{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:44:22Z","timestamp":1792896262528,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1038\/s41401-024-01377-7","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T07:02:33Z","timestamp":1726470153000},"page":"338-352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice"],"prefix":"10.1038","volume":"46","author":[{"given":"Jun-qiang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-li","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-zhi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-liu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-yong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-sen","family":"Huai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-hao","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-biao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"1377_CR1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1042\/BST20160303","volume":"45","author":"DTS Lin","year":"2017","unstructured":"Lin DTS, Davis NG, Conibear E. Targeting the Ras palmitoylation\/depalmitoylation cycle in cancer. Biochem Soc Trans. 2017;45:913\u201321.","journal-title":"Biochem Soc Trans"},{"key":"1377_CR2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1083\/jcb.201008160","volume":"191","author":"C Salaun","year":"2010","unstructured":"Salaun C, Greaves J, Chamberlain LH. The intracellular dynamic of protein palmitoylation. J Cell Biol. 2010;191:1229\u201338.","journal-title":"J Cell Biol"},{"key":"1377_CR3","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1074\/jbc.M112.421073","volume":"288","author":"E Kong","year":"2013","unstructured":"Kong E, Peng S, Chandra G, Sarkar C, Zhang Z, Bagh MB, et al. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43. J Biol Chem. 2013;288:9112\u201325.","journal-title":"J Biol Chem"},{"key":"1377_CR4","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07605","volume":"456","author":"R Kang","year":"2008","unstructured":"Kang R, Wan J, Arstikaitis P, Takahashi H, Huang K, Bailey AO, et al. Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature. 2008;456:904\u20139.","journal-title":"Nature"},{"key":"1377_CR5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cne.10492","volume":"455","author":"L Ahtiainen","year":"2003","unstructured":"Ahtiainen L, Van Diggelen OP, Jalanko A, Kopra O. Palmitoyl protein thioesterase 1 is targeted to the axons in neurons. J Comp Neurol. 2003;455:368\u201377.","journal-title":"J Comp Neurol"},{"key":"1377_CR6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/hmg\/10.1.69","volume":"10","author":"M Lehtovirta","year":"2001","unstructured":"Lehtovirta M, Kyttala A, Eskelinen EL, Hess M, Heinonen O, Jalanko A. Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL). Hum Mol Genet. 2001;10:69\u201375.","journal-title":"Hum Mol Genet"},{"key":"1377_CR7","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/hmg\/ddx074","volume":"26","author":"M Segal-Salto","year":"2017","unstructured":"Segal-Salto M, Hansson K, Sapir T, Kaplan A, Levy T, Schweizer M, et al. Proteomics insights into infantile neuronal ceroid lipofuscinosis (CLN1) point to the involvement of cilia pathology in the disease. Hum Mol Genet. 2017;26:1678.","journal-title":"Hum Mol Genet"},{"key":"1377_CR8","doi-asserted-by":"crossref","unstructured":"Vergoten G, Bailly C Binding of hydroxychloroquine and chloroquine dimers to palmitoyl-protein thioesterase 1 (PPT1) and its glycosylated forms: a computational approach. J Biomol Struct Dyn. 2022;40:8197\u20138205.","DOI":"10.1080\/07391102.2021.1908167"},{"key":"1377_CR9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pediatrneurol.2021.04.002","volume":"120","author":"EF Augustine","year":"2021","unstructured":"Augustine EF, Adams HR, de Los Reyes E, Drago K, Frazier M, Guelbert N, et al. Management of CLN1 disease: international clinical consensus. Pediatr Neurol. 