{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:01:21Z","timestamp":1780624881365,"version":"3.54.1"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002086"],"award-info":[{"award-number":["82002086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001187"],"award-info":[{"award-number":["82001187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371235"],"award-info":[{"award-number":["82371235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["SBGJ202403023"],"award-info":[{"award-number":["SBGJ202403023"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-026-04041-2","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:52:31Z","timestamp":1776948751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of susceptibility modules and genes through WGCNA and ceRNA network analysis in neuropathic pain-induced anxiodepression"],"prefix":"10.1038","volume":"16","author":[{"given":"Yongtao","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-6771","authenticated-orcid":false,"given":"Xin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"4041_CR1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","volume":"9","author":"R Baron","year":"2010","unstructured":"Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9:807\u201319. https:\/\/doi.org\/10.1016\/S1474-4422(10)70143-5.","journal-title":"Lancet Neurol"},{"key":"4041_CR2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neurol.2018.09.016","volume":"175","author":"D Bouhassira","year":"2019","unstructured":"Bouhassira D. Neuropathic pain: definition, assessment and epidemiology. Rev Neurol. 2019;175:16\u201325. https:\/\/doi.org\/10.1016\/j.neurol.2018.09.016.","journal-title":"Rev Neurol"},{"key":"4041_CR3","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/j.1532-2149.2013.00334.x","volume":"17","author":"F Radat","year":"2013","unstructured":"Radat F, Margot-Duclot A, Attal N. Psychiatric co-morbidities in patients with chronic peripheral neuropathic pain: a multicentre cohort study. Eur J Pain. 2013;17:1547\u201357. https:\/\/doi.org\/10.1002\/j.1532-2149.2013.00334.x.","journal-title":"Eur J Pain"},{"key":"4041_CR4","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.pain.2013.03.002","volume":"154","author":"C Berryman","year":"2013","unstructured":"Berryman C, Stanton TR, Jane Bowering K, Tabor A, McFarlane A, Lorimer Moseley G. Evidence for working memory deficits in chronic pain: a systematic review and meta-analysis. Pain. 2013;154:1181\u201396. https:\/\/doi.org\/10.1016\/j.pain.2013.03.002.","journal-title":"Pain"},{"key":"4041_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00441-019-03003-z","volume":"377","author":"M Humo","year":"2019","unstructured":"Humo M, Lu H, Yalcin I. The molecular neurobiology of chronic pain-induced depression. Cell Tissue Res. 2019;377:21\u201343. https:\/\/doi.org\/10.1007\/s00441-019-03003-z.","journal-title":"Cell Tissue Res"},{"key":"4041_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105957","volume":"174","author":"Q Liu","year":"2021","unstructured":"Liu Q, Li R, Yang W, Cui R, Li B. Role of neuroglia in neuropathic pain and depression. Pharmacol Res. 2021;174:105957. https:\/\/doi.org\/10.1016\/j.phrs.2021.105957.","journal-title":"Pharmacol Res"},{"key":"4041_CR7","doi-asserted-by":"publisher","DOI":"10.1155\/da\/7986150","volume":"2025","author":"Y Tian","year":"2025","unstructured":"Tian Y, Cai W, He C, Xu G, Song G, Chen K, et al. Study on the changes of brain function in adolescents with pain-depression comorbidity based on rs-FMRI. Depress Anxiety. 