{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T12:40:08Z","timestamp":1750423208102,"version":"3.41.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000062","name":"U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000093","name":"U.S. Department of Health & Human Services | NIH | Center for Information Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"U.S. Department of Health & Human Services | NIH | NIH Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute","doi-asserted-by":"publisher","award":["Z01HG200362"],"award-info":[{"award-number":["Z01HG200362"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Serum lipid levels, which are influenced by both genetic and environmental factors, are key determinants of cardiometabolic health and are influenced by both genetic and environmental factors. Improving our understanding of their underlying biological mechanisms can have important public health and therapeutic implications. Although psychosocial factors, including depression, anxiety, and perceived social support, are associated with serum lipid levels, it is unknown if they modify the effect of genetic loci that influence lipids. We conducted a genome-wide gene-by-psychosocial factor interaction (G\u00d7Psy) study in up to 133,157 individuals to evaluate if G\u00d7Psy influences serum lipid levels. We conducted a two-stage meta-analysis of G\u00d7Psy using both a one-degree of freedom (1df) interaction test and a joint 2df test of the main and interaction effects. In Stage 1, we performed G\u00d7Psy analyses on up to 77,413 individuals and promising associations (<jats:italic>P<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22125<\/jats:sup>) were evaluated in up to 55,744 independent samples in Stage 2. Significant findings (<jats:italic>P<\/jats:italic>\u2009&lt;\u20095\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) were identified based on meta-analyses of the two stages. There were 10,230 variants from 120 loci significantly associated with serum lipids. We identified novel associations for variants in four loci using the 1df test of interaction, and five additional loci using the 2df joint test that were independent of known lipid loci. Of these 9 loci, 7 could not have been detected without modeling the interaction as there was no evidence of association in a standard GWAS model. The genetic diversity of included samples was key in identifying these novel loci: four of the lead variants displayed very low frequency in European ancestry populations. Functional annotation highlighted promising loci for further experimental follow-up, particularly rs73597733 (<jats:italic>MACROD2<\/jats:italic>), rs59808825 (<jats:italic>GRAMD1B<\/jats:italic>), and rs11702544 (<jats:italic>RRP1B<\/jats:italic>). Notably, one of the genes in identified loci (<jats:italic>RRP1B<\/jats:italic>) was found to be a target of the approved drug Atenolol suggesting potential for drug repurposing. Overall, our findings suggest that taking interaction between genetic variants and psychosocial factors into account and including genetically diverse populations can lead to novel discoveries for serum lipids.<\/jats:p>","DOI":"10.1038\/s41398-025-03418-z","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T23:38:34Z","timestamp":1750376314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-9101","authenticated-orcid":false,"given":"Amy R.","family":"Bentley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5235-9037","authenticated-orcid":false,"given":"Michael R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon K.","family":"Musani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-4134","authenticated-orcid":false,"given":"Karen L.","family":"Schwander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-5421","authenticated-orcid":false,"given":"Thomas W.","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Sims","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-3028","authenticated-orcid":false,"given":"Tuomas O.","family":"Kilpel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-6783","authenticated-orcid":false,"given":"Hugues","family":"Aschard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Traci M.","family":"Bartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-8030","authenticated-orcid":false,"given":"Lawrence F.","family":"Bielak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Fang","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumaraswamy Naidu","family":"Chitrala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8346-3662","authenticated-orcid":false,"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-1735","authenticated-orcid":false,"given":"Mariaelisa","family":"Graff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-5068","authenticated-orcid":false,"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-0710","authenticated-orcid":false,"given":"Fernando P.","family":"Hartwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea R.V.R.","family":"Horimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-8464","authenticated-orcid":false,"given":"Elise","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-902X","authenticated-orcid":false,"given":"Alisa K.","family":"Manning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-4077","authenticated-orcid":false,"given":"Ilja M.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-809X","authenticated-orcid":false,"given":"Raymond","family":"Noordam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Richard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-5845","authenticated-orcid":false,"given":"Albert V.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-4070","authenticated-orcid":false,"given":"Yun Ju","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Vojinovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rujia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-2182","authenticated-orcid":false,"given":"Yujie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0933-2410","authenticated-orcid":false,"given":"Mary F.","family":"Feitosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4941-5106","authenticated-orcid":false,"given":"Sarah E.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7200-5455","authenticated-orcid":false,"given":"Leo-Pekka","family":"Lyytik\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-4608","authenticated-orcid":false,"given":"Giorgio","family":"Pistis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Rauramaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-3518","authenticated-orcid":false,"given":"Peter J.","family":"van der Most","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-8158","authenticated-orcid":false,"given":"Erin","family":"Ware","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-4315","authenticated-orcid":false,"given":"Stefan","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-1075","authenticated-orcid":false,"given":"Lisa R.","family":"Yanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-8695","authenticated-orcid":false,"given":"Dan E.","family":"Arking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna K.