{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:23:20Z","timestamp":1792790600646,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKZ0865"],"award-info":[{"award-number":["LJKZ0865"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The \"1+X\" Research Project conducted at the Second Hospital of Dalian Medical University","id":[{"id":"https:\/\/ror.org\/04c8eg608","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-025-03502-4","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T10:04:12Z","timestamp":1755511452000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0114-3999","authenticated-orcid":false,"given":"Ye","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-9311","authenticated-orcid":false,"given":"Shengming","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-1341","authenticated-orcid":false,"given":"Zhaoyang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"3502_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12696","volume":"52","author":"Y Jin","year":"2019","unstructured":"Jin Y, Cui R, Zhao L, Fan J, Li B. Mechanisms of Panax ginseng action as an antidepressant. Cell Prolif. 2019;52:e12696.","journal-title":"Cell Prolif"},{"key":"3502_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11641-8","volume":"10","author":"E Tunc-Ozcan","year":"2019","unstructured":"Tunc-Ozcan E, Peng CY, Zhu Y, Dunlop SR, Contractor A, Kessler JA. Activating newborn neurons suppresses depression and anxiety-like behaviors. Nat Commun. 2019;10:3768.","journal-title":"Nat Commun"},{"key":"3502_CR3","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.biopsych.2018.09.031","volume":"85","author":"EL Belleau","year":"2019","unstructured":"Belleau EL, Treadway MT, Pizzagalli DA. The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology. Biol Psychiatry. 2019;85:443\u201353.","journal-title":"Biol Psychiatry"},{"key":"3502_CR4","doi-asserted-by":"publisher","first-page":"4113","DOI":"10.1038\/s41380-022-01715-3","volume":"27","author":"M Bekhbat","year":"2022","unstructured":"Bekhbat M, Li Z, Mehta ND, Treadway MT, Lucido MJ, Woolwine BJ, et al. Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study. Mol Psychiatry. 2022;27:4113\u201321.","journal-title":"Mol Psychiatry"},{"key":"3502_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0521-7","volume":"9","author":"L Carboni","year":"2019","unstructured":"Carboni L, McCarthy DJ, Delafont B, Filosi M, Ivanchenko E, Ratti E, et al. Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies. Transl Psychiatry. 2019;9:182.","journal-title":"Transl Psychiatry"},{"key":"3502_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1009911","volume":"13","author":"Z Wang","year":"2022","unstructured":"Wang Z, Meng Z, Chen C. Screening of potential biomarkers in peripheral blood of patients with depression based on weighted gene co-expression network analysis and machine learning algorithms. Front Psychiatry. 2022;13:1009911.","journal-title":"Front Psychiatry"},{"key":"3502_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnrt.2024.100136","volume":"12","author":"H Huang","year":"2024","unstructured":"Huang H, Bach JR, Sharma HS, Chen L, Wu P, Sarnowska A, et al. The 2023 yearbook of Neurorestoratology. J Neurorestoratology. 2024;12:100136.","journal-title":"J Neurorestoratology"},{"key":"3502_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnrt.2023.100054","volume":"11","author":"H Huang","year":"2023","unstructured":"Huang H, Bach JR, Sharma HS, Saberi H, Jeon SR, Guo X, et al. The 2022 yearbook of Neurorestoratology. J Neurorestoratology. 2023;11:100054.","journal-title":"J Neurorestoratology"},{"key":"3502_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mito.2021.08.016","volume":"61","author":"A Tripathi","year":"2021","unstructured":"Tripathi A, Scaini G, Barichello T, Quevedo J, Pillai A. Mitophagy in depression: Pathophysiology and treatment targets. Mitochondrion. 2021;61:1\u201310.","journal-title":"Mitochondrion"},{"key":"3502_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cophys.2018.03.009","volume":"3","author":"A Lee","year":"2018","unstructured":"Lee A, Hirabayashi Y, Kwon SK, Lewis TL Jr., Polleux F. Emerging roles of mitochondria in synaptic transmission and neurodegeneration. Curr Opin Physiol. 2018;3:82\u201393.","journal-title":"Curr Opin Physiol"},{"key":"3502_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102522","volume":"58","author":"C Zuo","year":"2022","unstructured":"Zuo C, Cao H, Song Y, Gu Z, Huang Y, Yang Y, et al. Nrf2: An all-rounder in depression. Redox Biol. 2022;58:102522.","journal-title":"Redox Biol"},{"key":"3502_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","volume":"40","author":"JS Kerr","year":"2017","unstructured":"Kerr JS, Adriaanse BA, Greig NH, Mattson MP, Cader MZ, Bohr VA, et al. Mitophagy and Alzheimer\u2019s disease: cellular and molecular mechanisms. Trends Neurosci. 