2025;2025:7986150. https:\/\/doi.org\/10.1155\/da\/7986150.","journal-title":"Depress Anxiety"},{"key":"4041_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108052","volume":"170","author":"V Neugebauer","year":"2020","unstructured":"Neugebauer V, Mazzitelli M, Cragg B, Ji G, Navratilova E, Porreca F. Amygdala, neuropeptides, and chronic pain-related affective behaviors. Neuropharmacology. 2020;170:108052. https:\/\/doi.org\/10.1016\/j.neuropharm.2020.108052.","journal-title":"Neuropharmacology"},{"key":"4041_CR9","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s12035-018-1130-9","volume":"56","author":"WY Ong","year":"2019","unstructured":"Ong WY, Stohler CS, Herr DR. Role of the prefrontal cortex in pain processing. Mol Neurobiol. 2019;56:1137\u201366. https:\/\/doi.org\/10.1007\/s12035-018-1130-9.","journal-title":"Mol Neurobiol"},{"key":"4041_CR10","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/ejp.1697","volume":"25","author":"L T\u00f8ttrup","year":"2021","unstructured":"T\u00f8ttrup L, Diaz-Valencia G, Kamavuako EN, Jensen W. Modulation of SI and ACC response to noxious and non-noxious electrical stimuli after the spared nerve injury model of neuropathic pain. Eur J Pain. 2021;25:612\u201323. https:\/\/doi.org\/10.1002\/ejp.1697.","journal-title":"Eur J Pain"},{"key":"4041_CR11","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.biopsych.2014.08.004","volume":"77","author":"F Barthas","year":"2015","unstructured":"Barthas F, Sellmeijer J, Hugel S, Waltisperger E, Barrot M, Yalcin I. The anterior cingulate cortex is a critical hub for pain-induced depression. Biol Psychiatry. 2015;77:236\u201345. https:\/\/doi.org\/10.1016\/j.biopsych.2014.08.004.","journal-title":"Biol Psychiatry"},{"key":"4041_CR12","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/s41586-022-04711-3","volume":"605","author":"X Chen","year":"2022","unstructured":"Chen X, Du Y, Broussard GJ, Kislin M, Yuede CM, Zhang S, et al. Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning. Nature. 2022;605:722\u20137. https:\/\/doi.org\/10.1038\/s41586-022-04711-3.","journal-title":"Nature"},{"key":"4041_CR13","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1016\/j.celrep.2018.02.003","volume":"22","author":"A Sathyamurthy","year":"2018","unstructured":"Sathyamurthy A, Johnson KR, Matson KJE, Dobrott CI, Li L, Ryba AR, et al. Massively parallel single nucleus transcriptional profiling defines spinal cord neurons and their activity during behavior. Cell Rep. 2018;22:2216\u201325. https:\/\/doi.org\/10.1016\/j.celrep.2018.02.003.","journal-title":"Cell Rep"},{"key":"4041_CR14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.biopsych.2017.01.019","volume":"82","author":"F Barthas","year":"2017","unstructured":"Barthas F, Humo M, Gilsbach R, Waltisperger E, Karatas M, Leman S, et al. Cingulate overexpression of mitogen-activated protein kinase phosphatase-1 as a key factor for depression. Biol Psychiatry. 2017;82:370\u20139. https:\/\/doi.org\/10.1016\/j.biopsych.2017.01.019.","journal-title":"Biol Psychiatry"},{"key":"4041_CR15","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1038\/s41380-022-01519-5","volume":"27","author":"M Xia","year":"2022","unstructured":"Xia M, Liu J, Mechelli A, Sun X, Ma Q, Wang X, et al. Connectome gradient dysfunction in major depression and its association with gene expression profiles and treatment outcomes. Mol Psychiatry. 2022;27:1384\u201393. https:\/\/doi.org\/10.1038\/s41380-022-01519-5.","journal-title":"Mol Psychiatry"},{"key":"4041_CR16","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/nm.4386","volume":"23","author":"B Labonte","year":"2017","unstructured":"Labonte B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, et al. Sex-specific transcriptional signatures in human depression. Nat Med. 2017;23:1102\u201311. https:\/\/doi.org\/10.1038\/nm.4386.","journal-title":"Nat Med"},{"key":"4041_CR17","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.52586\/5006","volume":"26","author":"Z Deng","year":"2021","unstructured":"Deng Z, Cai W, Liu J, Deng A, Yang Y, Tu J, et al. Co-expression modules construction by WGCNA and identify potential hub genes and regulation pathways of postpartum depression. Front Biosci. 