{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:42:49Z","timestamp":1787002969257,"version":"build-2736575974"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"U.S. Department of Health & Human Services | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["P50MH080215"],"award-info":[{"award-number":["P50MH080215"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"U.S. Department of Health & Human Services | NIH | National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1RR024153"],"award-info":[{"award-number":["UL1RR024153"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-025-03388-2","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T07:28:56Z","timestamp":1755329336000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The role of reward-related brain activity in response to treatment and later depression severity: data from a randomized controlled trial in early adolescents with anxiety disorders"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-729X","authenticated-orcid":false,"given":"Cecilia A.","family":"Westbrook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Silk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-7744","authenticated-orcid":false,"given":"Erika E.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal D.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"McMakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-6961","authenticated-orcid":false,"given":"Philip C.","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Mannarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4816-0997","authenticated-orcid":false,"given":"Cecile D.","family":"Ladouceur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"3388_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1136\/ebmental-2021-300277","volume":"25","author":"JL Barican","year":"2022","unstructured":"Barican JL, Yung D, Schwartz C, Zheng Y, Georgiades K, Waddell C. Prevalence of childhood mental disorders in high-income countries: a systematic review and meta-analysis to inform policymaking. Evid Based Ment Health. 2022;25:36\u201344.","journal-title":"Evid Based Ment Health"},{"key":"3388_CR2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/da.22728","volume":"35","author":"JK Carpenter","year":"2018","unstructured":"Carpenter JK, Andrews LA, Witcraft SM, Powers MB, Smits JAJ, Hofmann SG. Cognitive behavioral therapy for anxiety and related disorders: a meta-analysis of randomized placebo-controlled trials. Depress Anxiety. 2018;35:502\u201314.","journal-title":"Depress Anxiety"},{"key":"3388_CR3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/YIC.0000000000000078","volume":"30","author":"B Bandelow","year":"2015","unstructured":"Bandelow B, Reitt M, R\u00f6ver C, Michaelis S, G\u00f6rlich Y, Wedekind D. Efficacy of treatments for anxiety disorders: a meta-analysis. Int Clin Psychopharmacol. 2015;30:183\u201392.","journal-title":"Int Clin Psychopharmacol"},{"key":"3388_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neubiorev.2018.09.022","volume":"95","author":"L Marwood","year":"2018","unstructured":"Marwood L, Wise T, Perkins AM, Cleare AJ. Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety. Neurosci Biobehav Rev. 2018;95:61\u201372.","journal-title":"Neurosci Biobehav Rev"},{"key":"3388_CR5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jaac.2021.04.014","volume":"61","author":"RP Auerbach","year":"2022","unstructured":"Auerbach RP, Pagliaccio D, Hubbard NA, Frosch I, Kremens R, Cosby E, et al. Reward-related neural circuitry in depressed and anxious adolescents: a human connectome project. J Am Acad Child Adolesc Psychiatry. 2022;61:308\u201320.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3388_CR6","doi-asserted-by":"publisher","first-page":"102588","DOI":"10.1016\/j.janxdis.2022.102588","volume":"89","author":"SL Sequeira","year":"2022","unstructured":"Sequeira SL, Forbes EE, Hanson JL, Silk JS. Positive valence systems in youth anxiety development: a scoping review. J Anxiety Disord. 