{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:01:58Z","timestamp":1789689718114,"version":"4.0.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"DOI":"10.1038\/s41401-026-01913-7","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:55:57Z","timestamp":1789682157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Small-molecule-induced neuron-specific hypoxia: recapitulating developmental angiogenesis for ischemic stroke therapy"],"prefix":"10.1038","author":[{"given":"Xiao-ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-yin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-mei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-you","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-qing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-gang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-fan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-dong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"1913_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","volume":"17","author":"VL Feigin","year":"2022","unstructured":"Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, et al. World stroke organization (WSO): global stroke fact sheet 2022. Int J Stroke. 2022;17:18\u201329.","journal-title":"Int J Stroke"},{"key":"1913_CR2","doi-asserted-by":"crossref","unstructured":"National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581\u20137.","DOI":"10.1056\/NEJM199512143332401"},{"key":"1913_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","volume":"378","author":"RG Nogueira","year":"2018","unstructured":"Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, et al. Thrombectomy 6 to 24\u2009h after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378:11\u201321.","journal-title":"N Engl J Med"},{"key":"1913_CR4","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, D\u00e1valos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5\u2009h after acute ischemic stroke. N Engl J Med. 2008;359:1317\u201329.","journal-title":"N Engl J Med"},{"key":"1913_CR5","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3389\/fneur.2019.00656","volume":"10","author":"M Krause","year":"2019","unstructured":"Krause M, Phan TG, Ma H, Sobey CG, Lim R. Cell-based therapies for stroke: are we there yet? Front Neurol. 2019;10:656.","journal-title":"Front Neurol"},{"key":"1913_CR6","doi-asserted-by":"publisher","first-page":"4644","DOI":"10.1111\/j.1742-4658.2009.07176.x","volume":"276","author":"K Arai","year":"2009","unstructured":"Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009;276:4644\u201352.","journal-title":"FEBS J."},{"key":"1913_CR7","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1097\/00004647-200110000-00011","volume":"21","author":"PS Manoonkitiwongsa","year":"2001","unstructured":"Manoonkitiwongsa PS, Jackson-Friedman C, McMillan PJ, Schultz RL, Lyden PD. Angiogenesis after stroke is correlated with increased numbers of macrophages: the clean-up hypothesis. J Cereb Blood Flow Metab. 2001;21:1223\u201331.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1913_CR8","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00401-009-0483-6","volume":"117","author":"H Beck","year":"2009","unstructured":"Beck H, Plate KH. Angiogenesis after cerebral ischemia. Acta Neuropathol. 2009;117:481\u201396.","journal-title":"Acta Neuropathol"},{"key":"1913_CR9","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1161\/01.STR.25.9.1794","volume":"25","author":"J Krupinski","year":"1994","unstructured":"Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 1994;25:1794\u20138.","journal-title":"Stroke"},{"key":"1913_CR10","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/s41401-023-01061-2","volume":"44","author":"J Fang","year":"2023","unstructured":"Fang J, Wang Z, Miao CY. Angiogenesis after ischemic stroke. Acta Pharmacol Sin. 2023;44:1305\u201321.","journal-title":"Acta Pharmacol Sin."},{"key":"1913_CR11","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","volume":"18","author":"Y Yang","year":"2020","unstructured":"Yang Y, Torbey MT. Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke. Curr Neuropharmacol. 2020;18:1250\u201365.","journal-title":"Curr Neuropharmacol"},{"key":"1913_CR12","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1172\/JCI9369","volume":"106","author":"ZG Zhang","year":"2000","unstructured":"Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest. 2000;106:829\u201338.","journal-title":"J Clin Invest"},{"key":"1913_CR13","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1242\/dev.01253","volume":"131","author":"P Martin","year":"2004","unstructured":"Martin P, Parkhurst SM. Parallels between tissue repair and embryo morphogenesis. Development. 2004;131:3021\u201334.","journal-title":"Development"},{"key":"1913_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/path.5589","volume":"253","author":"I Usansky","year":"2021","unstructured":"Usansky I, Jaworska P, Asti L, Kenny FN, Hobbs C, Sofra V, et al. A developmental basis for the anatomical diversity of dermis in homeostasis and wound repair. J Pathol. 