2021;26:1019\u201330. https:\/\/doi.org\/10.52586\/5006.","journal-title":"Front Biosci"},{"key":"4041_CR18","doi-asserted-by":"publisher","DOI":"10.61189\/109077nkhkny","author":"H Wu","year":"2024","unstructured":"Wu H, Wang K, Zhou M, Ma G, Xia Z, Wang L, et al. Pain biomarkers based on electroencephalogram: current status and prospect. Perioperative Precis Med. 2024. https:\/\/doi.org\/10.61189\/109077nkhkny.","journal-title":"Perioperative Precis Med"},{"key":"4041_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinforma. 2008;9:559. https:\/\/doi.org\/10.1186\/1471-2105-9-559.","journal-title":"BMC Bioinforma"},{"key":"4041_CR20","doi-asserted-by":"publisher","first-page":"703","DOI":"10.2147\/NDT.S244452","volume":"16","author":"G Zhang","year":"2020","unstructured":"Zhang G, Xu S, Yuan Z, Shen L. Weighted gene coexpression network analysis identifies specific modules and hub genes related to major depression. Neuropsychiatr Dis Treat. 2020;16:703\u201313. https:\/\/doi.org\/10.2147\/NDT.S244452.","journal-title":"Neuropsychiatr Dis Treat"},{"key":"4041_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0448-z","volume":"9","author":"Q Wang","year":"2019","unstructured":"Wang Q, Roy B, Dwivedi Y. Co-expression network modeling identifies key long non-coding RNA and mRNA modules in altering molecular phenotype to develop stress-induced depression in rats. Transl Psychiatry. 2019;9:125. https:\/\/doi.org\/10.1038\/s41398-019-0448-z.","journal-title":"Transl Psychiatry"},{"key":"4041_CR22","doi-asserted-by":"publisher","unstructured":"Yalcin I, Megat S, Barthas F, Waltisperger E, Kremer M, Salvat E, et al. The sciatic nerve cuffing model of neuropathic pain in mice. J Vis Exp. 2014. https:\/\/doi.org\/10.3791\/51608.","DOI":"10.3791\/51608"},{"key":"4041_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55\u201363. https:\/\/doi.org\/10.1016\/0165-0270(94)90144-9.","journal-title":"J Neurosci Methods"},{"key":"4041_CR24","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/s0165-0270(97)00097-6","volume":"76","author":"DM Dirig","year":"1997","unstructured":"Dirig DM, Salami A, Rathbun ML, Ozaki GT, Yaksh TL. Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. J Neurosci Methods. 1997;76:183\u201391. https:\/\/doi.org\/10.1016\/s0165-0270(97)00097-6.","journal-title":"J Neurosci Methods"},{"key":"4041_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/978-1-4939-8994-2_4","volume":"1916","author":"AK Kraeuter","year":"2019","unstructured":"Kraeuter AK, Guest PC, Sarnyai Z. The elevated plus maze test for measuring anxiety-like behavior in rodents. Methods Mol Biol. 2019;1916:69\u201374. https:\/\/doi.org\/10.1007\/978-1-4939-8994-2_4.","journal-title":"Methods Mol Biol"},{"key":"4041_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neulet.2017.08.019","volume":"658","author":"A Blasco-Serra","year":"2017","unstructured":"Blasco-Serra A, Gonz\u00e1lez-Soler EM, Cervera-Ferri A, Teruel-Mart\u00ed V, Valverde-Navarro AA. A standardization of the novelty-suppressed feeding test protocol in rats. Neurosci Lett. 2017;658:73\u20138. https:\/\/doi.org\/10.1016\/j.neulet.2017.08.019.","journal-title":"Neurosci Lett"},{"key":"4041_CR27","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","volume":"177","author":"B Petit-Demouliere","year":"2005","unstructured":"Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology. 