2022;89:102588.","journal-title":"J Anxiety Disord"},{"key":"3388_CR7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.neuroimage.2015.07.083","volume":"122","author":"MH Silverman","year":"2015","unstructured":"Silverman MH, Jedd K, Luciana M. Neural networks involved in adolescent reward processing: an activation likelihood estimation meta-analysis of functional neuroimaging studies. Neuroimage. 2015;122:427\u201339.","journal-title":"Neuroimage"},{"key":"3388_CR8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.neubiorev.2018.09.005","volume":"94","author":"B Larsen","year":"2018","unstructured":"Larsen B, Luna B. Adolescence as a neurobiological critical period for the development of higher-order cognition. Neurosci Biobehav Rev. 2018;94:179\u201395.","journal-title":"Neurosci Biobehav Rev"},{"key":"3388_CR9","doi-asserted-by":"crossref","unstructured":"Mackin DM, Nelson BD, Klein DN Chapter 40 - reward processing and depression: current findings and future directions. In: Martin CR, Hunter LA, Patel VB, Preedy VR, Rajendram R, editors. The neuroscience of depression [Internet]. London, UK: Academic Press; 2021 [cited 2024 Mar 13]. p. 425\u201333. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780128179352000519.","DOI":"10.1016\/B978-0-12-817935-2.00051-9"},{"key":"3388_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/jcpp.12502","volume":"57","author":"EA Crone","year":"2016","unstructured":"Crone EA, van Duijvenvoorde ACK, Peper JS. Annual research review: neural contributions to risk-taking in adolescence \u2013 developmental changes and individual differences. J Child Psychol Psychiatry. 2016;57:353\u201368.","journal-title":"J Child Psychol Psychiatry"},{"key":"3388_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.coph.2008.12.014","volume":"9","author":"KC Berridge","year":"2009","unstructured":"Berridge KC, Robinson TE, Aldridge JW. Dissecting components of reward: \u2018liking\u2019, \u2018wanting\u2019, and learning. Curr Opin Pharmacol. 2009;9:65\u201373.","journal-title":"Curr Opin Pharmacol"},{"key":"3388_CR12","unstructured":"Development and Definitions of the RDoC Domains and Constructs - National Institute of Mental Health (NIMH) [Internet]. [cited 2024 Sep 20]. Available from: https:\/\/www.nimh.nih.gov\/research\/research-funded-by-nimh\/rdoc\/development-and-definitions-of-the-rdoc-domains-and-constructs."},{"key":"3388_CR13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.biopsycho.2017.07.011","volume":"128","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Li Q, Wang Z, Liu X, Zheng Y. Temporal dynamics of reward anticipation in the human brain. Biol Psychol. 2017;128:89\u201397.","journal-title":"Biol Psychol"},{"key":"3388_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jad.2016.07.008","volume":"206","author":"MG Newman","year":"2016","unstructured":"Newman MG, Shin KE, Zuellig AR. Developmental risk factors in generalized anxiety disorder and panic disorder. J Affect Disord. 2016;206:94\u2013102.","journal-title":"J Affect Disord"},{"key":"3388_CR15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.copsyc.2014.12.011","volume":"4","author":"R Admon","year":"2015","unstructured":"Admon R, Pizzagalli DA. Dysfunctional reward processing in depression. Curr Opin Psychol. 2015;4:114\u20138.","journal-title":"Curr Opin Psychol"},{"key":"3388_CR16","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/09637214211049228","volume":"31","author":"A Weinberg","year":"2022","unstructured":"Weinberg A, Kujawa A, Riesel A. Understanding trajectories to anxiety and depression: neural responses to errors and rewards as indices of susceptibility to stressful life events. Curr Dir Psychol Sci. 2022;31:115\u201323.","journal-title":"Curr Dir Psychol Sci"},{"key":"3388_CR17","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1017\/S0033291712000207","volume":"42","author":"JS Silk","year":"2012","unstructured":"Silk JS, Davis S, McMakin DL, Dahl RE, Forbes EE. Why do anxious children become depressed teenagers? The role of social evaluative threat and reward processing. Psychol Med. 2012;42:2095\u2013107.","journal-title":"Psychol Med"},{"key":"3388_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.5127\/jep.052615","volume":"8","author":"TD Zbozinek","year":"2017","unstructured":"Zbozinek TD, Craske MG. The role of positive affect in enhancing extinction learning and exposure therapy for anxiety disorders. J Exp Psychopathol. 