{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:35:44Z","timestamp":1790454944976,"version":"4.1.0"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-025-03640-9","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T15:45:51Z","timestamp":1760715951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-1110","authenticated-orcid":false,"given":"Yu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8912-1863","authenticated-orcid":false,"given":"Ziyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8932-4743","authenticated-orcid":false,"given":"Jun-Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-8560","authenticated-orcid":false,"given":"Wenxian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-2426","authenticated-orcid":false,"given":"Yuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"3640_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","volume":"68","author":"KR Merikangas","year":"2011","unstructured":"Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, et al. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry. 2011;68:241\u201351.","journal-title":"Arch Gen Psychiatry"},{"key":"3640_CR2","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1038\/s41380-020-0657-0","volume":"25","author":"KS Kendler","year":"2020","unstructured":"Kendler KS. The origin of our modern concept of mania in texts from 1780 to 1900. Mol Psychiatry. 2020;25:1975\u201385.","journal-title":"Mol Psychiatry"},{"key":"3640_CR3","doi-asserted-by":"publisher","first-page":"6406","DOI":"10.1073\/pnas.0609625104","volume":"104","author":"K Roybal","year":"2007","unstructured":"Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, et al. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA. 2007;104:6406\u201311.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3640_CR4","doi-asserted-by":"publisher","first-page":"e39907","DOI":"10.7554\/eLife.39907","volume":"7","author":"SX Cao","year":"2018","unstructured":"Cao SX, Zhang Y, Hu XY, Hong B, Sun P, He HY, et al. ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines. Elife. 2018;7:e39907.","journal-title":"Elife"},{"key":"3640_CR5","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41588-019-0397-8","volume":"51","author":"EA Stahl","year":"2019","unstructured":"Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51:793\u2013803.","journal-title":"Nat Genet"},{"key":"3640_CR6","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/14737175.2019.1562338","volume":"19","author":"B Vai","year":"2019","unstructured":"Vai B, Bertocchi C, Benedetti F. Cortico-limbic connectivity as a possible biomarker for bipolar disorder: where are we now?. Expert Rev Neurother. 2019;19:159\u201372.","journal-title":"Expert Rev Neurother"},{"key":"3640_CR7","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1192\/bjo.2021.966","volume":"7","author":"R Strawbridge","year":"2021","unstructured":"Strawbridge R, Carter R, Saldarini F, Tsapekos D, Young AH. Inflammatory biomarkers and cognitive functioning in individuals with euthymic bipolar disorder: exploratory study. BJPsych Open. 2021;7:e126.","journal-title":"BJPsych Open"},{"key":"3640_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jpsychires.2014.04.017","volume":"56","author":"IE Bauer","year":"2014","unstructured":"Bauer IE, Pascoe MC, Wollenhaupt-Aguiar B, Kapczinski F, Soares JC. Inflammatory mediators of cognitive impairment in bipolar disorder. J Psychiatr Res. 2014;56:18\u201327.","journal-title":"J Psychiatr Res"},{"key":"3640_CR9","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","volume":"35","author":"M Berk","year":"2011","unstructured":"Berk M, Kapczinski F, Andreazza AC, Dean OM, Giorlando F, Maes M, et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev. 2011;35:804\u201317.","journal-title":"Neurosci Biobehav Rev"},{"key":"3640_CR10","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.7150\/ijbs.84923","volume":"19","author":"L Kong","year":"2023","unstructured":"Kong L, Guo X, Shen Y, Xu L, Huang H, Lu J, et al. Pushing the frontiers: optogenetics for illuminating the neural pathophysiology of bipolar disorder. Int J Biol Sci. 2023;19:4539\u201351.","journal-title":"Int J Biol Sci"},{"key":"3640_CR11","doi-asserted-by":"publisher","first-page":"5213","DOI":"10.1038\/s41380-020-0810-9","volume":"26","author":"X Yu","year":"2021","unstructured":"Yu X, Ba W, Zhao G, Ma Y, Harding EC, Yin L, et al. Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Mol Psychiatry. 2021;26:5213\u201328.","journal-title":"Mol Psychiatry"},{"key":"3640_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.eurpsy.2005.09.010","volume":"21","author":"JA de Souza Crippa","year":"2006","unstructured":"de Souza Crippa JA, Zuardi AW, Busatto GF, Sanches RF, Santos AC, Araujo D, et al. Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. Eur Psychiatry. 2006;21:291\u20139.","journal-title":"Eur Psychiatry"},{"key":"3640_CR13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.schres.2003.12.010","volume":"71","author":"K Kasai","year":"2004","unstructured":"Kasai K, McCarley RW, Salisbury DF, Onitsuka T, Demeo S, Yurgelun-Todd D, et al. Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study. Schizophr Res. 2004;71:65\u201376.","journal-title":"Schizophr Res"},{"key":"3640_CR14","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00406-006-0697-8","volume":"257","author":"R Brisch","year":"2007","unstructured":"Brisch R, Bernstein HG, Krell D, Stauch R, Trubner K, Dobrowolny H, et al. Volumetric analysis of septal region in schizophrenia and affective disorder. Eur Arch Psychiatry Clin Neurosci. 2007;257:140\u20138.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"3640_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ajp.2015.04.008","volume":"15","author":"NK Srivastava","year":"2015","unstructured":"Srivastava NK, Khanra S, Chail V, Khess CR. Clinical correlates of enlarged cavum septum pellucidum in schizophrenia: a revisit through computed tomography. Asian J Psychiatr. 2015;15:21\u201324.","journal-title":"Asian J Psychiatr"},{"key":"3640_CR16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1017\/S0033291700034838","volume":"26","author":"T Shioiri","year":"1996","unstructured":"Shioiri T, Oshitani Y, Kato T, Murashita J, Hamakawa H, Inubushi T, et al. Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia. Psychol Med. 1996;26:431\u20134.","journal-title":"Psychol Med"},{"key":"3640_CR17","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.euroneuro.2018.10.001","volume":"28","author":"GH Beraldi","year":"2018","unstructured":"Beraldi GH, Prado KS, Amann BL, Radua J, Friedman L, Elkis H. Meta-analyses of cavum septum pellucidum in mood disorders in comparison with healthy controls or schizophrenia. Eur Neuropsychopharmacol. 2018;28:1325\u201338.","journal-title":"Eur Neuropsychopharmacol"},{"key":"3640_CR18","first-page":"229","volume":"42","author":"R Landin-Romero","year":"2016","unstructured":"Landin-Romero R, Amann BL, Sarro S, Guerrero-Pedraza A, Vicens V, Rodriguez-Cano E, et al. Midline brain abnormalities across psychotic and mood disorders. Schizophr Bull. 2016;42:229\u201338.","journal-title":"Schizophr Bull"},{"key":"3640_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainresrev.2004.04.009","volume":"46","author":"TP Sheehan","year":"2004","unstructured":"Sheehan TP, Chambers RA, Russell DS. Regulation of affect by the lateral septum: implications for neuropsychiatry. Brain Res Brain Res Rev. 2004;46:71\u2013117.","journal-title":"Brain Res Brain Res Rev"},{"key":"3640_CR20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00406-010-0119-9","volume":"261","author":"R Brisch","year":"2011","unstructured":"Brisch R, Bernstein HG, Dobrowolny H, Krell D, Stauch R, Trubner K, et al. A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2011;261:47\u201358.