2005;177:245\u201355. https:\/\/doi.org\/10.1007\/s00213-004-2048-7.","journal-title":"Psychopharmacology"},{"key":"4041_CR28","doi-asserted-by":"publisher","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","volume":"43","author":"Gene Ontology C.","year":"2015","unstructured":"Gene Ontology C. Gene ontology consortium: going forward. Nucleic Acids Res. 2015;43:D1049\u201356. https:\/\/doi.org\/10.1093\/nar\/gku1179.","journal-title":"Nucleic Acids Res"},{"key":"4041_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa M. Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28:27\u201330.","journal-title":"Nucleic Acids Res"},{"key":"4041_CR30","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607\u2013D13. https:\/\/doi.org\/10.1093\/nar\/gky1131.","journal-title":"Nucleic Acids Res"},{"key":"4041_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15\u201320. https:\/\/doi.org\/10.1016\/j.cell.2004.12.035.","journal-title":"Cell"},{"key":"4041_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bbi.2012.10.007","volume":"31","author":"J Savitz","year":"2013","unstructured":"Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, et al. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun. 2013;31:161\u201371. https:\/\/doi.org\/10.1016\/j.bbi.2012.10.007.","journal-title":"Brain Behav Immun"},{"key":"4041_CR33","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2174\/187152809789352221","volume":"8","author":"M Berthold-Losleben","year":"2009","unstructured":"Berthold-Losleben M, Heitmann S, Himmerich H. Anti-inflammatory drugs in psychiatry. Inflamm Allergy Drug Targets. 2009;8:266\u201376.","journal-title":"Inflamm Allergy Drug Targets"},{"key":"4041_CR34","doi-asserted-by":"publisher","first-page":"4191","DOI":"10.1038\/s41380-020-00953-7","volume":"26","author":"LM Fiori","year":"2021","unstructured":"Fiori LM, Kos A, Lin R, Theroux JF, Lopez JP, Kuhne C, et al. miR-323a regulates ERBB4 and is involved in depression. Mol Psychiatry. 2021;26:4191\u2013204. https:\/\/doi.org\/10.1038\/s41380-020-00953-7.","journal-title":"Mol Psychiatry"},{"key":"4041_CR35","doi-asserted-by":"publisher","unstructured":"Li ZZ, Han WJ, Sun ZC, Chen Y, Sun JY, Cai GH, et al. Extracellular matrix protein laminin beta1 regulates pain sensitivity and anxiodepression-like behaviors in mice. J Clin Invest. 2021;131. https:\/\/doi.org\/10.1172\/JCI146323.","DOI":"10.1172\/JCI146323"},{"key":"4041_CR36","doi-asserted-by":"publisher","first-page":"6380","DOI":"10.1038\/s41380-021-01139-5","volume":"26","author":"X Li","year":"2021","unstructured":"Li X, Zhong H, Wang Z, Xiao R, Antonson P, Liu T, et al. Loss of liver X receptor beta in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice. Mol Psychiatry. 2021;26:6380\u201393. https:\/\/doi.org\/10.1038\/s41380-021-01139-5.","journal-title":"Mol Psychiatry"},{"key":"4041_CR37","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2021.12.003","volume":"185","author":"CS Wang","year":"2022","unstructured":"Wang CS, Kavalali ET, Monteggia LM. BDNF signaling in context: from synaptic regulation to psychiatric disorders. Cell. 2022;185:62\u201376. https:\/\/doi.org\/10.1016\/j.cell.2021.12.003.","journal-title":"Cell"},{"key":"4041_CR38","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.biopsych.2016.05.005","volume":"81","author":"MS Lener","year":"2017","unstructured":"Lener MS, Niciu MJ, Ballard ED, Park M, Park LT, Nugent AC, et al. Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine. Biol Psychiatry. 