{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:20:35Z","timestamp":1780449635629,"version":"3.54.1"},"reference-count":89,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":34,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00488"],"award-info":[{"award-number":["PI21\/00488"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Ministry of Economy and Competitiveness | Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD21\/0009\/0008 and RD24\/0003\/0002"],"award-info":[{"award-number":["RD21\/0009\/0008 and RD24\/0003\/0002"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-026-03838-5","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:04:54Z","timestamp":1769760294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of chronic ethanol consumption on brain GLP-1R gene expression in mice and humans"],"prefix":"10.1038","volume":"16","author":[{"given":"Abraham B.","family":"Torregrosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda S.","family":"Garc\u00eda-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-6975","authenticated-orcid":false,"given":"Samanta","family":"Ortu\u00f1o-Miquel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-1533","authenticated-orcid":false,"given":"Jorge","family":"Manzanares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"3838_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1176\/appi.ajp.20230488","volume":"180","author":"HR Kranzler","year":"2023","unstructured":"Kranzler HR. Overview of alcohol use disorder. Am J Psychiatry. 2023;180:565\u201372. https:\/\/doi.org\/10.1176\/appi.ajp.20230488.","journal-title":"Am J Psychiatry"},{"key":"3838_CR2","unstructured":"Organization, W. H. (Geneva, 2024)."},{"key":"3838_CR3","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1016\/j.mayocp.2020.01.030","volume":"95","author":"J Fairbanks","year":"2020","unstructured":"Fairbanks J, Umbreit A, Kolla BP, Karpyak VM, Schneekloth TD, Loukianova LL, et al. Evidence-based pharmacotherapies for alcohol use disorder: clinical pearls. Mayo Clin Proc. 2020;95:1964\u201377. https:\/\/doi.org\/10.1016\/j.mayocp.2020.01.030.","journal-title":"Mayo Clin Proc"},{"key":"3838_CR4","doi-asserted-by":"publisher","unstructured":"Liu, T, Shi, F, Guo, Z, Li, H, Qin D, Therapeutic potential of the novel GLP-1 receptor agonist semaglutide in alcohol use disorder. Pharmacopsychiatry, https:\/\/doi.org\/10.1055\/a-2550-6470 (2025).","DOI":"10.1055\/a-2550-6470"},{"key":"3838_CR5","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/JCP.0000000000002010","volume":"45","author":"SS Tanguturi Yella","year":"2025","unstructured":"Tanguturi Yella SS, Kota Sesha Brahma Sree KS, Mahato SK. The role of glucagon-like Peptide-1 receptor agonists in the treatment of alcohol use disorder: Current evidence and future directions. J Clin Psychopharmacol. 2025;45:372\u20135. https:\/\/doi.org\/10.1097\/JCP.0000000000002010.","journal-title":"J Clin Psychopharmacol"},{"key":"3838_CR6","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1124\/pr.115.011395","volume":"68","author":"C Graaf","year":"2016","unstructured":"Graaf C, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, et al. Glucagon-Like Peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes. Pharmacol Rev. 2016;68:954\u20131013. https:\/\/doi.org\/10.1124\/pr.115.011395.","journal-title":"Pharmacol Rev"},{"key":"3838_CR7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuint.2019.04.010","volume":"128","author":"NK Smith","year":"2019","unstructured":"Smith NK, Hackett TA, Galli A, Flynn CR. GLP-1: Molecular mechanisms and outcomes of a complex signaling system. Neurochem Int. 2019;128:94\u2013105. https:\/\/doi.org\/10.1016\/j.neuint.2019.04.010.","journal-title":"Neurochem Int"},{"key":"3838_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113326","volume":"42","author":"N Zaimia","year":"2023","unstructured":"Zaimia N, Obeid J, Varrault A, Sabatier J, Broca C, Gilon P, et al. GLP-1 and GIP receptors signal through distinct beta-arrestin 2-dependent pathways to regulate pancreatic beta cell function. Cell Rep. 2023;42:113326. https:\/\/doi.org\/10.1016\/j.celrep.2023.113326.","journal-title":"Cell Rep"},{"key":"3838_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2025.101895","volume":"14","author":"TM Al-Noshokaty","year":"2025","unstructured":"Al-Noshokaty TM, Abdelhamid R, Abdelmaksoud NM, Khaled A, Hossam M, Ahmed R, et al. Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential. Toxicol Rep. 2025;14:101895. https:\/\/doi.org\/10.1016\/j.toxrep.2025.101895.","journal-title":"Toxicol Rep"},{"key":"3838_CR10","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.molmet.2015.07.008","volume":"4","author":"SC Cork","year":"2015","unstructured":"Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Mol Metab. 