{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:35:04Z","timestamp":1787621704209,"version":"build-2736575974"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BDJ Open"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>The aim of this study was to study the effect of Molar Incisor Hypomineralisation (MIH) on Oral Health-Related Quality of Life (OHRQoL) in children at the mixed dentition stage and correlate it with their caries experience.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Subjects and methods<\/jats:title>\n                <jats:p>One hundred two children aged from 8 to 10 years were recruited, 51 with MIH and 51 as control. Caries experience was recorded using DMFT\/deft and ICDAS II. MIH-TNI index was used for classifying MIH severity. CPQ<jats:sub>8\u201310<\/jats:sub> with its Arabic version was used to evaluate OHRQoL. Mann\u2013Whitney <jats:italic>U<\/jats:italic> test and Kruskal\u2013Wallis test were used for comparisons (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean value for CPQ<jats:sub>8\u201310<\/jats:sub> in MIH group was 24.67 (\u00b111.84; median 23; range 6\u201355) in comparison to 21.04 (\u00b112.3; median 18; range 2\u201354) for the control group, with no significant difference between groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.109). A significantly higher value (<jats:italic>p<\/jats:italic>\u2009=\u20090.011) was recorded in patients with MIH-TNI 4 mean 32.16 (\u00b113.9; median 35; range from 7 to 55) in comparison to other categories of MIH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Children with and without MIH, with similar caries experience showed no difference in OHRQoL. However, the presence of the severe form of MIH including hypersensitivity and enamel disintegration negatively impacted those children\u2019s OHRQoL.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41405-024-00272-x","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T15:19:55Z","timestamp":1732979995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral health-related quality of life in Egyptian children with Molar Incisor Hypomineralisation. An observational study"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-2978","authenticated-orcid":false,"given":"Lamia Khairy","family":"Gadallah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Korayem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Wahby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"272_CR1","first-page":"114","volume":"4","author":"KL Weerheijm","year":"2003","unstructured":"Weerheijm KL. Molar incisor hypomineralisation (MIH). Eur J Paediatr Dent. 2003;4:114\u201320.","journal-title":"Eur J Paediatr Dent"},{"key":"272_CR2","first-page":"38","volume":"31","author":"LM Velandia","year":"2018","unstructured":"Velandia LM, \u00c1lvarez LV, Mej\u00eda LP, Rodr\u00edguez MJ. Oral health-related quality of life in Colombian children with molar-incisor hypomineralization. Acta Odontol Latinoam. 2018;31:38\u201344.","journal-title":"Acta Odontol Latinoam"},{"key":"272_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1159\/000047479","volume":"35","author":"KL Weerheijm","year":"2001","unstructured":"Weerheijm KL, J\u00e4levik B, Alaluusua S. Molar-incisor hypomineralisation. Caries Res. 2001;35:390\u20131.","journal-title":"Caries Res"},{"key":"272_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s40368-021-00668-5","volume":"23","author":"NA Lygidakis","year":"2022","unstructured":"Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2022;23:3\u201321.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR5","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000445726","volume":"50","author":"F Jeremias","year":"2016","unstructured":"Jeremias F, et al. Family-based genetic association for molar-incisor hypomineralization. Caries Res. 2016;50:310\u20138.","journal-title":"Caries Res"},{"key":"272_CR6","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/ipd.12327","volume":"28","author":"RJPB Teixeira","year":"2018","unstructured":"Teixeira RJPB, et al. Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study. Int J Paediatr Dent. 2018;28:198\u2013206.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR7","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/cdoe.12229","volume":"44","author":"MJ Silva","year":"2016","unstructured":"Silva MJ, Scurrah KJ, Craig JM, Manton DJ, Kilpatrick N. Etiology of molar incisor hypomineralization - a systematic review. Community Dent Oral Epidemiol. 2016;44:342\u201353.","journal-title":"Community Dent Oral Epidemiol"},{"key":"272_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s40368-021-00646-x","volume":"23","author":"E Garot","year":"2022","unstructured":"Garot E, Rouas P, Somani C, Taylor GD, Wong F, Lygidakis NA. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent 2022;23:23\u201338.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR9","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1365-263X.2008.00927.x","volume":"18","author":"S-Y Cho","year":"2008","unstructured":"Cho S-Y, Ki Y, Chu V. Molar incisor hypomineralization in Hong Kong Chinese children. Int J Paediatr Dent. 2008;18:348\u201352.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1080\/00016350902758607","volume":"67","author":"V Soviero","year":"2009","unstructured":"Soviero V, Haubek D, Trindade C, Da Matta T, Poulsen S. Prevalence and distribution of demarcated opacities and their sequelae in permanent 1st molars and incisors in 7 to 13-year-old Brazilian children. Acta Odontol Scand. 2009;67:170\u20135.","journal-title":"Acta Odontol Scand"},{"key":"272_CR11","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.21608\/edj.2020.40437.1222","volume":"66","author":"S Osman","year":"2020","unstructured":"Osman S, Elmasry E, Abd Al Gawad R. Prevalence of molar incisor hypominerlization among a group of egyptian children: a cross sectional study. Egypt Dent J. 2020;66:2021\u20138.","journal-title":"Egypt Dent J"},{"key":"272_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/2231-0762.115700","volume":"3","author":"D Bennadi","year":"2013","unstructured":"Bennadi D, Reddy CVK. Oral health related quality of life. J Int Soc Prev Community Dent. 2013;3:1\u20136.","journal-title":"J Int Soc Prev Community Dent"},{"key":"272_CR13","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1111\/j.1601-5037.2008.00293.x","volume":"6","author":"TS Barbosa","year":"2008","unstructured":"Barbosa TS, Gavi\u00e3o MBD. Oral health-related quality of life in children: part II. Effects of clinical oral health status. A systematic review. Int J Dent Hyg. 2008;6:100\u20137.","journal-title":"Int J Dent Hyg"},{"key":"272_CR14","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1365-263X.2007.00908.x","volume":"18","author":"TG Fagrell","year":"2008","unstructured":"Fagrell TG, Lingstr\u00f6m P, Olsson S, Steiniger F, Nor\u00e9n JG. Bacterial invasion of dentinal tubules beneath apparently intact but hypomineralized enamel in molar teeth with molar incisor hypomineralization. Int J Paediatr Dent. 2008;18:333\u201340.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95875-x","volume":"11","author":"T Linner","year":"2021","unstructured":"Linner T, Khazaei Y, B\u00fccher K, Pfisterer J, Hickel R, K\u00fchnisch J. Hypersensitivity in teeth affected by molar-incisor hypomineralization (MIH). Sci Rep. 2021;11:17922.","journal-title":"Sci Rep"},{"key":"272_CR16","doi-asserted-by":"publisher","unstructured":"Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur. Arch. Paediatr. Dent. 2022; 23. https:\/\/doi.org\/10.1007\/s40368-021-00668-5.","DOI":"10.1007\/s40368-021-00668-5"},{"key":"272_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF03262716","volume":"11","author":"NA Lygidakis","year":"2010","unstructured":"Lygidakis NA, Wong F, J\u00e4levik B, Vierrou A-M, Alaluusua S, Espelid I. Best clinical practice guidance for clinicians dealing with children presenting with Molar-Incisor-Hypomineralisation (MIH): an EAPD policy document. Eur Arch Paediatr Dent. 2010;11:75\u201381.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1046\/j.0960-7439.2001.00318.x","volume":"12","author":"B J\u00e4levik","year":"2002","unstructured":"J\u00e4levik B, Klingberg GA. Dental treatment, dental fear and behaviour management problems in children with severe enamel hypomineralization of their permanent first molars. Int J Paediatr Dent. 2002;12:24\u201332.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR19","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1111\/ipd.12271","volume":"27","author":"SC Leal","year":"2017","unstructured":"Leal SC, Oliveira TRM, Ribeiro APD. Do parents and children perceive molar-incisor hypomineralization as an oral health problem? Int J Paediatr Dent. 2017;27:372\u20139.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR20","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2016.vol30.0117","volume":"30","author":"NB Dantas-Neta","year":"2016","unstructured":"Dantas-Neta NB, et al. Impact of molar-incisor hypomineralization on oral health-related quality of life in schoolchildren. Braz Oral Res. 2016;30:e117.","journal-title":"Braz Oral Res"},{"key":"272_CR21","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1365-263X.2011.01128.x","volume":"21","author":"CM Da Costa-Silva","year":"2011","unstructured":"Da Costa-Silva CM, Ambrosano GMB, Jeremias F, De Souza JF, Mialhe FL. Increase in severity of molar-incisor hypomineralization and its relationship with the colour of enamel opacity: a prospective cohort study. Int J Paediatr Dent. 2011;21:333\u201341.