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"3640_CR21","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.schres.2018.08.029","volume":"204","author":"SY Kim","year":"2019","unstructured":"Kim SY, Park MH, Jung KI. Chronic schizophrenia with the absence of the septum pellucidum: a case report. Schizophr Res. 2019;204:430\u20131.","journal-title":"Schizophr Res"},{"key":"3640_CR22","first-page":"232","volume":"49","author":"I Alberdi-Paramo","year":"2021","unstructured":"Alberdi-Paramo I, Servan Rendon-Luna B. Organic bipolar disorder secondary to central neurocytoma resection: a case report. Actas Esp Psiquiatr. 2021;49:232\u20135.","journal-title":"Actas Esp Psiquiatr"},{"key":"3640_CR23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1097\/00005053-195812000-00002","volume":"127","author":"W Zeman","year":"1958","unstructured":"Zeman W, King FA. Tumors of the septum pellucidum and adjacent structures with abnormal affective behavior: an anterior midline structure syndrome. J Nerv Ment Dis. 1958;127:490\u2013502.","journal-title":"J Nerv Ment Dis"},{"key":"3640_CR24","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1038\/s41380-022-01922-y","volume":"28","author":"D Wang","year":"2023","unstructured":"Wang D, Pan X, Zhou Y, Wu Z, Ren K, Liu H, et al. Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety. Mol Psychiatry. 2023;28:1090\u20131100.","journal-title":"Mol Psychiatry"},{"key":"3640_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111402","volume":"40","author":"L Decarie-Spain","year":"2022","unstructured":"Decarie-Spain L, Liu CM, Lauer LT, Subramanian K, Bashaw AG, Klug ME, et al. Ventral hippocampus-lateral septum circuitry promotes foraging-related memory. Cell Rep. 2022;40:111402.","journal-title":"Cell Rep."},{"key":"3640_CR26","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11920-011-0191-5","volume":"13","author":"IF Brockington","year":"2011","unstructured":"Brockington IF. Menstrual psychosis: a bipolar disorder with a link to the hypothalamus. Curr Psychiatry Rep. 2011;13:193\u20137.","journal-title":"Curr Psychiatry Rep."},{"key":"3640_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-014-0007-8","volume":"2","author":"OA Abulseoud","year":"2014","unstructured":"Abulseoud OA, Camsari UM, Ruby CL, Mohamed K, Abdel Gawad NM, Kasasbeh A, et al. Lateral hypothalamic kindling induces manic-like behavior in rats: a novel animal model. Int J Bipolar Disord. 2014;2:7.","journal-title":"Int J Bipolar Disord"},{"key":"3640_CR28","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0315-21.2021","volume":"8","author":"CA Rizzi-Wise","year":"2021","unstructured":"Rizzi-Wise CA, Wang DV. Putting together pieces of the lateral septum: multifaceted functions and its neural pathways. eNeuro. 2021;8:ENEURO.0315-21.2021.","journal-title":"eNeuro"},{"key":"3640_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0163-1047(80)91247-9","volume":"30","author":"DJ Albert","year":"1980","unstructured":"Albert DJ, Chew GL. The septal forebrain and the inhibitory modulation of attack and defense in the rat. A review. Behav Neural Biol. 1980;30:357\u201388.","journal-title":"Behav Neural Biol"},{"key":"3640_CR30","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1037\/h0077524","volume":"92","author":"DJ Albert","year":"1978","unstructured":"Albert DJ, Wong RC. Hyperreactivity, muricide, and intraspecific aggression in the rat produced by infusion of local anesthetic into the lateral septum or surrounding areas. J Comp Physiol Psychol. 1978;92:1062\u201373.","journal-title":"J Comp Physiol Psychol"},{"key":"3640_CR31","doi-asserted-by":"publisher","first-page":"e073591","DOI":"10.1136\/bmj-2022-073591","volume":"381","author":"FS Goes","year":"2023","unstructured":"Goes FS. Diagnosis and management of bipolar disorders. BMJ. 2023;381:e073591.","journal-title":"BMJ"},{"key":"3640_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113062","volume":"42","author":"M Hashimoto","year":"2023","unstructured":"Hashimoto M, Brito SI, Venner A, Pasqualini AL, Yang TL, Allen D, et al. Lateral septum modulates cortical state to tune responsivity to threat stimuli. Cell Rep. 2023;42:113062.","journal-title":"Cell Rep."