{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:16:20Z","timestamp":1791951380045,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1038\/s41401-022-00941-3","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T08:03:08Z","timestamp":1660118588000},"page":"308-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1\u03b1\/NF-\u03baB\/inflammation pathway"],"prefix":"10.1038","volume":"44","author":[{"given":"Dai-gang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-yao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-qun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-she","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-feng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-jun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-zhong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou-ling","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-dong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-hong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"941_CR1","doi-asserted-by":"publisher","first-page":"549038","DOI":"10.3389\/fneur.2020.549038","volume":"11","author":"L Al-Hassany","year":"2020","unstructured":"Al-Hassany L, Haas J, Piccininni M, Kurth T, Maassen Van Den Brink A, Rohmann JL. Giving researchers a headache\u2014sex and gender differences in migraine. Front Neurol. 2020;11:549038.","journal-title":"Front Neurol"},{"key":"941_CR2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1080\/00325481.2020.1767402","volume":"132","author":"W Cooper","year":"2020","unstructured":"Cooper W, Doty EG, Hochstetler H, Hake A, Martin V. The current state of acute treatment for migraine in adults in the United States. Postgrad Med. 2020;132:581\u20139.","journal-title":"Postgrad Med"},{"key":"941_CR3","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1111\/head.14171","volume":"61","author":"JA Hranilovich","year":"2021","unstructured":"Hranilovich JA, Kaiser EA, Pace A, Barber M, Ziplow J. Headache in transgender and gender-diverse patients: a narrative review. Headache 2021;61:1040\u201350.","journal-title":"Headache"},{"key":"941_CR4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S0140-6736(04)15440-8","volume":"363","author":"SD Silberstein","year":"2004","unstructured":"Silberstein SD. Migraine. Lancet 2004;363:381\u201391.","journal-title":"Lancet"},{"key":"941_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1056\/NEJMra010917","volume":"346","author":"PJ Goadsby","year":"2002","unstructured":"Goadsby PJ, Lipton RB, Ferrari MD. Migraine-current understanding and treatment. N Engl J Med. 2002;346:257\u201370.","journal-title":"N Engl J Med."},{"key":"941_CR6","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1046\/j.1468-2982.2000.00116.x","volume":"20","author":"KM Welch","year":"2000","unstructured":"Welch KM, Mathew NT, Stone P, Rosamond W, Saiers J, Gutterman D. Tolerability of sumatriptan: clinical trials and post-marketing experience. Cephalalgia. 2000;20:687\u201395.","journal-title":"Cephalalgia"},{"key":"941_CR7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/brain\/123.1.9","volume":"123","author":"P Tfelt-Hansen","year":"2000","unstructured":"Tfelt-Hansen P, Saxena PR, Dahlof C, Pascual J, Lainez M, Henry P, et al. Ergotamine in the acute treatment of migraine: a review and European consensus. Brain. 2000;123:9\u201318. Pt 1","journal-title":"Brain"},{"key":"941_CR8","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S1474-4422(21)00409-9","volume":"21","author":"L Al-Hassany","year":"2022","unstructured":"Al-Hassany L, Goadsby PJ, Danser AHJ, MaassenVanDenBrink A. Calcitonin gene-related peptide-targeting drugs for migraine: how pharmacology might inform treatment decisions. Lancet Neurol. 2022;21:284\u201394.","journal-title":"Lancet Neurol"},{"key":"941_CR9","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s40265-020-01301-3","volume":"80","author":"LJ Scott","year":"2020","unstructured":"Scott LJ. Rimegepant: first approval. Drugs. 2020;80:741\u20136.","journal-title":"Drugs"},{"key":"941_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0807-1","volume":"18","author":"M Deen","year":"2017","unstructured":"Deen M, Correnti E, Kamm K, Kelderman T, Papetti L, Rubio-Beltr\u00e1n E, et al. Blocking CGRP in migraine patients\u2014a review of pros and cons. J Headache Pain. 2017;18:96.","journal-title":"J Headache Pain"},{"key":"941_CR11","doi-asserted-by":"publisher","first-page":"114291","DOI":"10.1016\/j.ab.2021.114291","volume":"634","author":"X Guo","year":"2021","unstructured":"Guo X, Yu C, Wang L, Zhang F, Wang K, Huang J, et al. Development and validation of a reporter gene assay for bioactivity determination of anti-CGRP monoclonal antibodies. Anal Biochem. 