.00381","volume":"11","author":"S Sun","year":"2018","unstructured":"Sun S, Han X, Li X, Song Q, Lu M, Jia M, et al. MicroRNA-212-5p prevents dopaminergic neuron death by inhibiting SIRT2 in MPTP-induced mouse model of Parkinson\u2019s disease. Front Mol Neurosci. 2018;11:381.","journal-title":"Front Mol Neurosci"},{"key":"3338_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0501-0","volume":"12","author":"X Xiao","year":"2019","unstructured":"Xiao X, Jiang Y, Liang W, Wang Y, Cao S, Yan H, et al. miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2. Mol Brain. 2019;12:78.","journal-title":"Mol Brain"},{"key":"3338_CR65","first-page":"540","volume":"22","author":"W Nong","year":"2022","unstructured":"Nong W, Bao C, Chen Y, Wei Z. miR-212-3p attenuates neuroinflammation of rats with Alzheimer\u2019s disease via regulating the SP1\/BACE1\/NLRP3\/Caspase-1 signaling pathway. Bosn J Basic Med Sci. 2022;22:540\u201352.","journal-title":"Bosn J Basic Med Sci"},{"key":"3338_CR66","doi-asserted-by":"publisher","first-page":"6721","DOI":"10.1093\/hmg\/ddv377","volume":"24","author":"PY Smith","year":"2015","unstructured":"Smith PY, Hernandez-Rapp J, Jolivette F, Lecours C, Bisht K, Goupil C, et al. miR-132\/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo. Hum Mol Genet. 2015;24:6721\u201335.","journal-title":"Hum Mol Genet"},{"key":"3338_CR67","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1007\/s12035-018-1314-3","volume":"55","author":"A Jawaid","year":"2019","unstructured":"Jawaid A, Woldemichael BT, Kremer EA, Laferriere F, Gaur N, Afroz T, et al. Memory decline and its reversal in aging and neurodegeneration involve miR-183\/96\/182 biogenesis. Mol Neurobiol. 2019;55:3451\u201362.","journal-title":"Mol Neurobiol"},{"key":"3338_CR68","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1101\/lm.039578.115","volume":"15","author":"KF Hansen","year":"2016","unstructured":"Hansen KF, Sakamoto K, Aten S, Snider KH, Loeser J, Hesse AM, et al. deletion of miR-132\/-212 impairs memory and alters the hippocampal transcriptome. Learn Mem. 2016;15:61\u201371.","journal-title":"Learn Mem"},{"key":"3338_CR69","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1093\/hmg\/ddt164","volume":"22","author":"HK Wong","year":"2013","unstructured":"Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, et al. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer\u2019s disease. Hum Mol Genet. 2013;22:3077\u201392.","journal-title":"Hum Mol Genet"},{"key":"3338_CR70","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.15252\/emmm.201606520","volume":"8","author":"E Salta","year":"2016","unstructured":"Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer\u2019s brain. EMBO Mol Med. 2016;8:1005\u201318.","journal-title":"EMBO Mol Med"},{"key":"3338_CR71","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.neurobiolaging.2016.12.015","volume":"51","author":"Y Wang","year":"2017","unstructured":"Wang Y, Veremeyko T, Wong AH, El Fatimy R, Wei Z, Cai W, et al. Downregulation of miR-132\/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer\u2019s disease. Neurobiol Aging. 2017;51:156\u201366.","journal-title":"Neurobiol Aging"},{"key":"3338_CR72","doi-asserted-by":"publisher","first-page":"167.e1","DOI":"10.1016\/j.neurobiolaging.2016.09.019","volume":"50","author":"S Pichler","year":"2017","unstructured":"Pichler S, Gu W, Hartl D, Gasparoni G, Leidinger P, Keller A, et al. The miRNome of Alzheimer\u2019s disease: consistent downregulation of the miR-132\/212 cluster. Neurobiol Aging. 2017;50:167.e1\u2013167.e10.","journal-title":"Neurobiol Aging"},{"key":"3338_CR73","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nrn.2017.90","volume":"18","author":"E Salta","year":"2017","unstructured":"Salta E, De Strooper B. Noncoding RNAs in neurodegeneration. Nat Rev Neurosci. 2017;18:627\u201340.","journal-title":"Nat Rev Neurosci"},{"key":"3338_CR74","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.3389\/fnins.2019.01208","volume":"13","author":"DJ Cha","year":"2019","unstructured":"Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, et al. miR-212 and miR-132 are downregulated in neurally derived plasma exosomes of Alzheimer\u2019s patients. Front Neurosci. 