},{"key":"3640_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23064-5","volume":"12","author":"VEM Oliveira","year":"2021","unstructured":"Oliveira VEM, Lukas M, Wolf HN, Durante E, Lorenz A, Mayer AL, et al. Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. Nat Commun. 2021;12:2900.","journal-title":"Nat Commun"},{"key":"3640_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27092-z","volume":"12","author":"D Mahadevia","year":"2021","unstructured":"Mahadevia D, Saha R, Manganaro A, Chuhma N, Ziolkowski-Blake A, Morgan AA, et al. Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections. Nat Commun. 2021;12:6796.","journal-title":"Nat Commun"},{"key":"3640_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172764","volume":"865","author":"A Pinna","year":"2019","unstructured":"Pinna A, Costa G, Contu L, Morelli M. Fos expression induced by olanzapine and risperidone in the central extended amygdala. Eur J Pharm. 2019;865:172764.","journal-title":"Eur J Pharm"},{"key":"3640_CR36","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0893-133X(97)00041-9","volume":"17","author":"GG Nomikos","year":"1997","unstructured":"Nomikos GG, Tham CS, Fibiger HC, Svensson TH. The putative atypical antipsychotic drug amperozide preferentially increases c-fos expression in rat medial prefrontal cortex and lateral septum. Neuropsychopharmacology. 1997;17:197\u2013201.","journal-title":"Neuropsychopharmacology"},{"key":"3640_CR37","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S0893-133X(98)00051-7","volume":"20","author":"A Pinna","year":"1999","unstructured":"Pinna A, Wardas J, Cozzolino A, Morelli M. Involvement of adenosine A2A receptors in the induction of c-fos expression by clozapine and haloperidol. Neuropsychopharmacology. 1999;20:44\u201351.","journal-title":"Neuropsychopharmacology"},{"key":"3640_CR38","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0006-8993(98)00087-0","volume":"791","author":"YJ Sun","year":"1998","unstructured":"Sun YJ, Suzuki M, Kurachi T, Murata M, Kurachi M. Expression of Fos protein in the limbic regions of the rat following haloperidol decanoate. Brain Res. 1998;791:125\u201336.","journal-title":"Brain Res"},{"key":"3640_CR39","doi-asserted-by":"publisher","first-page":"913","DOI":"10.7150\/thno.78777","volume":"13","author":"Z Huang","year":"2023","unstructured":"Huang Z, Zhang Y, Ma X, Feng Y, Zong X, Jordan JD, et al. Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity. Theranostics. 2023;13:913\u201330.","journal-title":"Theranostics"},{"key":"3640_CR40","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.neuron.2023.02.017","volume":"111","author":"XN Zhu","year":"2023","unstructured":"Zhu XN, Li J, Qiu GL, Wang L, Lu C, Guo YG, et al. Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter. Neuron. 2023;111:1626\u20131636 e1626.","journal-title":"Neuron"},{"key":"3640_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5389","volume":"5","author":"S Uchida","year":"2014","unstructured":"Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, et al. Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Nat Commun. 2014;5:4389.","journal-title":"Nat Commun"},{"key":"3640_CR42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nature12630","volume":"503","author":"K Han","year":"2013","unstructured":"Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013;503:72\u201377.","journal-title":"Nature"},{"key":"3640_CR43","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1038\/mp.2016.261","volume":"22","author":"YR Yang","year":"2017","unstructured":"Yang YR, Jung JH, Kim SJ, Hamada K, Suzuki A, Kim HJ, et al. Forebrain-specific ablation of phospholipase Cgamma1 causes manic-like behavior. Mol Psychiatry. 2017;22:1473\u201382.","journal-title":"Mol Psychiatry"},{"key":"3640_CR44","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1016\/S0140-6736(20)31544-0","volume":"396","author":"RS McIntyre","year":"2020","unstructured":"McIntyre RS, Berk M, Brietzke E, Goldstein BI, Lopez-Jaramillo C, Kessing LV, et al. Bipolar disorders. Lancet. 