2021;634:114291.","journal-title":"Anal Biochem"},{"key":"941_CR12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1055\/s-0042-111694","volume":"142","author":"C Gaul","year":"2017","unstructured":"Gaul C, Messlinger K, Holle-Lee D, Neeb L. Pathophysiology of headaches. Dtsch Med Wochenschr. 2017;142:402\u20138.","journal-title":"Dtsch Med Wochenschr"},{"key":"941_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1459-7","volume":"16","author":"W He","year":"2019","unstructured":"He W, Long T, Pan Q, Zhang S, Zhang Y, Zhang D, et al. Microglial NLRP3 inflammasome activation mediates IL-1beta release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model. J Neuroinflammation. 2019;16:78.","journal-title":"J Neuroinflammation"},{"key":"941_CR14","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/pme.12690","volume":"16","author":"N Chen","year":"2015","unstructured":"Chen N, Zhang J, Wang P, Guo J, Zhou M, He L. Functional alterations of pain processing pathway in migraine patients with cutaneous allodynia. Pain Med. 2015;16:1211\u201320.","journal-title":"Pain Med"},{"issue":"Suppl 1","key":"941_CR15","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s10072-015-2141-1","volume":"36","author":"C Lovati","year":"2015","unstructured":"Lovati C, Giani L, Castoldi D, Mariotti D\u2019Alessandro C, DeAngeli F, Capiluppi E, et al. Osmophobia in allodynic migraineurs: cause or consequence of central sensitization? Neurol Sci. 2015;36(Suppl 1):145\u20137.","journal-title":"Neurol Sci"},{"key":"941_CR16","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ana.21211","volume":"63","author":"RB Lipton","year":"2008","unstructured":"Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, et al. Cutaneous allodynia in the migraine population. Ann Neurol. 2008;63:148\u201358.","journal-title":"Ann Neurol"},{"key":"941_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0304-3940(02)00967-9","volume":"333","author":"M de Tommaso","year":"2002","unstructured":"de Tommaso M, Guido M, Libro G, Losito L, Sciruicchio V, Monetti C, et al. Abnormal brain processing of cutaneous pain in migraine patients during the attack. Neurosci Lett. 2002;333:29\u201332.","journal-title":"Neurosci Lett"},{"key":"941_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/1876386300902010011","volume":"2","author":"YJ Gao","year":"2009","unstructured":"Gao YJ, Ji RR. c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury? Open Pain J. 2009;2:11\u20137.","journal-title":"Open Pain J"},{"key":"941_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/head.12725","volume":"56","author":"JM Borkum","year":"2016","unstructured":"Borkum JM. Migraine triggers and oxidative stress: a narrative review and synthesis. Headache. 2016;56:12\u201335.","journal-title":"Headache"},{"key":"941_CR20","doi-asserted-by":"crossref","unstructured":"Goschorska M, Gutowska I, Baranowska-Bosiacka I, Barczak K, Chlubek D. The use of antioxidants in the treatment of migraine. Antioxidants. 2020;9:116.","DOI":"10.3390\/antiox9020116"},{"key":"941_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuroscience.2020.10.019","volume":"451","author":"Q Gong","year":"2020","unstructured":"Gong Q, Lin Y, Lu Z, Xiao Z. Microglia-astrocyte cross talk through IL-18\/IL-18R signaling modulates migraine-like behavior in experimental models of migraine. Neuroscience. 2020;451:207\u201315.","journal-title":"Neuroscience"},{"key":"941_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01353-0","volume":"22","author":"SE Erdener","year":"2021","unstructured":"Erdener SE, Kaya Z, Dalkara T. Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine. J Headache Pain. 2021;22:138.","journal-title":"J Headache Pain"},{"key":"941_CR23","doi-asserted-by":"publisher","first-page":"e105319","DOI":"10.1371\/journal.pone.0105319","volume":"9","author":"E Nagata","year":"2014","unstructured":"Nagata E, Fujii N, Hosomichi K, Mitsunaga S, Suzuki Y, Mashimo Y, et al. Possible association between dysfunction of vitamin D binding protein (GC Globulin) and migraine attacks. PLoS One. 2014;9:e105319.","journal-title":"PLoS One"},{"key":"941_CR24","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1007\/s10072-018-3493-0","volume":"39","author":"F Martami","year":"2018","unstructured":"Martami F, Razeghi Jahromi S, Togha M, Ghorbani Z, Seifishahpar M, Saidpour A. The serum level of inflammatory markers in chronic and episodic migraine: a case-control study. Neurol Sci. 2018;39:1741\u20139.","journal-title":"Neurol Sci"},{"key":"941_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s10072-014-2010-3","volume":"36","author":"F Wang","year":"2015","unstructured":"Wang F, He Q, Ren Z, Li F, Chen W, Lin X, et al. Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine. Neurol Sci. 2015;36:535\u201340.","journal-title":"Neurol Sci"},{"key":"941_CR26","first-page":"1111","volume":"15","author":"E Uzar","year":"2011","unstructured":"Uzar E, Evliyaoglu O, Yucel Y, Ugur Cevik M, Acar A, Guzel I, et al. Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Eur Rev Med Pharmacol Sci. 2011;15:1111\u20136.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"941_CR27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","volume":"30","author":"WG Kaelin Jr","year":"2008","unstructured":"Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30:393\u2013402.","journal-title":"Mol Cell"},{"key":"941_CR28","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3389\/fphar.2020.01191","volume":"11","author":"G Long","year":"2020","unstructured":"Long G, Chen H, Wu M, Li Y, Gao L, Huang S, et al. Antianemia drug roxadustat (FG-4592) protects against doxorubicin-induced cardiotoxicity by targeting antiapoptotic and antioxidative pathways. Front Pharmacol. 2020;11:1191.","journal-title":"Front Pharmacol"},{"key":"941_CR29","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1042\/CS20171625","volume":"132","author":"Y Yang","year":"2018","unstructured":"Yang Y, Yu X, Zhang Y, Ding G, Zhu C, Huang S, et al. Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury. Clin Sci (Lond). 2018;132:825\u201338.","journal-title":"Clin Sci (Lond)"},{"key":"941_CR30","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1080\/1028415X.2015.1133106","volume":"20","author":"S Kakio","year":"2017","unstructured":"Kakio S, Funakoshi-Tago M, Kobata K, Tamura H. Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells. Nutr Neurosci. 2017;20:336\u201342.","journal-title":"Nutr Neurosci"},{"key":"941_CR31","first-page":"4670834","volume":"2018","author":"H Wang","year":"2018","unstructured":"Wang H, Huo X, Chen H, Li B, Liu J, Ma W, et al. Hydrogen-rich saline activated autophagy via HIF-1\u03b1 pathways in neuropathic pain model. Biomed Res Int. 2018;2018:4670834.","journal-title":"Biomed Res Int"},{"key":"941_CR32","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1002\/cne.23072","volume":"520","author":"YL Hsieh","year":"2012","unstructured":"Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ, Hong CZ. Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1). J Comp Neurol. 2012;520:2903\u201316.","journal-title":"J Comp Neurol"},{"key":"941_CR33","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1159\/000504850","volume":"6","author":"ZL Li","year":"2020","unstructured":"Li ZL, Tu Y, Liu BC. Treatment of renal anemia with roxadustat: advantages and achievement. Kidney Dis. 2020;6:65\u201373.","journal-title":"Kidney Dis"},{"key":"941_CR34","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1007\/s13311-019-00807-3","volume":"17","author":"G Li","year":"2020","unstructured":"Li G, Zhao M, Cheng X, Zhao T, Feng Z, Zhao Y, et al. FG-4592 improves depressive-like behaviors through HIF-1-mediated neurogenesis and synapse plasticity in rats. Neurotherapeutics. 2020;17:664\u201375.","journal-title":"Neurotherapeutics"},{"key":"941_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.brainres.2015.12.017","volume":"1632","author":"K Wu","year":"2016","unstructured":"Wu K, Zhou K, Wang Y, Zhou Y, Tian N, Wu Y, et al. Stabilization of HIF-1\u03b1 by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. Brain Res. 2016;1632:19\u201326.","journal-title":"Brain Res"},{"key":"941_CR36","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1080\/0886022X.2021.1915801","volume":"43","author":"AF Miao","year":"2021","unstructured":"Miao AF, Liang JX, Yao L, Han JL, Zhou LJ. Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against renal ischemia\/reperfusion injury by inhibiting inflammation. Ren Fail. 2021;43:803\u201310.","journal-title":"Ren Fail"},{"key":"941_CR37","doi-asserted-by":"publisher","first-page":"103506","DOI":"10.1016\/j.resp.2020.103506","volume":"281","author":"F Han","year":"2020","unstructured":"Han F, Wu G, Han S, Li Z, Jia Y, Bai L, et al. Hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat (FG-4592) alleviates sepsis-induced acute lung injury. Respir Physiol Neurobiol. 2020;281:103506.","journal-title":"Respir Physiol Neurobiol"},{"key":"941_CR38","doi-asserted-by":"publisher","first-page":"E2516","DOI":"10.1073\/pnas.1523005113","volume":"113","author":"G Hoppe","year":"2016","unstructured":"Hoppe G, Yoon S, Gopalan B, Savage AR, Brown R, Case K, et al. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity. Proc Natl Acad Sci USA. 2016;113:E2516\u20132525.","journal-title":"Proc Natl Acad Sci USA"},{"key":"941_CR39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.pain.2013.10.004","volume":"155","author":"AA Pradhan","year":"2014","unstructured":"Pradhan AA, Smith ML, McGuire B, Tarash I, Evans CJ, Charles A. Characterization of a novel model of chronic migraine. Pain. 2014;155:269\u201374.","journal-title":"Pain"},{"key":"941_CR40","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","volume":"10","author":"JR Deuis","year":"2017","unstructured":"Deuis JR, Dvorakova LS, Vetter I. Methods used to evaluate pain behaviors in rodents. Front Mol Neurosci. 2017;10:284.","journal-title":"Front Mol Neurosci"},{"key":"941_CR41","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11011-020-00604-4","volume":"36","author":"L Singh","year":"2021","unstructured":"Singh L, Kaur A, Garg S, Bhatti R. Skimmetin\/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. Metab Brain Dis. 2021;36:111\u201321.","journal-title":"Metab Brain Dis"},{"key":"941_CR42","doi-asserted-by":"publisher","first-page":"e104458","DOI":"10.1371\/journal.pone.0104458","volume":"9","author":"MS Minett","year":"2014","unstructured":"Minett MS, Eijkelkamp N, Wood JN. Significant determinants of mouse pain behaviour. PLoS One. 2014;9:e104458.","journal-title":"PLoS One"},{"key":"941_CR43","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.neuropharm.2018.02.026","volume":"133","author":"Y Tang","year":"2018","unstructured":"Tang Y, Liu S, Shu H, Xing Y, Tao F. AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain. Neuropharmacology. 2018;133:462\u20139.","journal-title":"Neuropharmacology"},{"key":"941_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01736-1","volume":"17","author":"G Casili","year":"2020","unstructured":"Casili G, Lanza M, Filippone A, Campolo M, Paterniti I, Cuzzocrea S, et al. Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice. J Neuroinflammation. 2020;17:59.","journal-title":"J Neuroinflammation"},{"key":"941_CR45","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/FJC.0000000000000642","volume":"73","author":"J Ma","year":"2019","unstructured":"Ma J, Zhao D, Wang X, Ma C, Feng K, Zhang S, et al. LongShengZhi capsule reduces established atherosclerotic lesions in apoE-deficient mice by ameliorating hepatic lipid metabolism and inhibiting inflammation. J Cardiovasc Pharmacol. 2019;73:105\u201317.","journal-title":"J Cardiovasc Pharmacol"},{"key":"941_CR46","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jneumeth.2013.03.004","volume":"218","author":"V Pinskiy","year":"2013","unstructured":"Pinskiy V, Tolpygo AS, Jones J, Weber K, Franciotti N, Mitra PP. A low-cost technique to cryo-protect and freeze rodent brains, precisely aligned to stereotaxic coordinates for whole-brain cryosectioning. J Neurosci Methods. 2013;218:206\u201313.","journal-title":"J Neurosci Methods"},{"key":"941_CR47","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pharmthera.2010.01.002","volume":"126","author":"YJ Gao","year":"2010","unstructured":"Gao YJ, Ji RR. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther. 2010;126:56\u201368.","journal-title":"Pharmacol Ther"},{"key":"941_CR48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/ajh.26397","volume":"97","author":"DH Henry","year":"2022","unstructured":"Henry DH, Glaspy J, Harrup R, Mittelman M, Zhou A, Carraway HE, et al. Roxadustat for the treatment of anemia in patients with lower-risk myelodysplastic syndrome: Open-label, dose-selection, lead-in stage of a phase 3 study. Am J Hematol. 2022;97:174\u201384.","journal-title":"Am J Hematol"},{"issue":"Suppl 1","key":"941_CR49","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000085060","volume":"53","author":"PJ Goadsby","year":"2005","unstructured":"Goadsby PJ. Migraine, allodynia, sensitisation and all of that. Eur Neurol. 