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The hippocampus is a region of the brain that is commonly affected by both AD and depression and serves as a focal point for our study. We aim to understand the relationship of 1) depression and antidepressant medications to hippocampal subfield volume during normal aging, and 2) whether AD risk, as measured by amyloid and tau pathology and\n                    <jats:italic>APOE<\/jats:italic>\n                    4 status, impacts these relationships. We studied 2009 ethno-racially diverse cognitively unimpaired older adults aged 50 to 90 years who either had depression (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009630) or were not depressed (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091379). Participants with depression were further stratified by antidepressant medication usage. High-resolution MRI scans were used to calculate hippocampal subfield volumes that included the CA1, the subiculum, and a composite region that included the CA2, CA3, and the dentate gyrus (CA23DG). Having depression was associated with a smaller CA23DG, independent of amyloid and tau pathology in the brain. Within the subgroup of participants with depression, those who used antidepressant medications had smaller CA1 and CA23DG volumes than those who did not use these medications.\n                  <\/jats:p>","DOI":"10.1038\/s41398-026-04223-y","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:34:17Z","timestamp":1784039657000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depression and hippocampal subfield volume in older adults"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8399-7896","authenticated-orcid":false,"given":"Danielle","family":"Luu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4338-808X","authenticated-orcid":false,"given":"Alicia M.","family":"Twisselmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria R.","family":"Tennant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Terner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylan L.","family":"Davison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koral","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2921-3408","authenticated-orcid":false,"given":"Christopher R. 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