2020;396:1841\u201356.","journal-title":"Lancet"},{"key":"3640_CR45","doi-asserted-by":"publisher","first-page":"9988","DOI":"10.1523\/JNEUROSCI.0881-21.2021","volume":"41","author":"SW Hu","year":"2021","unstructured":"Hu SW, Zhang Q, Xia SH, Zhao WN, Li QZ, Yang JX, et al. Contralateral projection of anterior cingulate cortex contributes to mirror-image pain. J Neurosci. 2021;41:9988\u201310003.","journal-title":"J Neurosci"},{"key":"3640_CR46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000049255","volume":"45","author":"D Riemann","year":"2002","unstructured":"Riemann D, Voderholzer U, Berger M. Sleep and sleep-wake manipulations in bipolar depression. Neuropsychobiology. 2002;45:7\u201312.","journal-title":"Neuropsychobiology"},{"key":"3640_CR47","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1176\/ajp.144.2.201","volume":"144","author":"TA Wehr","year":"1987","unstructured":"Wehr TA, Sack DA, Rosenthal NE. Sleep reduction as a final common pathway in the genesis of mania. Am J Psychiatry. 1987;144:201\u20134.","journal-title":"Am J Psychiatry"},{"key":"3640_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115136","volume":"323","author":"F Pacchioni","year":"2023","unstructured":"Pacchioni F, Cavallini MC, Fregna L, Casoni F, Sarzetto A, Attanasio F, et al. Sleep changes during a spontaneous manic episode: PSG assessment in a clinical context. Psychiatry Res. 2023;323:115136.","journal-title":"Psychiatry Res"},{"key":"3640_CR49","doi-asserted-by":"publisher","first-page":"10288","DOI":"10.1073\/pnas.1308295110","volume":"110","author":"A Suzuki","year":"2013","unstructured":"Suzuki A, Sinton CM, Greene RW, Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci USA. 2013;110:10288\u201393.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3640_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101240","volume":"23","author":"T Honda","year":"2020","unstructured":"Honda T, Takata Y, Cherasse Y, Mizuno S, Sugiyama F, Takahashi S, et al. Ablation of ventral Midbrain\/Pons GABA neurons induces mania-like behaviors with altered sleep homeostasis and dopamine D(2)R-mediated sleep reduction. iScience. 2020;23:101240.","journal-title":"iScience"},{"key":"3640_CR51","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/bdi.12609","volume":"20","author":"LN Yatham","year":"2018","unstructured":"Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Bond DJ, Frey BN, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018;20:97\u2013170.","journal-title":"Bipolar Disord"},{"key":"3640_CR52","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1080\/17425255.2017.1386653","volume":"13","author":"T Richardson","year":"2017","unstructured":"Richardson T, Macaluso M. Clinically relevant treatment considerations regarding lithium use in bipolar disorder. Expert Opin Drug Metab Toxicol. 2017;13:1105\u201313.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"3640_CR53","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0165-0173(97)00009-X","volume":"24","author":"PY Risold","year":"1997","unstructured":"Risold PY, Swanson LW. Connections of the rat lateral septal complex. Brain Res Brain Res Rev. 1997;24:115\u201395.","journal-title":"Brain Res Brain Res Rev"},{"key":"3640_CR54","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41586-022-05484-5","volume":"613","author":"L Li","year":"2023","unstructured":"Li L, Durand-de Cuttoli R, Aubry AV, Burnett CJ, Cathomas F, Parise LF, et al. Social trauma engages lateral septum circuitry to occlude social reward. Nature. 2023;613:696\u2013703.","journal-title":"Nature"},{"key":"3640_CR55","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/7854_2020_153","volume":"48","author":"C Fabbri","year":"2021","unstructured":"Fabbri C. The role of genetics in bipolar disorder. Curr Top Behav Neurosci. 