{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:34:22Z","timestamp":1790033662389,"version":"4.0.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1038\/s41401-024-01317-5","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T03:01:50Z","timestamp":1718593310000},"page":"2277-2289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E\u2013deficient mice"],"prefix":"10.1038","volume":"45","author":[{"given":"Meng-yun","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-jing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-ming","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-bo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-miao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-ping","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo-wen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"1317_CR1","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/S0140-6736(19)30041-8","volume":"393","author":"Collaborators GBDD.","year":"2019","unstructured":"Collaborators GBDD. Health effects of dietary risks in 195 countries, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019;393:1958\u201372.","journal-title":"Lancet"},{"key":"1317_CR2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41392-022-01027-6","volume":"7","author":"SR Ma","year":"2022","unstructured":"Ma SR, Tong Q, Lin Y, Pan LB, Fu J, Peng R, et al. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. Signal Transduct Target Ther. 2022;7:207.","journal-title":"Signal Transduct Target Ther"},{"key":"1317_CR3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","volume":"592","author":"P Libby","year":"2021","unstructured":"Libby P. The changing landscape of atherosclerosis. Nature. 2021;592:524\u201333.","journal-title":"Nature"},{"key":"1317_CR4","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1161\/circ.131.suppl_2.o29","volume":"131","author":"D Mozaffarian","year":"2015","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association. Circulation. 2015;131:e29\u2013322.","journal-title":"Circulation"},{"key":"1317_CR5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","volume":"19","author":"RA Koeth","year":"2013","unstructured":"Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576\u201385.","journal-title":"Nat Med"},{"key":"1317_CR6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","volume":"2","author":"KB Pandey","year":"2009","unstructured":"Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev. 2009;2:270\u20138.","journal-title":"Oxid Med Cell Longev"},{"key":"1317_CR7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trsl.2016.05.003","volume":"176","author":"S Xu","year":"2016","unstructured":"Xu S, Koroleva M, Yin M, Jin ZG. Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells. Transl Res. 2016;176:18\u201328.e2","journal-title":"Transl Res"},{"key":"1317_CR8","doi-asserted-by":"crossref","first-page":"11525","DOI":"10.1073\/pnas.1613121113","volume":"113","author":"KC Wang","year":"2016","unstructured":"Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, et al. Flow-dependent YAP\/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci USA 2016;113:11525\u201330.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1317_CR9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature20602","volume":"540","author":"L Wang","year":"2016","unstructured":"Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, et al. Integrin-YAP\/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 2016;540:579\u201382.","journal-title":"Nature"},{"key":"1317_CR10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","volume":"88","author":"S Ma","year":"2019","unstructured":"Ma S, Meng Z, Chen R, Guan KL. The Hippo pathway: biology and pathophysiology. Annu Rev Biochem. 2019;88:577\u2013604.","journal-title":"Annu Rev Biochem"},{"key":"1317_CR11","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI122440","volume":"129","author":"B Li","year":"2019","unstructured":"Li B, He J, Lv H, Liu Y, Lv X, Zhang C, et al. c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow. J Clin Invest. 2019;129:1167\u201379.","journal-title":"J Clin Invest"},{"key":"1317_CR12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122505","volume":"306","author":"HC Huang","year":"2024","unstructured":"Huang HC, Wang TY, Rousseau J, Orlando M, Mungaray M, Michaud C, et al. Biomimetic nanodrug targets inflammation and suppresses YAP\/TAZ to ameliorate atherosclerosis. Biomaterials. 