2017;81:886\u201397. https:\/\/doi.org\/10.1016\/j.biopsych.2016.05.005.","journal-title":"Biol Psychiatry"},{"key":"4041_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105893","volume":"174","author":"S He","year":"2022","unstructured":"He S, Huang X, Zheng J, Zhang Y, Ruan X. An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain. Neurobiol Dis. 2022;174:105893. https:\/\/doi.org\/10.1016\/j.nbd.2022.105893.","journal-title":"Neurobiol Dis"},{"key":"4041_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/(SICI)1520-6394(1996)4:3<100::AID-DA2>3.0.CO;2-K","volume":"4","author":"A Kalueff","year":"1996","unstructured":"Kalueff A, Nutt DJ. Role of GABA in memory and anxiety. Depress Anxiety. 1996;4:100\u201310.","journal-title":"Depress Anxiety"},{"key":"4041_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cell.2018.12.016","volume":"176","author":"I Mody","year":"2019","unstructured":"Mody I. GABA(A)R modulator for postpartum depression. Cell. 2019;176:1. https:\/\/doi.org\/10.1016\/j.cell.2018.12.016.","journal-title":"Cell"},{"key":"4041_CR42","doi-asserted-by":"publisher","first-page":"3833","DOI":"10.1038\/s41380-022-01730-4","volume":"27","author":"GA Narayan","year":"2022","unstructured":"Narayan GA, Hill KR, Wengler K, He X, Wang J, Yang J, et al. Does the change in glutamate to GABA ratio correlate with change in depression severity? a randomized, double-blind clinical trial. Mol Psychiatry. 2022;27:3833\u201341. https:\/\/doi.org\/10.1038\/s41380-022-01730-4.","journal-title":"Mol Psychiatry"},{"key":"4041_CR43","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/s41380-022-01806-1","volume":"28","author":"GR Fries","year":"2023","unstructured":"Fries GR, Saldana VA, Finnstein J, Rein T. Molecular pathways of major depressive disorder converge on the synapse. Mol Psychiatry. 2023;28:284\u201397. https:\/\/doi.org\/10.1038\/s41380-022-01806-1.","journal-title":"Mol Psychiatry"},{"key":"4041_CR44","doi-asserted-by":"publisher","first-page":"6197","DOI":"10.1007\/s12035-019-1524-3","volume":"56","author":"JQ Wang","year":"2019","unstructured":"Wang JQ, Mao L. The ERK pathway: molecular mechanisms and treatment of depression. Mol Neurobiol. 2019;56:6197\u2013205. https:\/\/doi.org\/10.1007\/s12035-019-1524-3.","journal-title":"Mol Neurobiol"},{"key":"4041_CR45","doi-asserted-by":"publisher","first-page":"6309","DOI":"10.1007\/s12035-015-9535-1","volume":"53","author":"LM Mao","year":"2016","unstructured":"Mao LM, Wang JQ. Synaptically localized mitogen-activated protein kinases: local substrates and regulation. Mol Neurobiol. 2016;53:6309\u201315. https:\/\/doi.org\/10.1007\/s12035-015-9535-1.","journal-title":"Mol Neurobiol"},{"key":"4041_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.840567","volume":"13","author":"M Yan","year":"2022","unstructured":"Yan M, Bo X, Zhang X, Zhang J, Liao Y, Zhang H, et al. Mangiferin alleviates postpartum depression-like behaviors by inhibiting MAPK signaling in microglia. Front Pharmacol. 2022;13:840567. https:\/\/doi.org\/10.3389\/fphar.2022.840567.","journal-title":"Front Pharmacol"},{"key":"4041_CR47","doi-asserted-by":"publisher","unstructured":"Sundaram MV RTK\/Ras\/MAPK signaling. WormBook. 2006:1-19. Epub 2007\/12\/01. https:\/\/doi.org\/10.1895\/wormbook.1.80.1.","DOI":"10.1895\/wormbook.1.80.1"},{"key":"4041_CR48","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.2147\/DDDT.S229145","volume":"14","author":"T Wang","year":"2020","unstructured":"Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, et al. Diterpene ginkgolides exert an antidepressant effect through the NT3-TrkA and Ras-MAPK pathways. Drug Des Devel Ther. 2020;14:1279\u201394. https:\/\/doi.org\/10.2147\/DDDT.S229145.","journal-title":"Drug Des Devel Ther"},{"key":"4041_CR49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neunet.2019.11.022","volume":"123","author":"V Kornijcuk","year":"2020","unstructured":"Kornijcuk V, Kim D, Kim G, Jeong DS. Simplified calcium signaling cascade for synaptic plasticity. Neural Netw. 2020;123:38\u201351. https:\/\/doi.org\/10.1016\/j.neunet.2019.11.022.","journal-title":"Neural Netw"},{"key":"4041_CR50","doi-asserted-by":"publisher","unstructured":"Moreno C, Hermosilla T, Hardy P, Aballai V, Rojas P, Varela D Ca(v)1.2 activity and downstream signaling pathways in the hippocampus of an animal model of depression. Cells. 