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-1730","authenticated-orcid":false,"given":"Christie","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boerwinkle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yii-Der Ida","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha L.","family":"Daviglus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-325X","authenticated-orcid":false,"given":"Lisa","family":"de las Fuentes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0964-0111","authenticated-orcid":false,"given":"Paul S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A. C.","family":"Delaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Fretts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette","family":"Ekunwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica D.","family":"Faul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-2402","authenticated-orcid":false,"given":"Sami","family":"Heikkinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Homuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-8585","authenticated-orcid":false,"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-9593","authenticated-orcid":false,"given":"Carmen R.","family":"Isasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost Bruno","family":"Jonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-3852","authenticated-orcid":false,"given":"Liisa","family":"Keltikangas-J\u00e4rvinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirjo","family":"Komulainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldi T.","family":"Kraja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-1792","authenticated-orcid":false,"given":"Jose E.","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3238-7612","authenticated-orcid":false,"given":"Lenore","family":"Launer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Lifelines Cohort Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Aguirre-Gamboa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Deelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lude","family":"Franke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Kuivenhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban A.","family":"Lopera Maya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilja M.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Sanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris A.","family":"Swertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Visscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith M.","family":"Vonk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cisca","family":"Wijmenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Wray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-3019","authenticated-orcid":false,"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Lohman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-197X","authenticated-orcid":false,"given":"Annemarie I.","family":"Luik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5998-795X","authenticated-orcid":false,"given":"Ani W.","family":"Manichaikul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8500","authenticated-orcid":false,"given":"Pedro","family":"Marques-Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3697-6617","authenticated-orcid":false,"given":"Yuri","family":"Milaneschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanford E.","family":"Mwasongwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"O\u2019Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3872-7793","authenticated-orcid":false,"given":"Stephen S.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela J.","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Schwettmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Shikany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ou","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-5468","authenticated-orcid":false,"given":"Jennifer A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-2298","authenticated-orcid":false,"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nona","family":"Sotoodehnia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-8966","authenticated-orcid":false,"given":"E. Shyong","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2756-4370","authenticated-orcid":false,"given":"Kent D.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-1929","authenticated-orcid":false,"given":"Lesley","family":"Tinker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Y.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7276-3387","authenticated-orcid":false,"given":"Andr\u00e9 G.","family":"Uitterlinden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2374-9204","authenticated-orcid":false,"given":"Cornelia M.","family":"van Duijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"van Heemst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0583-5093","authenticated-orcid":false,"given":"Melanie","family":"Waldenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwee-Lin","family":"Wee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-2402","authenticated-orcid":false,"given":"David R.","family":"Weir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-7394","authenticated-orcid":false,"given":"Ko","family":"Willems van Dijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-6145","authenticated-orcid":false,"given":"Kristin L.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7388-0692","authenticated-orcid":false,"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-411X","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-4778","authenticated-orcid":false,"given":"Alan B.","family":"Zonderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-263X","authenticated-orcid":false,"given":"Ian J.","family":"Deary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-9554","authenticated-orcid":false,"given":"Christian","family":"Gieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J\u00f6rgen","family":"Grabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-2871","authenticated-orcid":false,"given":"Timo A.","family":"Lakka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-4427","authenticated-orcid":false,"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3925-3913","authenticated-orcid":false,"given":"Albertine J.","family":"Oldehinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-4259","authenticated-orcid":false,"given":"Martin","family":"Preisig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7793","authenticated-orcid":false,"given":"Ya-Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele K.