2024;306:122505.","journal-title":"Biomaterials"},{"key":"1317_CR13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.molmed.2021.04.009","volume":"27","author":"D D\u2019Amico","year":"2021","unstructured":"D\u2019Amico D, Andreux PA, Valdes P, Singh A, Rinsch C, Auwerx J. Impact of the natural compound urolithin a on health, disease, and aging. Trends Mol Med. 2021;27:687\u201399.","journal-title":"Trends Mol Med"},{"key":"1317_CR14","volume":"3","author":"A Singh","year":"2022","unstructured":"Singh A, D\u2019Amico D, Andreux PA, Fouassier AM, Blanco-Bose W, Evans M, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3:100633.","journal-title":"Cell Rep Med"},{"key":"1317_CR15","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","volume":"22","author":"D Ryu","year":"2016","unstructured":"Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Felix AA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016;22:879\u201388.","journal-title":"Nat Med"},{"key":"1317_CR16","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s43587-023-00473-3","volume":"3","author":"M Girotra","year":"2023","unstructured":"Girotra M, Chiang YH, Charmoy M, Ginefra P, Hope HC, Bataclan C, et al. Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems. Nat Aging. 2023;3:1057\u201366.","journal-title":"Nat Aging"},{"key":"1317_CR17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jnutbio.2009.04.012","volume":"21","author":"M Larrosa","year":"2010","unstructured":"Larrosa M, Gonzalez-Sarrias A, Yanez-Gascon MJ, Selma MV, Azorin-Ortuno M, Toti S, et al. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J Nutr Biochem. 2010;21:717\u201325.","journal-title":"J Nutr Biochem"},{"key":"1317_CR18","volume":"10","author":"R Singh","year":"2019","unstructured":"Singh R, Chandrashekharappa S, Bodduluri SR, Baby BV, Hegde B, Kotla NG, et al. Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway. Nat Commun. 2019;10:89.","journal-title":"Nat Commun"},{"key":"1317_CR19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112479","volume":"250","author":"B Tuohetaerbaike","year":"2020","unstructured":"Tuohetaerbaike B, Zhang Y, Tian Y, Zhang NN, Kang J, Mao X, et al. Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and AKT\/mTOR signaling pathway. J Ethnopharmacol. 2020;250:112479.","journal-title":"J Ethnopharmacol"},{"key":"1317_CR20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12933-017-0561-3","volume":"16","author":"M Savi","year":"2017","unstructured":"Savi M, Bocchi L, Mena P, Dall\u2019Asta M, Crozier A, Brighenti F, et al. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol. 2017;16:80.","journal-title":"Cardiovasc Diabetol"},{"key":"1317_CR21","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1039\/C9FO02471A","volume":"11","author":"QA Han","year":"2020","unstructured":"Han QA, Su D, Shi C, Liu P, Wang Y, Zhu B, et al. Urolithin A attenuated ox-LDL-induced cholesterol accumulation in macrophages partly through regulating miR-33a and ERK\/AMPK\/SREBP1 signaling pathways. Food Funct. 2020;11:3432\u201340.","journal-title":"Food Funct"},{"key":"1317_CR22","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/mnfr.201500827","volume":"60","author":"QA Han","year":"2016","unstructured":"Han QA, Yan C, Wang L, Li G, Xu Y, Xia X. Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK\/PPAR-gamma pathway. Mol Nutr Food Res. 2016;60:1933\u201343.","journal-title":"Mol Nutr Food Res"},{"key":"1317_CR23","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2019.101006","volume":"77","author":"X Feng","year":"2020","unstructured":"Feng X, Zhang L, Xu S, Shen AZ. ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: an updated review. Prog Lipid Res. 2020;77:101006.","journal-title":"Prog Lipid Res"},{"key":"1317_CR24","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1093\/eurheartj\/ehab551","volume":"42","author":"HN Ginsberg","year":"2021","unstructured":"Ginsberg HN, Packard CJ, Chapman MJ, Boren J, Aguilar-Salinas CA, Averna M, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J. 2021;42:4791\u2013806.","journal-title":"Eur Heart J"},{"key":"1317_CR25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41573-021-00198-1","volume":"20","author":"O Soehnlein","year":"2021","unstructured":"Soehnlein O, Libby P. Targeting inflammation in atherosclerosis - from experimental insights to the clinic. Nat Rev Drug Discov. 