{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:51:16Z","timestamp":1774482676633,"version":"3.50.1"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1038\/s41401-025-01692-7","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T07:26:22Z","timestamp":1764573982000},"page":"811-826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors"],"prefix":"10.1038","volume":"47","author":[{"given":"Xiang-hu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Naveed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-yun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"1692_CR1","doi-asserted-by":"crossref","unstructured":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry. 2022;9:137-50.","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"1692_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101675","volume":"54","author":"D Arias","year":"2022","unstructured":"Arias D, Saxena S, Verguet S. Quantifying the global burden of mental disorders and their economic value. EClinicalMedicine. 2022;54:101675.","journal-title":"EClinicalMedicine"},{"key":"1692_CR3","unstructured":"(IHME) IfHMaE. GBD Results. Seattle, WA: IHME, University of Washington, 2024."},{"key":"1692_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2021.101583","volume":"61","author":"SL Chellappa","year":"2022","unstructured":"Chellappa SL, Aeschbach D. Sleep and anxiety: From mechanisms to interventions. Sleep Med Rev. 2022;61:101583.","journal-title":"Sleep Med Rev"},{"key":"1692_CR5","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S0140-6736(21)00359-7","volume":"397","author":"BW Penninx","year":"2021","unstructured":"Penninx BW, Pine DS, Holmes EA, Reif A. Anxiety disorders. Lancet. 2021;397:914\u201327.","journal-title":"Lancet"},{"key":"1692_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.595584","volume":"11","author":"A Garakani","year":"2020","unstructured":"Garakani A, Murrough JW, Freire RC, Thom RP, Larkin K, Buono FD, et al. Pharmacotherapy of anxiety disorders: current and emerging treatment options. Front Psychiatry. 2020;11:595584.","journal-title":"Front Psychiatry"},{"key":"1692_CR7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1124\/pr.117.014381","volume":"70","author":"T Atkin","year":"2018","unstructured":"Atkin T, Comai S, Gobbi G. Drugs for insomnia beyond benzodiazepines: pharmacology, clinical applications, and discovery. Pharmacol Rev. 2018;70:197\u2013245.","journal-title":"Pharmacol Rev."},{"key":"1692_CR8","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cger.2021.04.003","volume":"37","author":"BX Lou","year":"2021","unstructured":"Lou BX, Oks M. Insomnia: pharmacologic treatment. Clin Geriatr Med. 2021;37:401\u201315.","journal-title":"Clin Geriatr Med."},{"key":"1692_CR9","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1001\/jamapsychiatry.2017.1273","volume":"74","author":"GA Bushnell","year":"2017","unstructured":"Bushnell GA, St\u00fcrmer T, Gaynes BN, Pate V, Miller M. Simultaneous antidepressant and benzodiazepine new use and subsequent long-term benzodiazepine use in adults with depression, United States, 2001-2014. JAMA Psychiatry. 2017;74:747\u201355.","journal-title":"JAMA Psychiatry"},{"key":"1692_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114515","volume":"191","author":"LE McKillop","year":"2021","unstructured":"McKillop LE, Fisher SP, Milinski L, Krone LB, Vyazovskiy VV. Diazepam effects on local cortical neural activity during sleep in mice. Biochem Pharmacol. 2021;191:114515.","journal-title":"Biochem Pharm"},{"key":"1692_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.22271\/27891623.2024.v4.i1a.49","volume":"4","author":"A Kampani","year":"2024","unstructured":"Kampani A. Adverse effects of antidepressant medications: a comparative analysis of different classes. Int J Res Psychiatry. 2024;4:21\u201332.","journal-title":"Int J Res Psychiatry"},{"key":"1692_CR12","doi-asserted-by":"crossref","unstructured":"Hutka P, Krivosova M, Muchova Z, Tonhajzerova I, Hamrakova A, Mlyncekova Z, et al. Association of sleep architecture and physiology with depressive disorder and antidepressants treatment. Int J Mol Sci. 2021;22.","DOI":"10.3390\/ijms22031333"},{"key":"1692_CR13","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","volume":"56","author":"J Liu","year":"2016","unstructured":"Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol. 2016;56:361\u201383.","journal-title":"Annu Rev Pharmacol Toxicol."},{"key":"1692_CR14","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S2215-0366(21)00034-1","volume":"8","author":"JJ Crouse","year":"2021","unstructured":"Crouse JJ, Carpenter JS, Song YJC, Hockey SJ, Naismith SL, Grunstein RR, et al. Circadian rhythm sleep-wake disturbances and depression in young people: implications for prevention and early intervention. Lancet Psychiatry. 2021;8:813\u201323.","journal-title":"Lancet Psychiatry"},{"key":"1692_CR15","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.1111\/bph.12720","volume":"171","author":"B Guardiola-Lemaitre","year":"2014","unstructured":"Guardiola-Lemaitre B, De Bodinat C, Delagrange P, Millan MJ, Munoz C, Moca\u00ebr E. Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties. Br J Pharmacol. 2014;171:3604\u201319.","journal-title":"Br J Pharmacol."},{"key":"1692_CR16","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nrd3140","volume":"9","author":"C de Bodinat","year":"2010","unstructured":"de Bodinat C, Guardiola-Lemaitre B, Moca\u00ebr E, Renard P, Mu\u00f1oz C, Millan MJ. Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discov. 2010;9:628\u201342.","journal-title":"Nat Rev Drug Discov"},{"key":"1692_CR17","doi-asserted-by":"crossref","unstructured":"Zhu Y, Li Y, Yu Z, Chen X, Lan T, Wang M, et al. Agomelatine alleviates depressive-like behaviors by suppressing hippocampal oxidative stress in the chronic social defeat stress model. Antioxidants (Basel). 2025;14:410.","DOI":"10.3390\/antiox14040410"},{"key":"1692_CR18","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/JCP.0b013e318184ff5b","volume":"28","author":"DJ Stein","year":"2008","unstructured":"Stein DJ, Ahokas AA, de Bodinat C. Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2008;28:561\u20136.","journal-title":"J Clin Psychopharmacol"},{"key":"1692_CR19","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1517\/13543784.2014.911840","volume":"23","author":"K Demyttenaere","year":"2014","unstructured":"Demyttenaere K. Agomelatine in treating generalized anxiety disorder. Expert Opin Investig Drugs. 2014;23:857\u201364.","journal-title":"Expert Opin Investig Drugs"},{"key":"1692_CR20","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1080\/14656566.2017.1359257","volume":"18","author":"M Buoli","year":"2017","unstructured":"Buoli M, Grassi S, Serati M, Altamura AC. Agomelatine for the treatment of generalized anxiety disorder. Expert Opin Pharmacother. 2017;18:1373\u20139.","journal-title":"Expert Opin Pharmacother"},{"key":"1692_CR21","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.neuropsychologia.2010.09.028","volume":"49","author":"CM Schumann","year":"2011","unstructured":"Schumann CM, Bauman MD, Amaral DG. Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders. Neuropsychologia. 2011;49:745\u201359.","journal-title":"Neuropsychologia"},{"key":"1692_CR22","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1176\/ajp.2006.163.6.1091","volume":"163","author":"CS Monk","year":"2006","unstructured":"Monk CS, Nelson EE, McClure EB, Mogg K, Bradley BP, Leibenluft E, et al. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. Am J Psychiatry. 2006;163:1091\u20137.","journal-title":"Am J Psychiatry"},{"key":"1692_CR23","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1523\/JNEUROSCI.3372-13.2014","volume":"34","author":"J Cha","year":"2014","unstructured":"Cha J, Greenberg T, Carlson JM, Dedora DJ, Hajcak G, Mujica-Parodi LR. Circuit-wide structural and functional measures predict ventromedial prefrontal cortex fear generalization: implications for generalized anxiety disorder. J Neurosci. 2014;34:4043\u201353.","journal-title":"J Neurosci"},{"key":"1692_CR24","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.tins.2021.11.005","volume":"45","author":"A Tomar","year":"2022","unstructured":"Tomar A, McHugh TJ. The impact of stress on the hippocampal spatial code. Trends Neurosci. 2022;45:120\u201332.","journal-title":"Trends Neurosci"},{"key":"1692_CR25","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s12264-023-01020-1","volume":"39","author":"HJ Shi","year":"2023","unstructured":"Shi HJ, Wang S, Wang XP, Zhang RX, Zhu LJ. Hippocampus: molecular, cellular, and circuit features in anxiety. Neurosci Bull. 2023;39:1009\u201326.","journal-title":"Neurosci Bull"},{"key":"1692_CR26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.tips.2014.09.011","volume":"35","author":"OF O\u2019Leary","year":"2014","unstructured":"O\u2019Leary OF, Cryan JF. A ventral view on antidepressant action: roles for adult hippocampal neurogenesis along the dorsoventral axis. Trends Pharmacol Sci. 2014;35:675\u201387.","journal-title":"Trends Pharmacol Sci."},{"key":"1692_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrn.2015.24","volume":"17","author":"P Zeidman","year":"2016","unstructured":"Zeidman P, Maguire EA. Anterior hippocampus: the anatomy of perception, imagination and episodic memory. Nat Rev Neurosci. 2016;17:173\u201382.","journal-title":"Nat Rev Neurosci"},{"key":"1692_CR28","doi-asserted-by":"publisher","first-page":"10825","DOI":"10.1073\/pnas.152112399","volume":"99","author":"KG Kjelstrup","year":"2002","unstructured":"Kjelstrup KG, Tuvnes FA, Steffenach HA, Murison R, Moser EI, Moser MB. Reduced fear expression after lesions of the ventral hippocampus. Proc Natl Acad Sci USA. 2002;99:10825\u201330.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1692_CR29","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.nlm.2004.02.005","volume":"81","author":"MA Trivedi","year":"2004","unstructured":"Trivedi MA. Coover GD. Lesions of the ventral hippocampus, but not the dorsal hippocampus, impair conditioned fear expression and inhibitory avoidance on the elevated T-maze. Neurobiol Learn Mem. 2004;81:172\u201384.","journal-title":"Neurobiol Learn Mem"},{"key":"1692_CR30","doi-asserted-by":"publisher","first-page":"6810","DOI":"10.1523\/JNEUROSCI.22-15-06810.2002","volume":"22","author":"A Vyas","year":"2002","unstructured":"Vyas A, Mitra R, Shankaranarayana Rao BS, Chattarji S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J Neurosci. 