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Treatment remains challenging, and effective interventions for adults are limited. The extrastriate body area (EBA), a cortical region involved in body representation, may contribute to the body perception disturbances. In this double-blind, placebo-controlled, randomized proof-of-concept trial, we investigated the therapeutic potential of targeted theta burst transcranial magnetic stimulation (TMS) of the EBA in patients with anorexia nervosa (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940). Participants received four weeks of active (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) or sham (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) TMS combined with body perception training, while a treatment-as-usual group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920) and a healthy control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940) served as comparators. Improvements in the primary outcome measure, the Body Shape Questionnaire, differed across groups over time, with active TMS showing faster improvement (after 4 weeks) relative to both control groups, that was sustained at 6 months follow-up. Moreover, active stimulation was associated with changes in EBA responses to self- versus non-self touch, shifting neural activity patterns more closely to those of healthy individuals. These findings provide preliminary evidence that individualized neuromodulation targeting a disorder-relevant neural substrate combined with behavioral training shows potential for effectively recalibrating disturbed body perception. By integrating brain stimulation with behavioral training, this study exemplifies a precision psychiatry approach that links neurobiological mechanisms to personalized therapeutic interventions in anorexia nervosa.\n                  <\/jats:p>","DOI":"10.1038\/s41398-026-04235-8","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:05:29Z","timestamp":1782929129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Theta burst stimulation of extrastriate body area for body perception in anorexia nervosa: a randomized controlled trial"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-3069","authenticated-orcid":false,"given":"Rebecca","family":"Boehme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-7380","authenticated-orcid":false,"given":"Reinoud","family":"Kaldewaij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-1170","authenticated-orcid":false,"given":"Morgan","family":"Frost-Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Enmalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Khoure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna","family":"Tell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"K\u00e4ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimmi","family":"Salerud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Rimhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Jackleus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barsj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Thordstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per A.","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6319-1786","authenticated-orcid":false,"given":"H\u00e5kan","family":"Olausson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-8029","authenticated-orcid":false,"given":"Maria","family":"Zetterqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"4235_CR1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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