2021;120:38\u201351.","journal-title":"Pediatr Neurol"},{"key":"1377_CR10","doi-asserted-by":"crossref","first-page":"e0239689","DOI":"10.1371\/journal.pone.0239689","volume":"16","author":"B Balouch","year":"2021","unstructured":"Balouch B, Nagorsky H, Pham T, LaGraff JT, Chu-LaGraff Q. Human INCL fibroblasts display abnormal mitochondrial and lysosomal networks and heightened susceptibility to ROS-induced cell death. PLoS One. 2021;16:e0239689.","journal-title":"PLoS One"},{"key":"1377_CR11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/13554794.2021.1905852","volume":"27","author":"R Kravljanac","year":"2021","unstructured":"Kravljanac R, Sims K. A case of juvenile CLN1- challenge in diagnosis and epilepsy treatment. Neurocase. 2021;27:165\u20138.","journal-title":"Neurocase"},{"key":"1377_CR12","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-016-0414-2","volume":"11","author":"RD Geraets","year":"2016","unstructured":"Geraets RD, Koh S, Hastings ML, Kielian T, Pearce DA, Weimer JM. Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis. Orphanet J Rare Dis. 2016;11:40.","journal-title":"Orphanet J Rare Dis"},{"key":"1377_CR13","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1172\/JCI33482","volume":"118","author":"SJ Kim","year":"2008","unstructured":"Kim SJ, Zhang Z, Sarkar C, Tsai PC, Lee YC, Dye L, et al. Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice. J Clin Invest. 2008;118:3075\u201386.","journal-title":"J Clin Invest"},{"key":"1377_CR14","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/hmg\/ddl078","volume":"15","author":"SJ Kim","year":"2006","unstructured":"Kim SJ, Zhang Z, Lee YC, Mukherjee AB. Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL. Hum Mol Genet. 2006;15:1580\u20136.","journal-title":"Hum Mol Genet"},{"key":"1377_CR15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/hmg\/ddm324","volume":"17","author":"H Wei","year":"2008","unstructured":"Wei H, Kim SJ, Zhang Z, Tsai PC, Wisniewski KE, Mukherjee AB. ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. Hum Mol Genet. 2008;17:469\u201377.","journal-title":"Hum Mol Genet"},{"key":"1377_CR16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/hmg\/ddu428","volume":"24","author":"JN Miller","year":"2015","unstructured":"Miller JN, Kovacs AD, Pearce DA. The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015;24:185\u201396.","journal-title":"Hum Mol Genet"},{"key":"1377_CR17","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/acn3.144","volume":"1","author":"A Bouchelion","year":"2014","unstructured":"Bouchelion A, Zhang Z, Li Y, Qian H, Mukherjee AB. Mice homozygous for c.451C>T mutation in Cln1 gene recapitulate INCL phenotype. Ann Clin Transl Neurol. 2014;1:1006\u201323.","journal-title":"Ann Clin Transl Neurol"},{"key":"1377_CR18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bcp.2015.06.031","volume":"97","author":"M Stoiljkovic","year":"2015","unstructured":"Stoiljkovic M, Kelley C, Nagy D, Hajos M. Modulation of hippocampal neuronal network oscillations by alpha7 nACh receptors. Biochem Pharmacol. 2015;97:445\u201353.","journal-title":"Biochem Pharmacol."},{"key":"1377_CR19","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.3390\/ijms23105586","volume":"23","author":"X Zhang","year":"2022","unstructured":"Zhang X, Wang M, Feng B, Zhang Q, Tong J, Wang M, et al. Seizures in PPT1 knock-in mice are associated with inflammatory activation of microglia. Int J Mol Sci. 2022;23:5586.","journal-title":"Int J Mol Sci"},{"key":"1377_CR20","doi-asserted-by":"crossref","first-page":"13118","DOI":"10.1073\/pnas.1201011109","volume":"109","author":"RH Andersson","year":"2012","unstructured":"Andersson RH, Johnston A, Herman PA, Winzer-Serhan UH, Karavanova I, Vullhorst D, et al. Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors. Proc Natl Acad Sci USA. 2012;109:13118\u201323.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1377_CR21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/381245a0","volume":"381","author":"L Mrzljak","year":"1996","unstructured":"Mrzljak L, Bergson C, Pappy M, Huff R, Levenson R, Goldman-Rakic PS. Localization of dopamine D4 receptors in GABAergic neurons of the primate brain. Nature. 1996;381:245\u20138.","journal-title":"Nature"},{"key":"1377_CR22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0006-8993(96)01422-9","volume":"752","author":"MA Ariano","year":"1997","unstructured":"Ariano MA, Wang J, Noblett KL, Larson ER, Sibley DR. Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera. Brain Res. 1997;752:26\u201334.","journal-title":"Brain Res"},{"key":"1377_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-328X(96)00235-5","volume":"45","author":"MC Defagot","year":"1997","unstructured":"Defagot MC, Malchiodi EL, Villar MJ, Antonelli MC. Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies. Brain Res Mol Brain Res. 1997;45:1\u201312.","journal-title":"Brain Res Mol Brain Res"},{"key":"1377_CR24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1046\/j.1460-9568.1998.00056.x","volume":"10","author":"C Mauger","year":"1998","unstructured":"Mauger C, Sivan B, Brockhaus M, Fuchs S, Civelli O, Monsma F Jr. Development and characterization of antibodies directed against the mouse D4 dopamine receptor. Eur J Neurosci. 1998;10:529\u201337.","journal-title":"Eur J Neurosci"},{"key":"1377_CR25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-3042.2001.00702.x","volume":"80","author":"A Rivera","year":"2002","unstructured":"Rivera A, Cuellar B, Giron FJ, Grandy DK, de la Calle A, Moratalla R. Dopamine D4 receptors are heterogeneously distributed in the striosomes\/matrix compartments of the striatum. J Neurochem. 2002;80:219\u201329.","journal-title":"J Neurochem"},{"key":"1377_CR26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0169-328X(94)00245-A","volume":"29","author":"M Matsumoto","year":"1995","unstructured":"Matsumoto M, Hidaka K, Tada S, Tasaki Y, Yamaguchi T. Full-length cDNA cloning and distribution of human dopamine D4 receptor. Brain Res Mol Brain Res. 1995;29:157\u201362.","journal-title":"Brain Res Mol Brain Res"},{"key":"1377_CR27","first-page":"647","volume":"26","author":"SB Li","year":"2016","unstructured":"Li SB, Du D, Hasan MT, Kohr G. D4 receptor activation differentially modulates hippocampal basal and apical dendritic synapses in freely moving mice. Cereb Cortex. 2016;26:647\u201355.","journal-title":"Cereb Cortex"},{"key":"1377_CR28","doi-asserted-by":"crossref","first-page":"26112","DOI":"10.1074\/jbc.M112.396648","volume":"288","author":"EY Yuen","year":"2013","unstructured":"Yuen EY, Zhong P, Li X, Wei J, Yan Z. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals. J Biol Chem. 2013;288:26112\u201320.","journal-title":"J Biol Chem"},{"key":"1377_CR29","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/acel.12666","volume":"16","author":"F Guo","year":"2017","unstructured":"Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323\u201333.","journal-title":"Aging Cell"},{"key":"1377_CR30","volume":"14","author":"Y Wang","year":"2022","unstructured":"Wang Y, Jin YK, Guo TC, Li ZR, Feng BY, Han JH, et al. Activation of dopamine 4 receptor subtype enhances gamma oscillations in hippocampal slices of aged mice. Front Aging Neurosci. 2022;14:838803.","journal-title":"Front Aging Neurosci"},{"key":"1377_CR31","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0269881110387840","volume":"25","author":"P Sood","year":"2011","unstructured":"Sood P, Idris NF, Cole S, Grayson B, Neill JC, Young AM. PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia. J Psychopharmacol. 2011;25:792\u2013800.","journal-title":"J Psychopharmacol"},{"key":"1377_CR32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0149-7634(99)00063-9","volume":"24","author":"D Vallone","year":"2000","unstructured":"Vallone D, Picetti R, Borrelli E. Structure and function of dopamine receptors. Neurosci Biobehav Rev. 2000;24:125\u201332.","journal-title":"Neurosci Biobehav Rev"},{"key":"1377_CR33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0163-7258(01)00145-0","volume":"91","author":"SB Glickstein","year":"2001","unstructured":"Glickstein SB, Schmauss C. Dopamine receptor functions: lessons from knockout mice [corrected]. Pharmacol Ther. 2001;91:63\u201383.","journal-title":"Pharmacol Ther."},{"key":"1377_CR34","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1523\/JNEUROSCI.19-21-09550.1999","volume":"19","author":"SC Dulawa","year":"1999","unstructured":"Dulawa SC, Grandy DK, Low MJ, Paulus MP, Geyer MA. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci. 1999;19:9550\u20136.","journal-title":"J Neurosci"},{"key":"1377_CR35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.pharmtox.39.1.313","volume":"39","author":"DR Sibley","year":"1999","unstructured":"Sibley DR. New insights into dopaminergic receptor function using antisense and genetically altered animals. Annu Rev Pharmacol Toxicol. 1999;39:313\u201341.","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"1377_CR36","doi-asserted-by":"crossref","first-page":"e0140661","DOI":"10.1371\/journal.pone.0140661","volume":"10","author":"B Ebersole","year":"2015","unstructured":"Ebersole B, Petko J, Woll M, Murakami S, Sokolina K, Wong V, et al. Effect of C-terminal S-palmitoylation on D2 dopamine receptor trafficking and stability. PLoS One. 2015;10:e0140661.","journal-title":"PLoS One"},{"key":"1377_CR37","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.bbamem.2016.06.021","volume":"1858","author":"X Zhang","year":"2016","unstructured":"Zhang X, Le HT, Zhang X, Zheng M, Choi BG, Kim KM. Palmitoylation on the carboxyl terminus tail is required for the selective regulation of dopamine D2 versus D3 receptors. Biochim Biophys Acta. 2016;1858:2152\u201362.","journal-title":"Biochim Biophys Acta"},{"key":"1377_CR38","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bbrc.2016.09.094","volume":"479","author":"X Zhang","year":"2016","unstructured":"Zhang X, Kim KM. Palmitoylation of the carboxyl-terminal tail of dopamine D(4) receptor is required for surface expression, endocytosis, and signaling. Biochem Biophys Res Commun. 2016;479:398\u2013403.","journal-title":"Biochem Biophys Res Commun"},{"key":"1377_CR39","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","volume":"8","author":"M Leger","year":"2013","unstructured":"Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, et al. Object recognition test in mice. Nat Protoc. 2013;8:2531\u20137.","journal-title":"Nat Protoc"},{"key":"1377_CR40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.compbiomed.2011.10.017","volume":"42","author":"JL Sfondouris","year":"2012","unstructured":"Sfondouris JL, Quebedeaux TM, Holdgraf C, Musto AE. Combined process automation for large-scale EEG analysis. Comput Biol Med. 2012;42:129\u201334.","journal-title":"Comput Biol Med"},{"key":"1377_CR41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuron.2005.06.035","volume":"47","author":"T Hayashi","year":"2005","unstructured":"Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron. 2005;47:709\u201323.","journal-title":"Neuron"},{"key":"1377_CR42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroscience.2021.09.005","volume":"475","author":"XE Xie","year":"2021","unstructured":"Xie XE, Li M, Feng B, Li J, Sun Z, Zhao Y, et al. The cellular mechanisms of dopamine modulation on the neuronal network oscillations in the CA3 area of rat hippocampal slices. Neuroscience. 2021;475:83\u201392.","journal-title":"Neuroscience"},{"key":"1377_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2017.05.012","volume":"1670","author":"YL Wang","year":"2017","unstructured":"Wang YL, Wang JG, Guo FL, Gao XH, Zhao DD, Zhang L, et al. Selective dopamine receptor 4 activation mediates the hippocampal neuronal calcium response via IP3 and ryanodine receptors. Brain Res. 2017;1670:1\u20135.","journal-title":"Brain Res"},{"key":"1377_CR44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/nan.12658","volume":"47","author":"HR Nelvagal","year":"2021","unstructured":"Nelvagal HR, Dearborn JT, Ostergaard JR, Sands MS, Cooper JD. Spinal manifestations of CLN1 disease start during the early postnatal period. Neuropathol Appl Neurobiol. 2021;47:251\u201367.","journal-title":"Neuropathol Appl Neurobiol"},{"key":"1377_CR45","doi-asserted-by":"crossref","first-page":"e2022261118","DOI":"10.1073\/pnas.2022261118","volume":"118","author":"W Yuan","year":"2021","unstructured":"Yuan W, Lu L, Rao M, Huang Y, Liu CE, Liu S, et al. GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proc Natl Acad Sci USA. 2021;118:e2022261118.