2002;22:6810\u20138.","journal-title":"J Neurosci"},{"key":"1692_CR31","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1093\/ijnp\/pyz048","volume":"22","author":"J Zhang","year":"2019","unstructured":"Zhang J, Qu Y, Chang L, Pu Y, Hashimoto K. (R)-Ketamine rapidly ameliorates the decreased spine density in the medial prefrontal cortex and hippocampus of susceptible mice after chronic social defeat stress. Int J Neuropsychopharmacol. 2019;22:675\u20139.","journal-title":"Int J Neuropsychopharmacol."},{"key":"1692_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.552787","volume":"13","author":"DS Sun","year":"2020","unstructured":"Sun DS, Zhong G, Cao HX, Hu Y, Hong XY, Li T, et al. Repeated restraint stress led to cognitive dysfunction by NMDA receptor-mediated hippocampal CA3 dendritic spine impairments in juvenile Sprague-Dawley rats. Front Mol Neurosci. 2020;13:552787.","journal-title":"Front Mol Neurosci."},{"key":"1692_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107566","volume":"26","author":"KJ Bjornson","year":"2023","unstructured":"Bjornson KJ, Vanderplow AM, Yang Y, Anderson DR, Kermath BA, Cahill ME. Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function. iScience. 2023;26:107566.","journal-title":"iScience"},{"key":"1692_CR34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","volume":"583","author":"BS McEwen","year":"2008","unstructured":"McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008;583:174\u201385.","journal-title":"Eur J Pharmacol."},{"key":"1692_CR35","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3758\/s13415-021-00973-y","volume":"22","author":"M Ghasemi","year":"2022","unstructured":"Ghasemi M, Navidhamidi M, Rezaei F, Azizikia A, Mehranfard N. Anxiety and hippocampal neuronal activity: Relationship and potential mechanisms. Cogn Affect Behav Neurosci. 2022;22:431\u201349.","journal-title":"Cogn Affect Behav Neurosci"},{"key":"1692_CR36","doi-asserted-by":"publisher","unstructured":"Cao B, Luo F, Zhang W, Luo R, Cai L, Wei Y, et al. Anatomical distribution of histone H3 acetylation in human hippocampus. Human Brain. 2024;3. https:\/\/doi.org\/10.37819\/hb.1.1900.","DOI":"10.37819\/hb.1.1900"},{"key":"1692_CR37","doi-asserted-by":"publisher","first-page":"e0154530","DOI":"10.1371\/journal.pone.0154530","volume":"11","author":"ME Zimmerman","year":"2016","unstructured":"Zimmerman ME, Ezzati A, Katz MJ, Lipton ML, Brickman AM, Sliwinski MJ, et al. Perceived stress Is differentially related to Hippocampal subfield volumes among older adults. PLoS One. 2016;11:e0154530.","journal-title":"PLoS One"},{"key":"1692_CR38","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1001\/archgenpsychiatry.2010.48","volume":"67","author":"A Soetanto","year":"2010","unstructured":"Soetanto A, Wilson RS, Talbot K, Un A, Schneider JA, Sobiesk M, et al. Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans. Arch Gen Psychiatry. 2010;67:448\u201357.","journal-title":"Arch Gen Psychiatry"},{"key":"1692_CR39","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.biopsych.2019.05.024","volume":"86","author":"EC Merz","year":"2019","unstructured":"Merz EC, Desai PM, Maskus EA, Melvin SA, Rehman R, Torres SD, et al. Socioeconomic disparities in chronic physiologic stress are associated with brain structure in children. Biol Psychiatry. 2019;86:921\u20139.","journal-title":"Biol Psychiatry"},{"key":"1692_CR40","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.cub.2018.03.012","volume":"28","author":"A Schumacher","year":"2018","unstructured":"Schumacher A, Villaruel FR, Ussling A, Riaz S, Lee ACH, Ito R. Ventral Hippocampal CA1 and CA3 differentially mediate learned approach-avoidance conflict processing. Curr Biol. 2018;28:1318\u20131324.e1314.","journal-title":"Curr Biol"},{"key":"1692_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112933","volume":"397","author":"A Charousaei","year":"2021","unstructured":"Charousaei A, Nasehi M, Babapour V, Vaseghi S, Zarrindast MR. The effect of 5-HT4 serotonin receptors in the CA3 hippocampal region on D-AP5-induced anxiolytic-like effects: isobolographic analyses. Behav Brain Res. 2021;397:112933.","journal-title":"Behav Brain Res."},{"key":"1692_CR42","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1093\/schbul\/sbs062","volume":"38","author":"CA Tamminga","year":"2012","unstructured":"Tamminga CA, Southcott S, Sacco C, Wagner AD, Ghose S. Glutamate dysfunction in hippocampus: relevance of dentate gyrus and CA3 signaling. Schizophr Bull. 2012;38:927\u201335.","journal-title":"Schizophr Bull"},{"key":"1692_CR43","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/npp.2012.140","volume":"38","author":"F Chenu","year":"2013","unstructured":"Chenu F, El Mansari M, Blier P. Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain. Neuropsychopharmacology. 