2017;8:13\u201339.","journal-title":"J Exp Psychopathol"},{"key":"3388_CR19","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.biopsych.2020.06.012","volume":"89","author":"DM Nielson","year":"2021","unstructured":"Nielson DM, Keren H, O\u2019Callaghan G, Jackson SM, Douka I, Vidal-Ribas P, et al. Great expectations: a critical review of and suggestions for the study of reward processing as a cause and predictor of depression. Biol Psychiatry. 2021;89:134\u201343.","journal-title":"Biol Psychiatry"},{"key":"3388_CR20","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1176\/appi.ajp.2020.20010094","volume":"178","author":"SL Sequeira","year":"2021","unstructured":"Sequeira SL, Silk JS, Ladouceur CD, Hanson JL, Ryan ND, Morgan JK, et al. Association of neural reward circuitry function with response to psychotherapy in youths with anxiety disorders. Am J Psychiatry. 2021;178:343\u201351.","journal-title":"Am J Psychiatry"},{"key":"3388_CR21","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1080\/15374416.2016.1138408","volume":"47","author":"JS Silk","year":"2018","unstructured":"Silk JS, Tan PZ, Ladouceur CD, Meller S, Siegle GJ, McMakin DL, et al. A randomized clinical trial comparing individual cognitive behavioral therapy and child-centered therapy for child anxiety disorders. J Clin Child Adolesc Psychol. 2018;47:542\u201354.","journal-title":"J Clin Child Adolesc Psychol"},{"key":"3388_CR22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1176\/appi.ajp.20240024","volume":"181","author":"CD Ladouceur","year":"2024","unstructured":"Ladouceur CD. Can cognitive-behavioral therapy normalize neural function in youths with pediatric anxiety disorders? A developmental neuroscience perspective. Am J Psychiatry. 2024;181:175\u20137.","journal-title":"Am J Psychiatry"},{"key":"3388_CR23","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jaac.2018.10.012","volume":"58","author":"JS Silk","year":"2019","unstructured":"Silk JS, Price RB, Rosen D, Ryan ND, Forbes EE, Siegle GJ, et al. A longitudinal follow-up study examining adolescent depressive symptoms as a function of prior anxiety treatment. J Am Acad Child Adolesc Psychiatry. 2019;58:359\u201367.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3388_CR24","doi-asserted-by":"publisher","first-page":"104895","DOI":"10.1016\/j.neubiorev.2022.104895","volume":"142","author":"E Schrammen","year":"2022","unstructured":"Schrammen E, Roesmann K, Rosenbaum D, Redlich R, Harenbrock J, Dannlowski U, et al. Functional neural changes associated with psychotherapy in anxiety disorders \u2013 a meta-analysis of longitudinal fMRI studies. Neurosci Biobehav Rev. 2022;142:104895.","journal-title":"Neurosci Biobehav Rev"},{"key":"3388_CR25","doi-asserted-by":"publisher","first-page":"853804","DOI":"10.3389\/fpsyg.2022.853804","volume":"13","author":"S Yuan","year":"2022","unstructured":"Yuan S, Wu H, Wu Y, Xu H, Yu J, Zhong Y, et al. Neural effects of cognitive behavioral therapy in psychiatric disorders: a systematic review and activation likelihood estimation meta-analysis. Front Psychol. 2022;13:853804 https:\/\/www.frontiersin.org\/journals\/psychology\/articles\/10.3389\/fpsyg.2022.853804.","journal-title":"Front Psychol"},{"key":"3388_CR26","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.jad.2020.12.182","volume":"282","author":"V La Buissonniere-Ariza","year":"2021","unstructured":"La Buissonniere-Ariza V, Fitzgerald K, Meoded A, Williams LL, Liu G, Goodman WK, et al. Neural correlates of cognitive behavioral therapy response in youth with negative valence disorders: a systematic review of the literature. J Affect Disord. 2021;282:1288\u2013307.","journal-title":"J Affect Disord"},{"key":"3388_CR27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1176\/appi.ajp.20220449","volume":"181","author":"SP Haller","year":"2024","unstructured":"Haller SP, Linke JO, Grassie HL, Jones EL, Pagliaccio D, Harrewijn A, et al. Normalization of fronto-parietal activation by cognitive-behavioral therapy in unmedicated pediatric patients with anxiety disorders. Am J Psychiatry. 