2015;4:718\u201331. https:\/\/doi.org\/10.1016\/j.molmet.2015.07.008.","journal-title":"Mol Metab"},{"key":"3838_CR11","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.2337\/db13-1440","volume":"63","author":"P Richards","year":"2014","unstructured":"Richards P, Parker HE, Adriaenssens AE, Hodgson JM, Cork SC, Trapp S, et al. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes. 2014;63:1224\u201333. https:\/\/doi.org\/10.2337\/db13-1440.","journal-title":"Diabetes"},{"key":"3838_CR12","doi-asserted-by":"publisher","unstructured":"Diz-Chaves, Y, Herrera-Perez, S, Gonzalez-Matias, LC, Lamas, JA, Mallo, F Glucagon-Like Peptide-1 (GLP-1) in the Integration of Neural and Endocrine Responses to Stress. Nutrients 12, https:\/\/doi.org\/10.3390\/nu12113304 (2020).","DOI":"10.3390\/nu12113304"},{"key":"3838_CR13","doi-asserted-by":"publisher","first-page":"eadr5051","DOI":"10.1126\/sciadv.adr5051","volume":"11","author":"R Merkel","year":"2025","unstructured":"Merkel R, Hernandez NS, Weir V, Zhang Y, Caffrey A, Rich MT, et al. An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. Sci Adv. 2025;11:eadr5051 https:\/\/doi.org\/10.1126\/sciadv.adr5051.","journal-title":"Sci Adv"},{"key":"3838_CR14","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.psyneuen.2012.11.009","volume":"38","author":"E Egecioglu","year":"2013","unstructured":"Egecioglu E, Steensland P, Fredriksson I, Feltmann K, Engel JA, Jerlhag E. The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents. Psychoneuroendocrinology. 2013;38:1259\u201370. https:\/\/doi.org\/10.1016\/j.psyneuen.2012.11.009.","journal-title":"Psychoneuroendocrinology"},{"key":"3838_CR15","doi-asserted-by":"publisher","first-page":"e61965","DOI":"10.1371\/journal.pone.0061965","volume":"8","author":"RH Shirazi","year":"2013","unstructured":"Shirazi RH, Dickson SL, Skibicka KP. Gut peptide GLP-1 and its analogue, Exendin-4, decrease alcohol intake and reward. PLoS One. 2013;8:e61965 https:\/\/doi.org\/10.1371\/journal.pone.0061965.","journal-title":"PLoS One"},{"key":"3838_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.599646","volume":"14","author":"VN Marty","year":"2020","unstructured":"Marty VN, Farokhnia M, Munier JJ, Mulpuri Y, Leggio L, Spigelman I. Long-acting glucagon-like Peptide-1 receptor agonists suppress voluntary alcohol intake in male wistar rats. Front Neurosci. 2020;14:599646. https:\/\/doi.org\/10.3389\/fnins.2020.599646.","journal-title":"Front Neurosci"},{"key":"3838_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104642","volume":"93","author":"C Aranas","year":"2023","unstructured":"Aranas C, Edvardsson CE, Shevchouk OT, Zhang Q, Witley S, Blid Skoldheden S, et al. Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats. EBioMedicine. 2023;93:104642. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104642.","journal-title":"EBioMedicine"},{"key":"3838_CR18","doi-asserted-by":"publisher","first-page":"R848","DOI":"10.1152\/ajpregu.1996.271.4.R848","volume":"271","author":"M Tang-Christensen","year":"1996","unstructured":"Tang-Christensen M, Larsen PJ, Goke R, Fink-Jensen A, Jessop DS, Moller M, et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol. 1996;271:R848\u2013856. https:\/\/doi.org\/10.1152\/ajpregu.1996.271.4.R848.","journal-title":"Am J Physiol"},{"key":"3838_CR19","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1046\/j.1471-4159.1996.67051982.x","volume":"67","author":"M Navarro","year":"1996","unstructured":"Navarro M, Rodriquez de Fonseca F, Alvarez E, Chowen JA, Zueco JA, Gomez R, et al. Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem. 1996;67:1982\u201391. https:\/\/doi.org\/10.1046\/j.1471-4159.1996.67051982.x.","journal-title":"J Neurochem"},{"key":"3838_CR20","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pbb.2017.07.014","volume":"160","author":"M Thomsen","year":"2017","unstructured":"Thomsen M, Dencker D, Wortwein G, Weikop P, Egecioglu E, Jerlhag E, et al. The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice. Pharmacol Biochem Behav. 2017;160:14\u201320. https:\/\/doi.org\/10.1016\/j.pbb.2017.07.014.","journal-title":"Pharmacol Biochem Behav"},{"key":"3838_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2025.105684","volume":"115","author":"CE Edvardsson","year":"2025","unstructured":"Edvardsson CE, Cadeddu D, Ericson M, Adermark L, Jerlhag E. An inhibitory GLP-1 circuit in the lateral septum modulates reward processing and alcohol intake in rodents. EBioMedicine. 