2013;38:275\u201384.","journal-title":"Neuropsychopharmacology"},{"key":"1692_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-75","volume":"14","author":"M Milanese","year":"2013","unstructured":"Milanese M, Tardito D, Musazzi L, Treccani G, Mallei A, Bonifacino T, et al. Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes. BMC Neurosci. 2013;14:75.","journal-title":"BMC Neurosci"},{"key":"1692_CR45","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/mp.2017.240","volume":"23","author":"J Castello","year":"2018","unstructured":"Castello J, LeFrancois B, Flajolet M, Greengard P, Friedman E, Rebholz H. CK2 regulates 5-HT4 receptor signaling and modulates depressive-like behavior. Mol Psychiatry. 2018;23:872\u201382.","journal-title":"Mol Psychiatry"},{"key":"1692_CR46","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.tips.2008.07.001","volume":"29","author":"MV King","year":"2008","unstructured":"King MV, Marsden CA, Fone KC. A role for the 5-HT1A, 5-HT4 and 5-HT6receptors in learning and memory. Trends Pharmacol Sci. 2008;29:482\u201392.","journal-title":"Trends Pharmacol Sci."},{"key":"1692_CR47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0165-6147(00)89081-1","volume":"16","author":"RM Eglen","year":"1995","unstructured":"Eglen RM, Wong EH, Dumuis A, Bockaert J. Central 5-HT4 receptors. Trends Pharmacol Sci. 1995;16:391\u20138.","journal-title":"Trends Pharmacol Sci."},{"key":"1692_CR48","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1038\/s41380-020-00994-y","volume":"26","author":"R Karayol","year":"2021","unstructured":"Karayol R, Medrihan L, Warner-Schmidt JL, Fait BW, Rao MN, Holzner EB, et al. Serotonin receptor 4 in the hippocampus modulates mood and anxiety. Mol Psychiatry. 2021;26:2334\u201349.","journal-title":"Mol Psychiatry"},{"key":"1692_CR49","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1071795","volume":"297","author":"K Nakazawa","year":"2002","unstructured":"Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science. 2002;297:211\u20138.","journal-title":"Science"},{"key":"1692_CR50","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cell.2014.09.014","volume":"159","author":"RJ Platt","year":"2014","unstructured":"Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 2014;159:440\u201355.","journal-title":"Cell"},{"key":"1692_CR51","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nature25509","volume":"554","author":"Y Yang","year":"2018","unstructured":"Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature. 2018;554:317\u201322.","journal-title":"Nature"},{"key":"1692_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.125","volume":"4","author":"F Boulle","year":"2014","unstructured":"Boulle F, Massart R, Stragier E, Paizanis E, Zaidan L, Marday S, et al. Hippocampal and behavioral dysfunctions in a mouse model of environmental stress: normalization by agomelatine. Transl Psychiatry. 2014;4:e485.","journal-title":"Transl Psychiatry."},{"key":"1692_CR53","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ejphar.2014.04.039","volume":"736","author":"M Dastgheib","year":"2014","unstructured":"Dastgheib M, Moezi L. Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide. Eur J Pharmacol. 2014;736:10\u20135.","journal-title":"Eur J Pharmacol."},{"key":"1692_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02479-x","volume":"19","author":"T Lan","year":"2022","unstructured":"Lan T, Wu Y, Zhang Y, Li S, Zhu Z, Wang L, et al. Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Galphai-2-PKA-ASK1 signaling pathway. J Neuroinflamm. 2022;19:117.","journal-title":"J Neuroinflamm"},{"key":"1692_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.673439","volume":"15","author":"J Zhang","year":"2021","unstructured":"Zhang J, Li SJ, Miao W, Zhang X, Zheng JJ, Wang C, et al. Oxytocin regulates synaptic transmission in the sensory cortices in a developmentally dynamic manner. Front Cell Neurosci. 2021;15:673439.","journal-title":"Front Cell Neurosci."},{"key":"1692_CR56","doi-asserted-by":"crossref","unstructured":"Giovannucci A, Friedrich J, Gunn P, Kalfon J, Brown BL, Koay SA, et al. CaImAn an open source tool for scalable calcium imaging data analysis. Elife. 2019:8:e38173.","DOI":"10.7554\/eLife.38173"},{"key":"1692_CR57","doi-asserted-by":"crossref","unstructured":"Moda-Sava RN, Murdock MH, Parekh PK, Fetcho RN, Huang BS, Huynh TN, et al. Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation. Science. 2019;364:eaat8078.","DOI":"10.1126\/science.aat8078"},{"key":"1692_CR58","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41586-021-03956-8","volume":"599","author":"X Wu","year":"2021","unstructured":"Wu X, Morishita W, Beier KT, Heifets BD, Malenka RC. 5-HT modulation of a medial septal circuit tunes social memory stability. Nature. 