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Here, using in vivo two-photon calcium imaging, we uncovered how the activity of dopamine-sensitive neurons in the medial nucleus of the central amygdala (CeM) is associated with appetitive and aversive experiences. We found that cocaine and sucrose strongly activated DRD1(+) neurons while suppressing DRD2(+) activity, whereas the aversive quinine stimulus predominantly engaged DRD2(+) neurons, particularly those not previously recruited by sucrose. Our findings suggest that DRD1(+) and DRD2(+) neurons differentially contribute to the processing of appetitive and aversive stimuli. Furthermore, by simultaneously monitoring facial expressions, we identified stimulus-specific behavioral responses to sucrose, quinine, and cocaine.<\/jats:p>","DOI":"10.1038\/s41398-026-04228-7","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:56:30Z","timestamp":1783090590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DRD1 and DRD2 dopamine-sensitive neurons in the central amygdala respond differently to rewarding and aversive stimuli"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-3674","authenticated-orcid":false,"given":"\u0141ukasz","family":"Bijoch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-1142","authenticated-orcid":false,"given":"Justyna","family":"Wi\u015bniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7247-0675","authenticated-orcid":false,"given":"Pawe\u0142","family":"Szczypkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Paw\u0142owska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Hajdukiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"Lapkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-5241","authenticated-orcid":false,"given":"Anna","family":"Beroun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"4228_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.brainres.2018.10.008","volume":"1713","author":"RN Gentry","year":"2019","unstructured":"Gentry RN, Schuweiler DR, Roesch MR. 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