2021;20:589\u2013610.","journal-title":"Nat Rev Drug Discov"},{"key":"1317_CR26","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","volume":"73","author":"S Xu","year":"2021","unstructured":"Xu S, Ilyas I, Little PJ, Li H, Kamato D, Zheng X, et al. Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies. Pharmacol Rev. 2021;73:924\u201367.","journal-title":"Pharmacol Rev"},{"key":"1317_CR27","volume":"175","author":"X Wu","year":"2022","unstructured":"Wu X, Xu M, Liu Z, Zhang Z, Liu Y, Luo S, et al. Pharmacological inhibition of IRAK1 and IRAK4 prevents endothelial inflammation and atherosclerosis in ApoE(-\/-) mice. Pharmacol Res. 2022;175:106043.","journal-title":"Pharmacol Res"},{"key":"1317_CR28","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1093\/eurheartj\/ehz303","volume":"40","author":"S Xu","year":"2019","unstructured":"Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, et al. The novel coronary artery disease risk gene JCAD\/KIAA1462 promotes endothelial dysfunction and atherosclerosis. Eur Heart J. 2019;40:2398\u2013408.","journal-title":"Eur Heart J"},{"key":"1317_CR29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.ATV.18.5.677","volume":"18","author":"O Traub","year":"1998","unstructured":"Traub O, Berk BC. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol. 1998;18:677\u201385.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1317_CR30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0092-8674(90)90230-C","volume":"62","author":"L Osborn","year":"1990","unstructured":"Osborn L. Leukocyte adhesion to endothelium in inflammation. Cell. 1990;62:3\u20136.","journal-title":"Cell"},{"key":"1317_CR31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","volume":"2","author":"Q Li","year":"2002","unstructured":"Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2:725\u201334.","journal-title":"Nat Rev Immunol"},{"key":"1317_CR32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","volume":"7","author":"P Kong","year":"2022","unstructured":"Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M. Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther. 2022;7:131.","journal-title":"Signal Transduct Target Ther"},{"key":"1317_CR33","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132:344\u201362.","journal-title":"Cell"},{"key":"1317_CR34","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.ajpath.2013.01.022","volume":"182","author":"B Mallavia","year":"2013","unstructured":"Mallavia B, Recio C, Oguiza A, Ortiz-Munoz G, Lazaro I, Lopez-Parra V, et al. Peptide inhibitor of NF-kappaB translocation ameliorates experimental atherosclerosis. Am J Pathol. 2013;182:1910\u201321.","journal-title":"Am J Pathol"},{"key":"1317_CR35","doi-asserted-by":"crossref","first-page":"ra85","DOI":"10.1126\/scisignal.aab2820","volume":"9","author":"JP Pradere","year":"2016","unstructured":"Pradere JP, Hernandez C, Koppe C, Friedman RA, Luedde T, Schwabe RF. Negative regulation of NF-kappaB p65 activity by serine 536 phosphorylation. Sci Signal. 2016;9:ra85.","journal-title":"Sci Signal"},{"key":"1317_CR36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/cvr\/cvs143","volume":"95","author":"SC Bir","year":"2012","unstructured":"Bir SC, Xiong Y, Kevil CG, Luo J. Emerging role of PKA\/eNOS pathway in therapeutic angiogenesis for ischaemic tissue diseases. Cardiovasc Res. 2012;95:7\u201318.","journal-title":"Cardiovasc Res"},{"key":"1317_CR37","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00424-009-0767-7","volume":"459","author":"I Fleming","year":"2010","unstructured":"Fleming I. Molecular mechanisms underlying the activation of eNOS. Pflug Arch. 2010;459:793\u2013806.","journal-title":"Pflug Arch"},{"key":"1317_CR38","doi-asserted-by":"publisher","unstructured":"Ren LY, Shi LM, Zheng YT. Reference materials for improving reliability of multiomics profiling. Phenomics. 2024. https:\/\/doi.org\/10.1007\/s43657-023-00153-7","DOI":"10.1007\/s43657-023-00153-7"},{"key":"1317_CR39","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-020-00634-6","volume":"18","author":"S Marquard","year":"2020","unstructured":"Marquard S, Thomann S, Weiler SME, Bissinger M, Lutz T, Sticht C, et al. Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis. Cell Commun Signal. 