2021;599:96\u2013101.","journal-title":"Nature"},{"key":"1692_CR59","doi-asserted-by":"publisher","first-page":"e0124633","DOI":"10.1371\/journal.pone.0124633","volume":"10","author":"M Stemmer","year":"2015","unstructured":"Stemmer M, Thumberger T, Del Sol Keyer M, Wittbrodt J, Mateo JL. CCTop: an intuitive, flexible and reliable CRISPR\/Cas9 target prediction tool. PLoS One. 2015;10:e0124633.","journal-title":"PLoS One"},{"key":"1692_CR60","doi-asserted-by":"publisher","first-page":"W171","DOI":"10.1093\/nar\/gkz365","volume":"47","author":"K Labun","year":"2019","unstructured":"Labun K, Montague TG, Krause M, Torres Cleuren YN, Tjeldnes H, Valen E. CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing. Nucleic Acids Res. 2019;47:W171\u2013W174.","journal-title":"Nucleic Acids Res"},{"key":"1692_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-015-0035-z","volume":"10","author":"V Pliatsika","year":"2015","unstructured":"Pliatsika V, Rigoutsos I. Off-Spotter\u201d: very fast and exhaustive enumeration of genomic lookalikes for designing CRISPR\/Cas guide RNAs. Biol Direct. 2015;10:4.","journal-title":"Biol Direct"},{"key":"1692_CR62","doi-asserted-by":"publisher","first-page":"181","DOI":"10.31887\/DCNS.2017.19.2\/wcarlezon","volume":"19","author":"KR Lezak","year":"2017","unstructured":"Lezak KR, Missig G, Carlezon WA Jr. Behavioral methods to study anxiety in rodents. Dialogues Clin Neurosci. 2017;19:181\u201391.","journal-title":"Dialogues Clin Neurosci"},{"key":"1692_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02517-8","volume":"19","author":"YL Gan","year":"2022","unstructured":"Gan YL, Wang CY, He RH, Hsu PC, Yeh HH, Hsieh TH, et al. FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus. J Neuroinflammation. 2022;19:152.","journal-title":"J Neuroinflammation"},{"key":"1692_CR64","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/FBP.0000000000000153","volume":"26","author":"U Demir Ozkay","year":"2015","unstructured":"Demir Ozkay U, Soztutar E, Can OD, Ucel UI, Ozturk Y, Ulupinar E. Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats. Behav Pharmacol. 2015;26:469\u201380.","journal-title":"Behav Pharmacol."},{"key":"1692_CR65","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1126\/science.aaf7560","volume":"353","author":"L Carrillo-Reid","year":"2016","unstructured":"Carrillo-Reid L, Yang W, Bando Y, Peterka DS, Yuste R. Imprinting and recalling cortical ensembles. Science. 2016;353:691\u20134.","journal-title":"Science"},{"key":"1692_CR66","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.biopsych.2015.03.010","volume":"77","author":"G Gonzalez-Burgos","year":"2015","unstructured":"Gonzalez-Burgos G, Cho RY, Lewis DA. Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia. Biol Psychiatry. 2015;77:1031\u201340.","journal-title":"Biol Psychiatry"},{"key":"1692_CR67","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.neuron.2017.03.019","volume":"94","author":"JP Hamm","year":"2017","unstructured":"Hamm JP, Peterka DS, Gogos JA, Yuste R. Altered cortical ensembles in mouse models of schizophrenia. Neuron. 2017;94:153\u2013167.e158.","journal-title":"Neuron"},{"key":"1692_CR68","doi-asserted-by":"publisher","first-page":"E4053","DOI":"10.1073\/pnas.1406077111","volume":"111","author":"JE Miller","year":"2014","unstructured":"Miller JE, Ayzenshtat I, Carrillo-Reid L, Yuste R. Visual stimuli recruit intrinsically generated cortical ensembles. Proc Natl Acad Sci USA. 2014;111:E4053\u20134061.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1692_CR69","doi-asserted-by":"publisher","unstructured":"Rubin AL, Walth M. A formal model of mood disorders based on the neural circuit dynamics of the triple network model. medRxiv. 2024.06.16.24309000; https:\/\/doi.org\/10.1101\/2024.06.16.24309000.","DOI":"10.1101\/2024.06.16.24309000"},{"key":"1692_CR70","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/hipo.22566","volume":"26","author":"J Cha","year":"2016","unstructured":"Cha J, Greenberg T, Song I, Blair Simpson H, Posner J, Mujica-Parodi LR. Abnormal hippocampal structure and function in clinical anxiety and comorbid depression. Hippocampus. 2016;26:545\u201353.","journal-title":"Hippocampus"},{"key":"1692_CR71","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918761257","volume":"14","author":"Z Chen","year":"2018","unstructured":"Chen Z, Chen X, Liu M, Ma L, Yu S. Lower hippocampal subfields volume in relation to anxiety in medication-overuse headache. Mol Pain. 2018;14:1744806918761257.","journal-title":"Mol Pain"},{"key":"1692_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpnec.2023.100224","volume":"17","author":"VH Dam","year":"2024","unstructured":"Dam VH, Andersen SH, Pedersen ST, Stenb\u00e6k DS, Frokjaer VG. Serotonin 4 receptor brain binding and oxytocin-promoted affective and social cognition in healthy women - a randomized controlled trial. Compr Psychoneuroendocrinol. 2024;17:100224.","journal-title":"Compr Psychoneuroendocrinol"},{"key":"1692_CR73","doi-asserted-by":"publisher","first-page":"9240","DOI":"10.1021\/jm300953p","volume":"55","author":"MA Brodney","year":"2012","unstructured":"Brodney MA, Johnson DE, Sawant-Basak A, Coffman KJ, Drummond EM, Hudson EL, et al. Identification of multiple 5-HT\u2084 partial agonist clinical candidates for the treatment of Alzheimer\u2019s disease. J Med Chem. 2012;55:9240\u201354.","journal-title":"J Med Chem"},{"key":"1692_CR74","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.21037\/tp-2025-100","volume":"14","author":"Z Shan","year":"2025","unstructured":"Shan Z, He C, Yang Q, Xiong J, Li M, Meng M, et al. Chenodeoxycholic acid activates the TGR5\/TRPA1-5-HT pathway to regulate intestinal motility in breastfed infants and mouse models. Transl Pediatr. 