2005;53(Suppl 1):10\u20136.","journal-title":"Eur Neurol"},{"key":"941_CR50","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1177\/03331024211014633","volume":"41","author":"AJ Wilkins","year":"2021","unstructured":"Wilkins AJ, Haigh SM, Mahroo OA, Plant GT. Photophobia in migraine: A symptom cluster? Cephalalgia. 2021;41:1240\u20138.","journal-title":"Cephalalgia"},{"key":"941_CR51","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s002210100809","volume":"140","author":"S Sugiyo","year":"2001","unstructured":"Sugiyo S, Yonehara N, Appenteng K, Nokubi T, Shigenaga Y, Takemura M. Effects of intrathecal c-fos antisense oligodeoxynucleotide on adjuvant-induced thermal hyperalgesia. Exp Brain Res. 2001;140:198\u2013205.","journal-title":"Exp Brain Res"},{"key":"941_CR52","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1523\/JNEUROSCI.22-02-00478.2002","volume":"22","author":"RR Ji","year":"2002","unstructured":"Ji RR, Befort K, Brenner GJ, Woolf CJ. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci. 2002;22:478\u201385.","journal-title":"J Neurosci"},{"key":"941_CR53","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/16040","volume":"2","author":"RR Ji","year":"1999","unstructured":"Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci. 1999;2:1114\u20139.","journal-title":"Nat Neurosci"},{"key":"941_CR54","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00281-018-0676-y","volume":"40","author":"R Ramachandran","year":"2018","unstructured":"Ramachandran R. Neurogenic inflammation and its role in migraine. Semin Immunopathol. 2018;40:301\u201314.","journal-title":"Semin Immunopathol"},{"key":"941_CR55","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1177\/0333102415598757","volume":"36","author":"M Ceylan","year":"2016","unstructured":"Ceylan M, Bayraktutan OF, Becel S, Atis O, Yalcin A, Kotan D. Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: Association with migraine characteristics. Cephalalgia. 2016;36:518\u201325.","journal-title":"Cephalalgia"},{"key":"941_CR56","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nrd4334","volume":"13","author":"RR Ji","year":"2014","unstructured":"Ji RR, Xu ZZ, Gao YJ. Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov. 2014;13:533\u201348.","journal-title":"Nat Rev Drug Discov"},{"key":"941_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-6","volume":"8","author":"J Yan","year":"2012","unstructured":"Yan J, Melemedjian OK, Price TJ, Dussor G. Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6). Mol Pain. 2012;8:6.","journal-title":"Mol Pain"},{"key":"941_CR58","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.18632\/aging.103031","volume":"12","author":"G Yao","year":"2020","unstructured":"Yao G, Man YH, Li AR, Guo Y, Dai Y, Wang P, et al. NO up-regulates migraine-related CGRP via activation of an Akt\/GSK-3beta\/NF-kappaB signaling cascade in trigeminal ganglion neurons. Aging. 2020;12:6370\u201384.","journal-title":"Aging"},{"key":"941_CR59","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11010-019-03603-x","volume":"461","author":"T Lai","year":"2019","unstructured":"Lai T, Chen L, Chen X, He J, Lv P, Ge H. Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK\/NF-small ka, CyrillicB signaling. Mol Cell Biochem. 2019;461:205\u201312.","journal-title":"Mol Cell Biochem"},{"key":"941_CR60","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.lfs.2016.03.005","volume":"151","author":"XL Liu","year":"2016","unstructured":"Liu XL, Lu J, Xing J. Stabilization of HIF-1alpha modulates VEGF and caspase-3 in the hippocampus of rats following transient global ischemia induced by asphyxial cardiac arrest. Life Sci. 2016;151:243\u20139.","journal-title":"Life Sci"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-022-00941-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-022-00941-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-022-00941-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:13:31Z","timestamp":1675210411000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-022-00941-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["941"],"URL":"https:\/\/doi.org\/10.1038\/s41401-022-00941-3","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,10]]},"assertion":[{"value":"30 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}