2020;18:166.","journal-title":"Cell Commun Signal"},{"key":"1317_CR40","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.2174\/0929867043364595","volume":"11","author":"A Gils","year":"2004","unstructured":"Gils A, Declerck PJ. Plasminogen activator inhibitor-1. Curr Med Chem. 2004;11:2323\u201334.","journal-title":"Curr Med Chem"},{"key":"1317_CR41","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/j.1538-7836.2005.01420.x","volume":"3","author":"DE Vaughan","year":"2005","unstructured":"Vaughan DE. PAI-1 and atherothrombosis. J Thromb Haemost. 2005;3:1879\u201383.","journal-title":"J Thromb Haemost"},{"key":"1317_CR42","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.tips.2022.06.009","volume":"43","author":"I Ilyas","year":"2022","unstructured":"Ilyas I, Little PJ, Liu Z, Xu Y, Kamato D, Berk BC, et al. Mouse models of atherosclerosis in translational research. Trends Pharmacol Sci. 2022;43:920\u201339.","journal-title":"Trends Pharmacol Sci"},{"key":"1317_CR43","doi-asserted-by":"crossref","first-page":"e3000688","DOI":"10.1371\/journal.pbio.3000688","volume":"18","author":"B Xia","year":"2020","unstructured":"Xia B, Shi XC, Xie BC, Zhu MQ, Chen Y, Chu XY, et al. Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice. PLoS Biol. 2020;18:e3000688.","journal-title":"PLoS Biol"},{"key":"1317_CR44","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/CIRCRESAHA.122.322418","volume":"132","author":"W Chen","year":"2023","unstructured":"Chen W, Tumanov S, Stanley CP, Kong SMY, Nadel J, Vigder N, et al. Destabilization of atherosclerotic plaque by bilirubin deficiency. Circ Res. 2023;132:812\u201327.","journal-title":"Circ Res"},{"key":"1317_CR45","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1056\/NEJMoa035655","volume":"349","author":"FD Kolodgie","year":"2003","unstructured":"Kolodgie FD, Gold HK, Burke AP, Fowler DR, Kruth HS, Weber DK, et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med. 2003;349:2316\u201325.","journal-title":"N Engl J Med"},{"key":"1317_CR46","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","volume":"123","author":"K Kobiyama","year":"2018","unstructured":"Kobiyama K, Ley K. Atherosclerosis. Circ Res. 2018;123:1118\u201320.","journal-title":"Circ Res"},{"key":"1317_CR47","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/01.ATV.20.5.1262","volume":"20","author":"R Virmani","year":"2000","unstructured":"Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262\u201375.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1317_CR48","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(19)30035-3","volume":"18","author":"L Saba","year":"2019","unstructured":"Saba L, Saam T, Jager HR, Yuan C, Hatsukami TS, Saloner D, et al. Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications. Lancet Neurol. 2019;18:559\u201372.","journal-title":"Lancet Neurol"},{"key":"1317_CR49","doi-asserted-by":"crossref","first-page":"923","DOI":"10.2174\/187446721406211220144326","volume":"14","author":"K Tian","year":"2021","unstructured":"Tian K, Xu S. Natural products and cardiovascular diseases. Curr Mol Pharmacol. 2021;14:923\u201324.","journal-title":"Curr Mol Pharmacol"},{"key":"1317_CR50","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/270418","volume":"2013","author":"JC Espin","year":"2013","unstructured":"Espin JC, Larrosa M, Garcia-Conesa MT, Tomas-Barberan F. Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far. Evid Based Complement Altern Med. 2013;2013:270418.","journal-title":"Evid Based Complement Altern Med"},{"key":"1317_CR51","unstructured":"USFDA. Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Center for Drug Evaluation and Research, USFDA, US Department of Health and Human Services. http:\/\/www.fda.gov\/cder\/guidance\/index, 2005."},{"key":"1317_CR52","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101019","volume":"66","author":"R Garcia-Villalba","year":"2022","unstructured":"Garcia-Villalba R, Gimenez-Bastida JA, Cortes-Martin A, Avila-Galvez MA, Tomas-Barberan FA, Selma MV, et al. Urolithins: a comprehensive update on their metabolism, bioactivity, and associated gut microbiota. Mol Nutr Food Res. 2022;66:e2101019.","journal-title":"Mol Nutr Food Res"},{"key":"1317_CR53","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1161\/01.cir.0000437740.48606.d1","volume":"129","author":"RH Eckel","year":"2014","unstructured":"Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, et al. 2013 AHA\/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129:S76\u201399.","journal-title":"Circulation"},{"key":"1317_CR54","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1093\/jn\/131.8.2082","volume":"131","author":"M Kaplan","year":"2001","unstructured":"Kaplan M, Hayek T, Raz A, Coleman R, Dornfeld L, Vaya J, et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr. 2001;131:2082\u20139.","journal-title":"J Nutr"},{"key":"1317_CR55","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0140-6736(23)00215-5","volume":"401","author":"PM Ridker","year":"2023","unstructured":"Ridker PM, Bhatt DL, Pradhan AD, Glynn RJ, MacFadyen JG, Nissen SE, et al. Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials. Lancet. 2023;401:1293\u2013301.","journal-title":"Lancet"},{"key":"1317_CR56","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2023.107238","volume":"153","author":"PM Ridker","year":"2023","unstructured":"Ridker PM. Targeting residual inflammatory risk: The next frontier for atherosclerosis treatment and prevention. Vasc Pharmacol. 2023;153:107238.","journal-title":"Vasc Pharmacol"},{"key":"1317_CR57","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cmet.2023.06.011","volume":"35","author":"S Verma","year":"2023","unstructured":"Verma S, Mazer CD, Connelly KA. Inflammation and cholesterol at the crossroads of vascular risk. Cell Metab. 2023;35:1095\u201398.","journal-title":"Cell Metab"},{"key":"1317_CR58","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","volume":"383","author":"SM Nidorf","year":"2020","unstructured":"Nidorf SM, Fiolet ATL, Mosterd A, Eikelboom JW, Schut A, Opstal TSJ, et al. Colchicine in patients with chronic coronary disease. N Engl J Med. 2020;383:1838\u201347.","journal-title":"N Engl J Med"},{"key":"1317_CR59","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jacc.2023.05.055","volume":"82","author":"K Nelson","year":"2023","unstructured":"Nelson K, Fuster V, Ridker PM. Low-dose colchicine for secondary prevention of coronary artery disease: JACC review topic of the week. J Am Coll Cardiol. 2023;82:648\u201360.","journal-title":"J Am Coll Cardiol"},{"key":"1317_CR60","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.devcel.2022.02.004","volume":"57","author":"S Vaidyanathan","year":"2022","unstructured":"Vaidyanathan S, Salmi TM, Sathiqu RM, McConville MJ, Cox AG, Brown KK. YAP regulates an SGK1\/mTORC1\/SREBP-dependent lipogenic program to support proliferation and tissue growth. Dev Cell. 2022;57:719\u201331. e8","journal-title":"Dev Cell"},{"key":"1317_CR61","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1111\/jcmm.14262","volume":"23","author":"Z Shu","year":"2019","unstructured":"Shu Z, Gao Y, Zhang G, Zhou Y, Cao J, Wan D, et al. A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice. J Cell Mol Med. 2019;23:3616\u201328.","journal-title":"J Cell Mol Med"},{"key":"1317_CR62","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","volume":"20","author":"AC Doran","year":"2020","unstructured":"Doran AC, Yurdagul A Jr, Tabas I. Efferocytosis in health and disease. Nat Rev Immunol. 2020;20:254\u201367.","journal-title":"Nat Rev Immunol"},{"key":"1317_CR63","doi-asserted-by":"crossref","first-page":"eabb0319","DOI":"10.1126\/scitranslmed.abb0319","volume":"13","author":"P Luan","year":"2021","unstructured":"Luan P, D\u2019Amico D, Andreux PA, Laurila PP, Wohlwend M, Li H, et al. Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy. Sci Transl Med. 2021;13:eabb0319.","journal-title":"Sci Transl Med"},{"key":"1317_CR64","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","volume":"1","author":"PA Andreux","year":"2019","unstructured":"Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019;1:595\u2013603.","journal-title":"Nat Metab"},{"key":"1317_CR65","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s43657-023-00095-0","volume":"3","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhong W, Li X, Shen F, Ma X, Yang Q, et al. Diets, gut microbiota and metabolites. Phenomics. 2023;3:268\u201384.","journal-title":"Phenomics"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01317-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01317-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01317-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:02:30Z","timestamp":1729270950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01317-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":65,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["1317"],"URL":"https:\/\/doi.org\/10.1038\/s41401-024-01317-5","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]},"assertion":[{"value":"30 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}