2025;14:1213\u201329.","journal-title":"Transl Pediatr"},{"key":"1692_CR75","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1053\/smrv.1999.0096","volume":"4","author":"JM Monti","year":"2000","unstructured":"Monti JM, Monti D. Sleep disturbance in generalized anxiety disorder and its treatment. Sleep Med Rev. 2000;4:263\u201376.","journal-title":"Sleep Med Rev"},{"key":"1692_CR76","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.5665\/sleep.2116","volume":"35","author":"AM Soehner","year":"2012","unstructured":"Soehner AM, Harvey AG. Prevalence and functional consequences of severe insomnia symptoms in mood and anxiety disorders: results from a nationally representative sample. Sleep. 2012;35:1367\u201375.","journal-title":"Sleep"},{"key":"1692_CR77","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1177\/00912174231166252","volume":"58","author":"DL Louie","year":"2023","unstructured":"Louie DL, Jegede OO, Hermes GL. Chronic use of benzodiazepines: The problem that persists. Int J Psychiatry Med. 2023;58:426\u201332.","journal-title":"Int J Psychiatry Med"},{"key":"1692_CR78","volume":"11","author":"N Zareifopoulos","year":"2019","unstructured":"Zareifopoulos N, Panayiotakopoulos G. Treatment options for acute agitation in psychiatric patients: theoretical and empirical evidence. Cureus. 2019;11:e6152.","journal-title":"Cureus"},{"key":"1692_CR79","doi-asserted-by":"publisher","first-page":"153","DOI":"10.12968\/hmed.2010.71.3.46979","volume":"71","author":"DS Baldwin","year":"2010","unstructured":"Baldwin DS, Lopes AT. Agomelatine in the treatment of mood and anxiety disorders. Br J Hosp Med. 2010;71:153\u20136.","journal-title":"Br J Hosp Med"},{"key":"1692_CR80","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/15622970902717024","volume":"10","author":"S Kasper","year":"2009","unstructured":"Kasper S, Hamon M. Beyond the monoaminergic hypothesis: agomelatine, a new antidepressant with an innovative mechanism of action. World J Biol Psychiatry. 2009;10:117\u201326.","journal-title":"World J Biol Psychiatry"},{"key":"1692_CR81","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.euroneuro.2005.11.007","volume":"16","author":"F Loiseau","year":"2006","unstructured":"Loiseau F, Le Bihan C, Hamon M, Thiebot MH. Effects of melatonin and agomelatine in anxiety-related procedures in rats: interaction with diazepam. Eur Neuropsychopharmacol. 2006;16:417\u201328.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1692_CR82","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s00213-004-1962-z","volume":"177","author":"MJ Millan","year":"2005","unstructured":"Millan MJ, Brocco M, Gobert A, Dekeyne A. Anxiolytic properties of agomelatine, an antidepressant with melatoninergic and serotonergic properties: role of 5-HT2C receptor blockade. Psychopharmacology. 2005;177:448\u201358.","journal-title":"Psychopharmacology"},{"key":"1692_CR83","doi-asserted-by":"publisher","first-page":"423","DOI":"10.9758\/cpn.2020.18.3.423","volume":"18","author":"SM Wang","year":"2020","unstructured":"Wang SM, Woo YS, Kim NY, Na HR, Lim HK, Bahk WM. Agomelatine for the treatment of generalized anxiety disorder: a meta-analysis. Clin Psychopharmacol Neurosci. 2020;18:423\u201333.","journal-title":"Clin Psychopharmacol Neurosci"},{"key":"1692_CR84","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/S0140-6736(18)31793-8","volume":"393","author":"A Slee","year":"2019","unstructured":"Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N. Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. Lancet. 2019;393:768\u201377.","journal-title":"Lancet"},{"key":"1692_CR85","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1177\/0269881115599385","volume":"29","author":"AL Montejo","year":"2015","unstructured":"Montejo AL, Deakin JF, Gaillard R, Harmer C, Meyniel F, Jabourian A, et al. Better sexual acceptability of agomelatine (25 and 50 mg) compared to escitalopram (20 mg) in healthy volunteers. A 9-week, placebo-controlled study using the PRSexDQ scale. J Psychopharmacol. 2015;29:1119\u201328.","journal-title":"J Psychopharmacol"},{"key":"1692_CR86","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1037\/0735-7044.116.5.884","volume":"116","author":"DM Bannerman","year":"2002","unstructured":"Bannerman DM, Deacon RM, Offen S, Friswell J, Grubb M, Rawlins JN. Double dissociation of function within the hippocampus: spatial memory and hyponeophagia. Behav Neurosci. 2002;116:884\u2013901.","journal-title":"Behav Neurosci"},{"key":"1692_CR87","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","volume":"164","author":"CA Jones","year":"2011","unstructured":"Jones CA, Watson DJ, Fone KC. Animal models of schizophrenia. Br J Pharmacol. 2011;164:1162\u201394.","journal-title":"Br J Pharmacol."},{"key":"1692_CR88","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1037\/0735-7044.118.1.63","volume":"118","author":"SB McHugh","year":"2004","unstructured":"McHugh SB, Deacon RM, Rawlins JN, Bannerman DM. Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behav Neurosci. 