2019;13:1208.","journal-title":"Front Neurosci"},{"key":"3338_CR75","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s40478-022-01407-7","volume":"10","author":"S Petry","year":"2022","unstructured":"Petry S, Keraudren R, Nateghi B, Loiselle A, Pircs K, Jakobsson J, et al. Widespread alterations in microRNA biogenesis in human Huntington\u2019s disease putamen. Acta Neuropathol Commun. 2022;10:106.","journal-title":"Acta Neuropathol Commun"},{"key":"3338_CR76","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3109\/09540261.2013.776523","volume":"25","author":"CU Onyike","year":"2013","unstructured":"Onyike CU, Diehl-Schmid J. The epidemiology of frontotemporal dementia. Int Rev Psychiatry. 2013;25:130\u20137.","journal-title":"Int Rev Psychiatry"},{"key":"3338_CR77","doi-asserted-by":"publisher","first-page":"pyae013","DOI":"10.1093\/ijnp\/pyae013","volume":"27","author":"P Ibrahim","year":"2024","unstructured":"Ibrahim P, Denniston R, Mitsuhashi H, Yang J, Fiori LM, \u017burawek D, et al. Profiling small RNA from brain extracellular vesicles in individuals with depression. Int J Neuropsychopharmacol. 2024;27:pyae013.","journal-title":"Int J Neuropsychopharmacol"},{"key":"3338_CR78","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1111\/jcmm.14050","volume":"24","author":"C Wu","year":"2019","unstructured":"Wu C, Miao C, Tang Q, Zhou X, Xi P, Chang P, et al. MiR-129-5p promotes docetaxel resistance in prostate cancer by down-regulating CAMK2N1 expression. J Cell Mol Med. 2019;24:2098\u2013108.","journal-title":"J Cell Mol Med"},{"key":"3338_CR79","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.3390\/biomedicines11072058","volume":"11","author":"A Boicean","year":"2023","unstructured":"Boicean A, Birsan S, Ichim C, Boeras I, Roman-Filip I, Blanca G, et al. Has-miR-129-5p\u2019s involvement in different disorders, from digestive cancer to neurodegenerative diseases. Biomedicines. 2023;11:2058.","journal-title":"Biomedicines"},{"key":"3338_CR80","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","volume":"19","author":"R Patani","year":"2023","unstructured":"Patani R, Hardingham GE, Liddelow SA. Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration. Nat Rev Neurol. 2023;19:395\u2013409.","journal-title":"Nat Rev Neurol"},{"key":"3338_CR81","first-page":"603","volume":"164","author":"B De Strooper","year":"2016","unstructured":"De Strooper B, Karran E. The cellular phase of Alzheimer\u2019s disease. Cell Tissue Res. 2016;164:603\u201315.","journal-title":"Cell Tissue Res"},{"key":"3338_CR82","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/S1474-4422(18)30490-3","volume":"18","author":"AM Arranz","year":"2019","unstructured":"Arranz AM, De Strooper B. The role of astroglia in Alzheimer\u2019s disease: pathophysiology and clinical implications. Lancet Neurol. 2019;18:406\u201314.","journal-title":"Lancet Neurol"},{"key":"3338_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111280","volume":"40","author":"D Shah","year":"2022","unstructured":"Shah D, Gsell W, Wahis J, Luckett ES, Jamoulle T, Vermaercke B, et al. Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer\u2019s disease. Cell Rep. 2022;40:111280.","journal-title":"Cell Rep"},{"key":"3338_CR84","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s13018-021-02432-3","volume":"16","author":"X Li","year":"2021","unstructured":"Li X, Qu M, Zhang J, Chen K, Ma X. CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p\/HIPK2 axis in rheumatoid arthritis. J Orthop Surg. 2021;16:302.","journal-title":"J Orthop Surg"},{"key":"3338_CR85","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2017.09.056","volume":"96","author":"NJ Allen","year":"2017","unstructured":"Allen NJ, Eroglu C. Cell biology of astrocyte-synapse interactions. Neuron. 2017;96:697\u2013708.","journal-title":"Neuron"},{"key":"3338_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24611-w","volume":"12","author":"SM H\u00fccker","year":"2021","unstructured":"H\u00fccker SM, Fehlmann T, Werno C, Weidele K, L\u00fcke F, Schlenska-Lange A, et al. Single-cell microRNA sequencing method comparison and application to cell lines and circulating lung tumor cells. Nat Commun. 2021;12:4316.","journal-title":"Nat Commun"},{"key":"3338_CR87","first-page":"39","volume":"26","author":"P Rao","year":"2013","unstructured":"Rao P, Benito E, Fischer A. MicroRNAs as biomarkers for CNS disease. Front Mol Neurosci. 