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-774X","authenticated-orcid":false,"given":"Michael","family":"Province","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Gauderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-0084","authenticated-orcid":false,"given":"Vilmundur","family":"Gudnason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-8859","authenticated-orcid":false,"given":"Catharina A.","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-412X","authenticated-orcid":false,"given":"Bernardo L.","family":"Horta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L. R.","family":"Kardia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7986-8560","authenticated-orcid":false,"given":"Charles","family":"Kooperberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-0742","authenticated-orcid":false,"given":"Ching-Ti","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis O.","family":"Mook-Kanamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7779-9672","authenticated-orcid":false,"given":"Brenda WJH","family":"Penninx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-5540","authenticated-orcid":false,"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8459","authenticated-orcid":false,"given":"Patricia A.","family":"Peyser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-2190","authenticated-orcid":false,"given":"Bruce M.","family":"Psaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-1723","authenticated-orcid":false,"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1233-7642","authenticated-orcid":false,"given":"Xueling","family":"Sim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8903-0366","authenticated-orcid":false,"given":"Kari E.","family":"North","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabeeru C.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-4810","authenticated-orcid":false,"given":"Laura","family":"Bierut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-3607","authenticated-orcid":false,"given":"Clint L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-4296","authenticated-orcid":false,"given":"Alanna C.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-053X","authenticated-orcid":false,"given":"Charles N.","family":"Rotimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-8158","authenticated-orcid":false,"given":"Myriam","family":"Fornage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin R.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"3418_CR1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41586-021-04064-3","volume":"600","author":"SE Graham","year":"2021","unstructured":"Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, et al. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021;600:675\u20139. https:\/\/doi.org\/10.1038\/s41586-021-04064-3.","journal-title":"Nature"},{"key":"3418_CR2","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41588-018-0064-5","volume":"50","author":"TJ Hoffmann","year":"2018","unstructured":"Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, et al. A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet. 2018;50:401\u201313. https:\/\/doi.org\/10.1038\/s41588-018-0064-5.","journal-title":"Nat Genet"},{"key":"3418_CR3","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/s41588-018-0222-9","volume":"50","author":"D Klarin","year":"2018","unstructured":"Klarin D, Damrauer SM, Cho K, Sun YV, Teslovich TM, Honerlaw J, et al. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nat Genet. 2018;50:1514\u201323. https:\/\/doi.org\/10.1038\/s41588-018-0222-9.","journal-title":"Nat Genet"},{"key":"3418_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1161\/CIRCGENETICS.108.829747","volume":"2","author":"BM Psaty","year":"2009","unstructured":"Psaty BM, O\u2019Donnell CJ, Gudnason V, Lunetta KL, Folsom AR, Rotter JI, et al. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet. 2009;2:73\u201380. https:\/\/doi.org\/10.1161\/CIRCGENETICS.108.829747.","journal-title":"Circ Cardiovasc Genet"},{"key":"3418_CR5","doi-asserted-by":"publisher","first-page":"e001649","DOI":"10.1161\/CIRCGENETICS.116.001649","volume":"10","author":"DC Rao","year":"2017","unstructured":"Rao DC, Sung YJ, Winkler TW, Schwander K, Borecki I, Cupples LA, et al. Multiancestry study of gene-lifestyle interactions for cardiovascular traits in 610 475 individuals from 124 cohorts: design and rationale. Circ Cardiovasc Genet. 2017;10:e001649 https:\/\/doi.org\/10.1161\/CIRCGENETICS.116.001649.","journal-title":"Circ Cardiovasc Genet"},{"key":"3418_CR6","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/s41588-019-0378-y","volume":"51","author":"AR Bentley","year":"2019","unstructured":"Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019;51:636\u201348. https:\/\/doi.org\/10.1038\/s41588-019-0378-y.","journal-title":"Nat Genet"},{"key":"3418_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08008-w","volume":"10","author":"TO Kilpelainen","year":"2019","unstructured":"Kilpelainen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun. 2019;10:376 https:\/\/doi.org\/10.1038\/s41467-018-08008-w.","journal-title":"Nat Commun"},{"key":"3418_CR8","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1093\/aje\/kwz005","volume":"188","author":"PS de Vries","year":"2019","unstructured":"de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, et al. Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions. Am J Epidemiol. 2019;188:1033\u201354. https:\/\/doi.org\/10.1093\/aje\/kwz005.","journal-title":"Am J Epidemiol"},{"key":"3418_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1235337","volume":"14","author":"L de Las Fuentes","year":"2023","unstructured":"de Las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ, et al. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. Front Genet. 2023;14:1235337 https:\/\/doi.org\/10.3389\/fgene.2023.1235337.","journal-title":"Front Genet"},{"key":"3418_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12958-0","volume":"10","author":"R Noordam","year":"2019","unstructured":"Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpel\u00e4inen TO, et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019;10:5121 https:\/\/doi.org\/10.1038\/s41467-019-12958-0.","journal-title":"Nat Commun"},{"key":"3418_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nrcardio.2016.181","volume":"14","author":"RM Carney","year":"2017","unstructured":"Carney RM, Freedland KE. Depression and coronary heart disease. Nat Rev Cardiol. 2017;14:145\u201355. https:\/\/doi.org\/10.1038\/nrcardio.2016.181.","journal-title":"Nat Rev Cardiol"},{"key":"3418_CR12","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1001\/jamapediatrics.2015.4121","volume":"170","author":"M Juonala","year":"2016","unstructured":"Juonala M, Pulkki-R\u00e5back L, Elovainio M, Hakulinen C, Magnussen CG, Sabin MA, et al. Childhood psychosocial factors and coronary artery calcification in adulthood: the cardiovascular risk in young finns study. JAMA Pediatrics. 2016;170:466\u201372. https:\/\/doi.org\/10.1001\/jamapediatrics.2015.4121.","journal-title":"JAMA Pediatrics"},{"key":"3418_CR13","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1001\/jama.2020.23068","volume":"324","author":"EL Harshfield","year":"2020","unstructured":"Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, et al. Association between depressive symptoms and incident cardiovascular diseases. JAMA. 2020;324:2396\u2013405. https:\/\/doi.org\/10.1001\/jama.2020.23068.","journal-title":"JAMA"},{"key":"3418_CR14","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1017\/s0033291720003566","volume":"52","author":"GH Li","year":"2022","unstructured":"Li GH, Cheung CL, Chung AK, Cheung BM, Wong IC, Fok MLY, et al. Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study. Psychol Med. 2022;52:1765\u201376. https:\/\/doi.org\/10.1017\/s0033291720003566.","journal-title":"Psychol Med"},{"key":"3418_CR15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.jad.2020.01.114","volume":"266","author":"YG Wei","year":"2020","unstructured":"Wei YG, Cai DB, Liu J, Liu RX, Wang SB, Tang YQ, et al. Cholesterol and triglyceride levels in first-episode patients with major depressive disorder: a meta-analysis of case-control studies. J Affect Disord. 2020;266:465\u201372. https:\/\/doi.org\/10.1016\/j.jad.2020.01.114.","journal-title":"J Affect Disord"},{"key":"3418_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1001\/jamapsychiatry.2022.4350","volume":"80","author":"A Tkachev","year":"2023","unstructured":"Tkachev A, Stekolshchikova E, Vanyushkina A, Zhang H, Morozova A, Zozulya S, et al. Lipid alteration signature in the blood plasma of individuals with schizophrenia, depression, and bipolar disorder. JAMA Psychiatry. 2023;80:250\u20139. https:\/\/doi.org\/10.1001\/jamapsychiatry.2022.4350.","journal-title":"JAMA Psychiatry"},{"key":"3418_CR17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.biopsych.2019.08.016","volume":"87","author":"M Bot","year":"2020","unstructured":"Bot M, Milaneschi Y, Al-Shehri T, Amin N, Garmaeva S, Onderwater GLJ, et al. Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls. Biol Psychiatry. 2020;87:409\u201318. https:\/\/doi.org\/10.1016\/j.biopsych.2019.08.016.","journal-title":"Biol Psychiatry"},{"key":"3418_CR18","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.bbi.2022.02.003","volume":"102","author":"CR Brydges","year":"2022","unstructured":"Brydges CR, Bhattacharyya S, Dehkordi SM, Milaneschi Y, Penninx B, Jansen R, et al. Metabolomic and inflammatory signatures of symptom dimensions in major depression. Brain, Behavior, Immun. 2022;102:42\u201352. https:\/\/doi.org\/10.1016\/j.bbi.2022.02.003.","journal-title":"Brain, Behavior, Immun"},{"key":"3418_CR19","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.3390\/genes14071405","volume":"14","author":"C Xu","year":"2023","unstructured":"Xu C, Padilla V, Lozano S, Gamez D, Su BB, Wang X, et al. APOE gene associated with dementia-related traits, depression, and anxiety in the hispanic population. Genes. 2023;14:1405.","journal-title":"Genes"},{"key":"3418_CR20","doi-asserted-by":"publisher","first-page":"112","DOI":"10.22038\/ijbms.2018.30825.7436","volume":"22","author":"WW Wang","year":"2019","unstructured":"Wang WW, Liu XL, Ruan Y, Wang L, Bao TH. Depression was associated with apolipoprotein E \u03b54 allele polymorphism: A meta-analysis. Iran J Basic Med Sci. 2019;22:112\u20137. https:\/\/doi.org\/10.22038\/ijbms.2018.30825.7436.","journal-title":"Iran J Basic Med Sci"},{"key":"3418_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01759-z","volume":"11","author":"M Zhang","year":"2021","unstructured":"Zhang M, Chen J, Yin Z, Wang L, Peng L. The association between depression and metabolic syndrome and its components: a bidirectional two-sample Mendelian randomization study. Transl Psychiatry. 2021;11:633 https:\/\/doi.org\/10.1038\/s41398-021-01759-z.","journal-title":"Transl Psychiatry"},{"key":"3418_CR22","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1001\/jamapsychiatry.2019.4712","volume":"77","author":"A Dregan","year":"2020","unstructured":"Dregan A, Rayner L, Davis KAS, Bakolis I, Arias de la Torre J, Das-Munshi J, et al. Associations between depression, arterial stiffness, and metabolic syndrome among adults in the UK Biobank Population Study: a mediation analysis. JAMA Psychiatry. 2020;77:598\u2013606. https:\/\/doi.org\/10.1001\/jamapsychiatry.2019.4712.","journal-title":"JAMA Psychiatry"},{"key":"3418_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.amjcard.2023.09.106","volume":"209","author":"BK Datta","year":"2023","unstructured":"Datta BK, Coughlin SS, Gummadi A, Mehrabian D, Ansa BE. Perceived social support and cardiovascular risk among nonelderly adults in the United States. Am J Cardiol. 2023;209:146\u201353. https:\/\/doi.org\/10.1016\/j.amjcard.2023.09.106.","journal-title":"Am J Cardiol"},{"key":"3418_CR24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2147\/dmso.S445890","volume":"17","author":"AC Garc\u00eda-Ulloa","year":"2024","unstructured":"Garc\u00eda-Ulloa AC, Miranda-Gil V, D\u00edaz-Pineda M, Garnica-Carrillo MF, Serrano-P\u00e9rez NH, Tron-Gomez MS, et al. Comparison of metabolic, lifestyle and mental health parameters in people with diabetes and relatives with and without family support. Diabetes Metab Syndr Obes: Targets Ther. 2024;17:239\u201345. https:\/\/doi.org\/10.2147\/dmso.S445890.","journal-title":"Diabetes Metab Syndr Obes: Targets Ther"},{"key":"3418_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.110944","volume":"159","author":"N Skogberg","year":"2022","unstructured":"Skogberg N, Castaneda AE, Agyemang C, Koponen P, Lilja E, Laatikainen T. The association of depressive and anxiety symptoms with the metabolic syndrome and its components among Russian, Somali, and Kurdish origin adults in Finland: a population-based study. J Psychosom Res. 2022;159:110944 https:\/\/doi.org\/10.1016\/j.jpsychores.2022.110944.","journal-title":"J Psychosom Res"},{"key":"3418_CR26","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","volume":"24","author":"Y Milaneschi","year":"2019","unstructured":"Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BWJH. Depression and obesity: evidence of shared biological mechanisms. Mol Psychiatry. 2019;24:18\u201333. https:\/\/doi.org\/10.1038\/s41380-018-0017-5.","journal-title":"Mol Psychiatry"},{"key":"3418_CR27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jad.2023.01.122","volume":"327","author":"L Zou","year":"2023","unstructured":"Zou L, Tian Y, Wang Y, Chen D, Lu X, Zeng Z, et al. High-cholesterol diet promotes depression- and anxiety-like behaviors in mice by impact gut microbe and neuroinflammation. J Affect Disord. 2023;327:425\u201338. https:\/\/doi.org\/10.1016\/j.jad.2023.01.122.","journal-title":"J Affect Disord"},{"key":"3418_CR28","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.1039\/D1FO00044F","volume":"12","author":"H Yu","year":"2021","unstructured":"Yu H, Qin X, Yu Z, Chen Y, Tang L, Shan W. Effects of high-fat diet on the formation of depressive-like behavior in mice. Food Funct. 2021;12:6416\u201331. https:\/\/doi.org\/10.1039\/D1FO00044F.","journal-title":"Food Funct"},{"key":"3418_CR29","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1192\/j.eurpsy.2022.32","volume":"65","author":"B Cheng","year":"2022","unstructured":"Cheng B, Cheng S, Jia Y, Liu L, Meng P, Qi X, et al. Genome-wide association studies in non-anxiety individuals identified novel risk loci for depression. Eur Psychiatry. 2022;65:e38 https:\/\/doi.org\/10.1192\/j.eurpsy.2022.32.","journal-title":"Eur Psychiatry"},{"key":"3418_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01782-8","volume":"12","author":"P Meng","year":"2022","unstructured":"Meng P, Ye J, Chu X, Cheng B, Cheng S, Liu L, et al. Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data. Transl Psychiatry. 