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR22","first-page":"512","volume":"26","author":"A Jokovic","year":"2004","unstructured":"Jokovic A, Locker D, Tompson B, Guyatt G. Questionnaire for measuring oral health-related quality of life in eight- to ten-year-old children. Pediatr Dent. 2004;26:512\u20138.","journal-title":"Pediatr Dent"},{"key":"272_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-14-40","volume":"14","author":"F Gilchrist","year":"2014","unstructured":"Gilchrist F, Rodd H, Deery C, Marshman Z. Assessment of the quality of measures of child oral health-related quality of life. BMC Oral Health. 2014;14:40.","journal-title":"BMC Oral Health"},{"key":"272_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12903-018-0622-3","volume":"18","author":"MO Folayan","year":"2018","unstructured":"Folayan MO, et al. Developmental defects of the enamel and its impact on the oral health quality of life of children resident in Southwest Nigeria. BMC Oral Health. 2018;18:1\u201310.","journal-title":"BMC Oral Health"},{"key":"272_CR25","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s40368-015-0178-8","volume":"16","author":"A Ghanim","year":"2015","unstructured":"Ghanim A, Elfrink M, Weerheijm K, Mari\u00f1o R, Manton D. A practical method for use in epidemiological studies on enamel hypomineralisation. Eur Arch Paediatr Dent J Eur Acad Paediatr Dent. 2015;16:235\u201346.","journal-title":"Eur Arch Paediatr Dent J Eur Acad Paediatr Dent"},{"key":"272_CR26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/0253-7176.116232","volume":"35","author":"J Charan","year":"2013","unstructured":"Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013;35:121\u20136.","journal-title":"Indian J Psychol Med"},{"key":"272_CR27","unstructured":"World Health Organization. Oral health surveys: basic methods. 3rd ed. Geneva: World Health Organization; 1987."},{"key":"272_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1177\/00220345440230030201","volume":"23","author":"AO Gruebbel","year":"1944","unstructured":"Gruebbel AO. A measurement of dental caries prevalence and treatment service for deciduous teeth. J Dent Res. 1944;23:163\u20138.","journal-title":"J Dent Res"},{"key":"272_CR29","doi-asserted-by":"publisher","first-page":"63","DOI":"10.17096\/jiufd.38691","volume":"49","author":"B Dikmen","year":"2015","unstructured":"Dikmen B. Icdas II criteria (international caries detection and assessment system). J Istanb Univ Fac Dent. 2015;49:63\u201372.","journal-title":"J Istanb Univ Fac Dent"},{"key":"272_CR30","doi-asserted-by":"publisher","first-page":"e574","DOI":"10.4317\/medoral.19890","volume":"19","author":"J-M Almerich-Silla","year":"2014","unstructured":"Almerich-Silla J-M, Boronat-Ferrer T, Montiel-Company J-M, Iranzo-Cort\u00e9s J-E. Caries prevalence in children from Valencia (Spain) using ICDAS II criteria, 2010. Med Oral Patol Oral Cir Bucal. 2014;19:e574\u201380.","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"272_CR31","unstructured":"World Health Organization. Oral health surveys. basic methods. 5th ed. Geneva: World Health Organization; 2013."},{"key":"272_CR32","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1600-0528.2007.00347.x","volume":"35","author":"AI Ismail","year":"2007","unstructured":"Ismail AI, et al. The international caries detection and assessment system (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol. 2007;35:170\u20138.","journal-title":"Community Dent Oral Epidemiol"},{"key":"272_CR33","first-page":"110","volume":"4","author":"KL Weerheijm","year":"2003","unstructured":"Weerheijm KL, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003;4:110\u20133.","journal-title":"Eur J Paediatr Dent"},{"key":"272_CR34","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s40368-017-0301-0","volume":"18","author":"R Steffen","year":"2017","unstructured":"Steffen R, Kr\u00e4mer N, Bekes K. The W\u00fcrzburg MIH concept: the MIH treatment need index (MIH TNI): a new index to assess and plan treatment in patients with molar incisior hypomineralisation (MIH). Eur Arch Paediatr Dent. 2017;18:355\u201361.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR35","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1007\/s11136-020-02545-y","volume":"29","author":"D Al-Blaihed","year":"2020","unstructured":"Al-Blaihed D, El-Housseiny AA, Farsi NJ, Farsi NM. Validity and reliability of the Arabic version of the child perceptions questionnaire for 8-10-year-old children. Qual Life Res. 2020;29:3131\u201341.","journal-title":"Qual Life Res"},{"key":"272_CR36","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1111\/ipd.12482","volume":"29","author":"PD Portella","year":"2019","unstructured":"Portella PD, Menoncin BLV, de Souza JF, de Menezes JVNB, Fraiz FC, da Assun\u00e7\u00e3o LRS. Impact of molar incisor hypomineralization on quality of life in children with early mixed dentition: a hierarchical approach. Int J Paediatr Dent. 2019;29:496\u2013506.