{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:51:59Z","timestamp":1791564719095,"version":"4.3.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transl Psychiatry"],"DOI":"10.1038\/s41398-026-04201-4","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:07:36Z","timestamp":1784174856000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Social isolation disrupts prefrontal excitatory\u2013inhibitory balance to impair social novelty memory in adult male mice"],"prefix":"10.1038","volume":"16","author":[{"given":"Quan","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laijian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-6694","authenticated-orcid":false,"given":"Danlei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-343X","authenticated-orcid":false,"given":"Guoqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7804-7437","authenticated-orcid":false,"given":"Jifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihui","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"4201_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc9699","volume":"373","author":"T Clutton-Brock","year":"2021","unstructured":"Clutton-Brock T. Social evolution in mammals. Science. 2021;373:eabc9699.","journal-title":"Science"},{"key":"4201_CR2","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1098\/rstb.2006.1994","volume":"362","author":"JB Silk","year":"2007","unstructured":"Silk JB. The adaptive value of sociality in mammalian groups. Philos Trans of R Soc B-Biological Sci. 2007;362:539\u201359.","journal-title":"Philos Trans of R Soc B-Biological Sci"},{"key":"4201_CR3","doi-asserted-by":"publisher","unstructured":"Kaidanovich-Beilin O, Lipina T, Vukobradovic I, Roder J, Woodgett JR Assessment of social interaction behaviors. J Vis Exp. 2011:2473. https:\/\/doi.org\/10.3791\/2473.","DOI":"10.3791\/2473"},{"key":"4201_CR4","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.neubiorev.2011.10.006","volume":"36","author":"MA van der Kooij","year":"2012","unstructured":"van der Kooij MA, Sandi C. Social memories in rodents: methods, mechanisms and modulation by stress. Neurosci Biobehav Rev. 2012;36:1763\u201372.","journal-title":"Neurosci Biobehav Rev"},{"key":"4201_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.110179","volume":"261","author":"G Castellano","year":"2024","unstructured":"Castellano G, Bonnet DSJ, Pietropaolo S. The role of gene-environment interactions in social dysfunction: focus on preclinical evidence from mouse studies. Neuropharmacology. 2024;261:110179.","journal-title":"Neuropharmacology"},{"key":"4201_CR6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S0889-1591(02)00073-9","volume":"17","author":"LC Hawkley","year":"2003","unstructured":"Hawkley LC, Cacioppo JT. Loneliness and pathways to disease. Brain Behav Immun. 2003;17:98\u2013105.","journal-title":"Brain Behav Immun"},{"key":"4201_CR7","doi-asserted-by":"publisher","first-page":"117701","DOI":"10.1016\/j.socscimed.2025.117701","volume":"366","author":"Z Yang","year":"2025","unstructured":"Yang Z, Liu C, He L, Zhao H, Jian J, Chen H, et al. Social isolation and loneliness increase the risk of coronary heart disease: insights from a prospective cohort study. Soc Sci Med. 2025;366:117701.","journal-title":"Soc Sci Med"},{"key":"4201_CR8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.puhe.2017.07.035","volume":"152","author":"N Leigh-Hunt","year":"2017","unstructured":"Leigh-Hunt N, Bagguley D, Bash K, Turner V, Turnbull S, Valtorta N, et al. An overview of systematic reviews on the public health consequences of social isolation and loneliness. Public Health. 2017;152:157\u201371.","journal-title":"Public Health"},{"key":"4201_CR9","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.biopsych.2017.10.030","volume":"83","author":"J Hiser","year":"2018","unstructured":"Hiser J, Koenigs M. The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology. Biol Psychiatry. 