{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:49:10Z","timestamp":1791816550670,"version":"4.3.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"DOI":"10.1038\/s41401-026-01840-7","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:37:55Z","timestamp":1781149075000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["METTL3 loss exacerbates colitis via m6A-dependent Slc39a8 regulation and epithelial lineage depletion"],"prefix":"10.1038","author":[{"given":"Hao","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-yun","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-huai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-ning","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-lang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fai Yiu","family":"Shum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-he","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-kai","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok M.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Tak Vai","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Ka Kei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"1840_CR1","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003\u20137.","journal-title":"Nature"},{"key":"1840_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.devcel.2020.12.020","volume":"56","author":"LE Sanman","year":"2021","unstructured":"Sanman LE, Chen IW, Bieber JM, Steri V, Trentesaux C, Hann B, et al. Transit-amplifying cells coordinate changes in intestinal epithelial cell-type composition. Dev Cell. 2021;56:356\u201365.e9.","journal-title":"Dev Cell"},{"key":"1840_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jcmgh.2017.03.007","volume":"4","author":"E Martini","year":"2017","unstructured":"Martini E, Krug SM, Siegmund B, Neurath MF, Becker C. Mend your fences: the epithelial barrier and its relationship with mucosal immunity in inflammatory bowel disease. Cell Mol Gastroenterol Hepatol. 2017;4:33\u201346.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1840_CR4","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/s41590-019-0415-0","volume":"20","author":"MF Neurath","year":"2019","unstructured":"Neurath MF. Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol. 2019;20:970\u20139.","journal-title":"Nat Immunol"},{"key":"1840_CR5","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41575-023-00769-0","volume":"20","author":"LM Hegarty","year":"2023","unstructured":"Hegarty LM, Jones GR, Bain CC. Macrophages in intestinal homeostasis and inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2023;20:538\u201353.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1840_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00612-x","volume":"12","author":"H Lu","year":"2024","unstructured":"Lu H, Suo Z, Lin J, Cong Y, Liu Z. Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease. Biomark Res. 2024;12:76.","journal-title":"Biomark Res"},{"key":"1840_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41575-023-00871-3","volume":"21","author":"C Danne","year":"2024","unstructured":"Danne C, Skerniskyte J, Marteyn B, Sokol H. Neutrophils: from IBD to the gut microbiota. Nat Rev Gastroenterol Hepatol. 2024;21:184\u201397.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1840_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1750743","volume":"16","author":"S Yu","year":"2025","unstructured":"Yu S, Zhang M, Niu W, Huang Y, Dou Z, Tian B, et al. Neutrophils in inflammatory bowel disease: disease-promoting versus protective functions. Front Immunol. 2025;16:1750743.","journal-title":"Front Immunol"},{"key":"1840_CR9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrm.2016.132","volume":"18","author":"BS Zhao","year":"2017","unstructured":"Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18:31\u201342.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1840_CR10","doi-asserted-by":"crossref","unstructured":"Zhang X, Su H, Chen H, Li Q, Liu X, Zhang L, et al. RNA modifications in gastrointestinal cancer: current status and future perspectives. Biomedicines. 2022;10:1918.","DOI":"10.3390\/biomedicines10081918"},{"key":"1840_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.935224","volume":"10","author":"H Chen","year":"2022","unstructured":"Chen H, Wang Y, Su H, Zhang X, Chen H, Yu J. RNA N6-methyladenine modification, cellular reprogramming, and cancer stemness. Front Cell Dev Biol. 2022;10:935224.","journal-title":"Front Cell Dev Biol"},{"key":"1840_CR12","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl5723","volume":"8","author":"T Zhang","year":"2022","unstructured":"Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, et al. m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-kappaB-mediated antiapoptotic pathway. Sci Adv. 2022;8:eabl5723.","journal-title":"Sci Adv"},{"key":"1840_CR13","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/j.devcel.2022.07.006","volume":"57","author":"J