{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:13:47Z","timestamp":1768554827102,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1038\/s41401-024-01392-8","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T13:01:58Z","timestamp":1727096518000},"page":"404-415","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adaptor protein Src-homology 2 domain containing E (SH2E) deficiency induces heart defect in zebrafish"],"prefix":"10.1038","volume":"46","author":[{"given":"Yu-lai","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang-xi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-min","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-fu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"1392_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404007331","volume":"6","author":"G Waksman","year":"2004","unstructured":"Waksman G, Kumaran S, Lubman O. SH2 domains: role, structure and implications for molecular medicine. Expert Rev Mol Med. 2004;6:1\u201318.","journal-title":"Expert Rev Mol Med"},{"key":"1392_CR2","doi-asserted-by":"crossref","DOI":"10.1016\/j.carpath.2020.107258","volume":"49","author":"YJ Huang","year":"2020","unstructured":"Huang YJ, Zhu L, Tan JY, Guo WC, Yang Z, Shi WH, et al. Correlation between SHP-1 and carotid plaque vulnerability in humans. Cardiovasc Pathol. 2020;49:107258.","journal-title":"Cardiovasc Pathol"},{"key":"1392_CR3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ng2073","volume":"39","author":"B Pandit","year":"2007","unstructured":"Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, et al. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet. 2007;39:1007\u201312.","journal-title":"Nat Genet"},{"key":"1392_CR4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng772","volume":"29","author":"M Tartaglia","year":"2001","unstructured":"Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet. 2001;29:465\u20138.","journal-title":"Nat Genet"},{"key":"1392_CR5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/jmg.39.8.571","volume":"39","author":"E Legius","year":"2002","unstructured":"Legius E, Schrander-Stumpel C, Schollen E, Pulles-Heintzberger C, Gewillig M, Fryns JP. PTPN11 mutations in LEOPARD syndrome. J Med Genet. 2002;39:571\u20134.","journal-title":"J Med Genet"},{"key":"1392_CR6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s13577-020-00430-x","volume":"34","author":"YG Lu","year":"2021","unstructured":"Lu YG, Tan H, Ma Q, Li XX, Cui J, Zhang X, et al. SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) prevents cardiac remodeling after myocardial infarction through ERK\/SMAD signaling pathway. Hum Cell. 2021;34:325\u201334.","journal-title":"Hum Cell"},{"key":"1392_CR7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/CIRCULATIONAHA.107.728865","volume":"117","author":"MI Kontaridis","year":"2008","unstructured":"Kontaridis MI, Yang WT, Bence KK, Cullen Darragh, Wang B, Bodyak N, et al. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal\u2013regulated kinase\/mitogen-activated protein kinase and RhoA signaling pathways. Circulation. 2008;117:1423\u201335.","journal-title":"Circulation"},{"key":"1392_CR8","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1242\/dev.106310","volume":"141","author":"M Bonetti","year":"2014","unstructured":"Bonetti M, Paardekooper Overman J, Tessadori F, No\u00ebl E, Bakkers J, den Hertog J. Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development. 2014;141:1961\u201370.","journal-title":"Development"},{"key":"1392_CR9","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1038\/sj.onc.1204769","volume":"20","author":"DC Flynn","year":"2001","unstructured":"Flynn DC. Adaptor proteins. Oncogene. 2001;20:6270\u20132.","journal-title":"Oncogene"},{"key":"1392_CR10","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.biocel.2012.07.004","volume":"45","author":"CV Diogo","year":"2013","unstructured":"Diogo CV, Suski JM, Lebiedzinska M, Karkucinska-Wieckowska A, Wojtala A, Pronicki M, et al. Cardiac mitochondrial dysfunction during hyperglycemia\u2014the role of oxidative stress and p66Shc signaling. Int J Biochem Cell Biol. 2013;45:114\u201322.","journal-title":"Int J Biochem Cell Biol"},{"key":"1392_CR11","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/eurheartj\/ehu400","volume":"36","author":"A Akhmedov","year":"2015","unstructured":"Akhmedov A, Montecucco F, Braunersreuther V, Camici GG, Jakob P, Reiner MF, et al. Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways. Eur Heart J. 2015;36:516\u201326.","journal-title":"Eur Heart J"},{"key":"1392_CR12","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/sj.onc.1201299","volume":"15","author":"T Oda","year":"1997","unstructured":"Oda T, Kujovich J, Reis M, Newman B, Druker BJ, et al. Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene. 1997;15:1255\u201362.","journal-title":"Oncogene"},{"key":"1392_CR13","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/dvdy.21990","volume":"238","author":"KS Wong","year":"2009","unstructured":"Wong KS, Proulx K, Rost MS, Sumanas S. Identification of vasculature\u2010specific genes by microarray analysis of Etsrp\/Etv2 overexpressing zebrafish embryos. Dev Dyn. 2009;238:1836\u201350.","journal-title":"Dev Dyn"},{"key":"1392_CR14","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1161\/ATVBAHA.116.308120","volume":"36","author":"J Chen","year":"2016","unstructured":"Chen J, Zhu RF, Li FF, Liang YL, Wang C, Qin YW, et al. MicroRNA-126a directs lymphangiogenesis through interacting with chemokine and Flt4 signaling in zebrafish. Arterioscler Thromb Vasc Biol. 2016;36:2381\u201393.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1392_CR15","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","volume":"313","author":"EN Olson","year":"2006","unstructured":"Olson EN. Gene regulatory networks in the evolution and development of the heart. Science. 2006;313:1922\u20137.","journal-title":"Science"},{"key":"1392_CR16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCRESAHA.112.300853","volume":"112","author":"AC Fahed","year":"2013","unstructured":"Fahed AC, Gelb BD, Seidman JG, Seidman CE. Genetics of congenital heart disease: the glass half empty. Circ Res. 2013;112:707\u201320.","journal-title":"Circ Res"},{"key":"1392_CR17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1242\/dmm.016170","volume":"7","author":"A Asnani","year":"2014","unstructured":"Asnani A, Peterson RT. The zebrafish as a tool to identify novel therapies for human cardiovascular disease. Dis Model Mech. 2014;7:763\u20137.","journal-title":"Dis Model Mech"},{"key":"1392_CR18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/dvdy.10356","volume":"228","author":"CJ Huang","year":"2003","unstructured":"Huang CJ, Tu CT, Hsiao CD, Hsieh FJ, Tsai HJ. Germ\u2010line transmission of a myocardium\u2010specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish. Dev Dyn. 2003;228:30\u201340.","journal-title":"Dev Dyn"},{"key":"1392_CR19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.devcel.2004.06.005","volume":"7","author":"K Kawakami","year":"2004","unstructured":"Kawakami K, Takeda H, Kawakami N, Kobasashi M, Matsuda N, Mishina M. A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish. Dev Cell. 2004;7:133\u201344.","journal-title":"Dev Cell"},{"key":"1392_CR20","first-page":"13","volume":"3","author":"DR Brown","year":"2016","unstructured":"Brown DR, Samsa LA, Qian L, Liu JD. Advances in the study of heart development and disease using zebrafish. J Cardiovasc Dev Dis. 2016;3:13.","journal-title":"J Cardiovasc Dev Dis"},{"key":"1392_CR21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/35047564","volume":"2","author":"DY Stainier","year":"2001","unstructured":"Stainier DY. Zebrafish genetics and vertebrate heart formation. Nat Rev Genet. 2001;2:39\u201348.","journal-title":"Nat Rev Genet"},{"key":"1392_CR22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/cvr\/cvr098","volume":"91","author":"J Bakkers","year":"2011","unstructured":"Bakkers J. Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovasc Res. 2011;91:279\u201388.","journal-title":"Cardiovasc Res"},{"key":"1392_CR23","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/CIRCRESAHA.122.320396","volume":"130","author":"JM Gonz\u00e1lez-Rosa","year":"2022","unstructured":"Gonz\u00e1lez-Rosa JM. Zebrafish models of cardiac disease: From fortuitous mutants to precision medicine. Cir Res. 2022;130:1803\u201326.","journal-title":"Cir Res"},{"key":"1392_CR24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nbt1409","volume":"26","author":"Y Doyon","year":"2008","unstructured":"Doyon Y, McCammon JM, Miller JC, Faraji F, Ngo C, Katibah GE, et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol. 2008;26:702\u20138.","journal-title":"Nat Biotechnol"},{"key":"1392_CR25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature11537","volume":"491","author":"VM Bedell","year":"2012","unstructured":"Bedell VM, Wang Y, Campbell JM, Poshusta TL, Starker CG, Krug II RG, et al. In vivo genome editing using a high-efficiency TALEN system. Nature. 