{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:29:32Z","timestamp":1793039372440,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1038\/s41401-021-00756-8","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T07:16:54Z","timestamp":1630307814000},"page":"1311-1323","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG"],"prefix":"10.1038","volume":"43","author":[{"given":"Liu-shan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-feng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"756_CR1","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.1038\/s41467-018-06898-4","volume":"9","author":"Y Wu","year":"2018","unstructured":"Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, et al. Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nat Commun. 2018;9:4772\u201382.","journal-title":"Nat Commun"},{"key":"756_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrrheum.2009.102","volume":"5","author":"M Kawai","year":"2009","unstructured":"Kawai M, Devlin MJ, Rosen CJ. Fat targets for skeletal health. Nat Rev Rheumatol. 2009;5:365\u201372.","journal-title":"Nat Rev Rheumatol"},{"key":"756_CR3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S2213-8587(14)70007-5","volume":"3","author":"MJ Devlin","year":"2015","unstructured":"Devlin MJ, Rosen CJ. The bone-fat interface: basic and clinical implications of marrow adiposity. Lancet Diabetes Endocrinol. 2015;3:141\u20137.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"756_CR4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/nyas.12327","volume":"1311","author":"EL Scheller","year":"2014","unstructured":"Scheller EL, Rosen CJ. What\u2019s the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health. Ann N Y Acad Sci. 2014;1311:14\u201330.","journal-title":"Ann N Y Acad Sci"},{"key":"756_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ecl.2013.09.004","volume":"43","author":"S Kurra","year":"2014","unstructured":"Kurra S, Fink DA, Siris ES. Osteoporosis-associated fracture and diabetes. Endocrin Metab Clin. 2014;43:233\u201343.","journal-title":"Endocrin Metab Clin"},{"key":"756_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.revmed.2019.10.332","volume":"41","author":"L Pijnenburg","year":"2020","unstructured":"Pijnenburg L, Felten R, Javier RM. [A review of avascular necrosis, of the hip and beyond]. Rev Med Interne. 2020;41:27\u201336.","journal-title":"Rev Med Interne"},{"key":"756_CR7","doi-asserted-by":"publisher","first-page":"Itc17","DOI":"10.7326\/AITC201708010","volume":"167","author":"KE Ensrud","year":"2017","unstructured":"Ensrud KE, Crandall CJ. Osteoporosis. Ann Intern Med. 2017;167:Itc17\u2013Itc31.","journal-title":"Ann Intern Med"},{"key":"756_CR8","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.4317\/medoral.23191","volume":"25","author":"A Eguia","year":"2020","unstructured":"Eguia A, Bagan-Debon L, Cardona F. Review and update on drugs related to the development of osteonecrosis of the jaw. Med Oral Patol Oral Cir Bucal. 2020;25:e71\u2013e83.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"756_CR9","doi-asserted-by":"publisher","first-page":"455","DOI":"10.5435\/JAAOS-22-07-455","volume":"22","author":"CG Zalavras","year":"2014","unstructured":"Zalavras CG, Lieberman JR. Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg. 2014;22:455\u201364.","journal-title":"J Am Acad Orthop Surg"},{"key":"756_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.7812\/TPP\/18-100","volume":"23","author":"MJ Lespasio","year":"2019","unstructured":"Lespasio MJ, Sodhi N, Mont MA. Osteonecrosis of the hip: a primer. Perm J. 2019;23:18\u2013100.","journal-title":"Perm J"},{"key":"756_CR11","doi-asserted-by":"publisher","first-page":"e24031","DOI":"10.1097\/MD.0000000000024031","volume":"100","author":"W Jin","year":"2021","unstructured":"Jin W, Yang X, Lu M. Juvenile-onset multifocal osteonecrosis in systemic lupus erythematosus: a case report. Medicine (Baltimore). 2021;100:e24031.","journal-title":"Medicine (Baltimore)"},{"key":"756_CR12","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1016\/j.bbadis.2018.09.015","volume":"1864","author":"GS Shen","year":"2018","unstructured":"Shen GS, Zhou HB, Zhang H, Chen B, Liu ZP, Yuan Y, et al. The GDF11-FTO-PPAR gamma axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. Bba-Mol Basis Dis. 2018;1864:3644\u201354.","journal-title":"Bba-Mol Basis Dis"},{"key":"756_CR13","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1001\/jama.2018.7498","volume":"319","author":"Force USPST","year":"2018","unstructured":"USPST Force, Curry SJ, Krist AH, Owens DK, Barry MJ, Caughey AB, et al. Screening for osteoporosis to prevent fractures: US Preventive Services Task Force recommendation statement. JAMA. 2018;319:2521\u201331.","journal-title":"JAMA"},{"key":"756_CR14","doi-asserted-by":"publisher","first-page":"818","DOI":"10.7326\/M15-1361","volume":"166","author":"A