Du","year":"2022","unstructured":"Du J, Sarkar R, Li Y, He L, Kang W, Liao W, et al. N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis. Dev Cell. 2022;57:1976\u201394.e8.","journal-title":"Dev Cell"},{"key":"1840_CR14","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949229","volume":"21","author":"B Han","year":"2020","unstructured":"Han B, Yan S, Wei S, Xiang J, Liu K, Chen Z, et al. YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness. EMBO Rep. 2020;21:e49229.","journal-title":"EMBO Rep"},{"key":"1840_CR15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.ebiom.2019.06.033","volume":"45","author":"NS Nunes","year":"2019","unstructured":"Nunes NS, Chandran P, Sundby M, Visioli F, da Costa Goncalves F, Burks SR, et al. Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway. EBioMedicine. 2019;45:495\u2013510.","journal-title":"EBioMedicine"},{"key":"1840_CR16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13287-015-0073-6","volume":"6","author":"A Banerjee","year":"2015","unstructured":"Banerjee A, Bizzaro D, Burra P, Di Liddo R, Pathak S, Arcidiacono D, et al. Umbilical cord mesenchymal stem cells modulate dextran sulfate sodium-induced acute colitis in immunodeficient mice. Stem Cell Res Ther. 2015;6:79.","journal-title":"Stem Cell Res Ther"},{"key":"1840_CR17","doi-asserted-by":"publisher","first-page":"18228","DOI":"10.3748\/wjg.v20.i48.18228","volume":"20","author":"C Goncalves Fda","year":"2014","unstructured":"Goncalves Fda C, Schneider N, Pinto FO, Meyer FS, Visioli F, Pfaffenseller B, et al. Intravenous vs intraperitoneal mesenchymal stem cells administration: what is the best route for treating experimental colitis? World J Gastroenterol. 2014;20:18228\u201339.","journal-title":"World J Gastroenterol"},{"key":"1840_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101144","volume":"4","author":"Y Pan","year":"2023","unstructured":"Pan Y, Chen H, Zhang X, Liu W, Ding Y, Huang D, et al. METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy. Cell Rep Med. 2023;4:101144.","journal-title":"Cell Rep Med"},{"key":"1840_CR19","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1136\/gutjnl-2022-328845","volume":"72","author":"Y Bao","year":"2023","unstructured":"Bao Y, Zhai J, Chen H, Wong CC, Liang C, Ding Y, et al. Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer. Gut. 2023;72:1497\u2013509.","journal-title":"Gut"},{"key":"1840_CR20","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, et al. Integrated analysis of multimodal single-cell data. Cell. 2021;184:3573\u201387.e29.","journal-title":"Cell"},{"key":"1840_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan CH, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088.","journal-title":"Nat Commun"},{"key":"1840_CR22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1126\/science.aax0249","volume":"367","author":"GS Gulati","year":"2020","unstructured":"Gulati GS, Sikandar SS, Wesche DJ, Manjunath A, Bharadwaj A, Berger MJ, et al. Single-cell transcriptional diversity is a hallmark of developmental potential. Science. 2020;367:405\u201311.","journal-title":"Science"},{"key":"1840_CR23","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1053\/j.gastro.2020.11.013","volume":"160","author":"H Chen","year":"2021","unstructured":"Chen H, Gao S, Liu W, Wong CC, Wu J, Wu J, et al. RNA N6-methyladenosine methyltransferase METTL3 facilitates colorectal cancer by activating the m6A-GLUT1-mTORC1 axis and is a therapeutic target. Gastroenterology. 2021;160:1284\u2013300.e16.","journal-title":"Gastroenterology"},{"key":"1840_CR24","doi-asserted-by":"crossref","unstructured":"Chen H, Pan Y, Zhou Q, Liang C, Wong CC, Zhou Y, et al. METTL3 inhibits anti-tumor immunity by targeting m6A-BHLHE41-CXCL1\/CXCR2 axis to promote colorectal cancer. Gastroenterology. 2022;163:891\u2013907.","DOI":"10.1053\/j.gastro.2022.06.024"},{"key":"1840_CR25","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen S, Zhou Y, Chen Y, Gu J. fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018;34:i884\u2013i90.","journal-title":"Bioinformatics"},{"key":"1840_CR26","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38:576\u201389.","journal-title":"Mol Cell"},{"key":"1840_CR27","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nbt.3122","volume":"33","author":"M Pertea","year":"2015","unstructured":"Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT, Salzberg SL. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol. 2015;33:290\u20135.","journal-title":"Nat Biotechnol"},{"key":"1840_CR28","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1261\/rna.058206.116","volume":"23","author":"A Antanaviciute","year":"2017","unstructured":"Antanaviciute A, Baquero-Perez B, Watson CM, Harrison SM, Lascelles C, Crinnion L, et al. m6aViewer: software for the detection, analysis, and visualization of N6-methyladenosine peaks from m6A-seq\/ME-RIP sequencing data. RNA. 2017;23:1493\u2013501.","journal-title":"RNA"},{"key":"1840_CR29","doi-asserted-by":"publisher","first-page":"5246","DOI":"10.7150\/thno.34713","volume":"9","author":"H Chen","year":"2019","unstructured":"Chen H, Wong CC, Liu D, Go MYY, Wu B, Peng S, et al. APLN promotes hepatocellular carcinoma through activating the PI3K\/Akt pathway and is a druggable target. Theranostics. 