2012;491:114\u20138.","journal-title":"Nature"},{"key":"1392_CR26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nbt.2501","volume":"31","author":"WY Hwang","year":"2013","unstructured":"Hwang WY, Fu YF, Reyon D, Maeder ML, Tsai SQ, Sander JD, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol. 2013;31:227\u20139.","journal-title":"Nat Biotechnol."},{"key":"1392_CR27","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41401-020-0431-5","volume":"42","author":"FF Li","year":"2021","unstructured":"Li FF, Liang YL, Han XS, Guan YN, Chen J, Wu P, et al. ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1. Acta Pharmacol Sin. 2021;42:414\u201321.","journal-title":"Acta Pharmacol Sin"},{"key":"1392_CR28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","volume":"3","author":"C Thisse","year":"2008","unstructured":"Thisse C, Thisse B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc. 2008;3:59\u201369.","journal-title":"Nat Protoc"},{"key":"1392_CR29","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1038\/s41596-020-0376-7","volume":"15","author":"JB He","year":"2020","unstructured":"He JB, Mo DS, Chen JY, Luo LF. Combined whole-mount fluorescence in situ hybridization and antibody staining in zebrafish embryos and larvae. Nat Protoc. 2020;15:3361\u201379.","journal-title":"Nat Protoc"},{"key":"1392_CR30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cbpc.2017.11.003","volume":"208","author":"JE Copper","year":"2018","unstructured":"Copper JE, Budgeon LR, Foutz CA, van Rossum DB, Vanselow DJ, hubley MJ, et al. Comparative analysis of fixation and embedding techniques for optimized histological preparation of zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2018;208:38\u201346.","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"1392_CR31","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1093\/hmg\/ddp362","volume":"18","author":"RL Zhang","year":"2009","unstructured":"Zhang RL, Yang JC, Zhu J, Xu XL. Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere\u2013membrane interaction, not sarcomere assembly. Hum Mol Genet. 2009;18:4130\u201340.","journal-title":"Hum Mol Genet"},{"key":"1392_CR32","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/CIRCRESAHA.112.269795","volume":"110","author":"VM French","year":"2012","unstructured":"French VM, van de Laar IM, Wessels MW, Rohe C, Roos-Hesselink JW, Wang GL, et al. NPHP4 variants are associated with pleiotropic heart malformations. Circ Res. 2012;110:1564\u201374.","journal-title":"Circ Res"},{"key":"1392_CR33","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/hmg\/ddr214","volume":"20","author":"K Slanchev","year":"2011","unstructured":"Slanchev K, P\u00fctz M, Schmitt A, Kramer-Zucker A, Walz G. Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Hum Mol Genet. 2011;20:3119\u201328.","journal-title":"Hum Mol Genet"},{"key":"1392_CR34","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.acvd.2013.07.001","volume":"106","author":"JM Schleich","year":"2013","unstructured":"Schleich JM, Abdulla T, Summers R, Houyel L. An overview of cardiac morphogenesis. Arch Cardiovasc Dis. 2013;106:612\u201323.","journal-title":"Arch Cardiovasc Dis"},{"key":"1392_CR35","doi-asserted-by":"crossref","DOI":"10.1242\/dev.162776","volume":"145","author":"A Desgrange","year":"2018","unstructured":"Desgrange A, Le Garrec JF, Meilhac SM. Left-right asymmetry in heart development and disease: forming the right loop. Development. 2018;145:dev162776.","journal-title":"Development"},{"key":"1392_CR36","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/s41588-022-01129-5","volume":"54","author":"B Hu","year":"2022","unstructured":"Hu B, Lelek S, Spanjaard B, EI-Sammak H, Sim\u00f5es MG, Mintcheva J, et al. Origin and function of activated fibroblast states during zebrafish heart regeneration. Nat Genet. 2022;54:1227\u201337.","journal-title":"Nat Genet"},{"key":"1392_CR37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30468-4","volume":"13","author":"C de Sena-Tom\u00e1s","year":"2022","unstructured":"de Sena-Tom\u00e1s C, Aleman AG, Ford C, Varshney A, Yao D, Harrington JK, et al. Activation of Nkx2. 5 transcriptional program is required for adult myocardial repair. Nat Commun. 2022;13:2970.","journal-title":"Nat Commun"},{"key":"1392_CR38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/dev.119.2.419","volume":"119","author":"TJ Lints","year":"1993","unstructured":"Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP. Nkx-2. 5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development. 