2021;48:41\u201360.","journal-title":"Curr Top Behav Neurosci"},{"key":"3640_CR56","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.neubiorev.2021.03.029","volume":"126","author":"HS Wirtshafter","year":"2021","unstructured":"Wirtshafter HS, Wilson MA. Lateral septum as a nexus for mood, motivation, and movement. Neurosci Biobehav Rev. 2021;126:544\u201359.","journal-title":"Neurosci Biobehav Rev"},{"key":"3640_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9521","volume":"6","author":"F Bender","year":"2015","unstructured":"Bender F, Gorbati M, Cadavieco MC, Denisova N, Gao X, Holman C, et al. Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway. Nat Commun. 2015;6:8521.","journal-title":"Nat Commun"},{"key":"3640_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1337207","volume":"18","author":"YJ Liu","year":"2024","unstructured":"Liu YJ, Wang Y, Wu JW, Zhou J, Song BL, Jiang Y, et al. GABAergic synapses from the ventral lateral septum to the paraventricular nucleus of hypothalamus modulate anxiety. Front Neurosci. 2024;18:1337207.","journal-title":"Front Neurosci"},{"key":"3640_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149548","volume":"699","author":"S Sun","year":"2024","unstructured":"Sun S, Xu J, Lin L, Jia M, Xue X, Wang Q, et al. Chemotherapeutic drug elemene induces pain and anxiety-like behaviors by activating GABAergic neurons in the lateral septum of mice. Biochem Biophys Res Commun. 2024;699:149548.","journal-title":"Biochem Biophys Res Commun"},{"key":"3640_CR60","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0165-0327(00)00344-X","volume":"61","author":"N McNaughton","year":"2000","unstructured":"McNaughton N, Gray JA. Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety. J Affect Disord. 2000;61:161\u201376.","journal-title":"J Affect Disord"},{"key":"3640_CR61","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.jad.2017.08.054","volume":"225","author":"KJS Lewis","year":"2018","unstructured":"Lewis KJS, Di Florio A, Forty L, Gordon-Smith K, Perry A, Craddock N, et al. Mania triggered by sleep loss and risk of postpartum psychosis in women with bipolar disorder. J Affect Disord. 2018;225:624\u20139.","journal-title":"J Affect Disord"},{"key":"3640_CR62","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1192\/bjp.159.4.576","volume":"159","author":"TA Wehr","year":"1991","unstructured":"Wehr TA. Sleep-loss as a possible mediator of diverse causes of mania. Br J Psychiatry. 1991;159:576\u20138.","journal-title":"Br J Psychiatry"},{"key":"3640_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101429","volume":"57","author":"J Scott","year":"2021","unstructured":"Scott J, Kallestad H, Vedaa O, Sivertsen B, Etain B. Sleep disturbances and first onset of major mental disorders in adolescence and early adulthood: a systematic review and meta-analysis. Sleep Med Rev. 2021;57:101429.","journal-title":"Sleep Med Rev"},{"key":"3640_CR64","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","volume":"381","author":"JR Geddes","year":"2013","unstructured":"Geddes JR, Miklowitz DJ. Treatment of bipolar disorder. Lancet. 2013;381:1672\u201382.","journal-title":"Lancet"},{"key":"3640_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0105-y","volume":"8","author":"FM Howells","year":"2018","unstructured":"Howells FM, Temmingh HS, Hsieh JH, van Dijen AV, Baldwin DS, Stein DJ. Electroencephalographic delta\/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder. Transl Psychiatry. 2018;8:75.","journal-title":"Transl Psychiatry"},{"key":"3640_CR66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.brainres.2018.10.024","volume":"1706","author":"Y Murata","year":"2019","unstructured":"Murata Y, Colonnese MT. Thalamic inhibitory circuits and network activity development. Brain Res. 2019;1706:13\u201323.","journal-title":"Brain Res"},{"key":"3640_CR67","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1037\/dev0001560","volume":"59","author":"JD Gilchrist","year":"2023","unstructured":"Gilchrist JD, Mitchell J, Qian W, Patte KA, Leatherdale ST. Bidirectional associations between sleep duration and emotion dysregulation across adolescence. Dev Psychol. 2023;59:1087\u201397.","journal-title":"Dev Psychol"},{"key":"3640_CR68","doi-asserted-by":"publisher","first-page":"3044","DOI":"10.1038\/s41380-023-02037-8","volume":"28","author":"X Li","year":"2023","unstructured":"Li X, Chen B, Zhang D, Wang S, Feng Y, Wu X, et al. A novel murine model of mania. Mol Psychiatry. 