{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:45:06Z","timestamp":1791859506287,"version":"4.3.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"DOI":"10.1038\/s41401-026-01932-4","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:48:15Z","timestamp":1791856095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["FTO promotes human NK cell proliferation yet restricts effector functions"],"prefix":"10.1038","author":[{"given":"Xiao-feng","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-chang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-xi","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-hua","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-qiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-chao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-cai","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"1932_CR1","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/ni1582","volume":"9","author":"E Vivier","year":"2008","unstructured":"Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol. 2008;9:503\u201310.","journal-title":"Nat Immunol"},{"key":"1932_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbag020","volume":"9","author":"Z Zhang","year":"2026","unstructured":"Zhang Z, Wang F, Liu R, Tian L, Cai L, Deng Y. Natural killer cells against viral infection: from basic biology to immunotherapy. Precis Clin Med. 2026;9:pbag020.","journal-title":"Precis Clin Med"},{"key":"1932_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41392-022-01058-z","volume":"7","author":"GH Ran","year":"2022","unstructured":"Ran GH, Lin YQ, Tian L, Zhang T, Yan DM, Yu JH, et al. Natural killer cell homing and trafficking in tissues and tumors: from biology to application. Signal Transduct Target Ther. 2022;7:205.","journal-title":"Signal Transduct Target Ther"},{"key":"1932_CR4","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41568-022-00491-0","volume":"22","author":"TJ Laskowski","year":"2022","unstructured":"Laskowski TJ, Biederst\u00e4dt A, Rezvani K. Natural killer cells in antitumour adoptive cell immunotherapy. Nat Rev Cancer. 2022;22:557\u201375.","journal-title":"Nat Rev Cancer"},{"key":"1932_CR5","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/aps.2015.41","volume":"36","author":"C Sun","year":"2015","unstructured":"Sun C, Sun H, Xiao W, Zhang C, Tian Z. Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy. Acta Pharmacol Sin. 2015;36:1191\u20139.","journal-title":"Acta Pharmacol Sin"},{"key":"1932_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0140-6736(24)02462-0","volume":"405","author":"A Ghobadi","year":"2025","unstructured":"Ghobadi A, Bachanova V, Patel K, Park JH, Flinn I, Riedell PA, et al. Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial. Lancet. 2025;405:127\u201336.","journal-title":"Lancet"},{"key":"1932_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz5618","volume":"12","author":"F Cichocki","year":"2020","unstructured":"Cichocki F, Bjordahl R, Gaidarova S, Mahmood S, Abujarour R, Wang H, et al. iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy. Sci Transl Med. 2020;12:eaaz5618.","journal-title":"Sci Transl Med"},{"key":"1932_CR8","doi-asserted-by":"publisher","first-page":"e505","DOI":"10.1016\/S2352-3026(25)00142-5","volume":"12","author":"P Strati","year":"2025","unstructured":"Strati P, Castro J, Goodman A, Bachanova V, Kamdar M, Awan FT, et al. Off-the-shelf induced pluripotent stem-cell-derived natural killer-cell therapy in relapsed or refractory B-cell lymphoma: a multicentre, open-label, phase 1 study. Lancet Haematol. 2025;12:e505\u201315.","journal-title":"Lancet Haematol"},{"key":"1932_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01558-0","volume":"21","author":"X Li","year":"2022","unstructured":"Li X, Ma S, Deng Y, Yi P, Yu J. Targeting the RNA m6A modification for cancer immunotherapy. Mol Cancer. 