{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:05:55Z","timestamp":1770350755863,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Funder: Brembo SpA, grant: Brembo \"3x1 project\""},{"name":"Funder: AIRC, Grant: MYNERVA project, #21267"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer J."],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, <jats:italic>n<\/jats:italic>\u2009=\u200948), polycythemia vera (PV, <jats:italic>n<\/jats:italic>\u2009=\u200942), myelofibrosis (MF, <jats:italic>n<\/jats:italic>\u2009=\u200956), and prefibrotic myelofibrosis (pre-PMF, <jats:italic>n<\/jats:italic>\u2009=\u200916), 15 major thromboses (3 arterial and 12 venous) were registered in 14 patients, of whom all, but one, were receiving LMW-heparin prophylaxis. After adjustment for the competing risk of death, the cumulative incidence of arterial and venous thromboembolic events (VTE) reached 8.5% after 60 days follow-up. Of note, 8 of 12 VTE were seen in ET. Interestingly, at COVID-19 diagnosis, MPN patients had significantly lower platelet count (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) than in the pre-COVID last follow-up.This decline was remarkably higher in ET (\u221223.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) than in PV (\u221216.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.1730) and was associated with higher mortality rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.0010) for pneumonia. The effects of possible predictors of thrombosis, selected from those clinically relevant and statistically significant in univariate analysis, were examined in a multivariate model. Independent risk factors were transfer to ICU (SHR\u2009=\u20093.73, <jats:italic>p<\/jats:italic>\u2009=\u20090.029), neutrophil\/lymphocyte ratio (SHR\u2009=\u20091.1, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and ET phenotype (SHR\u2009=\u20094.37, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). The enhanced susceptibility to ET-associated VTE and the associated higher mortality for pneumonia may recognize a common biological plausibility and deserve to be delved to tailor new antithrombotic regimens including antiplatelet drugs.<\/jats:p>","DOI":"10.1038\/s41408-021-00417-3","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T21:23:32Z","timestamp":1612905812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-6327","authenticated-orcid":false,"given":"Tiziano","family":"Barbui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-5827","authenticated-orcid":false,"given":"Valerio","family":"De Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Alvarez-Larran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-0812","authenticated-orcid":false,"given":"Alessandra","family":"Iurlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Masciulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-7084","authenticated-orcid":false,"given":"Alessandra","family":"Carobbio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Ghirardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Cancelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Maria","family":"Elli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Miguel","family":"Andrade-Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes Gasior","family":"Kabat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jaques","family":"Kiladjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8367-5668","authenticated-orcid":false,"given":"Francesca","family":"Palandri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Benevolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4752-0815","authenticated-orcid":false,"given":"Valentin","family":"Garcia-Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Laura","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-0504","authenticated-orcid":false,"given":"Maria Angeles","family":"Foncillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Montoya","family":"Morcillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9504","authenticated-orcid":false,"given":"Elisa","family":"Rumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Osorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-1686","authenticated-orcid":false,"given":"Massimiliano","family":"Bonifacio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-3524","authenticated-orcid":false,"given":"Keina Susana Quiroz","family":"Cervantes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Sagues","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9570-5542","authenticated-orcid":false,"given":"Gonzalo","family":"Carreno-Tarragona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Anna","family":"Sobas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Lunghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Patriarca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a Navas","family":"Elorza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Angona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Magro","family":"Mazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-8171","authenticated-orcid":false,"given":"Steffen","family":"Koschmieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Carli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7555-3361","authenticated-orcid":false,"given":"Beatriz","family":"Cuevas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4289-3113","authenticated-orcid":false,"given":"Juan