2025;115:105684. https:\/\/doi.org\/10.1016\/j.ebiom.2025.105684.","journal-title":"EBioMedicine"},{"key":"3838_CR22","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1111\/acer.13199","volume":"40","author":"G Sorensen","year":"2016","unstructured":"Sorensen G, Caine SB, Thomsen M. Effects of the GLP-1 agonist Exendin-4 on intravenous ethanol self-administration in mice. Alcohol Clin Exp Res. 2016;40:2247\u201352. https:\/\/doi.org\/10.1111\/acer.13199.","journal-title":"Alcohol Clin Exp Res"},{"key":"3838_CR23","doi-asserted-by":"publisher","first-page":"e159863","DOI":"10.1172\/jci.insight.159863","volume":"7","author":"MK Klausen","year":"2022","unstructured":"Klausen MK, Jensen ME, Moller M, Le Dous N, Jensen AO, Zeeman VA, et al. Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial. JCI Insight. 2022;7:e159863 https:\/\/doi.org\/10.1172\/jci.insight.159863.","journal-title":"JCI Insight"},{"key":"3838_CR24","doi-asserted-by":"publisher","first-page":"23m15068","DOI":"10.4088\/JCP.23m15068","volume":"85","author":"JR Richards","year":"2023","unstructured":"Richards JR, Dorand MF, Royal K, Mnajjed L, Paszkowiak M, Simmons WK. Significant decrease in alcohol use disorder symptoms secondary to semaglutide therapy for weight loss: A case series. J Clin Psychiatry. 2023;85:23m15068 https:\/\/doi.org\/10.4088\/JCP.23m15068.","journal-title":"J Clin Psychiatry"},{"key":"3838_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48267-2","volume":"13","author":"F Quddos","year":"2023","unstructured":"Quddos F, Hubshman Z, Tegge A, Sane D, Marti E, Kablinger AS, et al. Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity. Sci Rep. 2023;13:20998. https:\/\/doi.org\/10.1038\/s41598-023-48267-2.","journal-title":"Sci Rep"},{"key":"3838_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-17190-3","volume":"12","author":"M Farokhnia","year":"2022","unstructured":"Farokhnia M, Fede SJ, Grodin EN, Browning BD, Crozier ME, Schwandt ML, et al. Differential association between the GLP1R gene variants and brain functional connectivity according to the severity of alcohol use. Sci Rep. 2022;12:13027. https:\/\/doi.org\/10.1038\/s41598-022-17190-3.","journal-title":"Sci Rep"},{"key":"3838_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.68","volume":"5","author":"P Suchankova","year":"2015","unstructured":"Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, et al. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Transl Psychiatry. 2015;5:e583. https:\/\/doi.org\/10.1038\/tp.2015.68.","journal-title":"Transl Psychiatry"},{"key":"3838_CR28","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.psyneuen.2019.02.006","volume":"103","author":"D Vallof","year":"2019","unstructured":"Vallof D, Kalafateli AL, Jerlhag E. Brain region specific glucagon-like peptide-1 receptors regulate alcohol-induced behaviors in rodents. Psychoneuroendocrinology. 2019;103:284\u201395. https:\/\/doi.org\/10.1016\/j.psyneuen.2019.02.006.","journal-title":"Psychoneuroendocrinology"},{"key":"3838_CR29","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3233\/ADR-240026","volume":"8","author":"Y Yang","year":"2024","unstructured":"Yang Y, Tong M, de la Monte SM. Early-Stage moderate alcohol feeding dysregulates insulin-related metabolic hormone expression in the brain: Potential links to neurodegeneration including Alzheimer\u2019s disease. J Alzheimers Dis Rep. 2024;8:1211\u201328. https:\/\/doi.org\/10.3233\/ADR-240026.","journal-title":"J Alzheimers Dis Rep"},{"key":"3838_CR30","doi-asserted-by":"publisher","first-page":"5338","DOI":"10.3390\/ijms26115338","volume":"26","author":"JD Marquez-Meneses","year":"2025","unstructured":"Marquez-Meneses JD, Olaya-Bonilla SA, Barrera-Carreno S, Tibaduiza-Arevalo LC, Forero-Cardenas S, Carrillo-Vaca L, et al. GLP-1 analogues in the neurobiology of addiction: Translational insights and therapeutic perspectives. Int J Mol Sci. 2025;26:5338 https:\/\/doi.org\/10.3390\/ijms26115338.","journal-title":"Int J Mol Sci"},{"key":"3838_CR31","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13211","volume":"27","author":"M Farokhnia","year":"2022","unstructured":"Farokhnia M, Browning BD, Crozier ME, Sun H, Akhlaghi F, Leggio L. The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study. Addict Biol. 2022;27:e13211. https:\/\/doi.org\/10.1111\/adb.13211.","journal-title":"Addict Biol"},{"key":"3838_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/alcalc\/agt030","volume":"48","author":"A Thorsell","year":"2013","unstructured":"Thorsell A. The mu-opioid receptor and treatment response to naltrexone. Alcohol Alcohol. 2013;48:402\u20138. https:\/\/doi.org\/10.1093\/alcalc\/agt030.","journal-title":"Alcohol Alcohol"},{"key":"3838_CR33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neubiorev.2018.09.010","volume":"106","author":"AC Hansson","year":"2019","unstructured":"Hansson AC, Grunder G, Hirth N, Noori HR, Spanagel R, Sommer WH. Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. Neurosci Biobehav Rev. 2019;106:141\u201364. https:\/\/doi.org\/10.1016\/j.neubiorev.2018.09.010.","journal-title":"Neurosci Biobehav Rev"},{"key":"3838_CR34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/bs.pbr.2015.07.030","volume":"223","author":"W Berrettini","year":"2016","unstructured":"Berrettini W. Opioid neuroscience for addiction medicine: From animal models to FDA approval for alcohol addiction. Prog Brain Res. 2016;223:253\u201367. https:\/\/doi.org\/10.1016\/bs.pbr.2015.07.030.","journal-title":"Prog Brain Res"},{"key":"3838_CR35","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.2174\/1570159X20666220624111855","volume":"20","author":"D Cutuli","year":"2022","unstructured":"Cutuli D, Sampedro-Piquero P. BDNF and its role in the alcohol abuse initiated during early adolescence: evidence from preclinical and clinical studies. Curr Neuropharmacol. 2022;20:2202\u201320. https:\/\/doi.org\/10.2174\/1570159X20666220624111855.","journal-title":"Curr Neuropharmacol"},{"key":"3838_CR36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.drugalcdep.2018.08.036","volume":"193","author":"F Ornell","year":"2018","unstructured":"Ornell F, Hansen F, Schuch FB, Pezzini Rebelatto F, Tavares AL, Scherer JN, et al. Brain-derived neurotrophic factor in substance use disorders: A systematic review and meta-analysis. Drug Alcohol Depend. 2018;193:91\u2013103. https:\/\/doi.org\/10.1016\/j.drugalcdep.2018.08.036.","journal-title":"Drug Alcohol Depend"},{"key":"3838_CR37","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.2217\/pgs.13.217","volume":"14","author":"BS Haerian","year":"2013","unstructured":"Haerian BS. BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis. Pharmacogenomics. 2013;14:2055\u201365. https:\/\/doi.org\/10.2217\/pgs.13.217.","journal-title":"Pharmacogenomics"},{"key":"3838_CR38","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/wcs.1304","volume":"5","author":"CA Oomen","year":"2014","unstructured":"Oomen CA, Bekinschtein P, Kent BA, Saksida LM, Bussey TJ. Adult hippocampal neurogenesis and its role in cognition. Wiley Interdiscip Rev Cogn Sci. 2014;5:573\u201387. https:\/\/doi.org\/10.1002\/wcs.1304.","journal-title":"Wiley Interdiscip Rev Cogn Sci"},{"key":"3838_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neures.2022.05.008","volume":"183","author":"A Goto","year":"2022","unstructured":"Goto A. Synaptic plasticity during systems memory consolidation. Neurosci Res. 2022;183:1\u20136. https:\/\/doi.org\/10.1016\/j.neures.2022.05.008.","journal-title":"Neurosci Res"},{"key":"3838_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112069","volume":"42","author":"G Chen","year":"2023","unstructured":"Chen G, Lai S, Bao G, Ke J, Meng X, Lu S, et al. Distinct reward processing by subregions of the nucleus accumbens. Cell Rep. 2023;42:112069. https:\/\/doi.org\/10.1016\/j.celrep.2023.112069.","journal-title":"Cell Rep"},{"key":"3838_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1101\/sqb.2018.83.037457","volume":"83","author":"AM Klawonn","year":"2018","unstructured":"Klawonn AM, Malenka RC. Nucleus accumbens modulation in reward and aversion. Cold Spring Harb Symp Quant Biol. 2018;83:119\u201329. https:\/\/doi.org\/10.1101\/sqb.2018.83.037457.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"3838_CR42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/adb.12076","volume":"20","author":"A Ortega-Alvaro","year":"2015","unstructured":"Ortega-Alvaro A, Ternianov A, Aracil-Fernandez A, Navarrete F, Garcia-Gutierrez MS, Manzanares J. Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. Addict Biol. 2015;20:43\u201355. https:\/\/doi.org\/10.1111\/adb.12076.","journal-title":"Addict Biol"},{"key":"3838_CR43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/adb.12495","volume":"23","author":"A Viudez-Martinez","year":"2018","unstructured":"Viudez-Martinez A, Garcia-Gutierrez MS, Navarron CM, Morales-Calero MI, Navarrete F, Torres-Suarez AI, et al. Cannabidiol reduces ethanol consumption, motivation and relapse in mice. Addict Biol. 2018;23:154\u201364. https:\/\/doi.org\/10.1111\/adb.12495.","journal-title":"Addict Biol"},{"key":"3838_CR44","unstructured":"Paxinos G, Franklin KBJ. Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates. 5th edn. Academic Press; 2019."},{"key":"3838_CR45","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/s0076-6879(83)03025-6","volume":"103","author":"M Palkovits","year":"1983","unstructured":"Palkovits M. Punch sampling biopsy technique. Methods Enzymol. 1983;103:368\u201376. https:\/\/doi.org\/10.1016\/s0076-6879(83)03025-6.","journal-title":"Methods Enzymol"},{"key":"3838_CR46","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402\u20138. https:\/\/doi.org\/10.1006\/meth.2001.1262.","journal-title":"Methods"},{"key":"3838_CR47","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.alcohol.2016.02.005","volume":"52","author":"GT Sutherland","year":"2016","unstructured":"Sutherland GT, Sheedy D, Stevens J, McCrossin T, Smith CC, van Roijen M, et al. The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research. Alcohol. 