2022;21:76.","journal-title":"Mol Cancer"},{"key":"1932_CR10","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41392-022-01175-9","volume":"7","author":"L Cui","year":"2022","unstructured":"Cui L, Ma R, Cai J, Guo C, Chen Z, Yao L, et al. RNA modifications: importance in immune cell biology and related diseases. Signal Transduct Target Ther. 2022;7:334.","journal-title":"Signal Transduct Target Ther"},{"key":"1932_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbaf035","volume":"8","author":"Y Chen","year":"2025","unstructured":"Chen Y, Ding D, Tang X, Ma R, Zhou JK. RNA modifications in health and disease: from mechanistic insights to therapeutic applications. Precis Clin Med. 2025;8:pbaf035.","journal-title":"Precis Clin Med"},{"key":"1932_CR12","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1038\/s41401-022-01017-y","volume":"43","author":"L Zhai","year":"2022","unstructured":"Zhai L, Chen K, Hao B, Tan M. Proteomic characterization of post-translational modifications in drug discovery. Acta Pharmacol Sin. 2022;43:3112\u201329.","journal-title":"Acta Pharmacol Sin"},{"key":"1932_CR13","doi-asserted-by":"crossref","unstructured":"Yin X, Zhang Z, Qiu J, Gong Y, Bi Q, Meng M, et al. METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells. Cell Immunol. 2025;415\u20136:105011.","DOI":"10.1016\/j.cellimm.2025.105011"},{"key":"1932_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25803-0","volume":"12","author":"H Song","year":"2021","unstructured":"Song H, Song J, Cheng M, Zheng M, Wang T, Tian S, et al. METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells. Nat Commun. 2021;12:5522.","journal-title":"Nat Commun"},{"key":"1932_CR15","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202255681","volume":"24","author":"SM Kim","year":"2023","unstructured":"Kim SM, Oh SC, Lee SY, Kong LZ, Lee JH, Kim TD. FTO negatively regulates the cytotoxic activity of natural killer cells. EMBO Rep. 2023;24:e55681.","journal-title":"EMBO Rep"},{"key":"1932_CR16","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1158\/2326-6066.CIR-23-0339","volume":"12","author":"M Meng","year":"2024","unstructured":"Meng M, Zhong Z, Song L, Zhang Z, Yin X, Xie X, et al. mTOR Signaling promotes rapid m6A mRNA methylation to regulate NK-cell activation and effector functions. Cancer Immunol Res. 2024;12:1039\u201357.","journal-title":"Cancer Immunol Res"},{"key":"1932_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf248","volume":"215","author":"P Huang","year":"2025","unstructured":"Huang P, Wang H, Guan X, Pu R, Wu Y, Huang H, et al. UTY coordinates with UTX to repress NK cell development and maturation in males. J Immunol. 2025;215:vkaf248.","journal-title":"J Immunol"},{"key":"1932_CR18","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.3389\/fimmu.2019.01016","volume":"10","author":"P Huang","year":"2019","unstructured":"Huang P, Wang F, Yang Y, Lai W, Meng M, Wu S, et al. Hematopoietic-specific deletion of Foxo1 promotes NK cell specification and proliferation. Front Immunol. 2019;10:1016.","journal-title":"Front Immunol"},{"key":"1932_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07277-9","volume":"9","author":"F Wang","year":"2018","unstructured":"Wang F, Meng M, Mo B, Yang Y, Ji Y, Huang P, et al. Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function. Nat Commun. 2018;9:4874.","journal-title":"Nat Commun"},{"key":"1932_CR20","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1038\/s41401-023-01120-8","volume":"44","author":"YF Deng","year":"2023","unstructured":"Deng YF, Wu ST, Peng HY, Tian L, Li YN, Yang Y, et al. mTORC2 acts as a gatekeeper for mTORC1 deficiency-mediated impairments in ILC3 development. Acta Pharmacol Sin. 2023;44:2243\u201352.","journal-title":"Acta Pharmacol Sin"},{"key":"1932_CR21","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1016\/j.apsb.2025.02.034","volume":"15","author":"S Li","year":"2025","unstructured":"Li S, Liu Y, Yin X, Yang Y, Liu X, Qiu J, et al. Identification of a JAK-STAT-miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions. Acta Pharm Sin B. 2025;15:1922\u201337.","journal-title":"Acta Pharm Sin B"},{"key":"1932_CR22","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1158\/2326-6066.CIR-23-0359","volume":"12","author":"S Wu","year":"2024","unstructured":"Wu S, Peng H, Li S, Huang L, Wang X, Li Y, et al. The \u03c9-3 Polyunsaturated fatty acid docosahexaenoic acid enhances NK-cell antitumor effector functions. Cancer Immunol Res. 2024;12:744\u201358.","journal-title":"Cancer Immunol Res"},{"key":"1932_CR23","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1038\/s41401-024-01260-5","volume":"45","author":"JZ Jiao","year":"2024","unstructured":"Jiao JZ, Zhang Y, Zhang WJ, He M, Meng M, Liu T, et al. Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells. Acta Pharmacol Sin. 2024;45:1492\u2013505.","journal-title":"Acta Pharmacol Sin"},{"key":"1932_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102362","volume":"53","author":"C Wei","year":"2021","unstructured":"Wei C, Luo Q, Wang B, Long Y, Zhang M, Shan W, et al. Generation of a FTO gene knockout human embryonic stem cell line using CRISPR\/Cas9 editing. Stem Cell Res. 2021;53:102362.","journal-title":"Stem Cell Res"},{"key":"1932_CR25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jaci.2022.09.022","volume":"151","author":"EM Mace","year":"2023","unstructured":"Mace EM. Human natural killer cells: Form, function, and development. J Allergy Clin Immunol. 2023;151:371\u201385.","journal-title":"J Allergy Clin Immunol"},{"key":"1932_CR26","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1167\/iovs.05-1528","volume":"47","author":"Z Xu","year":"2006","unstructured":"Xu Z, Yu Y, Duh EJ. Vascular endothelial growth factor upregulates expression of ADAMTS1 in endothelial cells through protein kinase C signaling. Invest Ophthalmol Vis Sci. 2006;47:4059.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1932_CR27","doi-asserted-by":"publisher","first-page":"23656","DOI":"10.1074\/jbc.M212964200","volume":"278","author":"A Luque","year":"2003","unstructured":"Luque A, Carpizo DR, Iruela-Arispe ML. ADAMTS1\/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem. 2003;278:23656\u201365.","journal-title":"J Biol Chem"},{"key":"1932_CR28","doi-asserted-by":"publisher","first-page":"4941","DOI":"10.1091\/mbc.e09-03-0200","volume":"20","author":"S Fujimoto","year":"2009","unstructured":"Fujimoto S, Negishi M, Katoh H. RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex. Mol Biol Cell. 2009;20:4941\u201350.","journal-title":"Mol Biol Cell"},{"key":"1932_CR29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/JLB.4A0617-242RRR","volume":"105","author":"I Lisovsky","year":"2019","unstructured":"Lisovsky I, Kant S, Tremblay-McLean A, Isitman G, Kiani Z, Dupuy FP, et al. Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC. J Leukoc Biol. 2019;105:551\u201363.","journal-title":"J Leukoc Biol"},{"key":"1932_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1087155","volume":"14","author":"P Rascle","year":"2023","unstructured":"Rascle P, Woolley G, Jost S, Manickam C, Reeves RK. NK cell education: Physiological and pathological influences. Front Immunol. 2023;14:1087155.","journal-title":"Front Immunol"},{"key":"1932_CR31","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41423-021-00808-3","volume":"19","author":"F Fang","year":"2022","unstructured":"Fang F, Xie S, Chen M, Li Y, Yue J, Ma J, et al. Advances in NK cell production. Cell Mol Immunol. 2022;19:460\u201381.","journal-title":"Cell Mol Immunol"},{"key":"1932_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbplus.2020.100054","volume":"9","author":"S Redondo-Garc\u00eda","year":"2021","unstructured":"Redondo-Garc\u00eda S, Peris-Torres C, Caracuel-Peramos R, Rodr\u00edguez-Manzaneque JC. ADAMTS proteases and the tumor immune microenvironment: Lessons from substrates and pathologies. Matrix Biol. 2021;9:100054.","journal-title":"Matrix Biol"},{"key":"1932_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31288-7","volume":"8","author":"FJ Rodr\u00edguez-Baena","year":"2018","unstructured":"Rodr\u00edguez-Baena FJ, Redondo-Garc\u00eda S, Peris-Torres C, Martino-Echarri E, Fern\u00e1ndez-Rodr\u00edguez R, Plaza-Calonge MDC, et al. ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response. Sci Rep. 2018;8:13103.","journal-title":"Sci Rep"},{"key":"1932_CR34","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-immunol-042617-053335","volume":"36","author":"BB Au-Yeung","year":"2018","unstructured":"Au-Yeung BB, Shah NH, Shen L, Weiss A. ZAP-70 in signaling, biology, and disease. Annu Rev Immunol. 