2024 Mar;181:201\u201312.","journal-title":"Am J Psychiatry"},{"key":"3388_CR28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrn.2018.22","volume":"19","author":"J LeDoux","year":"2018","unstructured":"LeDoux J, Daw ND. Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour. Nat Rev Neurosci. 2018;19:269\u201382.","journal-title":"Nat Rev Neurosci"},{"key":"3388_CR29","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.1152\/jn.90355.2008","volume":"100","author":"JL Vincent","year":"2008","unstructured":"Vincent JL, Kahn I, Snyder AZ, Raichle ME, Buckner RL. Evidence for a frontoparietal control system revealed by intrinsic functional connectivity. J Neurophysiol. 2008;100:3328\u201342.","journal-title":"J Neurophysiol"},{"key":"3388_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/1073858412440596","volume":"19","author":"ML Seghier","year":"2013","unstructured":"Seghier ML. The angular gyrus: multiple functions and multiple subdivisions. Neuroscientist. 2013;19:43\u201361.","journal-title":"Neuroscientist"},{"key":"3388_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fnbeh.2017.00085","volume":"11","author":"N Kocsel","year":"2017","unstructured":"Kocsel N, Szab\u00f3 E, Galambos A, \u00c9des A, Pap D, Elliott R, et al. Trait rumination influences neural correlates of the anticipation but not the consumption phase of reward processing. Front Behav Neurosci. 2017;11:85 https:\/\/www.frontiersin.org\/journals\/behavioral-neuroscience\/articles\/10.3389\/fnbeh.2017.00085\/full.","journal-title":"Front Behav Neurosci"},{"key":"3388_CR32","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3389\/fpsyt.2020.00067","volume":"11","author":"A Erdman","year":"2020","unstructured":"Erdman A, Abend R, Jalon I, Artzi M, Gazit T, Avirame K, et al. Ruminative tendency relates to ventral striatum functionality: evidence from task and resting-state fMRI. Front Psychiatry. 2020;11:67 https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2020.00067\/full.","journal-title":"Front Psychiatry"},{"key":"3388_CR33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2045-5380-4-7","volume":"4","author":"EL Maresh","year":"2014","unstructured":"Maresh EL, Allen JP, Coan JA. Increased default mode network activity in socially anxious individuals during reward processing. Biol Mood Anxiety Disord. 2014;4:7.","journal-title":"Biol Mood Anxiety Disord"},{"key":"3388_CR34","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/hbm.22639","volume":"36","author":"RL Aupperle","year":"2015","unstructured":"Aupperle RL, Melrose AJ, Francisco A, Paulus MP, Stein MB. Neural substrates of approach-avoidance conflict decision-making. Hum Brain Mapp. 2015;36:449\u201362.","journal-title":"Hum Brain Mapp"},{"key":"3388_CR35","doi-asserted-by":"publisher","unstructured":"Bergman H, Maayan N, Kirkham AJ, Adams CE, Soares\u2010Weiser K. Schedule for Affective Disorders and Schizophrenia for School\u2010Age Children (K\u2010SADS) for diagnosing schizophrenia in children and adolescents with psychotic symptoms. Cochrane Database of Systematic Reviews 2015, Issue 6. Art. No.: CD011733. https:\/\/doi.org\/10.1002\/14651858.CD011733. Accessed 12 May 2025.","DOI":"10.1002\/14651858.CD011733"},{"key":"3388_CR36","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1097\/00004583-200209000-00006","volume":"41","author":"The research units on pediatric psychopharmacology anxiety study.","year":"2002","unstructured":"The research units on pediatric psychopharmacology anxiety study. The pediatric anxiety rating scale (PARS): development and psychometric properties. J Am Acad Child Adolesc Psychiatry. 2002;41:1061\u20139.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3388_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jaac.2012.10.006","volume":"52","author":"NE Caporino","year":"2013","unstructured":"Caporino NE, Brodman DM, Kendall PC, Albano AM, Sherrill J, Piacentini J, et al. Defining treatment response and remission in child anxiety: signal detection analysis using the pediatric anxiety rating scale. J Am Acad Child Adolesc Psychiatry. 