2016;52:33\u201339. https:\/\/doi.org\/10.1016\/j.alcohol.2016.02.005.","journal-title":"Alcohol"},{"key":"3838_CR48","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5","volume":"403","author":"I Merchenthaler","year":"1999","unstructured":"Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol. 1999;403:261\u201380. 10.1002\/(sici)1096-9861(19990111)403:2<261::aid-cne8>3.0.co;2-5.","journal-title":"J Comp Neurol"},{"key":"3838_CR49","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1210\/en.2017-00812","volume":"159","author":"CB Jensen","year":"2018","unstructured":"Jensen CB, Pyke C, Rasch MG, Dahl AB, Knudsen LB, Secher A. Characterization of the glucagonlike Peptide-1 receptor in male mouse brain using a novel antibody and in situ hybridization. Endocrinology. 2018;159:665\u201375. https:\/\/doi.org\/10.1210\/en.2017-00812.","journal-title":"Endocrinology"},{"key":"3838_CR50","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1002\/cne.24905","volume":"528","author":"DL Graham","year":"2020","unstructured":"Graham DL, Durai HH, Trammell TS, Noble BL, Mortlock DP, Galli A, et al. A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain. J Comp Neurol. 2020;528:2445\u201370. https:\/\/doi.org\/10.1002\/cne.24905.","journal-title":"J Comp Neurol"},{"key":"3838_CR51","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1111\/acer.14437","volume":"44","author":"TN Dixon","year":"2020","unstructured":"Dixon TN, McNally GP, Ong ZY. Glucagon-Like Peptide-1 receptor signaling in the ventral tegmental area reduces alcohol self-administration in male rats. Alcohol Clin Exp Res. 2020;44:2118\u201329. https:\/\/doi.org\/10.1111\/acer.14437.","journal-title":"Alcohol Clin Exp Res"},{"key":"3838_CR52","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1037\/pha0000620","volume":"31","author":"ML Allingbjerg","year":"2023","unstructured":"Allingbjerg ML, Hansen SN, Secher A, Thomsen M. Glucagon-like peptide-1 receptors in nucleus accumbens, ventral hippocampus, and lateral septum reduce alcohol reinforcement in mice. Exp Clin Psychopharmacol. 2023;31:612\u201320. https:\/\/doi.org\/10.1037\/pha0000620.","journal-title":"Exp Clin Psychopharmacol"},{"key":"3838_CR53","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/adb.12295","volume":"21","author":"D Vallof","year":"2016","unstructured":"Vallof D, Maccioni P, Colombo G, Mandrapa M, Jornulf JW, Egecioglu E, et al. The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents. Addict Biol. 2016;21:422\u201337. https:\/\/doi.org\/10.1111\/adb.12295.","journal-title":"Addict Biol"},{"key":"3838_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00923-1","volume":"10","author":"D Vallof","year":"2020","unstructured":"Vallof D, Kalafateli AL, Jerlhag E. Long-term treatment with a glucagon-like peptide-1 receptor agonist reduces ethanol intake in male and female rats. Transl Psychiatry. 2020;10:238. https:\/\/doi.org\/10.1038\/s41398-020-00923-1.","journal-title":"Transl Psychiatry"},{"key":"3838_CR55","doi-asserted-by":"publisher","first-page":"e170671","DOI":"10.1172\/jci.insight.170671","volume":"8","author":"V Chuong","year":"2023","unstructured":"Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R, et al. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI Insight. 2023;8:e170671 https:\/\/doi.org\/10.1172\/jci.insight.170671.","journal-title":"JCI Insight"},{"key":"3838_CR56","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00213-024-06637-2","volume":"242","author":"A Fink-Jensen","year":"2025","unstructured":"Fink-Jensen A, Wortwein G, Klausen MK, Holst JJ, Hartmann B, Thomsen M, et al. Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys. Psychopharmacology (Berl). 2025;242:63\u201370. https:\/\/doi.org\/10.1007\/s00213-024-06637-2.","journal-title":"Psychopharmacology (Berl)"},{"key":"3838_CR57","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/ph18050614","volume":"18","author":"M Urkon","year":"2025","unstructured":"Urkon M, Ferencz E, Szasz JA, Szabo MIM, Orban-Kis K, Szatmari S, et al. Antidiabetic GLP-1 receptor agonists have neuroprotective properties in experimental animal models of Alzheimer\u2019s disease. Pharmaceuticals (Basel). 2025;18:614 https:\/\/doi.org\/10.3390\/ph18050614.","journal-title":"Pharmaceuticals (Basel)"},{"key":"3838_CR58","doi-asserted-by":"publisher","DOI":"10.1177\/17562864251332035","volume":"18","author":"J Si","year":"2025","unstructured":"Si J, Yu K, Hao J, Wang J, Zhang L. The therapeutic effects and mechanisms of glucagon-like peptide-1 receptor agonists in neurocognitive disorders. Ther Adv Neurol Disord. 