2020;9. https:\/\/doi.org\/10.3390\/cells9122609.","DOI":"10.3390\/cells9122609"},{"key":"4041_CR51","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00221-021-06253-y","volume":"240","author":"J Liao","year":"2022","unstructured":"Liao J, Liu J, Long G, Lv X. MiR-30b-5p attenuates neuropathic pain by the CYP24A1-Wnt\/\u03b2-catenin signaling in CCI rats. Exp Brain Res. 2022;240:263\u201377. https:\/\/doi.org\/10.1007\/s00221-021-06253-y.","journal-title":"Exp Brain Res"},{"key":"4041_CR52","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1111\/ejn.13745","volume":"46","author":"CC Liu","year":"2017","unstructured":"Liu CC, Cheng JT, Li TY, Tan PH. Integrated analysis of microRNA and mRNA expression profiles in the rat spinal cord under inflammatory pain conditions. Eur J Neurosci. 2017;46:2713\u201328. https:\/\/doi.org\/10.1111\/ejn.13745.","journal-title":"Eur J Neurosci"},{"key":"4041_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01787-4","volume":"17","author":"D Li","year":"2020","unstructured":"Li D, Wang Y, Jin X, Hu D, Xia C, Xu H, et al. NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice. J Neuroinflammation. 2020;17:126. https:\/\/doi.org\/10.1186\/s12974-020-01787-4.","journal-title":"J Neuroinflammation"},{"key":"4041_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.npep.2011.05.005","volume":"46","author":"MM Nowacka","year":"2012","unstructured":"Nowacka MM, Obuchowicz E. Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action. Neuropeptides. 2012;46:1\u201310. https:\/\/doi.org\/10.1016\/j.npep.2011.05.005.","journal-title":"Neuropeptides"},{"key":"4041_CR55","doi-asserted-by":"publisher","unstructured":"Nunes FDD, Ferezin LP, Pereira SC, Figaro-Drumond FV, Pinheiro LC, Menezes IC, et al. The association of biochemical and genetic biomarkers in VEGF pathway with depression. Pharmaceutics. 2022;14. https:\/\/doi.org\/10.3390\/pharmaceutics14122757.","DOI":"10.3390\/pharmaceutics14122757"},{"key":"4041_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2022.109335","volume":"224","author":"S Deyama","year":"2023","unstructured":"Deyama S, Kaneda K. Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine. Neuropharmacology. 2023;224:109335. https:\/\/doi.org\/10.1016\/j.neuropharm.2022.109335.","journal-title":"Neuropharmacology"},{"key":"4041_CR57","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1002\/jbmr.2828","volume":"31","author":"JL Hamilton","year":"2016","unstructured":"Hamilton JL, Nagao M, Levine BR, Chen D, Olsen BR, Im HJ. Targeting VEGF and its receptors for the treatment of osteoarthritis and associated pain. J Bone Min Res. 2016;31:911\u201324. https:\/\/doi.org\/10.1002\/jbmr.2828.","journal-title":"J Bone Min Res"},{"key":"4041_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.639160","volume":"12","author":"SAP Dharshini","year":"2021","unstructured":"Dharshini SAP, Jemimah S, Taguchi YH, Gromiha MM. Exploring common therapeutic targets for neurodegenerative disorders using transcriptome study. Front Genet. 2021;12:639160. https:\/\/doi.org\/10.3389\/fgene.2021.639160.","journal-title":"Front Genet"},{"key":"4041_CR59","doi-asserted-by":"publisher","first-page":"e867","DOI":"10.1212\/wnl.0000000000006082","volume":"91","author":"S Janelidze","year":"2018","unstructured":"Janelidze S, Mattsson N, Stomrud E, Lindberg O, Palmqvist S, Zetterberg H, et al. CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology. 