2022;12:17 https:\/\/doi.org\/10.1038\/s41398-022-01782-8.","journal-title":"Transl Psychiatry"},{"key":"3418_CR31","doi-asserted-by":"publisher","first-page":"972196","DOI":"10.3389\/fgene.2022.972196","volume":"13","author":"D Pinakhina","year":"2023","unstructured":"Pinakhina D, Yermakovich D, Vergasova E, Kasyanov E, Rukavishnikov G, Rezapova V, et al. GWAS of depression in 4520 individuals from the Russian population highlights the role of MAGI2 (S-SCAM) in the gut-brain axis. Front Genet. 2023;13:972196 https:\/\/doi.org\/10.3389\/fgene.2022.972196.","journal-title":"Front Genet"},{"key":"3418_CR32","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/s41562-023-01579-9","volume":"7","author":"T Schoeler","year":"2023","unstructured":"Schoeler T, Speed D, Porcu E, Pirastu N, Pingault J-B, Kutalik Z. Participation bias in the UK Biobank distorts genetic associations and downstream analyses. Nat Hum Behav. 2023;7:1216\u201327. https:\/\/doi.org\/10.1038\/s41562-023-01579-9.","journal-title":"Nat Hum Behav"},{"key":"3418_CR33","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1038\/s41380-023-01960-0","volume":"28","author":"PP Silveira","year":"2023","unstructured":"Silveira PP, Pokhvisneva I, Howard DM, Meaney MJ. A sex-specific genome-wide association study of depression phenotypes in UK Biobank. Mol Psychiatry. 2023;28:2469\u201379. https:\/\/doi.org\/10.1038\/s41380-023-01960-0.","journal-title":"Mol Psychiatry"},{"key":"3418_CR34","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/ng.2795","volume":"45","author":"R Do","year":"2013","unstructured":"Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet. 2013;45:1345\u201352. https:\/\/doi.org\/10.1038\/ng.2795.","journal-title":"Nat Genet"},{"key":"3418_CR35","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1194\/jlr.P059477","volume":"56","author":"MB Lanktree","year":"2015","unstructured":"Lanktree MB, Elbers CC, Li Y, Zhang G, Duan Q, Karczewski KJ, et al. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration[S]. J Lipid Res. 2015;56:1781\u20136. https:\/\/doi.org\/10.1194\/jlr.P059477.","journal-title":"J Lipid Res"},{"key":"3418_CR36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ajhg.2014.01.009","volume":"94","author":"GM Peloso","year":"2014","unstructured":"Peloso GM, Auer PL, Bis JC, Voorman A, Morrison AC, Stitziel NO, et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014;94:223\u201332. https:\/\/doi.org\/10.1016\/j.ajhg.2014.01.009.","journal-title":"Am J Hum Genet"},{"key":"3418_CR37","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1093\/hmg\/ddx062","volume":"26","author":"CN Spracklen","year":"2017","unstructured":"Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, et al. Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Hum Mol Genet. 2017;26:1770\u201384. https:\/\/doi.org\/10.1093\/hmg\/ddx062.","journal-title":"Hum Mol Genet"},{"key":"3418_CR38","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nature09270","volume":"466","author":"TM Teslovich","year":"2010","unstructured":"Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707\u201313. https:\/\/doi.org\/10.1038\/nature09270.","journal-title":"Nature"},{"key":"3418_CR39","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/ng.2797","volume":"45","author":"CJ Willer","year":"2013","unstructured":"Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013;45:1274\u201383. https:\/\/doi.org\/10.1038\/ng.2797.","journal-title":"Nat Genet"},{"key":"3418_CR40","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"Human genomics.","year":"2015","unstructured":"Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348:648\u201360. https:\/\/doi.org\/10.1126\/science.1262110.","journal-title":"Science"},{"key":"3418_CR41","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1126\/science.1262110","volume":"348","author":"GTEx Consortium.","year":"2015","unstructured":"GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015;348:648\u201360. https:\/\/doi.org\/10.1126\/science.1262110.","journal-title":"Science"},{"key":"3418_CR42","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/s41588-023-01518-4","volume":"55","author":"M Kavousi","year":"2023","unstructured":"Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, et al. Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. Nat Genet. 2023;55:1651\u201364. https:\/\/doi.org\/10.1038\/s41588-023-01518-4.","journal-title":"Nat Genet"},{"key":"3418_CR43","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/s41397-019-0132-y","volume":"20","author":"L de Las Fuentes","year":"2020","unstructured":"de Las Fuentes L, Sung YJ, Sitlani CM, Avery CL, Bartz TM, Keyser C, et al. Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. Pharmacogenomics J. 2020;20:482\u201393. https:\/\/doi.org\/10.1038\/s41397-019-0132-y.","journal-title":"Pharmacogenomics J"},{"key":"3418_CR44","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s42003-022-03291-2","volume":"5","author":"ME Montasser","year":"2022","unstructured":"Montasser ME, Aslibekyan S, Srinivasasainagendra V, Tiwari HK, Patki A, Bagheri M, et al. An Amish founder population reveals rare-population genetic determinants of the human lipidome. Commun Biol. 2022;5:334 https:\/\/doi.org\/10.1038\/s42003-022-03291-2.","journal-title":"Commun Biol"},{"key":"3418_CR45","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1159\/000525411","volume":"81","author":"S Rao","year":"2022","unstructured":"Rao S, Baranova A, Yao Y, Wang J, Zhang F. Genetic relationships between attention-deficit\/hyperactivity disorder, autism spectrum disorder, and intelligence. Neuropsychobiology. 2022;81:484\u201396. https:\/\/doi.org\/10.1159\/000525411.","journal-title":"Neuropsychobiology"},{"key":"3418_CR46","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/s41593-021-00908-3","volume":"24","author":"R Karlsson Linn\u00e9r","year":"2021","unstructured":"Karlsson Linn\u00e9r R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, et al. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nat Neurosci. 2021;24:1367\u201376. https:\/\/doi.org\/10.1038\/s41593-021-00908-3.","journal-title":"Nat Neurosci"},{"key":"3418_CR47","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/s41588-018-0333-3","volume":"51","author":"PR Jansen","year":"2019","unstructured":"Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, et al. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nat Genet. 2019;51:394\u2013403. https:\/\/doi.org\/10.1038\/s41588-018-0333-3.","journal-title":"Nat Genet"},{"key":"3418_CR48","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41588-018-0309-3","volume":"51","author":"R Karlsson Linn\u00e9r","year":"2019","unstructured":"Karlsson Linn\u00e9r R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, et al. Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nat Genet. 2019;51:245\u201357. https:\/\/doi.org\/10.1038\/s41588-018-0309-3.","journal-title":"Nat Genet"},{"key":"3418_CR49","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/pcn.13430","volume":"76","author":"I Kushima","year":"2022","unstructured":"Kushima I, Imaeda M, Tanaka S, Kato H, Oya-Ito T, Nakatochi M, et al. Contribution of copy number variations to the risk of severe eating disorders. Psychiatry Clin Neurosci. 