{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:35:05Z","timestamp":1790883305184,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1038\/s41401-024-01358-w","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:03:37Z","timestamp":1724411017000},"page":"96-106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway"],"prefix":"10.1038","volume":"46","author":[{"given":"Hong-qin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-xi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-mei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"1358_CR1","doi-asserted-by":"crossref","unstructured":"Sakalihasani N, Michel JB, Katsargyris A, Kuivaniemi H, Defraigne JO, Nchimi A, et al. Abdominal aortic aneurysms. Nat Rev Dis Primers. 2018;4:34.","DOI":"10.1038\/s41572-018-0030-7"},{"key":"1358_CR2","doi-asserted-by":"crossref","first-page":"100035","DOI":"10.1016\/j.labinv.2022.100035","volume":"103","author":"YC Lin","year":"2023","unstructured":"Lin YC, Chen QY, Xiao J, Shen LC, Li XT, Yang YZ, et al. Mouse abdominal aortic aneurysm model induced by periarterial incubation of papain. Lab Invest. 2023;103:100035.","journal-title":"Lab Invest"},{"key":"1358_CR3","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s00261-017-1450-7","volume":"43","author":"BW Ullery","year":"2018","unstructured":"Ullery BW, Hallett RL, Fleischmann D. Epidemiology and contemporary management of abdominal aortic aneurysms. Abdom Radio. 2018;43:1032\u201343.","journal-title":"Abdom Radio"},{"key":"1358_CR4","first-page":"CD002945","volume":"18","author":"PA Cosford","year":"2007","unstructured":"Cosford PA, Leng GC. Screening for abdominal aortic aneurysm (Review). Cochrane Db Syst Rev. 2007;18:CD002945.","journal-title":"Cochrane Db Syst Rev"},{"key":"1358_CR5","doi-asserted-by":"crossref","first-page":"E1137","DOI":"10.1503\/cmaj.170118","volume":"189","author":"H Singh","year":"2017","unstructured":"Singh H, Bell N, Dickinson JA, Lewin G, Tonelli M, Thombs B, et al. Recommendations on screening for abdominal aortic aneurysm in primary care. Can Med Assoc J. 2017;189:E1137\u201345.","journal-title":"Can Med Assoc J"},{"key":"1358_CR6","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1161\/CIR.0b013e318245fac5","volume":"125","author":"VL Roger","year":"2012","unstructured":"Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart Disease and Stroke Statistics-2012 Update A Report From the American Heart Association. Circulation. 2012;125:E2\u2013220.","journal-title":"Circulation"},{"key":"1358_CR7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1097\/SLA.0000000000005716","volume":"277","author":"PG Song","year":"2023","unstructured":"Song PG, He YZ, Adeloye D, Zhu YF, Ye XX, Yi Q, et al. The global and regional prevalence of abdominal aortic aneurysms: a systematic review and modeling analysis. Ann Surg. 2023;277:912\u20139.","journal-title":"Ann Surg"},{"key":"1358_CR8","doi-asserted-by":"crossref","unstructured":"Yang Z, Kwok MK, Schooling CM, Liu J. Changes in cardiovascular disease burden in China after release of the 2011 Chinese guidelines for cardiovascular disease prevention: a bayesian causal impact analysis. Cardiovasc Innov Appl. 2023;8:20230069.","DOI":"10.15212\/CVIA.2023.0069"},{"key":"1358_CR9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/mva.2002.121308","volume":"35","author":"A Laupacis","year":"2002","unstructured":"Laupacis A, Investi PAT. Propranolol for small abdominal aortic aneurysms: results of a randomized trial. J Vasc Surg. 2002;35:72\u20139.","journal-title":"J Vasc Surg"},{"key":"1358_CR10","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.3390\/jcm11113017","volume":"11","author":"J Gruel","year":"2022","unstructured":"Gruel J, Grambow E, Weinrich M, Heller T, Gross J, Leuchter M, et al. Assessment of quality of life after endovascular and open abdominal aortic aneurysm repair: a retrospective single-center study. J Clin Med. 2022;11:3017.","journal-title":"J Clin Med"},{"key":"1358_CR11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIR.0b013e31820a55f5","volume":"123","author":"PA