2019;9:5246\u201360.","journal-title":"Theranostics"},{"key":"1840_CR30","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1038\/s41388-018-0196-1","volume":"37","author":"J Tang","year":"2018","unstructured":"Tang J, Chen H, Wong CC, Liu D, Li T, Wang X, et al. DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients. Oncogene. 2018;37:3006\u201321.","journal-title":"Oncogene"},{"key":"1840_CR31","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1046\/j.1365-2249.1998.00728.x","volume":"114","author":"LA Dieleman","year":"1998","unstructured":"Dieleman LA, Palmen MJ, Akol H, Bloemena E, Pena AS, Meuwissen SG, et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol. 1998;114:385\u201391.","journal-title":"Clin Exp Immunol"},{"key":"1840_CR32","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1016\/j.bbadis.2012.06.011","volume":"1822","author":"LA Davidson","year":"2012","unstructured":"Davidson LA, Goldsby JS, Callaway ES, Shah MS, Barker N, Chapkin RS. Alteration of colonic stem cell gene signatures during the regenerative response to injury. Biochim Biophys Acta. 2012;1822:1600\u20137.","journal-title":"Biochim Biophys Acta"},{"key":"1840_CR33","doi-asserted-by":"publisher","first-page":"6262","DOI":"10.1016\/j.cell.2021.11.031","volume":"184","author":"B Chen","year":"2021","unstructured":"Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, et al. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell. 2021;184:6262\u201380.e26.","journal-title":"Cell"},{"key":"1840_CR34","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.cell.2019.06.029","volume":"178","author":"CS Smillie","year":"2019","unstructured":"Smillie CS, Biton M, Ordovas-Montanes J, Sullivan KM, Burgin G, Graham DB, et al. Intra- and intercellular rewiring of the human colon during ulcerative colitis. Cell. 2019;178:714\u201330.e22.","journal-title":"Cell"},{"key":"1840_CR35","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1016\/j.cell.2024.05.001","volume":"187","author":"C Capdevila","year":"2024","unstructured":"Capdevila C, Miller J, Cheng L, Kornberg A, George JJ, Lee H, et al. Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells. Cell. 2024;187:3039\u201355.e14.","journal-title":"Cell"},{"key":"1840_CR36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jcmgh.2016.10.001","volume":"3","author":"YH Lo","year":"2017","unstructured":"Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, et al. Transcriptional regulation by ATOH1 and its target SPDEF in the intestine. Cell Mol Gastroenterol Hepatol. 2017;3:51\u201371.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"1840_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1365655","volume":"11","author":"Z Zhu","year":"2024","unstructured":"Zhu Z, Zhang W, Huo S, Huang T, Cao X, Zhang Y. TUBB, a robust biomarker with satisfying abilities in diagnosis, prognosis, and immune regulation via a comprehensive pan-cancer analysis. Front Mol Biosci. 2024;11:1365655.","journal-title":"Front Mol Biosci"},{"key":"1840_CR38","doi-asserted-by":"publisher","first-page":"207","DOI":"10.32604\/biocell.2021.014728","volume":"46","author":"P Yang","year":"2022","unstructured":"Yang P, Zou ZY, Gao XL. STMN1 promotes the proliferation and inhibits the apoptosis of acute myeloid leukemia cells by activating the PI3K\/Akt pathway. Biocell. 2022;46:207\u201318.","journal-title":"Biocell"},{"key":"1840_CR39","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s12672-025-01879-8","volume":"16","author":"C Wei","year":"2025","unstructured":"Wei C, Zhang X, Li H, Gu J, Xue F, Xie W, et al. STMN1 regulates the stemness of gastric cancer cells by binding to HN1L to activate the STAT3 signaling pathway. Discov Oncol. 2025;16:263.","journal-title":"Discov Oncol"},{"key":"1840_CR40","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41420-022-00849-1","volume":"8","author":"L Yang","year":"2022","unstructured":"Yang L, Wu G, Wu Q, Peng L, Yuan L. METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice. Cell Death Discov. 2022;8:62.","journal-title":"Cell Death Discov"},{"key":"1840_CR41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/cei\/uxae025","volume":"217","author":"M Fang","year":"2024","unstructured":"Fang M, Yao J, Zhang H, Sun J, Yin Y, Shi H, et al. Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in mice. Clin Exp Immunol. 2024;217:57\u201377.","journal-title":"Clin Exp Immunol"},{"key":"1840_CR42","doi-asserted-by":"crossref","unstructured":"Wang WA, Garofoli A, Ferrada E, Klimek C, Steurer B, Ingles-Prieto A, et al. Human genetic variants in SLC39A8 impact uptake and steady-state metal levels within the cell. Life Sci Alliance. 