2022;76:423\u20138. https:\/\/doi.org\/10.1111\/pcn.13430.","journal-title":"Psychiatry Clin Neurosci"},{"key":"3418_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-017-0137-9","volume":"8","author":"RJL Anney","year":"2017","unstructured":"Anney RJL, Ripke S, Anttila V, Grove J, Holmans P, Huang H, et al. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21 https:\/\/doi.org\/10.1186\/s13229-017-0137-9.","journal-title":"Mol Autism"},{"key":"3418_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59922-3","volume":"10","author":"E Bacchelli","year":"2020","unstructured":"Bacchelli E, Cameli C, Viggiano M, Igliozzi R, Mancini A, Tancredi R, et al. An integrated analysis of rare CNV and exome variation in Autism Spectrum Disorder using the Infinium PsychArray. Sci Rep. 2020;10:3198 https:\/\/doi.org\/10.1038\/s41598-020-59922-3.","journal-title":"Sci Rep"},{"key":"3418_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00902-6","volume":"10","author":"Y Wu","year":"2020","unstructured":"Wu Y, Cao H, Baranova A, Huang H, Li S, Cai L, et al. Multi-trait analysis for genome-wide association study of five psychiatric disorders. Transl Psychiatry. 2020;10:209 https:\/\/doi.org\/10.1038\/s41398-020-00902-6.","journal-title":"Transl Psychiatry"},{"key":"3418_CR53","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/schbul\/sbaa133","volume":"47","author":"TB Bigdeli","year":"2021","unstructured":"Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Genovese G, et al. Genome-wide association studies of schizophrenia and bipolar disorder in a diverse cohort of US veterans. Schizophrenia Bull. 2021;47:517\u201329. https:\/\/doi.org\/10.1093\/schbul\/sbaa133.","journal-title":"Schizophrenia Bull"},{"key":"3418_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42654-4","volume":"9","author":"TM Everson","year":"2019","unstructured":"Everson TM, Marsit CJ, Michael O\u2019Shea T, Burt A, Hermetz K, Carter BS, et al. Epigenome-wide analysis identifies genes and pathways linked to neurobehavioral variation in preterm infants. Sci Rep. 2019;9:6322 https:\/\/doi.org\/10.1038\/s41598-019-42654-4.","journal-title":"Sci Rep"},{"key":"3418_CR55","doi-asserted-by":"publisher","first-page":"368","DOI":"10.3390\/cells10020368","volume":"10","author":"K Crawford","year":"2021","unstructured":"Crawford K, Oliver PL, Agnew T, Hunn BHM, Ahel I. Behavioural characterisation of Macrod1 and Macrod2 knockout mice. Cells. 2021;10:368.","journal-title":"Cells"},{"key":"3418_CR56","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41380-017-0001-5","volume":"24","author":"WD Hill","year":"2019","unstructured":"Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, et al. A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. Mol Psychiatry. 2019;24:169\u201381. https:\/\/doi.org\/10.1038\/s41380-017-0001-5.","journal-title":"Mol Psychiatry"},{"key":"3418_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04362-x","volume":"9","author":"G Davies","year":"2018","unstructured":"Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018;9:2098 https:\/\/doi.org\/10.1038\/s41467-018-04362-x.","journal-title":"Nat Commun"},{"key":"3418_CR58","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41588-018-0147-3","volume":"50","author":"JJ Lee","year":"2018","unstructured":"Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nat Genet. 2018;50:1112\u201321. https:\/\/doi.org\/10.1038\/s41588-018-0147-3.","journal-title":"Nat Genet"},{"key":"3418_CR59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30110-3","volume":"13","author":"CC Fan","year":"2022","unstructured":"Fan CC, Loughnan R, Makowski C, Pecheva D, Chen C-H, Hagler DJ, et al. Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain. Nat Commun. 2022;13:2423 https:\/\/doi.org\/10.1038\/s41467-022-30110-3.","journal-title":"Nat Commun"},{"key":"3418_CR60","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj9446","volume":"7","author":"D van der Meer","year":"2021","unstructured":"van der Meer D, Kaufmann T, Shadrin AA, Makowski C, Frei O, Roelfs D, et al. The genetic architecture of human cortical folding. Sci Adv. 2021;7:eabj9446 https:\/\/doi.org\/10.1126\/sciadv.abj9446.","journal-title":"Sci Adv"},{"key":"3418_CR61","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41562-021-01069-w","volume":"5","author":"Z Sha","year":"2021","unstructured":"Sha Z, Schijven D, Carrion-Castillo A, Joliot M, Mazoyer B, Fisher SE, et al. The genetic architecture of structural left\u2013right asymmetry of the human brain. Nat Hum Behav. 2021;5:1226\u201339. https:\/\/doi.org\/10.1038\/s41562-021-01069-w.","journal-title":"Nat Hum Behav"},{"key":"3418_CR62","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s41593-021-00826-4","volume":"24","author":"SM Smith","year":"2021","unstructured":"Smith SM, Douaud G, Chen W, Hanayik T, Alfaro-Almagro F, Sharp K, et al. An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank. Nat Neurosci. 2021;24:737\u201345. https:\/\/doi.org\/10.1038\/s41593-021-00826-4.","journal-title":"Nat Neurosci"},{"key":"3418_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118603","volume":"244","author":"AA Shadrin","year":"2021","unstructured":"Shadrin AA, Kaufmann T, van der Meer D, Palmer CE, Makowski C, Loughnan R, et al. Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. Neuroimage. 2021;244:118603 https:\/\/doi.org\/10.1016\/j.neuroimage.2021.118603.","journal-title":"Neuroimage"},{"key":"3418_CR64","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/s41588-019-0512-x","volume":"51","author":"M Lam","year":"2019","unstructured":"Lam M, Chen C-Y, Li Z, Martin AR, Bryois J, Ma X, et al. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nat Genet. 2019;51:1670\u20138. https:\/\/doi.org\/10.1038\/s41588-019-0512-x.","journal-title":"Nat Genet"},{"key":"3418_CR65","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1001\/jamapsychiatry.2019.1335","volume":"76","author":"S Periyasamy","year":"2019","unstructured":"Periyasamy S, John S, Padmavati R, Rajendren P, Thirunavukkarasu P, Gratten J, et al. Association of schizophrenia risk with disordered niacin metabolism in an indian genome-wide association study. JAMA Psychiatry. 2019;76:1026\u201334. https:\/\/doi.org\/10.1001\/jamapsychiatry.2019.1335.","journal-title":"JAMA Psychiatry"},{"key":"3418_CR66","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41588-018-0059-2","volume":"50","author":"AF Pardi\u00f1as","year":"2018","unstructured":"Pardi\u00f1as AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genet. 2018;50:381\u20139. https:\/\/doi.org\/10.1038\/s41588-018-0059-2.","journal-title":"Nat Genet"},{"key":"3418_CR67","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1093\/schbul\/sby140","volume":"45","author":"M Ikeda","year":"2019","unstructured":"Ikeda M, Takahashi A, Kamatani Y, Momozawa Y, Saito T, Kondo K, et al. Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations\/diseases genetic effect. Schizophrenia Bull. 2019;45:824\u201334. https:\/\/doi.org\/10.1093\/schbul\/sby140.","journal-title":"Schizophrenia Bull"},{"key":"3418_CR68","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","volume":"604","author":"V Trubetskoy","year":"2022","unstructured":"Trubetskoy V, Pardi\u00f1as AF, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli TB, et al. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. 2022;604:502\u20138. https:\/\/doi.org\/10.1038\/s41586-022-04434-5.","journal-title":"Nature"},{"key":"3418_CR69","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/ng.3973","volume":"49","author":"Z Li","year":"2017","unstructured":"Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, et al. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nat Genet. 2017;49:1576\u201383. https:\/\/doi.org\/10.1038\/ng.3973.","journal-title":"Nat Genet"},{"key":"3418_CR70","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1192\/bjp.bp.116.195370","volume":"211","author":"J Hall","year":"2017","unstructured":"Hall J. Schizophrenia \u2014 an anxiety disorder? Br J Psychiatry. 2017;211:262\u20133. https:\/\/doi.org\/10.1192\/bjp.bp.116.195370.","journal-title":"Br J Psychiatry"},{"key":"3418_CR71","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1192\/bjp.2018.126","volume":"213","author":"A Bulbena","year":"2018","unstructured":"Bulbena A, Bulbena-Cabre A. Schizophrenia and anxiety: yes, they are relatives not just neighbours. Br J Psychiatry. 2018;213:498\u2013498. https:\/\/doi.org\/10.1192\/bjp.2018.126.","journal-title":"Br J Psychiatry"},{"key":"3418_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2021.158957","volume":"1866","author":"T Naito","year":"2021","unstructured":"Naito T, Saheki Y. GRAMD1-mediated accessible cholesterol sensing and transport. Biochimica et Biophysica Acta - Mol Cell Biol Lipids. 2021;1866:158957 https:\/\/doi.org\/10.1016\/j.bbalip.2021.158957.","journal-title":"Biochimica et Biophysica Acta - Mol Cell Biol Lipids"},{"key":"3418_CR73","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106524","volume":"40","author":"B Ercan","year":"2021","unstructured":"Ercan B, Naito T, Koh DHZ, Dharmawan D, Saheki Y. Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b. EMBO J. 2021;40:e106524 https:\/\/doi.org\/10.15252\/embj.2020106524.","journal-title":"EMBO J"},{"key":"3418_CR74","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf0966","volume":"382","author":"A Ferrari","year":"2023","unstructured":"Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, et al. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023;382:eadf0966 https:\/\/doi.org\/10.1126\/science.adf0966.","journal-title":"Science"},{"key":"3418_CR75","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1038\/s41588-022-01233-6","volume":"54","author":"KG Aragam","year":"2022","unstructured":"Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, et al. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nat Genet. 2022;54:1803\u201315. https:\/\/doi.org\/10.1038\/s41588-022-01233-6.","journal-title":"Nat Genet"},{"key":"3418_CR76","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ajhg.2018.11.008","volume":"104","author":"G Kichaev","year":"2019","unstructured":"Kichaev G, Bhatia G, Loh PR, Gazal S, Burch K, Freund MK, et al. Leveraging polygenic functional enrichment to improve GWAS power. Am J Hum Genet. 2019;104:65\u201375. https:\/\/doi.org\/10.1016\/j.ajhg.2018.11.008.","journal-title":"Am J Hum Genet"},{"key":"3418_CR77","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s00125-016-3863-1","volume":"59","author":"JM Moreno-Navarrete","year":"2016","unstructured":"Moreno-Navarrete JM, Jove M, Ortega F, Xifra G, Ricart W, Obis \u00c8, et al. Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity. Diabetologia. 2016;59:822\u201332. https:\/\/doi.org\/10.1007\/s00125-016-3863-1.","journal-title":"Diabetologia"},{"key":"3418_CR78","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1093\/hmg\/ddz070","volume":"28","author":"YJ Sung","year":"2019","unstructured":"Sung YJ, de las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, et al. A multi-ancestry genome-wide study incorporating gene\u2013smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019;28:2615\u201333. https:\/\/doi.org\/10.1093\/hmg\/ddz070.","journal-title":"Hum Mol Genet"},{"key":"3418_CR79","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ajhg.2018.01.015","volume":"102","author":"YJ Sung","year":"2018","unstructured":"Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, et al. A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. Am J Hum Genet. 2018;102:375\u2013400. https:\/\/doi.org\/10.1016\/j.ajhg.2018.01.015.","journal-title":"Am J Hum Genet"},{"key":"3418_CR80","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/s41380-018-0336-6","volume":"25","author":"AT Amare","year":"2020","unstructured":"Amare AT, Vaez A, Hsu YH, Direk N, Kamali Z, Howard DM, et al. Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression. Mol Psychiatry. 2020;25:1420\u20139. https:\/\/doi.org\/10.1038\/s41380-018-0336-6.","journal-title":"Mol Psychiatry"},{"key":"3418_CR81","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/s41586-021-04103-z","volume":"599","author":"JD Backman","year":"2021","unstructured":"Backman JD, Li AH, Marcketta A, Sun D, Mbatchou J, Kessler MD, et al. Exome sequencing and analysis of 454,787 UK Biobank participants. Nature. 2021;599:628\u201334. https:\/\/doi.org\/10.1038\/s41586-021-04103-z.","journal-title":"Nature"},{"key":"3418_CR82","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01035-6","volume":"10","author":"QS Li","year":"2020","unstructured":"Li QS, Tian C, Hinds D. Genome-wide association studies of antidepressant class response and treatment-resistant depression. Transl Psychiatry. 2020;10:360 https:\/\/doi.org\/10.1038\/s41398-020-01035-6.","journal-title":"Transl Psychiatry"},{"key":"3418_CR83","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.biopsych.2021.10.021","volume":"92","author":"BL Mitchell","year":"2022","unstructured":"Mitchell BL, Campos AI, Whiteman DC, Olsen CM, Gordon SD, Walker AJ, et al. The Australian genetics of depression study: new risk loci and dissecting heterogeneity between subtypes. Biol Psychiatry. 2022;92:227\u201335. https:\/\/doi.org\/10.1016\/j.biopsych.2021.10.021.","journal-title":"Biol Psychiatry"},{"key":"3418_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1188427","volume":"14","author":"AY Yakovchik","year":"2023","unstructured":"Yakovchik AY, Tolynyova DV, Kashtanova DA, Sutulova ER, Ivanov MV, Mamchur AA, et al. Genetics of psycho-emotional well-being: genome-wide association study and polygenic risk score analysis. Front Psychiatry. 