{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:31:07Z","timestamp":1789695067920,"version":"4.0.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1038\/s41401-025-01706-4","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:00:00Z","timestamp":1768381200000},"page":"903-916","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["\u03b2-Hydroxybutyrate improves glymphatic system function and alleviates cerebral edema in mice after ischemic stroke"],"prefix":"10.1038","volume":"47","author":[{"given":"Ming-jia","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-qi","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-wen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-chuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan-yu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"1706_CR1","doi-asserted-by":"crossref","unstructured":"GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20:795\u2013820.","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"1706_CR2","doi-asserted-by":"publisher","first-page":"e897","DOI":"10.1016\/S2468-2667(21)00228-0","volume":"6","author":"Q Ma","year":"2021","unstructured":"Ma Q, Li R, Wang L, Yin P, Wang Y, Yan C, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2021;6:e897\u2013906.","journal-title":"Lancet Public Health"},{"key":"1706_CR3","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/S1474-4422(24)00439-3","volume":"23","author":"AA Rabinstein","year":"2024","unstructured":"Rabinstein AA. Ischaemic brain oedema remains a major unmet need. Lancet Neurol. 2024;23:1171\u201373.","journal-title":"Lancet Neurol"},{"key":"1706_CR4","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1161\/STROKEAHA.114.006884","volume":"45","author":"TWK Battey","year":"2014","unstructured":"Battey TWK, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BCV, et al. Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke. 2014;45:3643\u201348.","journal-title":"Stroke"},{"key":"1706_CR5","volume":"11","author":"A Dower","year":"2022","unstructured":"Dower A, Mulcahy M, Maharaj M, Chen H, Lim CED, Li Y, et al. Surgical decompression for malignant cerebral oedema after ischaemic stroke. Cochrane Database Syst Rev. 2022;11:CD014989.","journal-title":"Cochrane Database Syst Rev"},{"key":"1706_CR6","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s12028-019-00782-9","volume":"32","author":"N Mohney","year":"2020","unstructured":"Mohney N, Alkhatib O, Koch S, O\u2019Phelan K, Merenda A. What is the role of hyperosmolar therapy in hemispheric stroke patients?. Neurocrit Care. 2020;32:609\u201319.","journal-title":"Neurocrit Care"},{"key":"1706_CR7","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/nep3.62","volume":"2","author":"M Thaysen","year":"2024","unstructured":"Thaysen M, Westi E, Clarkson AN, Wellendorph P, Kristensen M. Rodent ischemic stroke models and their relevance in preclinical research. Neuroprotection. 2024;2:296\u2013309.","journal-title":"Neuroprotection"},{"key":"1706_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/nep3.27","volume":"1","author":"A Bakreen","year":"2023","unstructured":"Bakreen A, Jolkkonen J. The potential of a combined cell-based therapy and rehabilitation approach for stroke recovery. Neuroprotection. 2023;1:117\u201329.","journal-title":"Neuroprotection"},{"key":"1706_CR9","doi-asserted-by":"publisher","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","volume":"34","author":"JJ Iliff","year":"2014","unstructured":"Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014;34:16180\u201393.","journal-title":"J Neurosci"},{"key":"1706_CR10","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. 2012;4:147ra111.","journal-title":"Sci Transl Med"},{"key":"1706_CR11","doi-asserted-by":"crossref","unstructured":"Liu K, Zhu J, Chang Y, Lin Z, Shi Z, Li X, et al. Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus. JCI Insight. 2021;6:e151835.","DOI":"10.1172\/jci.insight.151835"},{"key":"1706_CR12","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1161\/STROKEAHA.123.045941","volume":"55","author":"J Zhu","year":"2024","unstructured":"Zhu J, Mo J, Liu K, Chen Q, Li Z, He Y, et al. Glymphatic system impairment contributes to the formation of brain edema after ischemic stroke. Stroke. 