2021;253:315\u201325.","journal-title":"J Pathol"},{"key":"1913_CR15","doi-asserted-by":"publisher","first-page":"eaax2476","DOI":"10.1126\/sciadv.aax2476","volume":"5","author":"S Herberg","year":"2019","unstructured":"Herberg S, McDermott AM, Dang PN, Alt DS, Tang R, Dawahare JH, et al. Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair. Sci Adv. 2019;5:eaax2476.","journal-title":"Sci Adv"},{"key":"1913_CR16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/B978-0-12-391498-9.00005-X","volume":"108","author":"B Tonnarelli","year":"2014","unstructured":"Tonnarelli B, Centola M, Barbero A, Zeller R, Martin I. Re-engineering development to instruct tissue regeneration. Curr Top Dev Biol. 2014;108:319\u201338.","journal-title":"Curr Top Dev Biol"},{"key":"1913_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14583","volume":"8","author":"P Himmels","year":"2017","unstructured":"Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, et al. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017;8:14583.","journal-title":"Nat Commun"},{"key":"1913_CR18","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.conb.2021.04.005","volume":"69","author":"B Peguera","year":"2021","unstructured":"Peguera B, Segarra M, Acker-Palmer A. Neurovascular crosstalk coordinates the central nervous system development. Curr Opin Neurobiol. 2021;69:202\u201313.","journal-title":"Curr Opin Neurobiol"},{"key":"1913_CR19","doi-asserted-by":"publisher","first-page":"10137","DOI":"10.1073\/pnas.1619300114","volume":"114","author":"RL Matsuoka","year":"2017","unstructured":"Matsuoka RL, Rossi A, Stone OA, Stainier DYR. CNS-resident progenitors direct the vascularization of neighboring tissues. Proc Natl Acad Sci USA. 2017;114:10137\u201342.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1913_CR20","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.neuron.2015.09.050","volume":"88","author":"Y Cho","year":"2015","unstructured":"Cho Y, Shin JE, Ewan EE, Oh YM, Pita-Thomas W, Cavalli V. Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1\u03b1. Neuron. 2015;88:720\u201334.","journal-title":"Neuron"},{"key":"1913_CR21","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.devcel.2009.11.008","volume":"17","author":"SL Dunwoodie","year":"2009","unstructured":"Dunwoodie SL. The role of hypoxia in development of the mammalian embryo. Dev Cell. 2009;17:755\u201373.","journal-title":"Dev Cell"},{"key":"1913_CR22","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.cellsig.2013.05.018","volume":"25","author":"MR Pawlus","year":"2013","unstructured":"Pawlus MR, Hu CJ. Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cell Signal. 2013;25:1895\u2013903.","journal-title":"Cell Signal"},{"key":"1913_CR23","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1177\/0271678X20924107","volume":"40","author":"H Zhang","year":"2020","unstructured":"Zhang H, Rzechorzek W, Aghajanian A, Faber JE. Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke. J Cereb Blood Flow Metab. 2020;40:1806\u201322.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1913_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2023.104517","volume":"148","author":"A Sapkota","year":"2023","unstructured":"Sapkota A, Halder SK, Milner R. Hypoxia-induced vascular remodeling responses in the brain are much more robust than other organs. Microvasc Res. 2023;148:104517.","journal-title":"Microvasc Res"},{"key":"1913_CR25","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12987-021-00284-x","volume":"18","author":"SK Halder","year":"2021","unstructured":"Halder SK, Milner R. The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown. Fluids Barriers CNS. 2021;18:50.","journal-title":"Fluids Barriers CNS"},{"key":"1913_CR26","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1089\/ars.2010.3678","volume":"15","author":"F Bouillaud","year":"2011","unstructured":"Bouillaud F, Blachier F. Mitochondria and sulfide: a very old story of poisoning, feeding, and signaling? Antioxid Redox Signal. 2011;15:379\u201391.","journal-title":"Antioxid Redox Signal"},{"key":"1913_CR27","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5752","volume":"6","author":"J Jia","year":"2020","unstructured":"Jia J, Wang Z, Zhang M, Huang C, Song Y, Xu F, et al. SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. Sci Adv. 2020;6:eaaz5752.","journal-title":"Sci Adv."},{"key":"1913_CR28","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1038\/s41401-021-00698-1","volume":"43","author":"XL Yan","year":"2022","unstructured":"Yan XL, Xu FY, Ji JJ, Song P, Pei YQ, He MJ, et al. Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage. Acta Pharmacol Sin. 2022;43:811\u201328.","journal-title":"Acta Pharmacol Sin."},{"key":"1913_CR29","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/glia.22648","volume":"62","author":"W Huang","year":"2014","unstructured":"Huang W, Zhao N, Bai X, Karram K, Trotter J, Goebbels S, et al. Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development. Glia. 2014;62:896\u2013913.","journal-title":"Glia"},{"key":"1913_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.bbi.2014.03.003","volume":"40","author":"Q Jin","year":"2014","unstructured":"Jin Q, Cheng J, Liu Y, Wu J, Wang X, Wei S, et al. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia\/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav Immun. 2014;40:131\u201342.","journal-title":"Brain Behav Immun"},{"key":"1913_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104275","volume":"84","author":"X Zhang","year":"2022","unstructured":"Zhang X, Gong P, Zhao Y, Wan T, Yuan K, Xiong Y, et al. Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia\/reperfusion injury. EBioMedicine. 2022;84:104275.","journal-title":"EBioMedicine"},{"key":"1913_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1558-5","volume":"10","author":"J Li","year":"2019","unstructured":"Li J, Zhang J, Zhang Y, Wang Z, Song Y, Wei S, et al. TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. Cell Death Dis. 2019;10:328.","journal-title":"Cell Death Dis"},{"key":"1913_CR33","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O\u2019Keeffe S, et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. 2014;34:11929\u201347.","journal-title":"J Neurosci"},{"key":"1913_CR34","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41586-024-07493-y","volume":"632","author":"T W\u00e4lchli","year":"2024","unstructured":"W\u00e4lchli T, Ghobrial M, Schwab M, Takada S, Zhong H, Suntharalingham S, et al. Single-cell atlas of the human brain vasculature across development, adulthood and disease. Nature. 2024;632:603\u201313.","journal-title":"Nature"},{"key":"1913_CR35","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1038\/s41591-024-03150-z","volume":"30","author":"X Chen","year":"2024","unstructured":"Chen X, Huang Y, Huang L, Huang Z, Hao ZZ, Xu L, et al. A brain cell atlas integrating single-cell transcriptomes across human brain regions. Nat Med. 2024;30:2679\u201391.","journal-title":"Nat Med"},{"key":"1913_CR36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo7868","volume":"9","author":"H Zhang","year":"2023","unstructured":"Zhang H, Wang L, Cui J, Wang S, Han Y, Shao H, et al. Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression. Sci Adv. 2023;9:eabo7868.","journal-title":"Sci Adv"},{"key":"1913_CR37","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1111\/jnc.12695","volume":"129","author":"Y Wang","year":"2014","unstructured":"Wang Y, Jia J, Ao G, Hu L, Liu H, Xiao Y, et al. Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia. J Neurochem. 2014;129:827\u201338.","journal-title":"J Neurochem"},{"key":"1913_CR38","doi-asserted-by":"publisher","first-page":"14270","DOI":"10.1073\/pnas.1905309116","volume":"116","author":"R Rust","year":"2019","unstructured":"Rust R, Gr\u00f6nnert L, Gantner C, Enzler A, Mulders G, Weber RZ, et al. Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke. Proc Natl Acad Sci USA. 2019;116:14270\u20139.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1913_CR39","doi-asserted-by":"crossref","unstructured":"Korte N, Ilkan Z, Pearson CL, Pfeiffer T, Singhal P, Rock JR, et al. The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia. J Clin Invest 2022;132:e154118.","DOI":"10.1172\/JCI154118"},{"key":"1913_CR40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/intbio\/zyaa027","volume":"13","author":"LB Payne","year":"2021","unstructured":"Payne LB, Darden J, Suarez-Martinez AD, Zhao H, Hendricks A, Hartland C, et al. Pericyte migration and proliferation are tightly synchronized to endothelial cell sprouting dynamics. Integr Biol (Camb). 2021;13:31\u201343.","journal-title":"Integr Biol (Camb)"},{"key":"1913_CR41","doi-asserted-by":"publisher","first-page":"E8453","DOI":"10.1073\/pnas.1615322113","volume":"113","author":"EG Sozmen","year":"2016","unstructured":"Sozmen EG, Rosenzweig S, Llorente IL, DiTullio DJ, Machnicki M, Vinters HV, et al. Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice. Proc Natl Acad Sci USA. 2016;113:E8453\u2013e62.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1913_CR42","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1118981","volume":"2021","author":"P Guo","year":"2021","unstructured":"Guo P, Jin Z, Wang J, Sang A, Wu H. Irisin rescues blood-brain barrier permeability following traumatic brain injury and contributes to the neuroprotection of exercise in traumatic brain injury. Oxid Med Cell Longev. 2021;2021:1118981.","journal-title":"Oxid Med Cell Longev"},{"key":"1913_CR43","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1161\/STROKEAHA.120.028928","volume":"51","author":"M Kang","year":"2020","unstructured":"Kang M, Yao Y. Basement membrane changes in ischemic stroke. Stroke. 