2004;118:63\u201378.","journal-title":"Behav Neurosci"},{"key":"1692_CR89","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1111\/ejn.15944","volume":"57","author":"EC Bach","year":"2023","unstructured":"Bach EC, Ewin SE, Heaney CF, Carlson HN, Ortelli OA, Almonte AG, et al. Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus selectively reduces appetitive, but not consummatory, alcohol drinking-related behaviours. Eur J Neurosci. 2023;57:1241\u201359.","journal-title":"Eur J Neurosci"},{"key":"1692_CR90","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neuroscience.2010.11.033","volume":"174","author":"KM Christian","year":"2011","unstructured":"Christian KM, Miracle AD, Wellman CL, Nakazawa K. Chronic stress-induced hippocampal dendritic retraction requires CA3 NMDA receptors. Neuroscience. 2011;174:26\u201336.","journal-title":"Neuroscience"},{"key":"1692_CR91","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01789-1","volume":"12","author":"HM Hwang","year":"2022","unstructured":"Hwang HM, Hashimoto-Torii K. Activation of the anterior cingulate cortex ameliorates anxiety in a preclinical model of fetal alcohol spectrum disorders. Transl Psychiatry. 2022;12:24.","journal-title":"Transl Psychiatry"},{"key":"1692_CR92","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1093\/ijnp\/pyy006","volume":"21","author":"C Zhu","year":"2018","unstructured":"Zhu C, Liang M, Li Y, Feng X, Hong J, Zhou R. Involvement of epigenetic modifications of GABAergic interneurons in basolateral amygdala in anxiety-like phenotype of prenatally stressed mice. Int J Neuropsychopharmacol. 2018;21:570\u201381.","journal-title":"Int J Neuropsychopharmacol."},{"key":"1692_CR93","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/sj.npp.1300321","volume":"29","author":"AM Linden","year":"2004","unstructured":"Linden AM, Greene SJ, Bergeron M, Schoepp DD. Anxiolytic activity of the MGLU2\/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions. Neuropsychopharmacology. 2004;29:502\u201313.","journal-title":"Neuropsychopharmacology"},{"key":"1692_CR94","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1146\/annurev-psych-010814-015006","volume":"66","author":"HA Cameron","year":"2015","unstructured":"Cameron HA, Glover LR. Adult neurogenesis: beyond learning and memory. Annu Rev Psychol. 2015;66:53\u201381.","journal-title":"Annu Rev Psychol"},{"key":"1692_CR95","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1017\/S0033291720000604","volume":"51","author":"SE Murphy","year":"2021","unstructured":"Murphy SE, de Cates AN, Gillespie AL, Godlewska BR, Scaife JC, Wright LC, et al. Translating the promise of 5HT4 receptor agonists for the treatment of depression. Psychol Med. 2021;51:1111\u201320.","journal-title":"Psychol Med."},{"key":"1692_CR96","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1111\/j.1476-5381.1995.tb13303.x","volume":"114","author":"GP Reynolds","year":"1995","unstructured":"Reynolds GP, Mason SL, Meldrum A, De Keczer S, Parnes H, Eglen RM, et al. 5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases. Br J Pharmacol. 1995;114:993\u20138.","journal-title":"Br J Pharmacol."},{"key":"1692_CR97","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nrm3072","volume":"12","author":"JY Altarejos","year":"2011","unstructured":"Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol. 2011;12:141\u201351.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1692_CR98","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.neuropharm.2008.05.013","volume":"55","author":"J Bockaert","year":"2008","unstructured":"Bockaert J, Claeysen S, Compan V, Dumuis A. 5-HT4 receptors: history, molecular pharmacology and brain functions. Neuropharmacology. 2008;55:922\u201331.","journal-title":"Neuropharmacology"},{"key":"1692_CR99","doi-asserted-by":"crossref","unstructured":"Roux CM, Leger M, Freret T. Memory disorders related to hippocampal function: the interest of 5-HT4Rs targeting. Int J Mol Sci. 2021;22:12082.","DOI":"10.3390\/ijms222112082"},{"key":"1692_CR100","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1085\/jgp.20028484","volume":"119","author":"MA Albrecht","year":"2002","unstructured":"Albrecht MA, Colegrove SL, Friel DD. Differential regulation of ER Ca2+ uptake and release rates accounts for multiple modes of Ca2+-induced Ca2+\u00a0release. J Gen Physiol. 2002;119:211\u201333.","journal-title":"J Gen Physiol."},{"key":"1692_CR101","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.1091\/mbc.e08-07-0730","volume":"20","author":"XF Zhang","year":"2009","unstructured":"Zhang XF, Forscher P. Rac1 modulates stimulus-evoked Ca2+ release in neuronal growth cones via parallel effects on microtubule\/endoplasmic reticulum dynamics and reactive oxygen species production. Mol Biol Cell. 2009;20:3700\u201312.","journal-title":"Mol Biol Cell"},{"key":"1692_CR102","doi-asserted-by":"publisher","DOI":"10.1177\/20451253221105128","volume":"12","author":"MJ Millan","year":"2022","unstructured":"Millan MJ. Agomelatine for the treatment of generalized anxiety disorder: focus on its distinctive mechanism of action. Ther Adv Psychopharmacol. 