2023;28:3044\u201354.","journal-title":"Mol Psychiatry"},{"key":"3640_CR69","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/j.1399-5618.2007.00429.x","volume":"9","author":"X Huang","year":"2007","unstructured":"Huang X, Lei Z, El-Mallakh RS. Lithium normalizes elevated intracellular sodium. Bipolar Disord. 2007;9:298\u2013300.","journal-title":"Bipolar Disord"},{"issue":"Suppl 2","key":"3640_CR70","first-page":"17","volume":"37","author":"MJ Owens","year":"2003","unstructured":"Owens MJ, Nemeroff CB. Pharmacology of valproate. Psychopharmacol Bull. 2003;37(Suppl 2):17\u201324.","journal-title":"Psychopharmacol Bull"},{"key":"3640_CR71","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.1152\/jn.00578.2014","volume":"112","author":"K Qian","year":"2014","unstructured":"Qian K, Yu N, Tucker KR, Levitan ES, Canavier CC. Mathematical analysis of depolarization block mediated by slow inactivation of fast sodium channels in midbrain dopamine neurons. J Neurophysiol. 2014;112:2779\u201390.","journal-title":"J Neurophysiol"},{"key":"3640_CR72","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1002\/cne.901860408","volume":"186","author":"LW Swanson","year":"1979","unstructured":"Swanson LW, Cowan WM. The connections of the septal region in the rat. J Comp Neurol. 1979;186:621\u201355.","journal-title":"J Comp Neurol"},{"key":"3640_CR73","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0165-0173(97)00008-8","volume":"24","author":"PY Risold","year":"1997","unstructured":"Risold PY, Swanson LW. Chemoarchitecture of the rat lateral septal nucleus. Brain Res Brain Res Rev. 1997;24:91\u2013113.","journal-title":"Brain Res Brain Res Rev"},{"key":"3640_CR74","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1097\/ALN.0000000000003868","volume":"135","author":"D Wang","year":"2021","unstructured":"Wang D, Guo Q, Zhou Y, Xu Z, Hu SW, Kong XX, et al. GABAergic neurons in the dorsal-intermediate lateral septum regulate sleep-wakefulness and anesthesia in mice. Anesthesiology. 2021;135:463\u201381.","journal-title":"Anesthesiology"},{"key":"3640_CR75","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1020903","volume":"15","author":"R Olivares-Barraza","year":"2022","unstructured":"Olivares-Barraza R, Marcos JL, Martinez-Pinto J, Fuenzalida M, Bravo JA, Gysling K, et al. Corticotropin-releasing factor system in the lateral septum: Implications in the pathophysiology of obesity. Front Mol Neurosci. 2022;15:1020903.","journal-title":"Front Mol Neurosci"},{"key":"3640_CR76","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.cell.2013.12.040","volume":"156","author":"TE Anthony","year":"2014","unstructured":"Anthony TE, Dee N, Bernard A, Lerchner W, Heintz N, Anderson DJ. Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell. 2014;156:522\u201336.","journal-title":"Cell"},{"key":"3640_CR77","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/s41593-018-0330-y","volume":"22","author":"A Besnard","year":"2019","unstructured":"Besnard A, Gao Y, TaeWoo Kim M, Twarkowski H, Reed AK, Langberg T, et al. Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses. Nat Neurosci. 2019;22:436\u201346.","journal-title":"Nat Neurosci"},{"key":"3640_CR78","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.cub.2021.01.019","volume":"31","author":"S An","year":"2021","unstructured":"An S, Sun H, Wu M, Xie D, Hu SW, Ding HL, et al. Medial septum glutamatergic neurons control wakefulness through a septo-hypothalamic circuit. Curr Biol. 2021;31:1379\u20131392 e1374.","journal-title":"Curr Biol"},{"key":"3640_CR79","doi-asserted-by":"publisher","first-page":"4525","DOI":"10.1073\/pnas.1619700114","volume":"114","author":"C Kosse","year":"2017","unstructured":"Kosse C, Schone C, Bracey E, Burdakov D. Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice. Proc Natl Acad Sci USA. 2017;114:4525\u201330.