2018;36:127\u201356.","journal-title":"Annu Rev Immunol"},{"key":"1932_CR35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s00281-010-0196-x","volume":"32","author":"A Fischer","year":"2010","unstructured":"Fischer A, Picard C, Chemin K, Dogniaux S, le Deist F, Hivroz C. ZAP70: a master regulator of adaptive immunity. Semin Immunopathol. 2010;32:107\u201316.","journal-title":"Semin Immunopathol"},{"key":"1932_CR36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s41375-020-0809-x","volume":"35","author":"T Hideshima","year":"2020","unstructured":"Hideshima T, Ogiya D, Liu J, Harada T, Kurata K, Bae J, et al. Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways. Leukemia. 2020;35:177\u201388.","journal-title":"Leukemia"},{"key":"1932_CR37","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","volume":"74","author":"H Shi","year":"2019","unstructured":"Shi H, Wei J, He C. Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers. Mol Cell. 2019;74:640\u201350.","journal-title":"Mol Cell"},{"key":"1932_CR38","doi-asserted-by":"publisher","first-page":"6478","DOI":"10.1016\/j.apsb.2025.08.013","volume":"15","author":"X Su","year":"2025","unstructured":"Su X, Zang J, Wang Y, Zhang S, Wu P, Chen W, et al. IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules. Acta Pharm Sin B. 2025;15:6478\u201394.","journal-title":"Acta Pharm Sin B"},{"key":"1932_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.molimm.2018.07.015","volume":"115","author":"JT Gunesch","year":"2019","unstructured":"Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, et al. Genome-wide analyses and functional profiling of human NK cell lines. Mol Immunol. 2019;115:64\u201375.","journal-title":"Mol Immunol"},{"key":"1932_CR40","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/j.1600-0897.2011.00989.x","volume":"66","author":"A Braunschweig","year":"2011","unstructured":"Braunschweig A, Poehlmann TG, Busch S, Schleussner E, Markert UR. Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92. Am J Reprod Immunol. 2011;66:329\u201335.","journal-title":"Am J Reprod Immunol"},{"key":"1932_CR41","doi-asserted-by":"publisher","first-page":"9611","DOI":"10.1073\/pnas.161298098","volume":"98","author":"R Paolini","year":"2001","unstructured":"Paolini R, Molfetta R, Piccoli M, Frati L, Santoni A. Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement. Proc Natl Acad Sci USA. 2001;98:9611\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1932_CR42","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.urolonc.2008.05.003","volume":"27","author":"W Zhao","year":"2009","unstructured":"Zhao W, Xu Y, Kong D, Liu R, Zhang Z, Jin C, et al. Tissue-selective RNA interference in prostate cancer cell using prostate specific membrane antigen promoter\/enhancer. Urol Oncol. 2009;27:539\u201347.","journal-title":"Urol Oncol"},{"key":"1932_CR43","doi-asserted-by":"publisher","first-page":"e62","DOI":"10.1093\/nar\/gni061","volume":"33","author":"H Zhou","year":"2005","unstructured":"Zhou H, Xia XG, Xu Z. An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucleic Acids Res. 2005;33:e62.","journal-title":"Nucleic Acids Res"},{"key":"1932_CR44","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.1016\/j.apsb.2024.07.016","volume":"14","author":"L Liu","year":"2024","unstructured":"Liu L, Qiu Y, Suo Y, Tong S, Wang Y, Zhang X, et al. Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy. Acta Pharm Sin B. 2024;14:5382\u201392.","journal-title":"Acta Pharm Sin B"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01932-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01932-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01932-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:48:17Z","timestamp":1791856097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41401-026-01932-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":44,"alternative-id":["1932"],"URL":"https:\/\/doi.org\/10.1038\/s41401-026-01932-4","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"28 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}