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR37","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1590\/0103-6440201600990","volume":"27","author":"RA Melgar","year":"2016","unstructured":"Melgar RA, Pereira JT, Luz PB, Hugo FN, de Araujo FB. Differential impacts of caries classification in children and adults: a comparison of ICDAS and DMF-T. Braz Dent J. 2016;27:761\u20136.","journal-title":"Braz Dent J"},{"key":"272_CR38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/ipd.12233","volume":"27","author":"GCA Americano","year":"2017","unstructured":"Americano GCA, Jacobsen PE, Soviero VM, Haubek D. A systematic review on the association between molar incisor hypomineralization and dental caries. Int J Paediatr Dent. 2017;27:11\u201321.","journal-title":"Int J Paediatr Dent"},{"key":"272_CR39","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1055\/s-0042-1749360","volume":"17","author":"M Ben Salem","year":"2023","unstructured":"Ben Salem M, Chouchene F, Masmoudi F, Baaziz A, Maatouk F, Ghedira H. Are molar-incisor hypomineralization and hypomineralized second primary molars predictive of dental caries?: a systematic review. Eur J Dent. 2023;17:7\u201315.","journal-title":"Eur J Dent"},{"key":"272_CR40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s40368-021-00631-4","volume":"23","author":"B J\u00e4levik","year":"2022","unstructured":"J\u00e4levik B, Sabel N, Robertson A. Can molar incisor hypomineralization cause dental fear and anxiety or influence the oral health-related quality of life in children and adolescents?\u2014a systematic review. Eur Arch Paediatr Dent. 2022;23:65\u201378.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/healthcare12030370","volume":"12","author":"S Shields","year":"2024","unstructured":"Shields S, Chen T, Crombie F, Manton DJ, Silva M. The impact of molar incisor hypomineralisation on children and adolescents: a narrative review. Healthc. 2024;12:1\u201311.","journal-title":"Healthc"},{"key":"272_CR42","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1007\/s00784-021-04150-w","volume":"26","author":"T Joshi","year":"2022","unstructured":"Joshi T, Rahman A, Rienhoff S, Rienhoff J, Stamm T, Bekes K. Impact of molar incisor hypomineralization on oral health-related quality of life in 8-10-year-old children. Clin Oral Investig. 2022;26:1753\u20139.","journal-title":"Clin Oral Investig"},{"key":"272_CR43","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5005\/jp-journals-10005-2338","volume":"15","author":"FG Vieira","year":"2022","unstructured":"Vieira FG, Pintor AV, Silva F, Da, Neves ADA, Costa MD. Molar incisor hypomineralization-influence on dental caries experience indexes: a cross-sectional study. Int J Clin Pediatr Dent. 2022;15:65\u201368.","journal-title":"Int J Clin Pediatr Dent"},{"key":"272_CR44","first-page":"461","volume":"13","author":"J Opydo-Szymaczek","year":"2015","unstructured":"Opydo-Szymaczek J, Gerreth K. Developmental enamel defects of the permanent first molars and incisors and their association with dental caries in the region of Wielkopolska, Western Poland. Oral Health Prev Dent. 2015;13:461\u20139.","journal-title":"Oral Health Prev Dent"},{"key":"272_CR45","doi-asserted-by":"crossref","unstructured":"Al. B et. Molar-incisor hypomineralization and dental caries: a hierarchical approach in a populational-based study. Braz Dent J. 2021;32:74\u201382.","DOI":"10.1590\/0103-6440202104511"},{"key":"272_CR46","doi-asserted-by":"publisher","first-page":"379","DOI":"10.2147\/CCIDE.S324396","volume":"13","author":"S Al Dhubayb","year":"2021","unstructured":"Al Dhubayb S, Al Sultan M, Al Sudairi S, Hakami F, Al Sweleh FS. Ability of dentists and students to detect caries by using the international caries detection and assessment system. Clin Cosmet Investig Dent. 2021;13:379\u201387.","journal-title":"Clin Cosmet Investig Dent"},{"key":"272_CR47","doi-asserted-by":"publisher","unstructured":"Ghanim A, Elfrink M, Weerheijm K, Mari\u00f1o R, Manton D. A practical method for use in epidemiological studies on enamel hypomineralisation. Eur Arch Paediatr Dent. 2015;16. https:\/\/doi.org\/10.1007\/s40368-015-0178-8.","DOI":"10.1007\/s40368-015-0178-8"},{"key":"272_CR48","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s40368-017-0293-9","volume":"18","author":"A Ghanim","year":"2017","unstructured":"Ghanim A, et al. Molar incisor hypomineralisation (MIH) training manual for clinical field surveys and practice. Eur Arch Paediatr Dent. 2017;18:225\u201342.