2025;18:17562864251332035. https:\/\/doi.org\/10.1177\/17562864251332035.","journal-title":"Ther Adv Neurol Disord"},{"key":"3838_CR59","doi-asserted-by":"publisher","unstructured":"Kenzheshova, A, Moldasheva, A, Aljofan, M Neuroprotective role of the novel GLP-1R agonist semaglutide. Curr Med Chem, https:\/\/doi.org\/10.2174\/0109298673359635250401051339 (2025).","DOI":"10.2174\/0109298673359635250401051339"},{"key":"3838_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2021.107463","volume":"182","author":"LQ Zhang","year":"2021","unstructured":"Zhang LQ, Zhang W, Li T, Yang T, Yuan X, Zhou Y, et al. GLP-1R activation ameliorated novel-object recognition memory dysfunction via regulating hippocampal AMPK\/NF-kappaB pathway in neuropathic pain mice. Neurobiol Learn Mem. 2021;182:107463. https:\/\/doi.org\/10.1016\/j.nlm.2021.107463.","journal-title":"Neurobiol Learn Mem"},{"key":"3838_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.109872","volume":"99","author":"AJM Chaves Filho","year":"2020","unstructured":"Chaves Filho AJM, Cunha NL, de Souza AG, Soares MV, Juca PM, de Queiroz T, et al. The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2020;99:109872. https:\/\/doi.org\/10.1016\/j.pnpbp.2020.109872.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3838_CR62","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0024-3205(83)90031-0","volume":"32","author":"B Tabakoff","year":"1983","unstructured":"Tabakoff B, Hoffman PL. Alcohol interactions with brain opiate receptors. Life Sci. 1983;32:197\u2013204. https:\/\/doi.org\/10.1016\/0024-3205(83)90031-0.","journal-title":"Life Sci"},{"key":"3838_CR63","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1530-0277.1983.tb05416.x","volume":"7","author":"AS Levine","year":"1983","unstructured":"Levine AS, Hess S, Morley JE. Alcohol and the opiate receptor. Alcohol Clin Exp Res. 1983;7:83\u201384. https:\/\/doi.org\/10.1111\/j.1530-0277.1983.tb05416.x.","journal-title":"Alcohol Clin Exp Res"},{"key":"3838_CR64","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/j.1471-4159.1984.tb12836.x","volume":"43","author":"PL Hoffman","year":"1984","unstructured":"Hoffman PL, Chung CT, Tabakoff B. Effects of ethanol, temperature, and endogenous regulatory factors on the characteristics of striatal opiate receptors. J Neurochem. 1984;43:1003\u201310. https:\/\/doi.org\/10.1111\/j.1471-4159.1984.tb12836.x.","journal-title":"J Neurochem"},{"key":"3838_CR65","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/j.1471-4159.1981.tb00487.x","volume":"37","author":"B Tabakoff","year":"1981","unstructured":"Tabakoff B, Urwyler S, Hoffman PL. Ethanol alters kinetic characteristics and function of striatal morphine receptors. J Neurochem. 1981;37:518\u201321. https:\/\/doi.org\/10.1111\/j.1471-4159.1981.tb00487.x.","journal-title":"J Neurochem"},{"key":"3838_CR66","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S0022-3565(25)33171-X","volume":"222","author":"PL Hoffman","year":"1982","unstructured":"Hoffman PL, Urwyler S, Tabakoff B. Alterations in opiate receptor function after chronic ethanol exposure. J Pharmacol Exp Ther. 1982;222:182\u20139.","journal-title":"J Pharmacol Exp Ther"},{"key":"3838_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118170","volume":"188","author":"M Flores-Gomez","year":"2025","unstructured":"Flores-Gomez M, Cantero-Garcia N, Pineda-Gomez JP, Moh-Ahmed A, Flores-Burgess A, Diaz-Cabiale Z, et al. Galanin(1-15) and Naltrexone: A novel approach for alcohol use disorder in rats, involving the mesolimbic system. Biomed Pharmacother. 2025;188:118170. https:\/\/doi.org\/10.1016\/j.biopha.2025.118170.","journal-title":"Biomed Pharmacother"},{"key":"3838_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2024.173932","volume":"247","author":"HM Carvour","year":"2025","unstructured":"Carvour HM, Roemer C, Underwood DP, Padilla ES, Sandoval O, Robertson M, et al. Mu-opioid receptor knockout on Foxp2-expressing neurons reduces aversion-resistant alcohol drinking. Pharmacol Biochem Behav. 2025;247:173932. https:\/\/doi.org\/10.1016\/j.pbb.2024.173932.","journal-title":"Pharmacol Biochem Behav"},{"key":"3838_CR69","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/s0306-4522(98)00637-x","volume":"91","author":"J Turchan","year":"1999","unstructured":"Turchan J, Przewlocka B, Toth G, Lason W, Borsodi A, Przewlocki R. The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat. Neuroscience. 