2025;8:e202403028.","DOI":"10.26508\/lsa.202403028"},{"key":"1840_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41392-023-01679-y","volume":"9","author":"B Chen","year":"2024","unstructured":"Chen B, Yu P, Chan WN, Xie F, Zhang Y, Liang L, et al. Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther. 2024;9:6.","journal-title":"Signal Transduct Target Ther"},{"key":"1840_CR44","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1096\/fj.201902396R","volume":"34","author":"EK Choi","year":"2020","unstructured":"Choi EK, Aring L, Das NK, Solanki S, Inohara N, Iwase S, et al. Impact of dietary manganese on experimental colitis in mice. FASEB J. 2020;34:2929\u201343.","journal-title":"FASEB J"},{"key":"1840_CR45","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3164\/jcbn.24-64","volume":"76","author":"T Omatsu","year":"2025","unstructured":"Omatsu T, Takagi T, Yasuda T, Nakahata Y, Hayashi S, Mukai R, et al. The association between serum zinc level and clinical features in patients with inflammatory bowel disease. J Clin Biochem Nutr. 2025;76:50\u20138.","journal-title":"J Clin Biochem Nutr"},{"key":"1840_CR46","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s12011-023-03715-y","volume":"202","author":"C Wen","year":"2024","unstructured":"Wen C, Wang J, Sun Z, Zhong R, Li M, Shen X, et al. Dietary zinc ameliorates tnbs-induced colitis in mice associated with regulation of Th1\/Th2\/Th17 balance and NF-kappaB\/NLRP3 signaling pathway. Biol Trace Elem Res. 2024;202:659\u201370.","journal-title":"Biol Trace Elem Res"},{"key":"1840_CR47","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1007\/s12011-024-04193-6","volume":"203","author":"X Peng","year":"2025","unstructured":"Peng X, Yang Y, Zhong R, Yang Y, Yan F, Liang N, et al. Zinc and inflammatory bowel disease: from clinical study to animal experiment. Biol Trace Elem Res. 2025;203:624\u201334.","journal-title":"Biol Trace Elem Res"},{"key":"1840_CR48","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11693-008-9015-2","volume":"1","author":"H Zhu","year":"2007","unstructured":"Zhu H, Yang H, Owen MR. Combined microarray analysis uncovers self-renewal-related signaling in mouse embryonic stem cells. Syst Synth Biol. 2007;1:171\u201381.","journal-title":"Syst Synth Biol"},{"key":"1840_CR49","doi-asserted-by":"crossref","unstructured":"Liang J, Huang G, Liu X, Taghavifar F, Liu N, Wang Y, et al. The ZIP8\/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis. J Clin Invest. 2022;132:e157338.","DOI":"10.1172\/JCI157338"},{"key":"1840_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49049-8","volume":"15","author":"EK Choi","year":"2024","unstructured":"Choi EK, Rajendiran TM, Soni T, Park JH, Aring L, Muraleedharan CK, et al. The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease. Nat Commun. 2024;15:4775.","journal-title":"Nat Commun"},{"key":"1840_CR51","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41423-019-0208-2","volume":"16","author":"H Ma","year":"2019","unstructured":"Ma H, Tao W, Zhu S. T lymphocytes in the intestinal mucosa: defense and tolerance. Cell Mol Immunol. 2019;16:216\u201324.","journal-title":"Cell Mol Immunol"},{"key":"1840_CR52","doi-asserted-by":"crossref","unstructured":"Alghamdi KS, Kassar RH, Farrash WF, Obaid AA, Idris S, Siddig A, et al. Key disease-related genes and immune cell infiltration landscape in inflammatory bowel disease: a bioinformatics investigation. Int J Mol Sci. 2024;25:9751.","DOI":"10.3390\/ijms25179751"},{"key":"1840_CR53","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.crohns.2013.06.001","volume":"7","author":"F Magro","year":"2013","unstructured":"Magro F, Langner C, Driessen A, Ensari A, Geboes K, Mantzaris GJ, et al. European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis. 2013;7:827\u201351.","journal-title":"J Crohns Colitis"},{"key":"1840_CR54","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.jcmgh.2022.09.002","volume":"14","author":"L Kang","year":"2022","unstructured":"Kang L, Fang X, Song YH, He ZX, Wang ZJ, Wang SL, et al. Neutrophil-epithelial crosstalk during intestinal inflammation. Cell Mol Gastroenterol Hepatol. 2022;14:1257\u201367.","journal-title":"Cell Mol Gastroenterol Hepatol"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01840-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01840-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01840-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:02:03Z","timestamp":1781154123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01840-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":54,"alternative-id":["1840"],"URL":"https:\/\/doi.org\/10.1038\/s41401-026-01840-7","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"20 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare\u00a0no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}