Heidenreich","year":"2011","unstructured":"Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933\u201344.","journal-title":"Circulation"},{"key":"1358_CR12","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/ATVBAHA.118.312023","volume":"39","author":"JY Li","year":"2019","unstructured":"Li JY, Xia N, Wen S, Li D, Lu YZ, Gu MY, et al. IL (Interleukin)-33 suppresses abdominal aortic aneurysm by enhancing regulatory T-Cell expansion and activity. Arterioscl Throm Vas. 2019;39:446\u201358.","journal-title":"Arterioscl Throm Vas"},{"key":"1358_CR13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","volume":"124","author":"RA Quintana","year":"2019","unstructured":"Quintana RA, Taylor WR. Cellular mechanisms of aortic aneurysm formation. Circ Res. 2019;124:607\u201318.","journal-title":"Circ Res"},{"key":"1358_CR14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3390\/life12020191","volume":"12","author":"GQ Qian","year":"2022","unstructured":"Qian GQ, Adeyanju O, Olajuyin A, Guo X. Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells. Life. 2022;12:191.","journal-title":"Life"},{"key":"1358_CR15","doi-asserted-by":"crossref","first-page":"e158309","DOI":"10.1172\/JCI158309","volume":"132","author":"GZ Zhao","year":"2022","unstructured":"Zhao GZ, Zhao Y, Lu HC, Chang ZY, Liu HY, Wang HL, et al. BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis. J Clin Invest. 2022;132:e158309.","journal-title":"J Clin Invest"},{"key":"1358_CR16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10522-017-9685-9","volume":"18","author":"W Grabowska","year":"2017","unstructured":"Grabowska W, Sikora E, Bielak-Zmijewska A. Sirtuins, a promising target in slowing down the ageing process. Biogerontology. 2017;18:447\u201376.","journal-title":"Biogerontology"},{"key":"1358_CR17","doi-asserted-by":"crossref","first-page":"166403","DOI":"10.1016\/j.bbadis.2022.166403","volume":"1868","author":"K Riches-Suman","year":"2022","unstructured":"Riches-Suman K, Hussain A. Identifying and targeting the molecular signature of smooth muscle cells undergoing early vascular ageing. BBA Mol Basis Dis. 2022;1868:166403.","journal-title":"BBA Mol Basis Dis"},{"key":"1358_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2021.02.007","volume":"166","author":"T Xu","year":"2021","unstructured":"Xu T, Wang SS, Li X, Li XQ, Qu KY, Tong H, et al. Lithium chloride represses abdominal aortic aneurysm via regulating GSK3?\/SIRT1\/NF-?B signaling pathway. Free Radic Bio Med. 2021;166:1\u201310.","journal-title":"Free Radic Bio Med"},{"key":"1358_CR19","doi-asserted-by":"crossref","first-page":"e13377","DOI":"10.1111\/acel.13377","volume":"20","author":"XY Liu","year":"2021","unstructured":"Liu XY, Chen A, Liang QC, Yang XL, Dong QQ, Fu MW, et al. Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway. Aging Cell. 2021;20:e13377.","journal-title":"Aging Cell"},{"key":"1358_CR20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1447-0594.2008.00504.x","volume":"9","author":"L Zeng","year":"2009","unstructured":"Zeng L, Chen R, Liang FX, Tsuchiya H, Murai H, Nakahashi T, et al. Silent information regulator, Sirtuin 1, and age-related diseases. Geriatr Gerontol Int. 2009;9:7\u201315.","journal-title":"Geriatr Gerontol Int"},{"key":"1358_CR21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2012.01.017","volume":"148","author":"SJ Park","year":"2012","unstructured":"Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo HB, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012;148:421\u201333.","journal-title":"Cell"},{"key":"1358_CR22","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/mnfr.201300266","volume":"58","author":"CX Guo","year":"2014","unstructured":"Guo CX, Sinnott B, Niu B, Lowry MB, Fantacone ML, Gombart AF. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Mol Nutr Food Res. 2014;58:528\u201336.","journal-title":"Mol Nutr Food Res"},{"key":"1358_CR23","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/CIRCRESAHA.116.308895","volume":"119","author":"HZ Chen","year":"2016","unstructured":"Chen HZ, Wang F, Gao P, Pei JF, Liu Y, Xu TT, et al. Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm. Circ Res. 2016;119:1076\u201388.","journal-title":"Circ Res"},{"key":"1358_CR24","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1111\/jcmm.16485","volume":"25","author":"WY Tao","year":"2021","unstructured":"Tao WY, Hong YM, He HW, Han Q, Mao MM, Hu B, et al. MicroRNA-199a-5p aggravates angiotensin II-induced vascular smooth muscle cell senescence by targeting Sirtuin-1 in abdominal aortic aneurysm. J Cell Mol Med. 2021;25:6056\u201369.","journal-title":"J Cell Mol Med"},{"key":"1358_CR25","doi-asserted-by":"crossref","first-page":"e2107898118","DOI":"10.1073\/pnas.2107898118","volume":"118","author":"CY Zhang","year":"2021","unstructured":"Zhang CY, Zhao HM, Cai YJ, Xiong J, Mohan A, Lou DF, et al. Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm. Proc Natl Acad Sci USA. 2021;118:e2107898118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1358_CR26","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s10787-022-01059-y","volume":"30","author":"K Bagri","year":"2022","unstructured":"Bagri K, Deshmukh R. Vinpocetine restores cognitive and motor functions in Traumatic brain injury challenged rats. Inflammopharmacology. 2022;30:2243\u201359.","journal-title":"Inflammopharmacology"},{"key":"1358_CR27","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1007\/s00204-023-03546-9","volume":"97","author":"N Abdelmageed","year":"2023","unstructured":"Abdelmageed N, Twafik WAA, Morad OAR, Haridy M, Hassan R, Ahmed M, et al. Vinpocetine protects against chloroquine-induced cardiotoxicity by mitigating oxidative stress. Arch Toxicol. 2023;97:2763\u201370.","journal-title":"Arch Toxicol"},{"key":"1358_CR28","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12028-022-01499-y","volume":"37","author":"PK Panda","year":"2022","unstructured":"Panda PK, Ramachandran A, Panda P, Sharawat IK. Safety and efficacy of vinpocetine as a neuroprotective agent in acute ischemic stroke: a systematic review and meta-analysis. Neurocrit Care. 2022;37:314\u201325.","journal-title":"Neurocrit Care"},{"key":"1358_CR29","doi-asserted-by":"crossref","first-page":"107988","DOI":"10.1016\/j.yebeh.2021.107988","volume":"119","author":"KJ Meador","year":"2021","unstructured":"Meador KJ, Leeman-Markowski B, Medina AE, Illamola SM, Seliger J, Novak G, et al. Vinpocetine, cognition, and epilepsy. Epilepsy Behav. 2021;119:107988.","journal-title":"Epilepsy Behav"},{"key":"1358_CR30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S1734-1140(11)70574-6","volume":"63","author":"S Patyar","year":"2011","unstructured":"Patyar S, Prakash A, Modi M, Medhi B. Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep. 2011;63:618\u201328.","journal-title":"Pharmacol Rep"},{"key":"1358_CR31","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.2310\/6670.2008.00092","volume":"17","author":"KK Hannawa","year":"2009","unstructured":"Hannawa KK, Eliason JL, Upchurch GR. Gender differences in abdominal aortic aneurysms. Vascular. 2009;17:S30\u20139.","journal-title":"Vascular"},{"key":"1358_CR32","doi-asserted-by":"crossref","first-page":"e35312","DOI":"10.1371\/journal.pone.0035312","volume":"7","author":"G Cafueri","year":"2012","unstructured":"Cafueri G, Parodi F, Pistorio A, Bertolotto M, Ventura F, Gambini C, et al. Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition. PLoS One. 2012;7:e35312.","journal-title":"PLoS One"},{"key":"1358_CR33","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2018.07.021","volume":"174","author":"JJ Li","year":"2018","unstructured":"Li JJ, Pan CP, Zhang S, Spin JM, Deng A, Leung LLK, et al. Decoding the genomics of abdominal aortic aneurysm. Cell. 2018;174:1361.","journal-title":"Cell"},{"key":"1358_CR34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/ATVBAHA.117.309524","volume":"38","author":"P Robinet","year":"2018","unstructured":"Robinet P, Milewicz DM, Cassis LA, Leeper NJ, Lu HS, Smith JD. Consideration of sex differences in design and reporting of experimental arterial pathology studies-statement from ATVB council. Arterioscl Throm Vas. 2018;38:292\u2013303.","journal-title":"Arterioscl Throm Vas"},{"key":"1358_CR35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jvs.2016.07.105","volume":"66","author":"GY Lu","year":"2017","unstructured":"Lu GY, Su G, Davis JP, Schaheen B, Downs E, Roy RJ, et al. A novel chronic advanced stage abdominal aortic aneurysm murine model. J Vasc Surg. 2017;66:232\u2013U304.","journal-title":"J Vasc Surg"},{"key":"1358_CR36","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1161\/CIRCRESAHA.116.310022","volume":"120","author":"A Watson","year":"2017","unstructured":"Watson A, Nong ZX, Yin H, O\u2019Neil C, Fox S, Balint B. et al. Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease. Circ Res. 2017;120:1889\u2013902.","journal-title":"Circ Res"},{"key":"1358_CR37","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/ptr.7358","volume":"36","author":"ZY Zhai","year":"2022","unstructured":"Zhai ZY, Zhang XJ, Ding YC, Huang ZM, Li Q, Zheng MY, et al. Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-\u03baB and COX-2. Phytother Res. 2022;36:928\u201337.","journal-title":"Phytother Res"},{"key":"1358_CR38","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1042\/CS20201057","volume":"134","author":"CY Zhang","year":"2020","unstructured":"Zhang CY, Hsu CG, Mohan A, Shi HCA, Li DM, Yan C. Vinpocetine protects against the development of experimental abdominal aortic aneurysms. Clin Sci. 2020;134:2959\u201376.","journal-title":"Clin Sci"},{"key":"1358_CR39","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1124\/jpet.112.195446","volume":"343","author":"YJ Cai","year":"2012","unstructured":"Cai YJ, Knight WE, Guo SJ, Li JD, Knight PA, Yan C. Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration. J Pharmacol Exp Ther. 2012;343:479\u201388.","journal-title":"J Pharmacol Exp Ther"},{"key":"1358_CR40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bbrc.2013.03.092","volume":"434","author":"YJ Cai","year":"2013","unstructured":"Cai YJ, Li JD, Yan C. Vinpocetine attenuates lipid accumulation and atherosclerosis formation. Biochem Biophys Res Commun. 2013;434:439\u201343.","journal-title":"Biochem Biophys Res Commun"},{"key":"1358_CR41","doi-asserted-by":"crossref","first-page":"699","DOI":"10.14336\/AD.2018.1128","volume":"10","author":"WJ Guo","year":"2019","unstructured":"Guo WJ, Gao R, Zhang W, Ge WP, Ren M, Li BL, et al. IgE aggravates the senescence of smooth muscle cells in abdominal aortic aneurysm by upregulating LincRNA-p21. Aging Dis. 2019;10:699\u2013710.","journal-title":"Aging Dis"},{"key":"1358_CR42","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nm.1958","volume":"15","author":"K Satoh","year":"2009","unstructured":"Satoh K, Nigro P, Matoba T, O\u2019Dell MR, Cui ZQ, Shi X, et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 2009;15:649\u2013U144.","journal-title":"Nat Med"},{"key":"1358_CR43","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ajpath.2013.05.018","volume":"183","author":"V Deckert","year":"2013","unstructured":"Deckert V, Kretz B, Habbout A, Raghay K, Labb\u00e9 J, Abello N, et al. Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency. Am J Pathol. 2013;183:975\u201386.","journal-title":"Am J Pathol"},{"key":"1358_CR44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1067\/j.cpsurg.2017.01.001","volume":"54","author":"YH Shen","year":"2017","unstructured":"Shen YH, LeMaire SA. Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections. Curr Prob Surg. 2017;54:95\u2013155.","journal-title":"Curr Prob Surg"},{"key":"1358_CR45","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/ATVBAHA.122.317712","volume":"42","author":"H Sawada","year":"2022","unstructured":"Sawada H, Ohno-Urabe S, Ye D, Franklin MK, Moorleghen JJ, Howatt DA, et al. Inhibition of the renin-angiotensin system fails to suppress \u03b2-aminopropionitrile-induced thoracic aortopathy in mice-brief report. Arterioscl Throm Vas. 2022;42:1254\u201361.","journal-title":"Arterioscl Throm Vas"},{"key":"1358_CR46","first-page":"57589","volume":"16","author":"BO Aicher","year":"2018","unstructured":"Aicher BO, Mukhopadhyay S, Lu X, Muratoglu SC, Strickland DK, Ucuzian AA. Quantitative micro-CT analysis of aortopathy in a mouse model of \u03b2-aminopropionitrile-induced