2023;14:1188427 https:\/\/doi.org\/10.3389\/fpsyt.2023.1188427.","journal-title":"Front Psychiatry"},{"key":"3418_CR85","doi-asserted-by":"publisher","first-page":"6293","DOI":"10.1038\/s41380-021-01087-0","volume":"26","author":"H Wang","year":"2021","unstructured":"Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J, et al. Multi-ancestry genome-wide gene\u2013sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021;26:6293\u2013304. https:\/\/doi.org\/10.1038\/s41380-021-01087-0.","journal-title":"Mol Psychiatry"},{"key":"3418_CR86","doi-asserted-by":"publisher","first-page":"e0198166","DOI":"10.1371\/journal.pone.0198166","volume":"13","author":"MF Feitosa","year":"2018","unstructured":"Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE. 2018;13:e0198166 https:\/\/doi.org\/10.1371\/journal.pone.0198166.","journal-title":"PLoS ONE"},{"key":"3418_CR87","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.tcm.2019.05.001","volume":"30","author":"V Bucciarelli","year":"2020","unstructured":"Bucciarelli V, Caterino AL, Bianco F, Caputi CG, Salerni S, Sciomer S, et al. Depression and cardiovascular disease: The deep blue sea of women\u2019s heart. Trends Cardiovasc Med. 2020;30:170\u20136. https:\/\/doi.org\/10.1016\/j.tcm.2019.05.001.","journal-title":"Trends Cardiovasc Med"},{"key":"3418_CR88","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jad.2021.05.011","volume":"291","author":"L Xu","year":"2021","unstructured":"Xu L, Wang K, Wang S, Liu L, Lv X, Song Y. Sex differences in the association between serum lipids and depressive symptoms: a longitudinal population-based study. J Affect Disord. 2021;291:154\u201362. https:\/\/doi.org\/10.1016\/j.jad.2021.05.011.","journal-title":"J Affect Disord"},{"key":"3418_CR89","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1093\/abm\/kaad030","volume":"57","author":"M Blakoe","year":"2023","unstructured":"Blakoe M, Petrova D, Garcia-Retamero R, Gon\u00e7alves K, Catena A, Ram\u00edrez Hern\u00e1ndez JA, et al. Sex moderates the relationship between social support and cardiovascular prevention behaviors in middle-aged and older adults. Ann Behav Med. 2023;57:877\u201387. https:\/\/doi.org\/10.1093\/abm\/kaad030.","journal-title":"Ann Behav Med"},{"key":"3418_CR90","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1176\/ajp.2006.163.10.1821","volume":"163","author":"M Olfson","year":"2006","unstructured":"Olfson M, Marcus SC, Corey-Lisle P, Tuomari AV, Hines P, L\u2019Italien GJ. Hyperlipidemia following treatment with antipsychotic medications. Am J Psychiatry. 2006;163:1821\u20135. https:\/\/doi.org\/10.1176\/ajp.2006.163.10.1821.","journal-title":"Am J Psychiatry"},{"key":"3418_CR91","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499\u2013502.","journal-title":"Clin Chem"},{"key":"3418_CR92","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000099183","volume":"63","author":"P Kraft","year":"2007","unstructured":"Kraft P, Yen YC, Stram DO, Morrison J, Gauderman WJ. Exploiting gene-environment interaction to detect genetic associations. Hum Heredity. 2007;63:111\u20139. https:\/\/doi.org\/10.1159\/000099183.","journal-title":"Hum Heredity"},{"key":"3418_CR93","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-134","volume":"11","author":"YS Aulchenko","year":"2010","unstructured":"Aulchenko YS, Struchalin MV, van Duijn CM. ProbABEL package for genome-wide association analysis of imputed data. BMC Bioinforma. 2010;11:134 https:\/\/doi.org\/10.1186\/1471-2105-11-134.","journal-title":"BMC Bioinforma."},{"key":"3418_CR94","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/nprot.2014.071","volume":"9","author":"TW Winkler","year":"2014","unstructured":"Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Magi R, et al. Quality control and conduct of genome-wide association meta-analyses. Nat Protoc. 2014;9:1192\u2013212. https:\/\/doi.org\/10.1038\/nprot.2014.071.","journal-title":"Nat Protoc"},{"key":"3418_CR95","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/gepi.20546","volume":"35","author":"AK Manning","year":"2011","unstructured":"Manning AK, LaValley M, Liu CT, Rice K, An P, Liu Y, et al. Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP x environment regression coefficients. Genet Epidemiol. 2011;35:11\u201318. https:\/\/doi.org\/10.1002\/gepi.20546.","journal-title":"Genet Epidemiol"},{"key":"3418_CR96","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer CJ, Li Y, Abecasis GR. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics. 2010;26:2190\u20131. https:\/\/doi.org\/10.1093\/bioinformatics\/btq340.","journal-title":"Bioinformatics"},{"key":"3418_CR97","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe K, Taskesen E, van Bochoven A, Posthuma D. Functional mapping and annotation of genetic associations with FUMA. Nat Commun. 2017;8:1826 https:\/\/doi.org\/10.1038\/s41467-017-01261-5.","journal-title":"Nat Commun"},{"key":"3418_CR98","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ng.2892","volume":"46","author":"M Kircher","year":"2014","unstructured":"Kircher M, Witten DM, Jain P, O\u2019Roak BJ, Cooper GM, Shendure J. A general framework for estimating the relative pathogenicity of human genetic variants. Nat Genet. 2014;46:310\u20135. https:\/\/doi.org\/10.1038\/ng.2892.","journal-title":"Nat Genet"},{"key":"3418_CR99","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nmeth.1906","volume":"9","author":"J Ernst","year":"2012","unstructured":"Ernst J, Kellis M. ChromHMM: automating chromatin-state discovery and characterization. Nat Methods. 2012;9:215\u20136. https:\/\/doi.org\/10.1038\/nmeth.1906.","journal-title":"Nat Methods"},{"key":"3418_CR100","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481\u20137. https:\/\/doi.org\/10.1038\/ng.3538.","journal-title":"Nat Genet"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03418-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03418-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03418-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T12:03:54Z","timestamp":1750421034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03418-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":100,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3418"],"URL":"https:\/\/doi.org\/10.1038\/s41398-025-03418-z","relation":{},"ISSN":["2158-3188"],"issn-type":[{"type":"electronic","value":"2158-3188"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"assertion":[{"value":"20 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare the following competing interests: BMP serves on the Data and Safety Monitoring Board of a clinical trial funded by the manufacturer (Zoll LifeCor) and on the Steering Committee of the Yale Open Data Access Project funded by Johnson & Johnson; CMvD was sponsored by GlaxoSmithKline; HJG received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm and Janssen Cilag as well as research funding from Fresenius Medical Care; JBJ serves in the Advisory Board Novartis; Patent holder with Biocompatibles UK Ltd. (Franham, Surrey, UK) (Title: Treatment of eye diseases using encapsulated cells encoding and secreting neuroprotective factor and \/ or anti-angiogenic factor; Patent number: 20120263794), and Europ\u00e4ische Patentanmeldung 16 720 043.5 and Patent application US 2019 0085065 A1 (Agents for use in the therapeutic or prophylactic treatment of myopia or hyperopia).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"For all participating cohorts, the appropriate institutional review boards approved research activities and informed consent was obtained from each participant. Further details on all participating cohorts is given in the .","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}}],"article-number":"207"}}