2024;55:1393\u2013404.","journal-title":"Stroke"},{"key":"1706_CR13","doi-asserted-by":"publisher","first-page":"R1371","DOI":"10.1016\/j.cub.2021.08.026","volume":"31","author":"LM Hablitz","year":"2021","unstructured":"Hablitz LM, Nedergaard M. The glymphatic system. Curr Biol. 2021;31:R1371\u201375.","journal-title":"Curr Biol"},{"key":"1706_CR14","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1093\/brain\/awaa179","volume":"143","author":"IF Harrison","year":"2020","unstructured":"Harrison IF, Ismail O, Machhada A, Colgan N, Ohene Y, Nahavandi P, et al. Impaired glymphatic function and clearance of tau in an Alzheimer\u2019s disease model. Brain. 2020;143:2576\u201393.","journal-title":"Brain"},{"key":"1706_CR15","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ana.24271","volume":"76","author":"BT Kress","year":"2014","unstructured":"Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, et al. Impairment of paravascular clearance pathways in the aging brain. Ann Neurol. 2014;76:845\u201361.","journal-title":"Ann Neurol"},{"key":"1706_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.698036","volume":"13","author":"X Zhou","year":"2021","unstructured":"Zhou X, Li Y, Lenahan C, Ou Y, Wang M, He Y. Glymphatic system in the central nervous system, a novel therapeutic direction against brain edema after stroke. Front Aging Neurosci. 2021;13:698036.","journal-title":"Front Aging Neurosci"},{"key":"1706_CR17","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1016\/j.chom.2021.07.004","volume":"29","author":"CA Olson","year":"2021","unstructured":"Olson CA, Iniguez AJ, Yang GE, Fang P, Pronovost GN, Jameson KG, et al. Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia. Cell Host Microbe. 2021;29:1378\u201392.","journal-title":"Cell Host Microbe"},{"key":"1706_CR18","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1743-7075-2-28","volume":"2","author":"I Van der Auwera","year":"2005","unstructured":"Van der Auwera I, Wera S, Van Leuven F, Henderson ST. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer\u2019s disease. Nutr Metab. 2005;2:28.","journal-title":"Nutr Metab"},{"key":"1706_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.neuron.2006.09.016","volume":"52","author":"J Hardy","year":"2006","unstructured":"Hardy J. A hundred years of Alzheimer\u2019s disease research. Neuron. 2006;52:3\u201313.","journal-title":"Neuron"},{"key":"1706_CR20","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","volume":"11","author":"JM Tarasoff-Conway","year":"2015","unstructured":"Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, et al. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015;11:457\u201370.","journal-title":"Nat Rev Neurol"},{"key":"1706_CR21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3389\/fphys.2014.00260","volume":"5","author":"EN Dedkova","year":"2014","unstructured":"Dedkova EN, Blatter LA. Role of beta-hydroxybutyrate, its polymer poly-beta-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol. 2014;5:260.","journal-title":"Front Physiol"},{"key":"1706_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2024.114819","volume":"378","author":"X Tan","year":"2024","unstructured":"Tan X, Li X, Li R, Meng W, Xie Z, Li J, et al. beta-hydroxybutyrate alleviates neurological deficits by restoring glymphatic and inflammation after subarachnoid hemorrhage in mice. Exp Neurol. 2024;378:114819.","journal-title":"Exp Neurol"},{"key":"1706_CR23","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1096\/fj.201901984R","volume":"34","author":"Y Wu","year":"2020","unstructured":"Wu Y, Gong Y, Luan Y, Li Y, Liu J, Yue Z, et al. BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer\u2019s disease. FASEB J. 2020;34:1412\u201329.","journal-title":"FASEB J"},{"key":"1706_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.926128","volume":"16","author":"F Wang","year":"2022","unstructured":"Wang F, Xu C, Su C, Li J, Lin J. beta-Hydroxybutyrate attenuates painful diabetic neuropathy via restoration of the Aquaporin-4 polarity in the spinal glymphatic system. Front Neurosci. 2022;16:926128.","journal-title":"Front Neurosci"},{"key":"1706_CR25","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1152\/physrev.00011.2013","volume":"93","author":"EA Nagelhus","year":"2013","unstructured":"Nagelhus EA, Ottersen OP. Physiological roles of aquaporin-4 in brain. Physiol Rev. 2013;93:1543\u201362.","journal-title":"Physiol Rev"},{"key":"1706_CR26","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1073\/pnas.0437946100","volume":"100","author":"M Amiry-Moghaddam","year":"2003","unstructured":"Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug F, Froehner SC, et al. An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci USA. 2003;100:2106\u201311.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1706_CR27","doi-asserted-by":"crossref","unstructured":"Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, et al. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. Elife. 2018;7:e40070.","DOI":"10.7554\/eLife.40070"},{"key":"1706_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fncel.2016.00007","volume":"10","author":"J Landgrave-Gomez","year":"2016","unstructured":"Landgrave-Gomez J, Mercado-Gomez OF, Vazquez-Garcia M, Rodriguez-Molina V, Cordova-Davalos L, Arriaga-Avila V, et al. Anticonvulsant effect of time-restricted feeding in a pilocarpine-induced seizure model: metabolic and epigenetic implications. Front Cell Neurosci. 2016;10:7.","journal-title":"Front Cell Neurosci"},{"key":"1706_CR29","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s00592-020-01552-2","volume":"57","author":"W Luo","year":"2020","unstructured":"Luo W, Yu Y, Wang H, Liu K, Wang Y, Huang M, et al. Up-regulation of MMP-2 by histone H3K9 beta-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat. Acta Diabetol. 2020;57:1501\u20139.","journal-title":"Acta Diabetol"},{"key":"1706_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2018.00001","volume":"12","author":"J Zhang","year":"2018","unstructured":"Zhang J, Li X, Ren Y, Zhao Y, Xing A, Jiang C, et al. Intermittent fasting alleviates the increase of lipoprotein lipase expression in brain of a mouse model of Alzheimer\u2019s disease: possibly mediated by beta-hydroxybutyrate. Front Cell Neurosci. 2018;12:1.","journal-title":"Front Cell Neurosci"},{"key":"1706_CR31","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13006","volume":"32","author":"J Zhu","year":"2022","unstructured":"Zhu J, Li Z, Ji Z, Wu Y, He Y, Liu K, et al. Glycocalyx is critical for blood-brain barrier integrity by suppressing caveolin1-dependent endothelial transcytosis following ischemic stroke. Brain Pathol. 2022;32:e13006.","journal-title":"Brain Pathol"},{"key":"1706_CR32","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.bbi.2020.04.057","volume":"88","author":"W Chen","year":"2020","unstructured":"Chen W, Huang P, Zeng H, Lin J, Shi Z, Yao X. Cocaine-induced structural and functional impairments of the glymphatic pathway in mice. Brain Behav Immun. 2020;88:97\u2013104.","journal-title":"Brain Behav Immun"},{"key":"1706_CR33","doi-asserted-by":"crossref","unstructured":"Smith AJ, Yao X, Dix JA, Jin B, Verkman AS. Test of the \u2018glymphatic\u2019 hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchym. Elife. 2017;6:e27679.","DOI":"10.7554\/eLife.27679"},{"key":"1706_CR34","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nprot.2016.151","volume":"12","author":"BV Ineichen","year":"2017","unstructured":"Ineichen BV, Schnell L, Gullo M, Kaiser J, Schneider MP, Mosberger AC, et al. Direct, long-term intrathecal application of therapeutics to the rodent CNS. Nat Protoc. 2017;12:104\u201331.","journal-title":"Nat Protoc"},{"key":"1706_CR35","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fnmol.2017.00144","volume":"10","author":"X He","year":"2017","unstructured":"He X, Liu D, Zhang Q, Liang F, Dai G, Zeng J, et al. Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged mice. Front Mol Neurosci. 2017;10:144.","journal-title":"Front Mol Neurosci"},{"key":"1706_CR36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-020-2493-4","volume":"583","author":"JE Moore","year":"2020","unstructured":"Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020;583:699\u2013710.","journal-title":"Nature"},{"key":"1706_CR37","doi-asserted-by":"crossref","unstructured":"Ulamek-Koziol M, Czuczwar SJ, Januszewski S, Pluta R. Ketogenic diet and epilepsy. Nutrients. 2019;11:2510.","DOI":"10.3390\/nu11102510"},{"key":"1706_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175933","volume":"955","author":"C Lin","year":"2023","unstructured":"Lin C, Wang S, Xie J, Zhu J, Xu J, Liu K, et al. Ketogenic diet and beta-Hydroxybutyrate alleviate ischemic brain injury in mice via an IRAKM-dependent pathway. Eur J Pharmacol. 2023;955:175933.","journal-title":"Eur J Pharmacol"},{"key":"1706_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106365","volume":"120","author":"C Lin","year":"2024","unstructured":"Lin C, Wang S, Wei X, Liu K, Peng Y, Yu M, et al. \u03b2-Hydroxybutyrate inhibits FOXO3a by histone H3K9 \u03b2-Hydroxybutyrylation to ameliorate stroke-related sarcopenia. J Funct Foods. 