aortic aneurysm and dissection. J Vis Exp. 2018;16:57589.","journal-title":"J Vis Exp"},{"key":"1358_CR47","first-page":"E210","volume":"43","author":"X Guo","year":"2023","unstructured":"Guo X, Cai DP, Dong K, Li CX, Xu ZY, Chen SY. DOCK2 deficiency attenuates abdominal aortic aneurysm formation-brief report. Arterioscl Throm Vas. 2023;43:E210\u20137.","journal-title":"Arterioscl Throm Vas"},{"key":"1358_CR48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41569-018-0114-9","volume":"16","author":"J Golledge","year":"2019","unstructured":"Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16:225\u201342.","journal-title":"Nat Rev Cardiol"},{"key":"1358_CR49","volume":"20","author":"JJ Liu","year":"2022","unstructured":"Liu JJ, Liu MY, Feng JX, Zhu HQ, Wu JL, Zhang H, et al. Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN\/HOCL\/ERK signaling pathways. J Transl Med. 2022;20:461.","journal-title":"J Transl Med"},{"key":"1358_CR50","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2009.80","volume":"6","author":"FAMVI Hellenthal","year":"2009","unstructured":"Hellenthal FAMVI, Buurman WA, Wodzig WKWH, Schurink GWH.Biomarkers of AAA progression. Part 1: extracell matrix degeneration.Nat Rev Cardiol. 2009;6:464\u201374.","journal-title":"Nat Rev Cardiol"},{"key":"1358_CR51","doi-asserted-by":"crossref","first-page":"152","DOI":"10.18632\/aging.100719","volume":"7","author":"R de Cabo","year":"2015","unstructured":"de Cabo R, Liu LJ, Ali A, Price N, Zhang J, Wang MY, et al. Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts. Aging-Us. 2015;7:152\u201366.","journal-title":"Aging-Us"},{"key":"1358_CR52","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5582\/bst.2018.01063","volume":"12","author":"L Zhang","year":"2018","unstructured":"Zhang L, Wei CS, Ruan YJ, Zhang YA, Zhou YL, Lei D. Serum containing Buyang Huanwu decoction prevents age-associated migration and invasion of human vascular smooth muscle cells by up regulating SIRT1 expression. Biosci Trends. 2018;12:282\u201390.","journal-title":"Biosci Trends"},{"key":"1358_CR53","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbrc.2018.04.136","volume":"500","author":"VC Khanh","year":"2018","unstructured":"Khanh VC, Zulkifli AF, Tokunaga C, Yamashita T, Hiramatsu Y, Ohneda O. Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1. Biochem Biophys Res Commun. 2018;500:682\u201390.","journal-title":"Biochem Biophys Res Commun"},{"key":"1358_CR54","doi-asserted-by":"crossref","first-page":"6492029","DOI":"10.1155\/2019\/6492029","volume":"2019","author":"S Lamichane","year":"2019","unstructured":"Lamichane S, Baek SH, Kim YJ, Park JH, Lamichane BD, Jang WB, et al. MHY2233 attenuates replicative cellular senescence in human endothelial progenitor cells SIRT1 signaling. Oxid Med Cell Longev. 2019;2019:6492029.","journal-title":"Oxid Med Cell Longev"},{"key":"1358_CR55","doi-asserted-by":"crossref","first-page":"1170-+","DOI":"10.1038\/s41556-020-00579-5","volume":"22","author":"CY Xu","year":"2020","unstructured":"Xu CY, Wang L, Fozouni P, Evjen G, Chandra V, Jiang J, et al. SIRT1 is downregulated by autophagy in senescence and ageing. Nat Cell Biol. 2020;22:1170-+.","journal-title":"Nat Cell Biol"},{"key":"1358_CR56","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2017.11.041","volume":"819","author":"YS Zhang","year":"2018","unstructured":"Zhang YS, Li JD, Yan C. An update on vinpocetine: new discoveries and clinical implications. Eur J Pharmacol. 2018;819:30\u20134.","journal-title":"Eur J Pharmacol"},{"key":"1358_CR57","doi-asserted-by":"crossref","first-page":"112571","DOI":"10.1016\/j.physbeh.2019.112571","volume":"208","author":"AA Ali","year":"2019","unstructured":"Ali AA, Ahmed HI, Khaleel SA, Abu-Elfotuh K. Vinpocetine mitigates aluminum-induced cognitive impairment in socially isolated rats. Physiol Behav. 