Qaseem","year":"2017","unstructured":"Qaseem A, Forciea MA, McLean RM, Denberg TD, Clinical Guidelines Committee of the American College of Physicians Barry MJ. et al. Treatment of low bone density or osteoporosis to prevent fractures in men and women: a clinical practice guideline update from the American College of Physicians. Ann Intern Med. 2017;166:818\u201339.","journal-title":"Ann Intern Med"},{"key":"756_CR15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.7326\/M19-0533","volume":"171","author":"HA Fink","year":"2019","unstructured":"Fink HA, MacDonald R, Forte ML, Rosebush CE, Ensrud KE, Schousboe JT, et al. Long-term drug therapy and drug discontinuations and holidays for osteoporosis fracture prevention: a systematic review. Ann Intern Med. 2019;171:37\u201350.","journal-title":"Ann Intern Med"},{"key":"756_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/jbmr.2708","volume":"31","author":"RA Adler","year":"2016","unstructured":"Adler RA, El-Hajj Fuleihan G, Bauer DC, Camacho PM, Clarke BL, Clines GA, et al. Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a Task Force of the American Society for Bone and Mineral Research. J Bone Min Res. 2016;31:16\u201335.","journal-title":"J Bone Min Res"},{"key":"756_CR17","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1001\/jama.2010.1360","volume":"304","author":"DE Sellmeyer","year":"2010","unstructured":"Sellmeyer DE. Atypical fractures as a potential complication of long-term bisphosphonate therapy. JAMA. 2010;304:1480\u20134.","journal-title":"JAMA"},{"key":"756_CR18","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1101\/gad.262766.115","volume":"29","author":"Y Yue","year":"2015","unstructured":"Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 2015;29:1343\u201355.","journal-title":"Genes Dev"},{"key":"756_CR19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/cr.2014.3","volume":"24","author":"XL Ping","year":"2014","unstructured":"Ping XL, Sun BF, Wang L, Xiao W, Yang X, Wang WJ, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014;24:177\u201389.","journal-title":"Cell Res"},{"key":"756_CR20","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.cell.2020.05.012","volume":"181","author":"S Zaccara","year":"2020","unstructured":"Zaccara S, Jaffrey SR. A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA. Cell. 2020;181:1582\u201395.","journal-title":"Cell"},{"key":"756_CR21","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.ccell.2017.02.013","volume":"31","author":"S Zhang","year":"2017","unstructured":"Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, et al. m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell. 2017;31:591\u2013606.","journal-title":"Cancer Cell"},{"key":"756_CR22","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature20568","volume":"540","author":"T Lence","year":"2016","unstructured":"Lence T, Akhtar J, Bayer M, Schmid K, Spindler L, Ho CH, et al. m6A modulates neuronal functions and sex determination in Drosophila. Nature. 2016;540:242\u20137.","journal-title":"Nature"},{"key":"756_CR23","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","volume":"161","author":"X Wang","year":"2015","unstructured":"Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161:1388\u201399.","journal-title":"Cell"},{"key":"756_CR24","first-page":"1","volume":"0","author":"L Sun","year":"2020","unstructured":"Sun L, Wan A, Zhou Z, Chen D, Liang H, Liu C, et al. RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer. Gut. 2020;0:1\u201315.","journal-title":"Gut"},{"key":"756_CR25","doi-asserted-by":"publisher","first-page":"e103181","DOI":"10.15252\/embj.2019103181","volume":"39","author":"Z Lin","year":"2020","unstructured":"Lin Z, Niu Y, Wan A, Chen D, Liang H, Chen X, et al. RNA m6A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy. EMBO J. 2020;39:e103181.","journal-title":"EMBO J"},{"key":"756_CR26","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.molcel.2018.08.011","volume":"71","author":"J Wei","year":"2018","unstructured":"Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, et al. Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol Cell. 2018;71:973\u201385.","journal-title":"Mol Cell"},{"key":"756_CR27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.ccell.2019.03.006","volume":"35","author":"Y Huang","year":"2019","unstructured":"Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 2019;35:677\u201391.","journal-title":"Cancer Cell"},{"key":"756_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/nar\/gku1276","volume":"43","author":"Y Huang","year":"2015","unstructured":"Huang Y, Yan J, Li Q, Li J, Gong S, Zhou H, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015;43:373\u201384.","journal-title":"Nucleic Acids Res"},{"key":"756_CR29","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.1016\/j.celrep.2017.02.059","volume":"18","author":"Q Cui","year":"2017","unstructured":"Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, et al. m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 2017;18:2622\u201334.","journal-title":"Cell Rep"},{"key":"756_CR30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1039\/C4SC02554G","volume":"6","author":"JDW Toh","year":"2015","unstructured":"Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, et al. A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N(6)-methyladenosine demethylase FTO. Chem Sci. 2015;6:112\u201322.","journal-title":"Chem Sci"},{"key":"756_CR31","doi-asserted-by":"publisher","first-page":"e14005","DOI":"10.1371\/journal.pone.0014005","volume":"5","author":"X Gao","year":"2010","unstructured":"Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One. 2010;5:e14005.","journal-title":"PLoS One"},{"key":"756_CR32","doi-asserted-by":"publisher","first-page":"e45142","DOI":"10.1371\/journal.pone.0045142","volume":"7","author":"P Benisch","year":"2012","unstructured":"Benisch P, Schilling T, Klein-Hitpass L, Frey SP, Seefried L, Raaijmakers N, et al. The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One. 2012;7:e45142.","journal-title":"PLoS One"},{"key":"756_CR33","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1042\/CS20181064","volume":"133","author":"W Liao","year":"2019","unstructured":"Liao W, Ning Y, Xu HJ, Zou WZ, Hu J, Liu XZ, et al. BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head. Clin Sci (Lond). 2019;133:1955\u201375.","journal-title":"Clin Sci (Lond)"},{"key":"756_CR34","doi-asserted-by":"publisher","first-page":"8055","DOI":"10.1096\/fj.201801618RRR","volume":"33","author":"HJ Xu","year":"2019","unstructured":"Xu HJ, Liao W, Liu XZ, Hu J, Zou WZ, Ning Y, et al. Down-regulation of exosomal microRNA-224-3p derived from bone marrow-derived mesenchymal stem cells potentiates angiogenesis in traumatic osteonecrosis of the femoral head. FASEB J. 2019;33:8055\u201368.","journal-title":"FASEB J"},{"key":"756_CR35","doi-asserted-by":"publisher","first-page":"18435","DOI":"10.1002\/jcb.29161","volume":"120","author":"S Xiang","year":"2019","unstructured":"Xiang S, Li Z, Weng X. The role of lncRNA RP11-154D6 in steroid-induced osteonecrosis of the femoral head through BMSC regulation. J Cell Biochem. 2019;120:18435\u201345.","journal-title":"J Cell Biochem"},{"key":"756_CR36","doi-asserted-by":"publisher","first-page":"8777","DOI":"10.18632\/aging.102264","volume":"11","author":"X Yang","year":"2019","unstructured":"Yang X, Yang J, Lei P, Wen T. LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c\/SATB2 axis. Aging (Albany NY). 2019;11:8777\u201391.","journal-title":"Aging (Albany NY)"},{"key":"756_CR37","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1002\/stem.103","volume":"27","author":"F Granero Molto","year":"2009","unstructured":"Granero Molto F, Weis JA, Miga MI, Landis B, Myers TJ, O\u2019Rear L, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells. 2009;27:1887\u201398.","journal-title":"Stem Cells"},{"key":"756_CR38","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1136\/bmj.289.6444.539","volume":"289","author":"PG Newrick","year":"1984","unstructured":"Newrick PG, Langton-Hewer R. Motor neurone disease: can we do better? A study of 42 patients. Br Med J (Clin Res Ed). 1984;289:539\u201342.","journal-title":"Br Med J (Clin Res Ed)"},{"key":"756_CR39","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gpb.2012.12.002","volume":"11","author":"Y Niu","year":"2013","unstructured":"Niu Y, Zhao X, Wu YS, Li MM, Wang XJ, Yang YG. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics. 2013;11:8\u201317.","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"756_CR40","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1038\/s41467-019-10669-0","volume":"10","author":"S Yang","year":"2019","unstructured":"Yang S, Wei JB, Cui YH, Parka G, Shah P, Deng Y, et al. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019;10:2782\u201395.","journal-title":"Nat Commun"},{"key":"756_CR41","doi-asserted-by":"publisher","first-page":"21441","DOI":"10.1073\/pnas.2000516117","volume":"117","author":"YR Xiao","year":"2020","unstructured":"Xiao YR, Thakkar KN, Zhao HJ, Broughton J, Li Y, Seoane JA, et al. The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proc Natl Acad Sci USA. 2020;117:21441\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"756_CR42","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.apsb.2018.06.001","volume":"8","author":"Y Niu","year":"2018","unstructured":"Niu Y, Wan A, Lin Z, Lu X, Wan GN. (6)-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development. Acta Pharm Sin B. 2018;8:833\u201343.","journal-title":"Acta Pharm Sin