1999;91:971\u20137. https:\/\/doi.org\/10.1016\/s0306-4522(98)00637-x.","journal-title":"Neuroscience"},{"key":"3838_CR70","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/BF01999765","volume":"9","author":"C Gianoulakis","year":"1994","unstructured":"Gianoulakis C, de Waele JP. Genetics of alcoholism: role of the endogenous opioid system. Metab Brain Dis. 1994;9:105\u201331. https:\/\/doi.org\/10.1007\/BF01999765.","journal-title":"Metab Brain Dis"},{"key":"3838_CR71","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1017\/S146114571200017X","volume":"16","author":"EM Weerts","year":"2013","unstructured":"Weerts EM, McCaul ME, Kuwabara H, Yang X, Xu X, Dannals RF, et al. Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects. Int J Neuropsychopharmacol. 2013;16:47\u201353. https:\/\/doi.org\/10.1017\/S146114571200017X.","journal-title":"Int J Neuropsychopharmacol"},{"key":"3838_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123795","volume":"377","author":"J Hou","year":"2025","unstructured":"Hou J, Deng Q, Wu J, Chen W. Adolescent intermittent alcohol exposure induces adult cognitive deficits via disrupting the septo-hippocampal cholinergic projections. Life Sci. 2025;377:123795. https:\/\/doi.org\/10.1016\/j.lfs.2025.123795.","journal-title":"Life Sci"},{"key":"3838_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1568085","volume":"16","author":"M Arioli","year":"2025","unstructured":"Arioli M, Bossert I, D\u2019Ambrosio D, Manera M, Andreolli EM, Canessa N, et al. Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence from (18)F-FDG-PET. Front Psychol. 2025;16:1568085. https:\/\/doi.org\/10.3389\/fpsyg.2025.1568085.","journal-title":"Front Psychol"},{"key":"3838_CR74","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt0200","volume":"11","author":"Y Cheng","year":"2025","unstructured":"Cheng Y, Magnard R, Langdon AJ, Lee D, Janak PH. Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum. Sci Adv. 2025;11:eadt0200. https:\/\/doi.org\/10.1126\/sciadv.adt0200.","journal-title":"Sci Adv"},{"key":"3838_CR75","doi-asserted-by":"publisher","DOI":"10.1111\/nan.70011","volume":"51","author":"F Garcia-Dolores","year":"2025","unstructured":"Garcia-Dolores F, Hernandez-Torres MA, Fuentes-Medel E, Diaz A, Guevara J, Baltazar-Gaytan E, et al. Atrophy and higher levels of inflammatory-related markers in the posterior cerebellar lobe cortex in chronic alcohol use disorder: A cross-sectional study. Neuropathol Appl Neurobiol. 2025;51:e70011. https:\/\/doi.org\/10.1111\/nan.70011.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3838_CR76","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-3-031-81908-7_11","volume":"1473","author":"DB Matthews","year":"2025","unstructured":"Matthews DB, Kerr E, Zank A, Hartwig J, Garscia A, Stumo S, et al. Recent investigations designed to unravel the interaction of age and alcohol on behavior and cognition: Potential neurobiological mechanisms. Adv Exp Med Biol. 2025;1473:243\u201356. https:\/\/doi.org\/10.1007\/978-3-031-81908-7_11.","journal-title":"Adv Exp Med Biol"},{"key":"3838_CR77","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-73347-2","volume":"14","author":"S Liu","year":"2024","unstructured":"Liu S, Xie X, Zhao D, Jin N, Hu Y, Wang W, et al. Alcohol use disorder disrupts BDNF maturation via the PAI-1 pathway which could be reversible with abstinence. Sci Rep. 2024;14:22150. https:\/\/doi.org\/10.1038\/s41598-024-73347-2.","journal-title":"Sci Rep"},{"key":"3838_CR78","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3390\/brainsci14060583","volume":"14","author":"M Malewska-Kasprzak","year":"2024","unstructured":"Malewska-Kasprzak M, Skibinska M, Dmitrzak-Weglarz M. Alterations in neurotrophins in alcohol-addicted patients during alcohol withdrawal. Brain Sci. 2024;14:583 https:\/\/doi.org\/10.3390\/brainsci14060583.","journal-title":"Brain Sci"},{"key":"3838_CR79","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13078","volume":"27","author":"SJ Nieto","year":"2022","unstructured":"Nieto SJ, Haile CN, Quave CB, Harding MJ, Nielsen DA, Meisch RA, et al. Paternal alcohol exposure reduces acquisition of operant alcohol self-administration and affects Bdnf DNA methylation in male and female offspring. Addict Biol. 2022;27:e13078. https:\/\/doi.org\/10.1111\/adb.13078.","journal-title":"Addict Biol"},{"key":"3838_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.113090","volume":"401","author":"NL Hogan","year":"2021","unstructured":"Hogan NL, Jaehne EJ, Bak S, Djouma E, van den Buuse M. Brain-Derived neurotrophic factor Val66Met induces female-specific changes in impulsive behaviour and alcohol self-administration in mice. Behav Brain Res. 2021;401:113090. https:\/\/doi.org\/10.1016\/j.bbr.2020.113090.","journal-title":"Behav Brain Res"},{"key":"3838_CR81","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1124\/jpet.300.3.958","volume":"300","author":"T Perry","year":"2002","unstructured":"Perry T, Lahiri DK, Chen D, Zhou J, Shaw KT, Egan JM, et al. A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther. 2002;300:958\u201366. https:\/\/doi.org\/10.1124\/jpet.300.3.958.","journal-title":"J Pharmacol Exp Ther"},{"key":"3838_CR82","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/jnc.12036","volume":"123","author":"K Velmurugan","year":"2012","unstructured":"Velmurugan K, Bouchard R, Mahaffey G, Pugazhenthi S. Neuroprotective actions of glucagon-like peptide-1 in differentiated human neuroprogenitor cells. J Neurochem. 