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1377_CR46","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.neuron.2018.02.001","volume":"97","author":"W Cao","year":"2018","unstructured":"Cao W, Lin S, Xia QQ, Du YL, Yang Q, Zhang MY, et al. Gamma oscillation dysfunction in mPFc leads to social deficits in neuroligin 3 R451C knockin mice. Neuron. 2018;97:1253\u201360.e7.","journal-title":"Neuron"},{"key":"1377_CR47","doi-asserted-by":"crossref","DOI":"10.1038\/srep12752","volume":"5","author":"JT Dearborn","year":"2015","unstructured":"Dearborn JT, Harmon SK, Fowler SC, O\u2019Malley KL, Taylor GT, Sands MS, et al. Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers. Sci Rep. 2015;5:12752.","journal-title":"Sci Rep."},{"key":"1377_CR48","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/lm.053555.121","volume":"29","author":"F Sayegh","year":"2022","unstructured":"Sayegh F, Herraiz L, Colom M, Lopez S, Rampon C, Dahan L. D1\/5 dopamine receptors are necessary for learning a novel context. Learn Mem. 2022;29:142\u20135.","journal-title":"Learn Mem"},{"key":"1377_CR49","doi-asserted-by":"crossref","unstructured":"Gulfo MC, Lebowitz JJ, Ramos C, Hwang DW, Nasrallah K, Castillo PE. Dopamine D2 receptors in hilar mossy cells regulate excitatory transmission and hippocampal function. Proc Natl Acad Sci USA 2023;120:e2307509120.","DOI":"10.1073\/pnas.2307509120"},{"key":"1377_CR50","volume":"4","author":"HR Sim","year":"2013","unstructured":"Sim HR, Choi TY, Lee HJ, Kang EY, Yoon S, Han PL, et al. Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours. Nat Commun. 2013;4:1579.","journal-title":"Nat Commun"},{"key":"1377_CR51","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0197-4580(00)00149-4","volume":"21","author":"V Kaasinen","year":"2000","unstructured":"Kaasinen V. Age-related dopamine D2\/D3 receptor loss in extrastriatal regions of the human brain. Neurobiol Aging. 2000;21:683\u20138.","journal-title":"Neurobiol Aging"},{"key":"1377_CR52","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1038\/s41380-021-01214-x","volume":"26","author":"J Lubec","year":"2021","unstructured":"Lubec J, Kalaba P, Hussein AM, Feyissa DD, Kotob MH, Mahmmoud RR, et al. Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition. Mol psychiatry. 2021;26:7076\u201390.","journal-title":"Mol psychiatry"},{"key":"1377_CR53","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.aam9080","volume":"357","author":"LF Burbulla","year":"2017","unstructured":"Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson\u2019s disease. Science. 2017;357:1255\u201361.","journal-title":"Science"},{"key":"1377_CR54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113141","volume":"212","author":"G Giorgioni","year":"2021","unstructured":"Giorgioni G, Del Bello F, Pavletic P, Quaglia W, Botticelli L, Cifani C, et al. Recent findings leading to the discovery of selective dopamine D(4) receptor ligands for the treatment of widespread diseases. Eur J Med Chem. 2021;212:113141.","journal-title":"Eur J Med Chem"},{"key":"1377_CR55","volume":"83","author":"J Xin","year":"2019","unstructured":"Xin J, Fan T, Guo P, Wang J. Identification of functional divergence sites in dopamine receptors of vertebrates. Comput Biol Chem. 2019;83:107140.","journal-title":"Comput Biol Chem"},{"key":"1377_CR56","doi-asserted-by":"crossref","first-page":"E622","DOI":"10.1152\/ajpendo.00657.2007","volume":"294","author":"HW Chang","year":"2008","unstructured":"Chang HW, Wu VC, Huang CY, Huang HY, Chen YM, Chu TS, et al. D4 dopamine receptor enhances angiotensin II-stimulated aldosterone secretion through PKC-\u03b5 and calcium signaling. Am J Physiol-Endocrinol Metab. 2008;294:E622\u2013E9.","journal-title":"Am J Physiol-Endocrinol Metab"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01377-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01377-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01377-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T16:12:51Z","timestamp":1737389571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01377-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1377"],"URL":"https:\/\/doi.org\/10.1038\/s41401-024-01377-7","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"25 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}