2013;52:57\u201367.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3388_CR38","volume-title":"Mood and feelings questionnaire (MFQ)","author":"A Angold","year":"1987","unstructured":"Angold A, Costello EJ. Mood and feelings questionnaire (MFQ). Durham: Developmental Epidemiology Program, Duke University; 1987."},{"key":"3388_CR39","unstructured":"Kendall PC, Hedtke KA The coping cat program workbook. Ardmore, PA: Workbook Publishing; 2006."},{"key":"3388_CR40","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/00004583-200404000-00005","volume":"43","author":"JA Cohen","year":"2004","unstructured":"Cohen JA, Deblinger E, Mannarino AP, Steer RA. A multisite, randomized controlled trial for children with sexual abuse\u2013related PSTD symptoms. J Am Acad Child Adolesc Psychiatry. 2004;43:393\u2013402.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3388_CR41","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.neuroimage.2010.04.244","volume":"52","author":"MW Schlund","year":"2010","unstructured":"Schlund MW, Siegle GJ, Ladouceur CD, Silk JS, Cataldo MF, Forbes EE, et al. Nothing to fear? Neural systems supporting avoidance behavior in healthy youths. Neuroimage. 2010;52:710\u20139.","journal-title":"Neuroimage"},{"key":"3388_CR42","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","volume":"16","author":"O Esteban","year":"2019","unstructured":"Esteban O, Markiewicz CJ, Blair RW, Moodie CA, Isik AI, Erramuzpe A, et al. fMRIPrep: a robust preprocessing pipeline for functional MRI. Nat Methods. 2019;16:111\u20136.","journal-title":"Nat Methods"},{"key":"3388_CR43","unstructured":"FSL - FslWiki [Internet]. [cited 2022 Sep 14]. Available from: https:\/\/fsl.fmrib.ox.ac.uk\/fsl\/fslwiki."},{"key":"3388_CR44","doi-asserted-by":"publisher","first-page":"7900","DOI":"10.1073\/pnas.1602413113","volume":"113","author":"A Eklund","year":"2016","unstructured":"Eklund A, Nichols TE, Knutsson H. Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates. Proc Natl Acad Sci USA. 2016;113:7900\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3388_CR45","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/nmeth.1635","volume":"8","author":"T Yarkoni","year":"2011","unstructured":"Yarkoni T, Poldrack RA, Nichols TE, Van Essen DC, Wager TD. Large-scale automated synthesis of human functional neuroimaging data. Nat Methods. 2011;8:665\u201370.","journal-title":"Nat Methods"},{"key":"3388_CR46","first-page":"65","volume":"6","author":"S Holm","year":"1979","unstructured":"Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat. 1979;6:65\u201370.","journal-title":"Scand J Stat"},{"key":"3388_CR47","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.biopsych.2016.12.010","volume":"81","author":"CJ Charpentier","year":"2017","unstructured":"Charpentier CJ, Aylward J, Roiser JP, Robinson OJ. Enhanced risk aversion, but not loss aversion, in unmedicated pathological anxiety. Biol Psychiatry. 2017;81:1014\u201322.","journal-title":"Biol Psychiatry"},{"key":"3388_CR48","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s10802-012-9611-1","volume":"40","author":"MJ Dugas","year":"2012","unstructured":"Dugas MJ, Laugesen N, Bukowski WM. Intolerance of uncertainty, fear of anxiety, and adolescent worry. J Abnorm Child Psychol. 2012;40:863\u201370.","journal-title":"J Abnorm Child Psychol"},{"key":"3388_CR49","doi-asserted-by":"publisher","first-page":"e0255292","DOI":"10.1371\/journal.pone.0255292","volume":"16","author":"S Jauhar","year":"2021","unstructured":"Jauhar S, Fortea L, Solanes A, Albajes-Eizagirre A, McKenna PJ, Radua J. Brain activations associated with anticipation and delivery of monetary reward: a systematic review and meta-analysis of fMRI studies. PLoS ONE. 2021;16:e0255292.","journal-title":"PLoS ONE"},{"key":"3388_CR50","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1146\/annurev-neuro-071013-014030","volume":"38","author":"ME Raichle","year":"2015","unstructured":"Raichle ME. The brain\u2019s default mode network. Annu Rev Neurosci. 