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Dr. K. Hashimoto has also received research support from Otsuka (Japan). Other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This trial was approved by the Institutional Scientific Research and Clinical Trials Ethics Committee of the First Affiliated Hospital of Zhengzhou University (2023-KY-1213). The study protocol was thoroughly explained to patients in advance, and written informed consent was obtained from all participants. The trial was registered prior to patient enrollment in the Chinese Clinical Trial Registry: chictr.org.cn (ChiCTR2400079641).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"501"}}