2017;40:151\u201366.","journal-title":"Trends Neurosci"},{"key":"3502_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1813-9","volume":"10","author":"X Shu","year":"2019","unstructured":"Shu X, Sun Y, Sun X, Zhou Y, Bian Y, Shu Z, et al. The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression. Cell Death Dis. 2019;10:577.","journal-title":"Cell Death Dis"},{"key":"3502_CR14","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/bcpt.13452","volume":"127","author":"Q Wei","year":"2020","unstructured":"Wei Q, Zhou W, Zheng J, Li D, Wang M, Feng L, et al. Antidepressant effects of 3-(3,4-methylenedioxy-5-trifluoromethyl phenyl)-2E-propenoic acid isobutyl amide involve TSPO-mediated mitophagy signalling pathway. Basic Clin Pharmacol Toxicol. 2020;127:380\u20138.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3502_CR15","doi-asserted-by":"publisher","first-page":"e93388","DOI":"10.1371\/journal.pone.0093388","volume":"9","author":"Z Liu","year":"2014","unstructured":"Liu Z, Li X, Sun N, Xu Y, Meng Y, Yang C, et al. Microarray profiling and co-expression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder. PLoS One. 2014;9:e93388.","journal-title":"PLoS One"},{"key":"3502_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.112","volume":"2","author":"R Belzeaux","year":"2012","unstructured":"Belzeaux R, Bergon A, Jeanjean V, Loriod B, Formisano-Tr\u00e9ziny C, Verrier L, et al. Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode. Transl Psychiatry. 2012;2:e185.","journal-title":"Transl Psychiatry"},{"key":"3502_CR17","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/s41593-020-0621-y","volume":"23","author":"C Nagy","year":"2020","unstructured":"Nagy C, Maitra M, Tanti A, Suderman M, Th\u00e9roux JF, Davoli MA, et al. Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons. Nat Neurosci. 2020;23:771\u201381.","journal-title":"Nat Neurosci"},{"key":"3502_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155519","volume":"128","author":"L Su","year":"2024","unstructured":"Su L, Lu H, Zhang D, Zhu X, Li J, Zong Y, et al. Total paeony glycoside relieves neuroinflammation to exert antidepressant effect via the interplay between NLRP3 inflammasome, pyroptosis and autophagy. Phytomedicine. 2024;128:155519.","journal-title":"Phytomedicine"},{"key":"3502_CR19","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.bbi.2024.04.036","volume":"119","author":"Q Liu","year":"2024","unstructured":"Liu Q, Zhao JN, Fang ZT, Wang X, Zhang BG, He Y, et al. BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy. Brain Behav Immun. 2024;119:648\u201364.","journal-title":"Brain Behav Immun"},{"key":"3502_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbrc.2022.02.106","volume":"602","author":"Y Sun","year":"2022","unstructured":"Sun Y, Cong T, Li L, Li J, Wu H, Chen X, et al. Baclofen attenuates cognitive deficits in post-cardiac arrest brain injury. Biochem Biophys Res Commun. 2022;602:135\u201341.","journal-title":"Biochem Biophys Res Commun"},{"key":"3502_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2024.110871","volume":"207","author":"XX Zheng","year":"2024","unstructured":"Zheng XX, Zhang CF, Li LQ, Ye JR, Ren SY, Zhang Z, et al. Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-\u03baB. Brain Res Bull. 2024;207:110871.","journal-title":"Brain Res Bull"},{"key":"3502_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jpsychires.2024.06.004","volume":"176","author":"Y Sun","year":"2024","unstructured":"Sun Y, Zhao D, Song Q, Cong T, Li L, Wu H, et al. NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis. J Psychiatr Res. 2024;176:119\u201328.","journal-title":"J Psychiatr Res"},{"key":"3502_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02303-y","volume":"18","author":"H Li","year":"2021","unstructured":"Li H, Xiang Y, Zhu Z, Wang W, Jiang Z, Zhao M, et al. Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat. J Neuroinflammation. 2021;18:254.","journal-title":"J Neuroinflammation"},{"key":"3502_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02614-z","volume":"13","author":"D Yao","year":"2023","unstructured":"Yao D, Li R, Hao J, Huang H, Wang X, Ran L, et al. Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. Transl Psychiatry. 2023;13:310.","journal-title":"Transl Psychiatry"},{"key":"3502_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20275-0","volume":"12","author":"H Liu","year":"2021","unstructured":"Liu H, Li Y, Sun S, Xin Q, Liu S, Mu X, et al. Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions. Nat Commun. 2021;12:114.","journal-title":"Nat Commun"},{"key":"3502_CR26","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1093\/brain\/awac407","volume":"146","author":"F Gonzalez-Ortiz","year":"2023","unstructured":"Gonzalez-Ortiz F, Turton M, Kac PR, Smirnov D, Premi E, Ghidoni R, et al. Brain-derived tau: a novel blood-based biomarker for Alzheimer\u2019s disease-type neurodegeneration. Brain. 