2018;91:e867\u2013e77. https:\/\/doi.org\/10.1212\/wnl.0000000000006082.","journal-title":"Neurology"},{"key":"4041_CR60","doi-asserted-by":"publisher","unstructured":"Baek JH, Son H, Kang JS, Yoo DY, Chung HJ, Lee DK, et al. Long-term hyperglycemia causes depressive behaviors in mice with hypoactive glutamatergic activity in the medial prefrontal cortex, which is not reversed by insulin treatment. Cells. 2022;11. https:\/\/doi.org\/10.3390\/cells11244012.","DOI":"10.3390\/cells11244012"},{"key":"4041_CR61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jpsychires.2016.06.017","volume":"82","author":"J Zhao","year":"2016","unstructured":"Zhao J, Verwer RW, van Wamelen DJ, Qi XR, Gao SF, Lucassen PJ, et al. Prefrontal changes in the glutamate-glutamine cycle and neuronal\/glial glutamate transporters in depression with and without suicide. J Psychiatr Res. 2016;82:8\u201315. https:\/\/doi.org\/10.1016\/j.jpsychires.2016.06.017.","journal-title":"J Psychiatr Res"},{"key":"4041_CR62","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neulet.2017.04.055","volume":"651","author":"Y Zhao","year":"2017","unstructured":"Zhao Y, Zhang M, Liu H, Wang J. Signaling by growth\/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration. Neurosci Lett. 2017;651:36\u201342. https:\/\/doi.org\/10.1016\/j.neulet.2017.04.055.","journal-title":"Neurosci Lett"},{"key":"4041_CR63","doi-asserted-by":"publisher","first-page":"7397","DOI":"10.1523\/JNEUROSCI.1434-07.2007","volume":"27","author":"J Samanta","year":"2007","unstructured":"Samanta J, Burke GM, McGuire T, Pisarek AJ, Mukhopadhyay A, Mishina Y, et al. BMPR1a signaling determines numbers of oligodendrocytes and calbindin-expressing interneurons in the cortex. J Neurosci. 2007;27:7397\u2013407. https:\/\/doi.org\/10.1523\/JNEUROSCI.1434-07.2007.","journal-title":"J Neurosci"},{"key":"4041_CR64","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1523\/JNEUROSCI.4459-09.2010","volume":"30","author":"V Sahni","year":"2010","unstructured":"Sahni V, Mukhopadhyay A, Tysseling V, Hebert A, Birch D, McGuire TL, et al. BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury. J Neurosci. 2010;30:1839\u201355. https:\/\/doi.org\/10.1523\/JNEUROSCI.4459-09.2010.","journal-title":"J Neurosci"},{"key":"4041_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04690-3","volume":"13","author":"A Zhao","year":"2022","unstructured":"Zhao A, Li D, Mao X, Yang M, Deng W, Hu W, et al. GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling. Cell Death Dis. 2022;13:260. https:\/\/doi.org\/10.1038\/s41419-022-04690-3.","journal-title":"Cell Death Dis"},{"key":"4041_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0590-7","volume":"9","author":"M Khanbabaei","year":"2019","unstructured":"Khanbabaei M, Hughes E, Ellegood J, Qiu LR, Yip R, Dobry J, et al. Precocious myelination in a mouse model of autism. Transl Psychiatry. 2019;9:251. https:\/\/doi.org\/10.1038\/s41398-019-0590-7.","journal-title":"Transl Psychiatry"},{"key":"4041_CR67","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1007\/s11571-021-09724-8","volume":"16","author":"P Verma","year":"2022","unstructured":"Verma P, Shakya M. Machine learning model for predicting major depressive disorder using RNA-Seq data: optimization of classification approach. Cogn Neurodyn. 2022;16:443\u201353. https:\/\/doi.org\/10.1007\/s11571-021-09724-8.","journal-title":"Cogn Neurodyn"},{"key":"4041_CR68","doi-asserted-by":"publisher","first-page":"549","DOI":"10.4103\/psychiatry.IndianJPsychiatry_858_20","volume":"63","author":"P Verma","year":"2021","unstructured":"Verma P, Shakya M. Transcriptomics and sequencing analysis of gene expression profiling for major depressive disorder. Indian J Psychiatry. 