2020;51:1344\u201352.","journal-title":"Stroke"},{"key":"1913_CR44","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1126\/science.1164594","volume":"322","author":"JM Stenman","year":"2008","unstructured":"Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008;322:1247\u201350.","journal-title":"Science"},{"key":"1913_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/CIRCULATIONAHA.115.015982","volume":"133","author":"KA Tran","year":"2016","unstructured":"Tran KA, Zhang X, Predescu D, Huang X, Machado RF, G\u00f6thert JR, et al. Endothelial \u03b2-catenin signaling is required for maintaining adult blood-brain barrier integrity and central nervous system homeostasis. Circulation. 2016;133:177\u201386.","journal-title":"Circulation"},{"key":"1913_CR46","doi-asserted-by":"publisher","first-page":"e1008659","DOI":"10.1371\/journal.pgen.1008659","volume":"16","author":"M Kaukonen","year":"2020","unstructured":"Kaukonen M, Quintero IB, Mukarram AK, Hyt\u00f6nen MK, Holopainen S, Wickstr\u00f6m K, et al. A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PLoS Genet. 2020;16:e1008659.","journal-title":"PLoS Genet"},{"key":"1913_CR47","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1161\/ATVBAHA.119.312388","volume":"39","author":"LD Jensen","year":"2019","unstructured":"Jensen LD, Hot B, Ramsk\u00f6ld D, Germano RFV, Yokota C, Giatrellis S, et al. Disruption of the extracellular matrix progressively impairs central nervous system vascular maturation downstream of \u03b2-catenin signaling. Arterioscler Thromb Vasc Biol. 2019;39:1432\u201347.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1913_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03261-x","volume":"21","author":"X Huang","year":"2024","unstructured":"Huang X, Wei P, Fang C, Yu M, Yang S, Qiu L, et al. Compromised endothelial Wnt\/\u03b2-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia. J Neuroinflamm. 2024;21:265.","journal-title":"J Neuroinflamm"},{"key":"1913_CR49","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adr4049","volume":"17","author":"RS Rogers","year":"2025","unstructured":"Rogers RS, Mootha VK. Hypoxia as a medicine. Sci Transl Med. 2025;17:eadr4049.","journal-title":"Sci Transl Med"},{"key":"1913_CR50","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1038\/s41593-025-02010-4","volume":"28","author":"E Marutani","year":"2025","unstructured":"Marutani E, Miranda M, Durham TJ, Kim SH, Russell DL, Wiesenthal PP, et al. Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson\u2019s disease. Nat Neurosci. 2025;28:1858\u201367.","journal-title":"Nat Neurosci"},{"key":"1913_CR51","doi-asserted-by":"crossref","unstructured":"Wang H, Miranda M, Marutani E, Lichtenegger P, Wojtkiewicz GR, Ichinose F, et al. Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2\u03b1. J Clin Invest. 2024;134:e185569.","DOI":"10.1172\/JCI185569"},{"key":"1913_CR52","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41580-023-00631-w","volume":"24","author":"L P\u00e9rez-Guti\u00e9rrez","year":"2023","unstructured":"P\u00e9rez-Guti\u00e9rrez L, Ferrara N. Biology and therapeutic targeting of vascular endothelial growth factor A. Nat Rev Mol Cell Biol. 2023;24:816\u201334.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1913_CR53","doi-asserted-by":"publisher","first-page":"e0216385","DOI":"10.1371\/journal.pone.0216385","volume":"14","author":"D Detaille","year":"2019","unstructured":"Detaille D, Pasdois P, S\u00e9mont A, Dos Santos P, Diolez P. An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One. 2019;14:e0216385.","journal-title":"PLoS One"},{"key":"1913_CR54","doi-asserted-by":"publisher","first-page":"21972","DOI":"10.1073\/pnas.0908047106","volume":"106","author":"A Papapetropoulos","year":"2009","unstructured":"Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, et al. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci USA. 2009;106:21972\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1913_CR55","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cell.2018.03.001","volume":"173","author":"A Longchamp","year":"2018","unstructured":"Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Trevi\u00f1o-Villarreal JH, et al. AmiNo acid restriction triggers angiogenesis via GCN2\/ATF4 regulation of VEGF and H2S production. Cell. 2018;173:117\u201329.e14.","journal-title":"Cell"},{"key":"1913_CR56","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/s41589-024-01583-8","volume":"20","author":"R Kumar","year":"2024","unstructured":"Kumar R, Vitvitsky V, Sethaudom A, Singhal R, Solanki S, Alibeckoff S, et al. Sulfide oxidation promotes hypoxic angiogenesis and neovascularization. Nat Chem Biol. 2024;20:1294\u2013304.","journal-title":"Nat Chem Biol"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01913-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01913-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01913-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:03:16Z","timestamp":1789686196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01913-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":56,"alternative-id":["1913"],"URL":"https:\/\/doi.org\/10.1038\/s41401-026-01913-7","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"23 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}