1993;119:419\u201331.","journal-title":"Development"},{"key":"1392_CR39","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2006.08.052","volume":"127","author":"A Lepilina","year":"2006","unstructured":"Lepilina A, Coon AN, Kikuchi K, Holdway JE, Roberts RW, Burns CG, et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell. 2006;127:607\u201319.","journal-title":"Cell"},{"key":"1392_CR40","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1002\/dvdy.23882","volume":"241","author":"C Singleman","year":"2012","unstructured":"Singleman C, Holtzman NG. Analysis of postembryonic heart development and maturation in the zebrafish, Danio rerio. Dev Dyn. 2012;241:1993\u20132004.","journal-title":"Dev Dyn"},{"key":"1392_CR41","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/archdischild-2021-322858","volume":"107","author":"M Zenker","year":"2022","unstructured":"Zenker M, Edouard T, Blair JC, Cappa M. Noonan syndrome: improving recognition and diagnosis. Arch Dis Child. 2022;107:1073\u20138.","journal-title":"Arch Dis Child"},{"key":"1392_CR42","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3390\/ijms20071626","volume":"20","author":"M Jim\u00e9nez-Mart\u00ednez","year":"2019","unstructured":"Jim\u00e9nez-Mart\u00ednez M, Stamatakis K, Fresno M. The dual-specificity phosphatase 10 (DUSP10): its role in cancer, inflammation, and immunity. Int J Mol Sci. 2019;20:1626.","journal-title":"Int J Mol Sci"},{"key":"1392_CR43","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/CIRCRESAHA.110.226928","volume":"108","author":"JW Gordon","year":"2011","unstructured":"Gordon JW, Shaw JA, Kirshenbaum LA. Multiple facets of NF-\u03baB in the heart: to be or not to NF-\u03baB. Circ Res. 2011;108:1122\u201332.","journal-title":"Circ Res"},{"key":"1392_CR44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0014-5793(00)01415-0","volume":"472","author":"BY Kim","year":"2000","unstructured":"Kim BY, Kang DO, Oh WK, Kim JH, Choi YK, Jang JS, et al. Involvement of SH2-SH2-SH3 domain of phospholipase C\u03b31 in NF-\u03baB signaling. FEBS Lett. 2000;472:45\u20139.","journal-title":"FEBS Lett"},{"key":"1392_CR45","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/cvr\/cvp237","volume":"84","author":"L Zelarayan","year":"2009","unstructured":"Zelarayan L, Renger A, Noack C, Zafiriou MP, Gehrke C, van der Nagel R, et al. NF-\u03baB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res. 2009;84:416\u201324.","journal-title":"Cardiovasc Res"},{"key":"1392_CR46","doi-asserted-by":"crossref","first-page":"H1531","DOI":"10.1152\/ajpheart.00216.2011","volume":"301","author":"H Ishida","year":"2011","unstructured":"Ishida H, Kogaki S, Narita J, Ichimori H, Nawa N, Okada Y, et al. LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt\/GSK-3\u03b2\/\u03b2-catenin signaling. Am J Physiol Heart Circ Physiol. 2011;301:H1531\u20139.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1392_CR47","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI44972","volume":"121","author":"TM Marin","year":"2011","unstructured":"Marin TM, Keith K, Davies B, Conner DA, Guha P, Kalaitzidis D, et al. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome\u2013associated PTPN11 mutation. J Clin Invest. 2011;121:1026\u201343.","journal-title":"J Clin Invest"},{"key":"1392_CR48","doi-asserted-by":"crossref","first-page":"H231","DOI":"10.1152\/ajpheart.00665.2011","volume":"302","author":"C Schramm","year":"2012","unstructured":"Schramm C, Fine DM, Edwards MA, Reeb AN, Krenz M. The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Am J Physiol Heart Circ Physiol. 2012;302:H231\u201343.","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01392-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01392-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01392-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T16:13:46Z","timestamp":1737389626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-024-01392-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1392"],"URL":"https:\/\/doi.org\/10.1038\/s41401-024-01392-8","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]},"assertion":[{"value":"3 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest. Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences has applied for a patent, China Patent Application No. 202311014379.7 by inventors Qing Jing, Yang-xi Hu, Yu-lai Liang and Zhi-hua Liu for the usage of L-selenomethionine in antioxidant stress and alleviation of cardiac developmental defects caused by SH2E gene mutations described in this paper under the support of the Program of EnShi TuJia and Miao Autonomous Prefecture Bureau of Scientific and Technological Affairs.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}