2021;63:549\u201353. https:\/\/doi.org\/10.4103\/psychiatry.IndianJPsychiatry_858_20.","journal-title":"Indian J Psychiatry"},{"key":"4041_CR69","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41586-023-06299-8","volume":"620","author":"C Guo","year":"2023","unstructured":"Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023;620:200\u20138. https:\/\/doi.org\/10.1038\/s41586-023-06299-8.","journal-title":"Nature"},{"key":"4041_CR70","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1080\/21655979.2020.1771068","volume":"11","author":"Z Wang","year":"2020","unstructured":"Wang Z, Song K, Zhao W, Zhao Z. Dendritic cells in tumor microenvironment promoted the neuropathic pain via paracrine inflammatory and growth factors. Bioengineered. 2020;11:661\u201378. https:\/\/doi.org\/10.1080\/21655979.2020.1771068.","journal-title":"Bioengineered"},{"key":"4041_CR71","doi-asserted-by":"publisher","first-page":"4900","DOI":"10.1007\/s12010-023-04774-6","volume":"196","author":"H Zhang","year":"2024","unstructured":"Zhang H, Zhang Y, Xu K, Wang L, Zhou X, Yang M, et al. Inhibition of FLT1 attenuates neurodevelopmental abnormalities and cognitive impairment in offspring caused by maternal prenatal stress. Appl Biochem Biotechnol. 2024;196:4900\u201313. https:\/\/doi.org\/10.1007\/s12010-023-04774-6.","journal-title":"Appl Biochem Biotechnol"},{"key":"4041_CR72","doi-asserted-by":"publisher","first-page":"5650","DOI":"10.1007\/s12035-024-04616-4","volume":"62","author":"Y Liu","year":"2025","unstructured":"Liu Y, Jin F, Chen Q, Liu M, Li X, Zhou L, et al. PDGFR-\u03b1 mediated the neuroinflammation and autophagy via the JAK2\/STAT3 signaling pathway contributing to depression-like behaviors in myofascial pain syndrome rats. Mol Neurobiol. 2025;62:5650\u201363. https:\/\/doi.org\/10.1007\/s12035-024-04616-4.","journal-title":"Mol Neurobiol"},{"key":"4041_CR73","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00018-021-04026-y","volume":"79","author":"E Tunc-Ozcan","year":"2021","unstructured":"Tunc-Ozcan E, Brooker SM, Bonds JA, Tsai YH, Rawat R, McGuire TL, et al. Hippocampal BMP signaling as a common pathway for antidepressant action. Cell Mol Life Sci. 2021;79:31. https:\/\/doi.org\/10.1007\/s00018-021-04026-y.","journal-title":"Cell Mol Life Sci"},{"key":"4041_CR74","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s42003-025-07590-2","volume":"8","author":"X Wang","year":"2025","unstructured":"Wang X, Wu S, Zuo J, Li K, Chen Y, Fan Z, et al. Selective activation of SIGMAR1 in anterior cingulate cortex glutamatergic neurons facilitates comorbid pain in depression in male mice. Commun Biol. 2025;8:150. https:\/\/doi.org\/10.1038\/s42003-025-07590-2.","journal-title":"Commun Biol"},{"key":"4041_CR75","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/npr2.12393","volume":"44","author":"S Deyama","year":"2024","unstructured":"Deyama S, Li XY, Duman RS. Neuron-specific deletion of VEGF or its receptor Flk-1 occludes the antidepressant-like effects of desipramine and fluoxetine in mice. Neuropsychopharmacol Rep. 2024;44:246\u20139. https:\/\/doi.org\/10.1002\/npr2.12393.","journal-title":"Neuropsychopharmacol Rep"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04041-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04041-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04041-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:29:17Z","timestamp":1780622957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04041-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4041"],"URL":"https:\/\/doi.org\/10.1038\/s41398-026-04041-2","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"1 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"302"}}