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3640_CR80","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1002\/jnr.24828","volume":"99","author":"RF Wang","year":"2021","unstructured":"Wang RF, Guo H, Jiang SY, Liu ZL, Qu WM, Huang ZL, et al. Control of wakefulness by lateral hypothalamic glutamatergic neurons in male mice. J Neurosci Res. 2021;99:1689\u2013703.","journal-title":"J Neurosci Res"},{"key":"3640_CR81","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.cub.2016.05.078","volume":"26","author":"A Venner","year":"2016","unstructured":"Venner A, Anaclet C, Broadhurst RY, Saper CB, Fuller PM. A novel population of wake-promoting GABAergic neurons in the ventral lateral hypothalamus. Curr Biol. 2016;26:2137\u201343.","journal-title":"Curr Biol"},{"key":"3640_CR82","doi-asserted-by":"publisher","first-page":"4840","DOI":"10.1523\/JNEUROSCI.2850-20.2021","volume":"41","author":"M Gazea","year":"2021","unstructured":"Gazea M, Furdan S, Sere P, Oesch L, Molnar B, Di Giovanni G, et al. Reciprocal lateral hypothalamic and raphe GABAergic projections promote wakefulness. J Neurosci. 2021;41:4840\u20139.","journal-title":"J Neurosci"},{"key":"3640_CR83","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1001\/jamapsychiatry.2021.3654","volume":"79","author":"GM Hosang","year":"2022","unstructured":"Hosang GM, Martin J, Karlsson R, Lundstrom S, Larsson H, Ronald A, et al. Association of etiological factors for hypomanic symptoms, bipolar disorder, and other severe mental illnesses. JAMA Psychiatry. 2022;79:143\u201350.","journal-title":"JAMA Psychiatry"},{"key":"3640_CR84","doi-asserted-by":"publisher","first-page":"eadh9974","DOI":"10.1126\/scitranslmed.adh9974","volume":"16","author":"Y Xia","year":"2024","unstructured":"Xia Y, Xia C, Jiang Y, Chen Y, Zhou J, Dai R, et al. Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders. Sci Transl Med. 2024;16:eadh9974 https:\/\/doi.org\/10.1126\/scitranslmed.adh9974.","journal-title":"Sci Transl Med"},{"key":"3640_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101115","volume":"72","author":"L Zhang","year":"2024","unstructured":"Zhang L, Swaab DF. Sex differences in bipolar disorder: the dorsolateral prefrontal cortex as an etiopathogenic region. Front Neuroendocrinol. 2024;72:101115.","journal-title":"Front Neuroendocrinol"},{"key":"3640_CR86","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-018-0120-1","volume":"6","author":"M Nederlof","year":"2018","unstructured":"Nederlof M, Heerdink ER, Egberts ACG, Wilting I, Stoker LJ, Hoekstra R, et al. Monitoring of patients treated with lithium for bipolar disorder: an international survey. Int J Bipolar Disord. 2018;6:12.","journal-title":"Int J Bipolar Disord"},{"key":"3640_CR87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52058-z","volume":"9","author":"A Lopachev","year":"2019","unstructured":"Lopachev A, Volnova A, Evdokimenko A, Abaimov D, Timoshina Y, Kazanskaya R, et al. Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation. Sci Rep. 2019;9:15627.","journal-title":"Sci Rep."},{"key":"3640_CR88","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pnpbp.2018.07.002","volume":"88","author":"E Wendler","year":"2019","unstructured":"Wendler E, de Souza CP, Dornellas APS, Santos LE, Ferreira ST, Galduroz JCF, et al. Mania-like elevated mood in rats: enhanced 50-kHz ultrasonic vocalizations after sleep deprivation. Prog Neuropsychopharmacol Biol Psychiatry. 2019;88:142\u201350.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03640-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03640-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03640-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T16:03:55Z","timestamp":1760717035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-025-03640-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":88,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3640"],"URL":"https:\/\/doi.org\/10.1038\/s41398-025-03640-9","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"10 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"409"}}