2015;38:433\u201347.","journal-title":"Annu Rev Neurosci"},{"key":"3388_CR51","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/scan\/nsq080","volume":"6","author":"MG Berman","year":"2011","unstructured":"Berman MG, Peltier S, Nee DE, Kross E, Deldin PJ, Jonides J. Depression, rumination and the default network. Soc Cogn Affect Neurosci. 2011;6:548\u201355.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"3388_CR52","doi-asserted-by":"publisher","first-page":"3318","DOI":"10.1002\/hbm.25019","volume":"41","author":"E Dohmatob","year":"2020","unstructured":"Dohmatob E, Dumas G, Bzdok D. Dark control: the default mode network as a reinforcement learning agent. Hum Brain Mapp. 2020;41:3318\u201341.","journal-title":"Hum Brain Mapp"},{"key":"3388_CR53","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1017\/S0033291718004154","volume":"50","author":"H Rubin-Falcone","year":"2020","unstructured":"Rubin-Falcone H, Weber J, Kishon R, Ochsner K, Delaparte L, Dor\u00e9 B, et al. Neural predictors and effects of cognitive behavioral therapy for depression: the role of emotional reactivity and regulation. Psychol Med. 2020;50:146\u201360.","journal-title":"Psychol Med"},{"key":"3388_CR54","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1162\/jocn_a_01202","volume":"30","author":"ML Rosen","year":"2018","unstructured":"Rosen ML, Sheridan MA, Sambrook KA, Peverill MR, Meltzoff AN, McLaughlin KA. The role of visual association cortex in associative memory formation across development. J Cogn Neurosci. 2018;30:365\u201380.","journal-title":"J Cogn Neurosci"},{"key":"3388_CR55","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jad.2020.09.074","volume":"278","author":"Q Liu","year":"2021","unstructured":"Liu Q, Ely BA, Schwartz JJ, Alonso CM, Stern ER, Gabbay V. Reward function as an outcome predictor in youth with mood and anxiety symptoms. J Affect Disord. 2021;278:433\u201342.","journal-title":"J Affect Disord"},{"key":"3388_CR56","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nrn3313","volume":"13","author":"EA Crone","year":"2012","unstructured":"Crone EA, Dahl RE. Understanding adolescence as a period of social\u2013affective engagement and goal flexibility. Nat Rev Neurosci. 2012;13:636\u201350.","journal-title":"Nat Rev Neurosci"},{"key":"3388_CR57","first-page":"289","volume":"2","author":"KR Luking","year":"2017","unstructured":"Luking KR, Nelson BD, Infantolino ZP, Sauder CL, Hajcak G. Internal consistency of functional magnetic resonance imaging and electroencephalography measures of reward in late childhood and early adolescence. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2:289\u201397.","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03388-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03388-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03388-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T04:49:20Z","timestamp":1757393360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03388-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,16]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3388"],"URL":"https:\/\/doi.org\/10.1038\/s41398-025-03388-2","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,16]]},"assertion":[{"value":"31 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. Kendall receives royalties from the sale of materials related to the treatment of anxiety in youth. Dr. Forbes has received consulting fees from Brown University, George Mason University, University of California Berkeley, University of California Los Angeles, and Vanderbilt University. Dr. Ladouceur receives consulting fees from Boys Town National Research Hospital Institute for Human Neuroscience. The other authors report no financial relationships with commercial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All study procedures were approved by the University of Pittsburgh Institutional Review Board (IRB#PRO07110273) and all methods were performed in accordance with relevant guidelines and regulations. All parents provided written informed consent and all youth provided written assent after receiving a complete description of the study at the clinical intake visit.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"286"}}