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-19821-0","volume":"8","author":"A Negre-Barber","year":"2018","unstructured":"Negre-Barber A, Montiel-Company JM, Catal\u00e1-Pizarro M, Almerich-Silla JM. Degree of severity of molar incisor hypomineralization and its relation to dental caries. Sci Rep. 2018;8:1\u20137.","journal-title":"Sci Rep"},{"key":"272_CR50","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/adj.12567","volume":"63","author":"ML Owen","year":"2018","unstructured":"Owen ML, Ghanim A, Elsby D, Manton DJ. Hypomineralized second primary molars: prevalence, defect characteristics and relationship with dental caries in Melbourne preschool children. Aust Dent J. 2018;63:72\u201380.","journal-title":"Aust Dent J"},{"key":"272_CR51","doi-asserted-by":"publisher","first-page":"324","DOI":"10.17796\/1053-4625-43.5.4","volume":"43","author":"TV Guti\u00e9rrez","year":"2019","unstructured":"Guti\u00e9rrez TV, Ortega CCB, P\u00e9rez NP, P\u00e9rez AG. Impact of molar incisor hypomineralization on oral health-related quality of life in mexican schoolchildren. J Clin Pediatr Dent. 2019;43:324\u201330.","journal-title":"J Clin Pediatr Dent"},{"key":"272_CR52","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s40368-020-00556-4","volume":"22","author":"FMCS Dias","year":"2021","unstructured":"Dias FMCS, Gradella CMF, Ferreira MC, Oliveira LB. Molar\u2013incisor hypomineralization: parent\u2019s and children\u2019s impact perceptions on the oral health-related quality of life. Eur Arch Paediatr Dent. 2021;22:273\u201382.","journal-title":"Eur Arch Paediatr Dent"},{"key":"272_CR53","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/00016357.2020.1863461","volume":"79","author":"L Bandeira Lopes","year":"2021","unstructured":"Bandeira Lopes L, Machado V, Botelho J, Haubek D. Molar-incisor hypomineralization: an umbrella review. Acta Odontol Scand. 2021;79:359\u201369.","journal-title":"Acta Odontol Scand"},{"key":"272_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-024-51223-3","volume":"14","author":"C Sekundo","year":"2024","unstructured":"Sekundo C, Jung M, Muscholl C, Frese C. Oral health-related quality of life and survival analysis after preventive and restorative treatment of molar-incisor hypomineralisation. Sci Rep. 2024;14:1\u20139.","journal-title":"Sci Rep"},{"key":"272_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01509-z","volume":"21","author":"P Ellakany","year":"2021","unstructured":"Ellakany P, Fouda SM, Alghamdi M, Bakhurji E. Factors affecting dental self-confidence and satisfaction with dental appearance among adolescents in Saudi Arabia: a cross sectional study. BMC Oral Health. 2021;21:149.","journal-title":"BMC Oral Health"},{"key":"272_CR56","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.2319\/102715-722","volume":"86","author":"G Rossini","year":"2016","unstructured":"Rossini G, Parrini S, Castroflorio T, Fortini A, Deregibus A, Debernardi CL. Children\u2019s perceptions of smile esthetics and their influence on social judgment. Angle Orthod. 2016;86:1050\u20135.","journal-title":"Angle Orthod"}],"container-title":["BDJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41405-024-00272-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41405-024-00272-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41405-024-00272-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T16:02:51Z","timestamp":1732982571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41405-024-00272-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["272"],"URL":"https:\/\/doi.org\/10.1038\/s41405-024-00272-x","relation":{},"ISSN":["2056-807X"],"issn-type":[{"value":"2056-807X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]},"assertion":[{"value":"1 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests. This study was reviewed and approved by the Medical Research Ethics Committee (MREC) of the National Research Centre, with reference number (03470233). Prior to carrying out the research, written informed consents were signed by the parents or legal guardians of the participating children and verbal assents were also obtained from the children themselves.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was reviewed and approved by the Medical Research Ethics Committee (MREC) of the National Research Centre, with reference number (03470233).Prior to carrying out the research, written informed consents were signed by the parents or legal guardians of the participating children and verbal assents were also obtained from the children themselves.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"89"}}