2024;120:106365.","journal-title":"J Funct Foods"},{"key":"1706_CR40","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-nutr-071816-064916","volume":"37","author":"JC Newman","year":"2017","unstructured":"Newman JC, Verdin E. beta-Hydroxybutyrate: a signaling metabolite. Annu Rev Nutr. 2017;37:51\u201376.","journal-title":"Annu Rev Nutr"},{"key":"1706_CR41","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1126\/science.1227166","volume":"339","author":"T Shimazu","year":"2013","unstructured":"Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, et al. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013;339:211\u201314.","journal-title":"Science"},{"key":"1706_CR42","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrd4360","volume":"13","author":"KJ Falkenberg","year":"2014","unstructured":"Falkenberg KJ, Johnstone RW. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nat Rev Drug Discov. 2014;13:673\u201391.","journal-title":"Nat Rev Drug Discov"},{"key":"1706_CR43","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature10849","volume":"483","author":"J Graff","year":"2012","unstructured":"Graff J, Rei D, Guan J, Wang W, Seo J, Hennig KM, et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 2012;483:222\u201326.","journal-title":"Nature"},{"key":"1706_CR44","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12035-022-03083-z","volume":"60","author":"H Lu","year":"2023","unstructured":"Lu H, Ashiqueali R, Lin CI, Walchale A, Clendaniel V, Matheson R, et al. Histone deacetylase 3 inhibition decreases cerebral edema and protects the blood-brain barrier after stroke. Mol Neurobiol. 2023;60:235\u201346.","journal-title":"Mol Neurobiol"},{"key":"1706_CR45","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1073\/pnas.1016071107","volume":"107","author":"MP Creyghton","year":"2010","unstructured":"Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci USA. 2010;107:21931\u201336.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1706_CR46","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022112012","volume":"41","author":"M Wang","year":"2022","unstructured":"Wang M, Chen Z, Zhang Y. CBP\/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos. EMBO J. 2022;41:e112012.","journal-title":"EMBO J"},{"key":"1706_CR47","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1016\/j.molcel.2021.03.008","volume":"81","author":"T Narita","year":"2021","unstructured":"Narita T, Ito S, Higashijima Y, Chu WK, Neumann K, Walter J, et al. Enhancers are activated by p300\/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release. Mol Cell. 2021;81:2166\u201382.","journal-title":"Mol Cell"},{"key":"1706_CR48","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/ng.154","volume":"40","author":"Z Wang","year":"2008","unstructured":"Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, et al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet. 2008;40:897\u2013903.","journal-title":"Nat Genet"},{"key":"1706_CR49","doi-asserted-by":"crossref","unstructured":"Ishida K, Yamada K, Nishiyama R, Hashimoto T, Nishida I, Abe Y, et al. Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration. J Exp Med. 2022;219:e20211275.","DOI":"10.1084\/jem.20211275"},{"key":"1706_CR50","doi-asserted-by":"publisher","unstructured":"Zhang H, Wang J, Zhang S, Yan D, Dong Y, Zhang P, et al. Aquaporin 4 and its isoforms regulation ameliorate AQP4 Mis-localization-induced glymphatic dysfunction in ischemic stroke. J Adv Res. 2025. https:\/\/doi.org\/10.1016\/j.jare.2025.05.022. Online ahead of print.","DOI":"10.1016\/j.jare.2025.05.022"},{"key":"1706_CR51","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jare.2023.03.004","volume":"56","author":"X Si","year":"2024","unstructured":"Si X, Dai S, Fang Y, Tang J, Wang Z, Li Y, et al. Matrix metalloproteinase-9 inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson\u2019s disease. J Adv Res. 2024;56:125\u201336.","journal-title":"J Adv Res"},{"key":"1706_CR52","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/glia.24477","volume":"72","author":"C Moelo","year":"2024","unstructured":"Moelo C, Quillevere A, Le Roy L, Timsit S. (S)-roscovitine, a CDK inhibitor, decreases cerebral edema and modulates AQP4 and alpha1-syntrophin interaction on a pre-clinical model of acute ischemic stroke. Glia. 2024;72:322\u201337.","journal-title":"Glia"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01706-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01706-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01706-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:02:20Z","timestamp":1774479740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-025-01706-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["1706"],"URL":"https:\/\/doi.org\/10.1038\/s41401-025-01706-4","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}