Carlos","family":"Hernandez-Boluda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma Lopez","family":"Abadia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca Xicoy","family":"Cirici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-284X","authenticated-orcid":false,"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Garrote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Daffini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Cavalca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Bellosillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Benajiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Curto-Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Betti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-7502","authenticated-orcid":false,"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Maria","family":"Vannucchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"417_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s11481-020-09944-5","volume":"15","author":"J Machhi","year":"2020","unstructured":"Machhi, J. et al. The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections. J. Neuroimmune Pharmacol. 15, 359\u2013386 (2020).","journal-title":"J. Neuroimmune Pharmacol."},{"key":"417_CR2","doi-asserted-by":"publisher","unstructured":"Rodr\u00edguez, C. et al. Pulmonary endothelial dysfunction and thrombotic complications in COVID-19 patients. Am. J. Respir. Cell Mol. Biol. https:\/\/doi.org\/10.1165\/rcmb.2020-0359PS (2020).","DOI":"10.1165\/rcmb.2020-0359PS"},{"key":"417_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241742","volume":"15","author":"AE Mesas","year":"2020","unstructured":"Mesas, A. E. et al. Predictors of in-hospital COVID-19 mortality: a comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions. PLoS ONE 15, e0241742 (2020).","journal-title":"PLoS ONE"},{"key":"417_CR4","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/cells9071652","volume":"9","author":"R Amraei","year":"2020","unstructured":"Amraei, R. & Rahimi, N. COVID-19, renin\u2013angiotensin system and endothelial dysfunction. Cells 9, 1652 (2020).","journal-title":"Cells"},{"key":"417_CR5","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","volume":"395","author":"Z Varga","year":"2020","unstructured":"Varga, Z. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 395, 1417\u20131418 (2020).","journal-title":"Lancet"},{"key":"417_CR6","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/rth2.12439","volume":"4","author":"S Nopp","year":"2020","unstructured":"Nopp, S., Moik, F., Jilma, B., Pabinger, I. & Ay, C. Risk of venous thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Res. Pract. Thromb. Haemost. 4, 1178\u20131191 (2020).","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"417_CR7","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/S1473-3099(20)30434-5","volume":"20","author":"L Carsana","year":"2020","unstructured":"Carsana, L. et al. Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study. Lancet Infect. Dis. 20, 1135\u20131140 (2020).","journal-title":"Lancet Infect. Dis."},{"key":"417_CR8","doi-asserted-by":"publisher","first-page":"106135","DOI":"10.1016\/j.rmed.2020.106135","volume":"172","author":"K Mueller-Peltzer","year":"2020","unstructured":"Mueller-Peltzer, K. et al. Pulmonary artery thrombi are co-located with opacifications in SARS-CoV2 induced ARDS. Respir. Med. 172, 106135 (2020).","journal-title":"Respir. Med."},{"key":"417_CR9","doi-asserted-by":"publisher","unstructured":"Mandal, A. K. J., Kho, J., Ioannou, A., Van den Abbeele, K. & Missouris C. G. Covid-19 and in situ pulmonary artery thrombosis. Respir. Med. https:\/\/doi.org\/10.1016\/j.rmed.2020.106176 (2020).","DOI":"10.1016\/j.rmed.2020.106176"},{"key":"417_CR10","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1182\/blood-2013-03-460154","volume":"122","author":"T Barbui","year":"2013","unstructured":"Barbui, T., Finazzi, G. & Falanga, A. Myeloproliferative neoplasms and thrombosis. Blood 122, 2176\u20132184 (2013).","journal-title":"Blood"},{"key":"417_CR11","doi-asserted-by":"publisher","first-page":"268","DOI":"10.7326\/L18-0245","volume":"169","author":"M Hultcrantz","year":"2018","unstructured":"Hultcrantz, M., Bj\u00f6rkholm, M., Landgren, O., Kristinsson, S. Y. & Andersson, T. M. L. Risk for arterial and venous thrombosis in patients with myeloproliferative neoplasms. Ann. Intern. Med. 169, 268 (2018).","journal-title":"Ann. Intern. Med."},{"key":"417_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5387-9","volume":"19","author":"T Rungjirajittranon","year":"2019","unstructured":"Rungjirajittranon, T., Owattanapanich, W., Ungprasert, P., Siritanaratkul, N. & Ruchutrakool, T. A systematic review and meta-analysis of the prevalence of thrombosis and bleeding at diagnosis of Philadelphia-negative myeloproliferative neoplasms. BMC Cancer 19, 184 (2019).","journal-title":"BMC Cancer"},{"key":"417_CR13","doi-asserted-by":"publisher","first-page":"100706","DOI":"10.1016\/j.blre.2020.100706","volume":"42","author":"RM Shallis","year":"2020","unstructured":"Shallis, R. M. et al. Epidemiology of the classical myeloproliferative neoplasms: the four corners of an expansive and complex map. Blood Rev. 42, 100706 (2020).","journal-title":"Blood Rev."