2023;146:1152\u201365.","journal-title":"Brain"},{"key":"3502_CR27","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1007\/s12035-022-02822-6","volume":"59","author":"HS Ghaith","year":"2022","unstructured":"Ghaith HS, Nawar AA, Gabra MD, Abdelrahman ME, Nafady MH, Bahbah EI, et al. A literature review of traumatic brain injury biomarkers. Mol Neurobiol. 2022;59:4141\u201358.","journal-title":"Mol Neurobiol"},{"key":"3502_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jad.2017.07.001","volume":"233","author":"BS Gadad","year":"2018","unstructured":"Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, et al. Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks. J Affect Disord. 2018;233:3\u201314.","journal-title":"J Affect Disord"},{"key":"3502_CR29","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.sleep.2005.08.008","volume":"7","author":"CM Morin","year":"2006","unstructured":"Morin CM, LeBlanc M, Daley M, Gregoire JP, M\u00e9rette C. Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Med. 2006;7:123\u201330.","journal-title":"Sleep Med"},{"key":"3502_CR30","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1111\/jcmm.14170","volume":"23","author":"H Fang","year":"2019","unstructured":"Fang H, Tu S, Sheng J, Shao A. Depression in sleep disturbance: a review on a bidirectional relationship, mechanisms and treatment. J Cell Mol Med. 2019;23:2324\u201332.","journal-title":"J Cell Mol Med"},{"key":"3502_CR31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neures.2023.04.006","volume":"211","author":"S Yasugaki","year":"2025","unstructured":"Yasugaki S, Okamura H, Kaneko A, Hayashi Y. Bidirectional relationship between sleep and depression. Neurosci Res. 2025;211:57\u201364.","journal-title":"Neurosci Res"},{"key":"3502_CR32","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.3390\/antiox10121950","volume":"10","author":"IC Lee","year":"2021","unstructured":"Lee IC, Chiang KL. Clinical diagnosis and treatment of leigh syndrome based on SURF1: genotype and phenotype. Antioxidants (Basel). 2021;10:1950.","journal-title":"Antioxidants (Basel)"},{"key":"3502_CR33","doi-asserted-by":"publisher","first-page":"e0144441","DOI":"10.1371\/journal.pone.0144441","volume":"10","author":"LD Li","year":"2015","unstructured":"Li LD, Sun HF, Liu XX, Gao SP, Jiang HL, Hu X, et al. Down-regulation of NDUFB9 promotes breast cancer cell proliferation, metastasis by mediating mitochondrial metabolism. PLoS One. 2015;10:e0144441.","journal-title":"PLoS One"},{"key":"3502_CR34","doi-asserted-by":"publisher","first-page":"10076","DOI":"10.3390\/ijms221810076","volume":"22","author":"A Vera-Montecinos","year":"2021","unstructured":"Vera-Montecinos A, Rodr\u00edguez-Mias R, MacDowell KS, Garc\u00eda-Bueno B, Bris \u00c1G, Caso JR, et al. Analysis of molecular networks in the cerebellum in chronic schizophrenia: modulation by early postnatal life stressors in murine models. Int J Mol Sci. 2021;22:10076.","journal-title":"Int J Mol Sci"},{"key":"3502_CR35","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1126\/science.aaa1934","volume":"347","author":"A Zeisel","year":"2015","unstructured":"Zeisel A, Mu\u00f1oz-Manchado AB, Codeluppi S, L\u00f6nnerberg P, La Manno G, Jur\u00e9us A, et al. Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science. 2015;347:1138\u201342.","journal-title":"Science"},{"key":"3502_CR36","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.biopsych.2017.05.024","volume":"82","author":"F Corey","year":"2017","unstructured":"Corey F, Mounira B, Etienne SJBP. Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives. Biol Psychiatry. 2017;82:549\u201359.","journal-title":"Biol Psychiatry"},{"key":"3502_CR37","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1176\/appi.ajp.20220478","volume":"180","author":"C Chatzinakos","year":"2023","unstructured":"Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, et al. Single-nucleus transcriptome profiling of dorsolateral prefrontal cortex: mechanistic roles for neuronal gene expression, including the 17q21.31 Locus, in PTSD stress response. Am J Psychiatry. 2023;180:739\u201354.","journal-title":"Am J Psychiatry"},{"key":"3502_CR38","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/mp.2010.120","volume":"16","author":"B Luscher","year":"2011","unstructured":"Luscher B, Shen Q, Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry. 2011;16:383\u2013406.","journal-title":"Mol Psychiatry"},{"key":"3502_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","volume":"99","author":"S Antoniuk","year":"2019","unstructured":"Antoniuk S, Bijata M, Ponimaskin E, Wlodarczyk J. Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability. Neurosci Biobehav Rev. 2019;99:101\u201316.","journal-title":"Neurosci Biobehav Rev"},{"key":"3502_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115652","volume":"167","author":"Y Song","year":"2023","unstructured":"Song Y, Cao H, Zuo C, Gu Z, Huang Y, Miao J, et al. Mitochondrial dysfunction: a fatal blow in depression. Biomed Pharmacother. 2023;167:115652.","journal-title":"Biomed Pharmacother"},{"key":"3502_CR41","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/1570159X14666160229114755","volume":"14","author":"Y Bansal","year":"2016","unstructured":"Bansal Y, Kuhad A. Mitochondrial dysfunction in depression. Curr Neuropharmacol. 2016;14:610\u20138.","journal-title":"Curr Neuropharmacol"},{"key":"3502_CR42","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41386-021-01101-7","volume":"47","author":"DA Pizzagalli","year":"2022","unstructured":"Pizzagalli DA, Roberts AC. Prefrontal cortex and depression. Neuropsychopharmacology. 2022;47:225\u201346.","journal-title":"Neuropsychopharmacology"},{"key":"3502_CR43","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.biopsych.2022.02.014","volume":"92","author":"S Lin","year":"2022","unstructured":"Lin S, Huang L, Luo ZC, Li X, Jin SY, Du ZJ, et al. The ATP level in the medial prefrontal cortex regulates depressive-like behavior via the medial prefrontal cortex-lateral habenula pathway. Biol Psychiatry. 2022;92:179\u201392.","journal-title":"Biol Psychiatry"},{"key":"3502_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1015639","volume":"9","author":"M Shi","year":"2022","unstructured":"Shi M, Dong Z, Zhao K, He X, Sun Y, Ren J, et al. Novel insights into exhaustive exercise-induced myocardial injury: Focusing on mitochondrial quality control. Front Cardiovasc Med. 2022;9:1015639.","journal-title":"Front Cardiovasc Med"},{"key":"3502_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116869","volume":"239","author":"LH Khedr","year":"2019","unstructured":"Khedr LH, Nassar NN, Rashed L, El-Denshary ED, Abdel-Tawab AM. TLR4 signaling modulation of PGC1-\u03b1 mediated mitochondrial biogenesis in the LPS-Chronic mild stress model: Effect of fluoxetine and pentoxiyfylline. Life Sci. 2019;239:116869.","journal-title":"Life Sci"},{"key":"3502_CR46","doi-asserted-by":"publisher","first-page":"5634","DOI":"10.2174\/1381612820666140305230546","volume":"20","author":"KJ Tronstad","year":"2014","unstructured":"Tronstad KJ, Nooteboom M, Nilsson LI, Nikolaisen J, Sokolewicz M, Grefte S, et al. Regulation and quantification of cellular mitochondrial morphology and content. Curr Pharm Des. 2014;20:5634\u201352.","journal-title":"Curr Pharm Des"},{"key":"3502_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2673-z","volume":"11","author":"Y Shi","year":"2020","unstructured":"Shi Y, Tao M, Ma X, Hu Y, Huang G, Qiu A, et al. Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy. Cell Death Dis. 2020;11:467.","journal-title":"Cell Death Dis"},{"key":"3502_CR48","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1080\/15548627.2023.2276639","volume":"20","author":"H Wang","year":"2024","unstructured":"Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, et al. CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction. Autophagy. 2024;20:590\u2013613.","journal-title":"Autophagy"},{"key":"3502_CR49","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/ncb2012","volume":"12","author":"S Geisler","year":"2010","unstructured":"Geisler S, Holmstr\u00f6m KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, et al. PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1. Nat Cell Biol. 2010;12:119\u201331.","journal-title":"Nat Cell Biol"},{"key":"3502_CR50","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1080\/15548627.2015.1063763","volume":"11","author":"C Meissner","year":"2015","unstructured":"Meissner C, Lorenz H, Hehn B, Lemberg MK. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2\/Parkin-dependent mitophagy. Autophagy. 2015;11:1484\u201398.","journal-title":"Autophagy"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03502-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03502-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03502-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T06:33:26Z","timestamp":1757399606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03502-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3502"],"URL":"https:\/\/doi.org\/10.1038\/s41398-025-03502-4","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,18]]},"assertion":[{"value":"16 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All experimental protocols were performed in strict compliance with the National Institutes of Health (NIH) Guidelines for the Care and Use of Laboratory Animals and were approved by the Animal Experiment Ethics Committee of Dalian Medical University (No: AEE19087).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"292"}}