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GABA<jats:sub>A<\/jats:sub> receptor sensitivity to neurosteroid-modulation is dependent on its subunit composition. In the present study, we used quantitative reverse transcription polymerase chain reactions (RT-qPCR) to compare messenger ribonucleic acid (mRNA) expression of GABA<jats:sub>A<\/jats:sub> receptor subunits in peripheral mononuclear cells (PBMCs) across the menstrual cycle in 29 women with PMDD and 27 controls. We related mRNA subunit expression to serum levels of neurosteroids and to functional activation of the amygdala, a key brain region involved in emotion generation, measured using functional magnetic resonance imaging (fMRI). Women with PMDD had lower mRNA expression of the delta GABA<jats:sub>A<\/jats:sub> receptor subunit during the symptomatic, luteal phase (compared to the asymptomatic, follicular phase) of the menstrual cycle. Lower delta mRNA expression was related to higher amygdala activation in PMDD women. GABA<jats:sub>A<\/jats:sub> receptors incorporating the delta subunit are especially sensitive to neurosteroid modulation. 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No conflicts of interest are declared by the other authors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All data collection and recordings were performed according to Good Clinical Practice (GCP) standards and data collection, management and storage complied to General Data Protection Regulation (GDPR) laws. The study protocol was approved by the regional ethical review board in Ume\u00e5 (2016-111-31M, 2017-266-32M) and written informed consent was provided by all participants. Brain imaging results are presented after normalization to a standard template and are therefore not identifiable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"255"}}