2018;83:638\u201347.","journal-title":"Biol Psychiatry"},{"key":"4201_CR10","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.cell.2021.02.028","volume":"184","author":"CR Lee","year":"2021","unstructured":"Lee CR, Chen A, Tye KM. The neural circuitry of social homeostasis: consequences of acute versus chronic social isolation. Cell. 2021;184:1500\u201316.","journal-title":"Cell"},{"key":"4201_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.124052","volume":"382","author":"J Wu","year":"2025","unstructured":"Wu J, Luo Z, Xiong N, Gan C, Chen W. Social hierarchy modulates cognitive flexibility through basal forebrain-prefrontal cholinergic projections. Life Sci. 2025;382:124052.","journal-title":"Life Sci"},{"key":"4201_CR12","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt9008","volume":"11","author":"Y Liu","year":"2025","unstructured":"Liu Y, Wang Y, Xie G, Yang Q, Bhattacherjee A, Zhang C, et al. A molecularly defined mpfc-bla circuit specifically regulates social novelty preference. Sci Adv. 2025;11:eadt9008.","journal-title":"Sci Adv"},{"key":"4201_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406192","volume":"12","author":"J Zhou","year":"2025","unstructured":"Zhou J, Yin Z, Chen Z, Fu H, Li Q, Li S, et al. Essential role of the anterior piriform cortex in mediating social novelty output via a top-down circuit. Adv Sci. 2025;12:e2406192.","journal-title":"Adv Sci"},{"key":"4201_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104803","volume":"141","author":"AV Fortier","year":"2022","unstructured":"Fortier AV, Meisner OC, Nair AR, Chang S. Prefrontal circuits guiding social preference: implications in autism spectrum disorder. Neurosci And Biobehav Rev. 2022;141:104803.","journal-title":"Neurosci And Biobehav Rev"},{"key":"4201_CR15","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1113\/JP286284","volume":"603","author":"Z Fekete","year":"2025","unstructured":"Fekete Z, Weisz F, Karl\u00f3cai MR, Veres JM, Andr\u00e1si T, H\u00e1jos N. Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex. J of Physiology-London. 2025;603:6423\u201344.","journal-title":"J of Physiology-London"},{"key":"4201_CR16","doi-asserted-by":"publisher","first-page":"55684","DOI":"10.7554\/eLife.55684","volume":"9","author":"S Trakoshis","year":"2020","unstructured":"Trakoshis S, Mart\u00ednez-Ca\u00f1ada P, Rocchi F, Canella C, You W, Chakrabarti B, et al. Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women. Elife. 2020;9:55684.","journal-title":"Elife"},{"key":"4201_CR17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1038\/s41386-025-02154-8","volume":"51","author":"CM Goodpaster","year":"2026","unstructured":"Goodpaster CM, Christensen CR, Alturki MB, Denardo LA. Prefrontal cortex development and its implications in mental illness. Neuropsychopharmacology. 2026;51:114\u201328.","journal-title":"Neuropsychopharmacology"},{"key":"4201_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.110101","volume":"260","author":"DH Mediane","year":"2024","unstructured":"Mediane DH, Basu S, Cahill EN, Anastasiades PG. Medial prefrontal cortex circuitry and social behaviour in autism. Neuropharmacology. 2024;260:110101.","journal-title":"Neuropharmacology"},{"key":"4201_CR19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.semcdb.2021.05.017","volume":"118","author":"DC Li","year":"2021","unstructured":"Li DC, Hinton EA, Gourley SL. Persistent behavioral and neurobiological consequences of social isolation during adolescence. Semin Cell Developmental Biol. 2021;118:73\u201382.","journal-title":"Semin Cell Developmental Biol"},{"key":"4201_CR20","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1038\/s41380-024-02540-6","volume":"29","author":"DC Li","year":"2024","unstructured":"Li DC, Hinton EA, Guo J, Knight KA, Sequeira MK, Wynne ME, et al. Social experience in adolescence shapes prefrontal cortex structure and function in adulthood. Mol Psychiatry. 2024;29:2787\u201398.","journal-title":"Mol Psychiatry"},{"key":"4201_CR21","doi-asserted-by":"publisher","first-page":"E7097","DOI":"10.1073\/pnas.1606351113","volume":"113","author":"H Tada","year":"2016","unstructured":"Tada H, Miyazaki T, Takemoto K, Takase K, Jitsuki S, Nakajima W, et al. Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex. Proc of Natl Acad Sci USA. 2016;113:E7097\u2013E7105.","journal-title":"Proc of Natl Acad Sci USA"},{"key":"4201_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112306","volume":"379","author":"KI Ohta","year":"2020","unstructured":"Ohta KI, Suzuki S, Warita K, Sumitani K, Tenkumo C, Ozawa T, et al. The effects of early life stress on the excitatory\/inhibitory balance of the medial prefrontal cortex. Behavioural Brain Res. 2020;379:112306.","journal-title":"Behavioural Brain Res"},{"key":"4201_CR23","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/s41593-020-0695-6","volume":"23","author":"K Yamamuro","year":"2020","unstructured":"Yamamuro K, Bicks LK, Leventhal MB, Kato D, Im S, Flanigan ME, et al. A prefrontal-paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice. Nat Neurosci. 