2019;208:112571.","journal-title":"Physiol Behav"},{"key":"1358_CR58","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10557-017-6719-0","volume":"31","author":"MP Wu","year":"2017","unstructured":"Wu MP, Zhang YS, Xu XB, Zhou Q, Li JD, Yan C. Vinpocetine attenuates pathological cardiac remodeling by inhibiting cardiac hypertrophy and fibrosis. Cardiovasc Drug Ther. 2017;31:157\u201366.","journal-title":"Cardiovasc Drug Ther"},{"key":"1358_CR59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cca.2014.07.019","volume":"437","author":"XY Luo","year":"2014","unstructured":"Luo XY, Qu SL, Tang ZH, Zhang Y, Liu MH, Peng J, et al. SIRT1 in cardiovascular aging. Clin Chim Acta. 2014;437:106\u201314.","journal-title":"Clin Chim Acta"},{"key":"1358_CR60","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCRESAHA.122.320888","volume":"131","author":"A Mengozzi","year":"2022","unstructured":"Mengozzi A, Costantino S, Paneni F, Duranti E, Nannipieri M, Mancini R, et al. Targeting SIRT1 rescues age- and obesity-induced microvascular dysfunction in ex vivo human vessels. Circ Res. 2022;131:476\u201391.","journal-title":"Circ Res"},{"key":"1358_CR61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jgg.2018.01.002","volume":"45","author":"ZQ Zhang","year":"2018","unstructured":"Zhang ZQ, Xu J, Liu Y, Wang TT, Pei JF, Cheng LQ, et al. Mouse macrophage specific knockout of influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation. J Genet Genom. 2018;45:25\u201332.","journal-title":"J Genet Genom"},{"key":"1358_CR62","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/cvr\/cvn224","volume":"80","author":"QJ Zhang","year":"2008","unstructured":"Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, et al. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. 2008;80:191\u20139.","journal-title":"Cardiovasc Res"},{"key":"1358_CR63","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.yjmcc.2007.08.008","volume":"43","author":"H Ota","year":"2007","unstructured":"Ota H, Akishita M, Masato E, Iijima K, Masao K, Ouchi Y. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol. 2007;43:571\u20139.","journal-title":"J Mol Cell Cardiol"},{"key":"1358_CR64","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1128\/MCB.21.20.6748-6757.2001","volume":"21","author":"WY Wei","year":"2001","unstructured":"Wei WY, Hemmer RM, Sedivy JM. Role of p14 in replicative and induced senescence of human fibroblasts. Mol Cell Biol. 2001;21:6748\u201357.","journal-title":"Mol Cell Biol"},{"key":"1358_CR65","doi-asserted-by":"crossref","first-page":"e158447","DOI":"10.1172\/JCI158447","volume":"132","author":"S Miwa","year":"2022","unstructured":"Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. J Clin Invest. 2022;132:e158447.","journal-title":"J Clin Invest"},{"key":"1358_CR66","doi-asserted-by":"crossref","first-page":"101468","DOI":"10.1016\/j.arr.2021.101468","volume":"72","author":"S Kaushik","year":"2021","unstructured":"Kaushik S, Tasset I, Arias E, Pampliega O, Wong E, Martinez-Vicente M, et al. Autophagy and the hallmarks of aging. Ageing Res Rev. 2021;72:101468.","journal-title":"Ageing Res Rev"},{"key":"1358_CR67","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0531-5565(03)00132-3","volume":"38","author":"LM Gerland","year":"2003","unstructured":"Gerland LM, Peyrol S, Lallemand C, Branche R, Magaud JP, Ffrench M. Association of increased autophagic inclusions labeled for \u03b2-galactosidase with fibroblastic aging. Exp Gerontol. 2003;38:887\u201395.","journal-title":"Exp Gerontol"},{"key":"1358_CR68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature15548","volume":"527","author":"ZX Dou","year":"2015","unstructured":"Dou ZX, Xu CY, Donahue G, Shimi T, Pan JA, Zhu JJ, et al. Autophagy mediates degradation of nuclear lamina. Nature. 2015;527:105\u20139.","journal-title":"Nature"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01358-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01358-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01358-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T01:05:09Z","timestamp":1735866309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01358-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["1358"],"URL":"https:\/\/doi.org\/10.1038\/s41401-024-01358-w","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"28 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}