2013;26:39.","journal-title":"Front Mol Neurosci"},{"key":"3338_CR88","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrd.2016.246","volume":"16","author":"R Rupaimoole","year":"2017","unstructured":"Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16:203\u201322.","journal-title":"Nat Rev Drug Discov"},{"key":"3338_CR89","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3233\/JAD-180364","volume":"65","author":"P Piscopo","year":"2018","unstructured":"Piscopo P, Grasso M, Puopolo M, D\u2019Acunto E, Talarico G, Crestini A, et al. Circulating miR-127-3p as a potential biomarker for differential diagnosis in frontotemporal dementia. J Alzheimer\u2019s Dis. 2018;65:455\u201364.","journal-title":"J Alzheimer\u2019s Dis"},{"key":"3338_CR90","doi-asserted-by":"publisher","first-page":"240.e1","DOI":"10.1016\/j.neurobiolaging.2019.01.024","volume":"84","author":"M Grasso","year":"2019","unstructured":"Grasso M, Piscopo P, Talarico G, Ricci L, Crestini A, Tosto G, et al. Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects. Neurobiol Aging. 2019;84:240.e1\u2013240.e12.","journal-title":"Neurobiol Aging"},{"key":"3338_CR91","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1002\/acn3.51674","volume":"9","author":"V Kmetzsch","year":"2022","unstructured":"Kmetzsch V, Latouche M, Saracino D, Rinaldi D, Camuzat A, Gareau T, et al. MicroRNA signatures in genetic frontotemporal dementia and amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2022;9:1778\u201391.","journal-title":"Ann Clin Transl Neurol"},{"key":"3338_CR92","doi-asserted-by":"publisher","first-page":"14723","DOI":"10.3390\/ijms232314723","volume":"23","author":"C Fenoglio","year":"2022","unstructured":"Fenoglio C, Serpente M, Visconte C, Arcaro M, Sorrentino F, D\u2019Anca M, et al. Circulating non-coding RNA levels are altered in autosomal dominant frontotemporal dementia. Int J Mol Sci. 2022;23:14723.","journal-title":"Int J Mol Sci"},{"key":"3338_CR93","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12916","volume":"49","author":"I Magen","year":"2023","unstructured":"Magen I, Yacovzada NS, Warren JD, Heller C, Swift I, Bobeva Y, et al. microRNA-based predictor for diagnosis of frontotemporal dementia. Neuropathol Appl Neurobiol. 2023;49:e12916.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3338_CR94","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01627-w","volume":"11","author":"M Goldberg","year":"2021","unstructured":"Goldberg M, Islam RM, Kerimolgu C, Lacelin C, Burkhart S, Kr\u00fcger DM, et al. Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501. Transl Psychiatry. 2021;11:514.","journal-title":"Transl Psychiatry"},{"key":"3338_CR95","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1159\/000507285","volume":"49","author":"Z Li","year":"2020","unstructured":"Li Z, Chen Q, Liu J, Du Y. Physical exercise ameliorates the cognitive function and attenuates the neuroinflammation of Alzheimer\u2019s disease via miR-129-5p. Dement Geriatr Cogn Disord. 2020;49:163\u20139.","journal-title":"Dement Geriatr Cogn Disord"},{"key":"3338_CR96","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.3390\/nu15173688","volume":"15","author":"P Pinto-Hernandez","year":"2023","unstructured":"Pinto-Hernandez P, Castilla-Silgado J, Coto-Vilcapoma A, Fern\u00e1ndez-Sanjurjo M, Fern\u00e1ndez-Garc\u00eda B, Tom\u00e1s-Zapico C, et al. Modulation of microRNAs through lifestyle changes in Alzheimer\u2019s disease. Nutrients. 2023;15:3688.","journal-title":"Nutrients"},{"key":"3338_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.137732","volume":"826","author":"J Chen","year":"2024","unstructured":"Chen J, Su C, Ma Z, Ou X, Zhan M, Hu J. Aerobic exercise suppresses cognitive injury in patients with Alzheimer\u2019s disease by regulating long non-coding RNA TUG1. Neurosci Lett. 2024;826:137732.","journal-title":"Neurosci Lett"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03338-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03338-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03338-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:02:51Z","timestamp":1744369371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03338-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":97,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3338"],"URL":"https:\/\/doi.org\/10.1038\/s41398-025-03338-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.15.589528","asserted-by":"object"}]},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"12 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"142"}}