2020;23:1240\u201352.","journal-title":"Nat Neurosci"},{"key":"4201_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147755","volume":"1777","author":"AG Mcgrath","year":"2022","unstructured":"Mcgrath AG, Briand LA. Post-weaning social isolation causes sex-specific alterations to dendritic spine density in subregions of the prefrontal cortex and nucleus accumbens of adult mice. Brain Res. 2022;1777:147755.","journal-title":"Brain Res"},{"key":"4201_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2024.107264","volume":"172","author":"AN Ciano","year":"2025","unstructured":"Ciano AN, Poggini S, Reccagni A, Barezzi C, Salciccia C, Poleggi A, et al. Adolescent social isolation induces sex-specific behavioral and neural alterations. Psychoneuroendocrinology. 2025;172:107264.","journal-title":"Psychoneuroendocrinology"},{"key":"4201_CR26","doi-asserted-by":"publisher","DOI":"10.1101\/lm.054059.124","volume":"32","author":"S Hanif","year":"2025","unstructured":"Hanif S, Sclar M, Lee J, Nichols C, Likhtik E, Burghardt NS. Social isolation during adolescence differentially affects spatial learning in adult male and female mice. Learn Mem. 2025;32:a054059.","journal-title":"Learn Mem"},{"key":"4201_CR27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.cell.2014.10.035","volume":"159","author":"M H\u00fcbener","year":"2014","unstructured":"H\u00fcbener M, Bonhoeffer T. Neuronal plasticity: beyond the critical period. Cell. 2014;159:727\u201337.","journal-title":"Cell"},{"key":"4201_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2022.1086680","volume":"16","author":"TM Mowery","year":"2022","unstructured":"Mowery TM, Garraghty PE. Adult neuroplasticity employs developmental mechanisms. Front Syst Neurosci. 2022;16:1086680.","journal-title":"Front Syst Neurosci"},{"key":"4201_CR29","doi-asserted-by":"publisher","unstructured":"Watanabe S, Al OA, Shao AS, Liang J Social isolation model: a noninvasive rodent model of stress and anxiety. J Vis Exp 2022:https:\/\/doi.org\/10.3791\/64567.","DOI":"10.3791\/64567"},{"key":"4201_CR30","doi-asserted-by":"publisher","first-page":"6038","DOI":"10.1016\/j.cub.2025.10.083","volume":"24","author":"D Liu","year":"2025","unstructured":"Liu D, Zheng X, Wang L, Zhang W, Che Y, Du J, et al. Orexinergic lateral hypothalamus-anterior cingulate cortex circuit alleviates chronic stress-induced anxiety-like behaviors. Curr Biol. 2025;24:6038\u201353.","journal-title":"Curr Biol"},{"key":"4201_CR31","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.neuron.2019.02.026","volume":"102","author":"H Xu","year":"2019","unstructured":"Xu H, Liu L, Tian Y, Wang J, Li J, Zheng J, et al. A disinhibitory microcircuit mediates conditioned social fear in the prefrontal cortex. Neuron. 2019;102:668\u201382.","journal-title":"Neuron"},{"key":"4201_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02151-1","volume":"12","author":"H Wang","year":"2022","unstructured":"Wang H, Li F, Zheng X, Meng L, Chen M, Hui Y, et al. Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice. Transl Psychiatry. 2022;12:380.","journal-title":"Transl Psychiatry"},{"key":"4201_CR33","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00213-023-06381-z","volume":"240","author":"I Chaibi","year":"2023","unstructured":"Chaibi I, Ait-Mansour I, Tari M, Bennis M, Ba-M\u2019Hamed S. Effects of topiramate on morphological and structural alterations of the anterior cingulate cortex in aggressive socially isolated mice. Psychopharmacology. 2023;240:1473\u201392.","journal-title":"Psychopharmacology"},{"key":"4201_CR34","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.neuron.2023.10.027","volume":"112","author":"B Guo","year":"2024","unstructured":"Guo B, Xi K, Mao H, Ren K, Xiao H, Hartley ND, et al. Cb1r dysfunction of inhibitory synapses in the acc drives chronic social isolation stress-induced social impairments in male mice. Neuron. 2024;112:441\u201357.","journal-title":"Neuron"},{"key":"4201_CR35","doi-asserted-by":"publisher","first-page":"114698","DOI":"10.1016\/j.physbeh.2024.114698","volume":"287","author":"Y Jin","year":"2024","unstructured":"Jin Y, Song D, Quan Z, Ni J, Qing H. The regulatory effect of the anterior cingulate cortex on helping behavior in juvenile social isolation model mice. Physiol Behav. 