},{"key":"417_CR14","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/joim.13019","volume":"287","author":"M Hultcrantz","year":"2020","unstructured":"Hultcrantz, M. et al. Incidence of myeloproliferative neoplasms\u2014trends by subgroup and age in a population-based study in Sweden. J. Intern. Med. 287, 448\u2013454 (2020).","journal-title":"J. Intern. Med."},{"key":"417_CR15","unstructured":"World Health Organization. Laboratory Testing for Coronavirus Disease 2019 (COVID-19) in Suspected Human Cases: Interim Guidance. https:\/\/www.who.int\/publications-detail\/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117. Accessed 19 March 2020."},{"key":"417_CR16","unstructured":"World Health Organization. International Statistical Classification of Diseases and Related Health Problems\u201410th Revision, edition 2010. 3 v https:\/\/www.who.int\/classifications\/icd\/ICD10Volume2_en_2010.pdf"},{"key":"417_CR17","doi-asserted-by":"publisher","unstructured":"Barbui, T., et al. High mortality rate of COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib. Leukemia 2021; E-pub ahead of print as https:\/\/doi.org\/10.1038\/s41375-020-01107-y.","DOI":"10.1038\/s41375-020-01107-y"},{"key":"417_CR18","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.thromres.2020.04.024","volume":"191","author":"C Lodigiani","year":"2020","unstructured":"Lodigiani, C. et al. Humanitas COVID-19 Task Force. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb. Res. 191, 9\u201314 (2020).","journal-title":"Thromb. Res."},{"key":"417_CR19","first-page":"30767-6","volume":"S0890-5096","author":"I Cheruiyot","year":"2020","unstructured":"Cheruiyot, I. et al. Arterial thrombosis in coronavirus disease 2019 patients: a rapid systematic review. Ann. Vasc. Surg. S0890-5096, 30767-6 (2020).","journal-title":"Ann. Vasc. Surg."},{"key":"417_CR20","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s11239-020-02231-3","volume":"50","author":"B Marchandot","year":"2020","unstructured":"Marchandot, B. et al. Thromboprophylaxis: balancing evidence and experience during the COVID-19 pandemic. J. Thromb. Thrombol. 50, 799\u2013808 (2020).","journal-title":"J. Thromb. Thrombol."},{"key":"417_CR21","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1111\/jth.14929","volume":"18","author":"AC Spyropoulos","year":"2020","unstructured":"Spyropoulos, A. C. et al. Subcommittee on Perioperative, Critical Care Thrombosis, Haemostasis of the Scientific, Standardization Committee of the International Society on Thrombosis and Haemostasis. Scientific and Standardization Committee communication: clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. J. Thromb. Haemost. 18, 1859\u20131865 (2020).","journal-title":"J. Thromb. Haemost."},{"key":"417_CR22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11239-020-02146-z","volume":"50","author":"M Artifoni","year":"2020","unstructured":"Artifoni, M. et al. Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors. J. Thromb. Thrombolysis 50, 211\u2013216 (2020).","journal-title":"J. Thromb. Thrombolysis"},{"key":"417_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1182\/blood.2020006520","volume":"136","author":"H Al-Samkari","year":"2020","unstructured":"Al-Samkari, H. et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood 136, 489\u2013500 (2020).","journal-title":"Blood"},{"key":"417_CR24","doi-asserted-by":"publisher","unstructured":"Wool G. D. & Miller J. L. The impact of COVID-19 disease on platelets and coagulation. Pathobiology https:\/\/doi.org\/10.1159\/000512007 (2020).","DOI":"10.1159\/000512007"},{"key":"417_CR25","doi-asserted-by":"crossref","unstructured":"Wolach, O. et al. Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Sci. Transl. Med. 10, eaan8292 (2018).","DOI":"10.1126\/scitranslmed.aan8292"},{"key":"417_CR26","doi-asserted-by":"publisher","first-page":"118431","DOI":"10.1016\/j.lfs.2020.118431","volume":"260","author":"S Vinayagam","year":"2020","unstructured":"Vinayagam, S. & Sattu, K. SARS-CoV-2 and coagulation disorders in different organs. Life Sci. 260, 118431 (2020).","journal-title":"Life Sci."}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41408-021-00417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41408-021-00417-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41408-021-00417-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T15:39:41Z","timestamp":1669909181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41408-021-00417-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["417"],"URL":"https:\/\/doi.org\/10.1038\/s41408-021-00417-3","relation":{},"ISSN":["2044-5385"],"issn-type":[{"value":"2044-5385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,4]]},"assertion":[{"value":"23 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"21"}}