B"},{"key":"756_CR43","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s13679-015-0143-1","volume":"4","author":"JR Speakman","year":"2015","unstructured":"Speakman JR. The \u2018Fat Mass and Obesity Related\u2019 (FTO) gene: mechanisms of impact on obesity and energy balance. Curr Obes Rep. 2015;4:73\u201391.","journal-title":"Curr Obes Rep"},{"key":"756_CR44","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.tig.2010.02.006","volume":"26","author":"KA Fawcett","year":"2010","unstructured":"Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet. 2010;26:266\u201374.","journal-title":"Trends Genet"},{"key":"756_CR45","doi-asserted-by":"publisher","first-page":"615","DOI":"10.7150\/ijbs.17051","volume":"13","author":"QY Yang","year":"2017","unstructured":"Yang QY, Xiao TC, Guo J, Su ZQ. Complex relationship between obesity and the fat mass and obesity locus. Int J Biol Sci. 2017;13:615\u201329.","journal-title":"Int J Biol Sci"},{"key":"756_CR46","doi-asserted-by":"publisher","first-page":"6385","DOI":"10.1111\/jcmm.15284","volume":"24","author":"B Mi","year":"2020","unstructured":"Mi B, Xiong Y, Yan C, Chen L, Xue H, Panayi AC, et al. Methyltransferase-like 3-mediated N6-methyladenosine modification of miR-7212-5p drives osteoblast differentiation and fracture healing. J Cell Mol Med. 2020;24:6385\u201396.","journal-title":"J Cell Mol Med"},{"key":"756_CR47","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.3390\/ijms21051660","volume":"21","author":"D Li","year":"2020","unstructured":"Li D, Cai L, Meng R, Feng Z, Xu Q. METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export. Int J Mol Sci. 2020;21:1660\u201377.","journal-title":"Int J Mol Sci"},{"key":"756_CR48","doi-asserted-by":"publisher","first-page":"14515","DOI":"10.1074\/jbc.M700030200","volume":"282","author":"S Kang","year":"2007","unstructured":"Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, Macdougald OA. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT\/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem. 2007;282:14515\u201324.","journal-title":"J Biol Chem"},{"key":"756_CR49","first-page":"9","volume":"33","author":"G Viccica","year":"2010","unstructured":"Viccica G, Francucci CM, Marcocci C. The role of PPARgamma for the osteoblastic differentiation. J Endocrinol Invest. 2010;33:9\u201312.","journal-title":"J Endocrinol Invest"},{"key":"756_CR50","doi-asserted-by":"publisher","first-page":"7443","DOI":"10.1038\/ncomms8443","volume":"6","author":"DP Marciano","year":"2015","unstructured":"Marciano DP, Kuruvilla DS, Boregowda SV, Asteian A, Hughes TS, Garcia-Ordonez R, et al. Pharmacological repression of PPARgamma promotes osteogenesis. Nat Commun. 2015;6:7443\u201358.","journal-title":"Nat Commun"},{"key":"756_CR51","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.2337\/db07-1700","volume":"57","author":"AF Marvelle","year":"2008","unstructured":"Marvelle AF, Lange LA, Qin L, Adair LS, Mohlke KL. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort. Diabetes. 2008;57:1987\u201391.","journal-title":"Diabetes"},{"key":"756_CR52","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","volume":"16","author":"X Wang","year":"2020","unstructured":"Wang X, Wu R, Liu Y, Zhao Y, Bi Z, Yao Y, et al. m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7. Autophagy. 2020;16:1221\u201335.","journal-title":"Autophagy"},{"key":"756_CR53","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","volume":"163","author":"KD Meyer","year":"2015","unstructured":"Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, et al. 5\u2019 UTR m6A promotes Cap-independent translation. Cell. 2015;163:999\u20131010.","journal-title":"Cell"},{"key":"756_CR54","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","volume":"505","author":"X Wang","year":"2014","unstructured":"Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, et al. N(6)-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117\u201320.","journal-title":"Nature"},{"key":"756_CR55","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.bone.2007.06.017","volume":"41","author":"TH Lin","year":"2007","unstructured":"Lin TH, Yang RS, Tang CH, Lin CP, Fu WM. PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. Bone. 2007;41:562\u201374.","journal-title":"Bone"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-021-00756-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-021-00756-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-021-00756-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T09:08:19Z","timestamp":1651482499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-021-00756-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["756"],"URL":"https:\/\/doi.org\/10.1038\/s41401-021-00756-8","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"assertion":[{"value":"31 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}