2024;287:114698.","journal-title":"Physiol Behav"},{"key":"4201_CR36","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/7854_2015_430","volume":"30","author":"S Tzanoulinou","year":"2017","unstructured":"Tzanoulinou S, Sandi C. The programming of the social brain by stress during childhood and adolescence: from rodents to humans. Curr Top Behav Neurosci. 2017;30:411\u201329.","journal-title":"Curr Top Behav Neurosci"},{"key":"4201_CR37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/npp.2015.181","volume":"41","author":"Y Chen","year":"2016","unstructured":"Chen Y, Baram TZ. Toward understanding how early-life stress reprograms cognitive and emotional brain networks. Neuropsychopharmacology. 2016;41:197\u2013206.","journal-title":"Neuropsychopharmacology"},{"key":"4201_CR38","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nrn2639","volume":"10","author":"SJ Lupien","year":"2009","unstructured":"Lupien SJ, Mcewen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Reviews Neurosci. 2009;10:434\u201345.","journal-title":"Nat Reviews Neurosci"},{"key":"4201_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s40520-024-02925-1","volume":"37","author":"A Nakou","year":"2025","unstructured":"Nakou A, Dragioti E, Bastas N, Zagorianakou N, Kakaidi V, Tsartsalis D, et al. Loneliness, social isolation, and living alone: a comprehensive systematic review, meta-analysis, and meta-regression of mortality risks in older adults. Aging Clin And Exp Res. 2025;37:29.","journal-title":"Aging Clin And Exp Res"},{"key":"4201_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2025.105831","volume":"246","author":"A Vall\u00e9e","year":"2025","unstructured":"Vall\u00e9e A. Sex differences in the impact of social isolation and loneliness on mortality. Public Health. 2025;246:105831.","journal-title":"Public Health"},{"key":"4201_CR41","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105336","volume":"9","author":"M Morr","year":"2022","unstructured":"Morr M, Noell J, Sassin D, Daniels J, Philipsen A, Becker B, et al. Lonely in the dark: trauma memory and sex-specific dysregulation of amygdala reactivity to fear signals. Adv Sci. 2022;9:e2105336.","journal-title":"Adv Sci"},{"key":"4201_CR42","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-018-0874-2","volume":"20","author":"SL Ferri","year":"2018","unstructured":"Ferri SL, Abel T, Brodkin ES. Sex differences in autism spectrum disorder: a review. Curr Psychiatry Rep. 2018;20:9.","journal-title":"Curr Psychiatry Rep"},{"key":"4201_CR43","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/jnr.25000","volume":"101","author":"S Calderoni","year":"2023","unstructured":"Calderoni S. Sex\/gender differences in children with autism spectrum disorder: a brief overview on epidemiology, symptom profile, and neuroanatomy. J of Neurosci Res. 2023;101:739\u201350.","journal-title":"J of Neurosci Res"},{"key":"4201_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01091-y","volume":"10","author":"MAA Meyer","year":"2020","unstructured":"Meyer MAA, Anst\u00f6tz M, Ren LY, Fiske MP, Guedea AL, Grayson VS, et al. Stress-related memories disrupt sociability and associated patterning of hippocampal activity: a role of hilar oxytocin receptor-positive interneurons. Transl Psychiatry. 2020;10:428.","journal-title":"Transl Psychiatry"},{"key":"4201_CR45","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/s41386-024-01987-z","volume":"50","author":"R Bredewold","year":"2025","unstructured":"Bredewold R, Washington C, Veenema AH. Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum. Neuropsychopharmacology. 2025;50:630\u20139.","journal-title":"Neuropsychopharmacology"},{"key":"4201_CR46","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2021.0057","volume":"377","author":"AM Borie","year":"2022","unstructured":"Borie AM, Young LJ, Liu RC. Sex-specific and social experience-dependent oxytocin-endocannabinoid interactions in the nucleus accumbens: implications for social behaviour. Philos Trans of R Soc B-Biological Sci. 2022;377:20210057.","journal-title":"Philos Trans of R Soc B-Biological Sci"},{"key":"4201_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100504","volume":"3","author":"SE Maloney","year":"2023","unstructured":"Maloney SE, Sarafinovska S, Weichselbaum C, Mccullough KB, Swift RG, Liu Y, et al. A comprehensive assay of social motivation reveals sex-specific roles of autism-associated genes and oxytocin. Cell Rep Methods. 