2022;12:20451253221105128.","journal-title":"Ther Adv Psychopharmacol"},{"key":"1692_CR103","doi-asserted-by":"publisher","first-page":"124","DOI":"10.26689\/jcnr.v6i5.4363","volume":"6","author":"Y-m Zhang","year":"2022","unstructured":"Zhang YM, Bai N, Wang H, Wang J. Anti-anxiety effects of prelimbic 5-HT4 receptors in the rat model of Parkinson\u2019s disease: evidence from behavioral and electrophysiological study. J Clin Nurs Res. 2022;6:124\u201331.","journal-title":"J Clin Nurs Res."},{"key":"1692_CR104","doi-asserted-by":"publisher","DOI":"10.1038\/srep03881","volume":"4","author":"R Bell","year":"2014","unstructured":"Bell R, Duke AA, Gilmore PE, Page D, B\u00e8gue L. Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2\/5-HT3\/5-HT4 ligands. Sci Rep. 2014;4:3881.","journal-title":"Sci Rep."},{"key":"1692_CR105","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1017\/S1461145711000782","volume":"15","author":"J Pascual-Brazo","year":"2012","unstructured":"Pascual-Brazo J, Castro E, D\u00edaz \u00c1, Valdiz\u00e1n EM, Pilar-Cu\u00e9llar F, Vidal R, et al. Modulation of neuroplasticity pathways and antidepressant-like behavioural responses following the short-term (3 and 7 days) administration of the 5-HT4 receptor agonist RS67333. Int J Neuropsychopharmacol. 2012;15:631\u201343.","journal-title":"Int J Neuropsychopharmacol."},{"key":"1692_CR106","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1177\/1073858414561303","volume":"22","author":"BA Samuels","year":"2016","unstructured":"Samuels BA, Mendez-David I, Faye C, David SA, Pierz KA, Gardier AM, et al. Serotonin 1A and serotonin 4 receptors: essential mediators of the neurogenic and behavioral actions of antidepressants. Neuroscientist. 2016;22:26\u201345.","journal-title":"Neuroscientist"},{"key":"1692_CR107","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.1523\/JNEUROSCI.16-15-04810.1996","volume":"16","author":"SE File","year":"1996","unstructured":"File SE, Gonzalez LE, Andrews N. Comparative study of pre- and postsynaptic 5-HT1A receptor modulation of anxiety in two ethological animal tests. J Neurosci. 1996;16:4810\u20135.","journal-title":"J Neurosci."},{"key":"1692_CR108","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.3389\/fpsyg.2018.02201","volume":"9","author":"Y Liu","year":"2018","unstructured":"Liu Y, Zhao J, Guo W. Emotional roles of mono-aminergic neurotransmitters in major depressive disorder and anxiety disorders. Front Psychol. 2018;9:2201.","journal-title":"Front Psychol"},{"key":"1692_CR109","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.jchemneu.2011.05.001","volume":"41","author":"RA McDevitt","year":"2011","unstructured":"McDevitt RA, Neumaier JF. Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective. J Chem Neuroanat. 2011;41:234\u201346.","journal-title":"J Chem Neuroanat"},{"key":"1692_CR110","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3389\/fpsyt.2020.00443","volume":"11","author":"GE Tafet","year":"2020","unstructured":"Tafet GE, Nemeroff CB. Pharmacological treatment of anxiety disorders: the role of the HPA Axis. Front Psychiatry. 2020;11:443.","journal-title":"Front Psychiatry"},{"key":"1692_CR111","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature15698","volume":"527","author":"A Adhikari","year":"2015","unstructured":"Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ, et al. Basomedial amygdala mediates top-down control of anxiety and fear. Nature. 2015;527:179\u201385.","journal-title":"Nature"},{"key":"1692_CR112","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1631\/jzus.B2200642","volume":"25","author":"Y Du","year":"2024","unstructured":"Du Y, Li Z, Zhao Y, Han J, Hu W, Liu Z. Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions. J Zhejiang Univ Sci B. 2024;25:23\u201337.","journal-title":"J Zhejiang Univ Sci B"},{"key":"1692_CR113","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1053\/j.gastro.2011.03.011","volume":"140","author":"LA Kilpatrick","year":"2011","unstructured":"Kilpatrick LA, Labus JS, Coveleskie K, Hammer C, Rappold G, Tillisch K, et al. The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome. Gastroenterology. 2011;140:1943\u201351.","journal-title":"Gastroenterology"},{"key":"1692_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107428","volume":"26","author":"DJ Laster","year":"2023","unstructured":"Laster DJ, Akel NS, Hendrixson JA, James A, Crawford JA, Fu Q, et al. CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system. iScience. 2023;26:107428.","journal-title":"iScience"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01692-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01692-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01692-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:02:14Z","timestamp":1774479734000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01692-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":114,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["1692"],"URL":"https:\/\/doi.org\/10.1038\/s41401-025-01692-7","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]},"assertion":[{"value":"13 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}