2012;123:919\u201331. https:\/\/doi.org\/10.1111\/jnc.12036.","journal-title":"J Neurochem"},{"key":"3838_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.regpep.2014.04.003","volume":"190-191","author":"N Ohtake","year":"2014","unstructured":"Ohtake N, Saito M, Eto M, Seki K. Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex. Regul Pept. 2014;190-191:1\u201311. https:\/\/doi.org\/10.1016\/j.regpep.2014.04.003.","journal-title":"Regul Pept"},{"key":"3838_CR84","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/fcp.12192","volume":"30","author":"E Gumuslu","year":"2016","unstructured":"Gumuslu E, Mutlu O, Celikyurt IK, Ulak G, Akar F, Erden F, et al. Exenatide enhances cognitive performance and upregulates neurotrophic factor gene expression levels in diabetic mice. Fundam Clin Pharmacol. 2016;30:376\u201384. https:\/\/doi.org\/10.1111\/fcp.12192.","journal-title":"Fundam Clin Pharmacol"},{"key":"3838_CR85","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1007\/s43440-021-00274-8","volume":"73","author":"J Detka","year":"2021","unstructured":"Detka J, Glombik K. Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression. Pharmacol Rep. 2021;73:1020\u201332. https:\/\/doi.org\/10.1007\/s43440-021-00274-8.","journal-title":"Pharmacol Rep"},{"key":"3838_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113537","volume":"143","author":"N Siddeeque","year":"2024","unstructured":"Siddeeque N, Hussein MH, Abdelmaksoud A, Bishop J, Attia AS, Elshazli RM, et al. Neuroprotective effects of GLP-1 receptor agonists in neurodegenerative Disorders: A Large-Scale Propensity-Matched cohort study. Int Immunopharmacol. 2024;143:113537. https:\/\/doi.org\/10.1016\/j.intimp.2024.113537.","journal-title":"Int Immunopharmacol"},{"key":"3838_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18491","volume":"9","author":"Q Ma","year":"2023","unstructured":"Ma Q, Wang L, Liu XX, An ZG, Luo X, Zhang LL, et al. GLP-1 plays a protective role in hippocampal neuronal cells by activating cAMP-CREB-BDNF signaling pathway against CORT+HG-induced toxicity. Heliyon. 2023;9:e18491. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18491.","journal-title":"Heliyon"},{"key":"3838_CR88","doi-asserted-by":"publisher","first-page":"970925","DOI":"10.3389\/fnins.2022.970925","volume":"16","author":"N Reich","year":"2022","unstructured":"Reich N, Holscher C. The neuroprotective effects of glucagon-like peptide 1 in Alzheimer\u2019s and Parkinson\u2019s disease: An in-depth review. Front Neurosci. 2022;16:970925 https:\/\/doi.org\/10.3389\/fnins.2022.970925.","journal-title":"Front Neurosci"},{"key":"3838_CR89","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1080\/1028415X.2022.2112439","volume":"26","author":"Y Liu","year":"2023","unstructured":"Liu Y, Hu Z, Wang J, Liao Y, Shu L. Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R\/BDNF\/TrkB signaling. Nutr Neurosci. 2023;26:997\u20131010. https:\/\/doi.org\/10.1080\/1028415X.2022.2112439.","journal-title":"Nutr Neurosci"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-03838-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-03838-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-03838-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T09:59:59Z","timestamp":1772704799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-03838-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":89,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3838"],"URL":"https:\/\/doi.org\/10.1038\/s41398-026-03838-5","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"11 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. All animal procedures were approved by the Ethics and Research Integrity Committee of Miguel Hern\u00e1ndez University (approval number: UMH.IN.JM.01.21) and were conducted in accordance with institutional and national guidelines for the care and use of laboratory animals. Human samples were obtained from the New South Wales Tissue Resource Centre (NSWBTRC) at the University of Sydney, Australia. The use of these samples was approved by the Ethics and Research Integrity Committee of Miguel Hern\u00e1ndez University (approval number: IN-JM-001-11), in accordance with the biobank\u2019s governance procedures. Written informed consent was obtained from all participants prior to sample collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"123"}}