2023;3:100504.","journal-title":"Cell Rep Methods"},{"key":"4201_CR48","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.biopsych.2020.08.023","volume":"89","author":"B Xing","year":"2021","unstructured":"Xing B, Mack NR, Guo KM, Zhang YX, Ramirez B, Yang SS, et al. A subpopulation of prefrontal cortical neurons is required for social memory. Biol Psychiatry. 2021;89:521\u201331.","journal-title":"Biol Psychiatry"},{"key":"4201_CR49","doi-asserted-by":"publisher","first-page":"3740","DOI":"10.1038\/s41380-025-02963-9","volume":"30","author":"M Li","year":"2025","unstructured":"Li M, Wang SZ, Zhao YB, Tang X, Xu L, Wang H, et al. Rac1 in parvalbumin neurons of the medial prefrontal cortex governs rapid forgetting of social memory. Mol Psychiatry. 2025;30:3740\u201351.","journal-title":"Mol Psychiatry"},{"key":"4201_CR50","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1093\/cercor\/bhx010","volume":"28","author":"K Yamamuro","year":"2018","unstructured":"Yamamuro K, Yoshino H, Ogawa Y, Makinodan M, Toritsuka M, Yamashita M, et al. Social isolation during the critical period reduces synaptic and intrinsic excitability of a subtype of pyramidal cell in mouse prefrontal cortex. Cereb Cortex. 2018;28:998\u20131010.","journal-title":"Cereb Cortex"},{"key":"4201_CR51","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fncel.2020.00105","volume":"14","author":"K Yamamuro","year":"2020","unstructured":"Yamamuro K, Yoshino H, Ogawa Y, Okamura K, Nishihata Y, Makinodan M, et al. Juvenile social isolation enhances the activity of inhibitory neuronal circuits in the medial prefrontal cortex. Front Cell Neurosci. 2020;14:105.","journal-title":"Front Cell Neurosci"},{"key":"4201_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109104","volume":"35","author":"G Park","year":"2021","unstructured":"Park G, Ryu C, Kim S, Jeong SJ, Koo JW, Lee YS, et al. Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice. Cell Rep. 2021;35:109104.","journal-title":"Cell Rep"},{"key":"4201_CR53","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuroscience.2025.09.030","volume":"586","author":"S Varman","year":"2025","unstructured":"Varman S, Caldwell G, Coutellier L. Regrouping reverses social impairments and prefrontal parvalbumin-perineuronal nets alterations induced by post-weaning social isolation in male mice. Neuroscience. 2025;586:77\u201387.","journal-title":"Neuroscience"},{"key":"4201_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2025.138331","volume":"865","author":"T Sanada","year":"2025","unstructured":"Sanada T, Ichisaka S, Hata Y. Enriched environment during adulthood temporarily ameliorates aggression induced by post-weaning social isolation in rats. Neurosci Lett. 2025;865:138331.","journal-title":"Neurosci Lett"},{"key":"4201_CR55","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1111\/ejn.15966","volume":"57","author":"AP Vu","year":"2023","unstructured":"Vu AP, Lam D, Denney C, Lee KV, Plemel JR, Jackson J. Social isolation produces a sex- and brain region-specific alteration of microglia state. Eur J of Neurosci. 2023;57:1481\u201397.","journal-title":"Eur J of Neurosci"},{"key":"4201_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2023.1190291","volume":"17","author":"V Heng","year":"2023","unstructured":"Heng V, Zigmond M, Smeyne RJ. Neuroanatomical and neurochemical effects of prolonged social isolation in adult mice. Front Neuroanatomy. 2023;17:1190291.","journal-title":"Front Neuroanatomy"},{"key":"4201_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05632-2","volume":"7","author":"M Makinodan","year":"2017","unstructured":"Makinodan M, Ikawa D, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, et al. Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function. Sci Rep. 2017;7:5481.","journal-title":"Sci Rep"}],"container-title":["Translational Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04201-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04201-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04201-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:02:03Z","timestamp":1791561723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41398-026-04201-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4201"],"URL":"https:\/\/doi.org\/10.1038\/s41398-026-04201-4","relation":{},"ISSN":["2158-3188"],"issn-type":[{"value":"2158-3188","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"546"}}