{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:44:27Z","timestamp":1762296267856,"version":"build-2065373602"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["UVA2014-6824","UVA2014-6824","UVA2014-6824","UVA2014-6824"],"award-info":[{"award-number":["UVA2014-6824","UVA2014-6824","UVA2014-6824","UVA2014-6824"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer J."],"DOI":"10.1038\/s41408-025-01405-7","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:58:44Z","timestamp":1762253924000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic lymphocytic leukemia specificity analyses unveil bacterial lipopolysaccharides as the cognate ligands of established stereotyped BCR subsets"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5855-4119","authenticated-orcid":false,"given":"Jerry","family":"Janssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thera A. M.","family":"Wormhoudt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Beentjes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harutai","family":"Nimaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok P. M.","family":"van Kessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Ellen","family":"van der Schoot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-1891","authenticated-orcid":false,"given":"Arnon P.","family":"Kater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2078-3220","authenticated-orcid":false,"given":"Anton W.","family":"Langerak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6495-0329","authenticated-orcid":false,"given":"Ten","family":"Feizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-3441","authenticated-orcid":false,"given":"Jeroen E. J.","family":"Guikema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-3138","authenticated-orcid":false,"given":"Richard J.","family":"Bende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carel J. M.","family":"van Noesel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"1405_CR1","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1084\/jem.20050068","volume":"201","author":"RJ Bende","year":"2005","unstructured":"Bende RJ, Aarts WM, de Jong D, Pals ST, van Noesel CJ. Among B-cell non-Hodgkin\u2019s lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J Exp Med. 2005;201:1229\u201341.","journal-title":"J Exp Med"},{"key":"1405_CR2","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1182\/blood.2020007039","volume":"137","author":"A Agathangelidis","year":"2021","unstructured":"Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, et al. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Blood. 2021;137:1365\u201376.","journal-title":"Blood"},{"key":"1405_CR3","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1111\/bjh.17964","volume":"196","author":"RJ Bende","year":"2022","unstructured":"Bende RJ, Janssen J, van Noesel CJM. Higher-order of chronic lymphocytic leukaemia (CLL) classification: shared antigenic specificities of stereotyped B-cell receptor subsets as defined by the European Research Initiative on CLL consortium. Br J Haematol. 2022;196:e60\u2013e63.","journal-title":"Br J Haematol"},{"key":"1405_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2119\/2008-00102.Catera","volume":"14","author":"R Catera","year":"2008","unstructured":"Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, et al. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med. 2008;14:665\u201374.","journal-title":"Mol Med"},{"key":"1405_CR5","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1172\/JCI24387","volume":"115","author":"M Herve","year":"2005","unstructured":"Herve M, Xu K, Ng YS, Wardemann H, Albesiano E, Messmer BT, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Investig. 2005;115:1636\u201343.","journal-title":"J Clin Investig"},{"key":"1405_CR6","doi-asserted-by":"crossref","unstructured":"Hoogeboom R, Wormhoudt TA, Schipperus MR, Langerak AW, Dunn-Walters DK, Guikema JE, et al. A novel chronic lymphocytic leukemia subset expressing mutated IGHV3-7-encoded rheumatoid factor B-cell receptors that are functionally proficient. Leukemia. 2013;27:738\u201340.","DOI":"10.1038\/leu.2012.238"},{"key":"1405_CR7","doi-asserted-by":"publisher","first-page":"e550","DOI":"10.1097\/HS9.0000000000000550","volume":"5","author":"J Janssen","year":"2021","unstructured":"Janssen J, Donner N, Li Z, Wormhoudt TAM, Wagner K, Guikema JEJ, et al. A major Subset of mutated CLL expresses affinity-selected and functionally proficient rheumatoid factors. Hemasphere. 2021;5:e550.","journal-title":"Hemasphere"},{"key":"1405_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1084\/jem.20121801","volume":"210","author":"R Hoogeboom","year":"2013","unstructured":"Hoogeboom R, van Kessel KP, Hochstenbach F, Wormhoudt TA, Reinten RJ, Wagner K, et al. A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi. J Exp Med. 2013;210:59\u201370.","journal-title":"J Exp Med"},{"key":"1405_CR9","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/leu.2014.266","volume":"29","author":"R Hoogeboom","year":"2015","unstructured":"Hoogeboom R, Reinten RJ, Schot JJ, Guikema JE, Bende RJ, van Noesel CJ. In vitro induction of antibody secretion of primary B-cell chronic lymphocytic leukaemia cells. Leukemia. 2015;29:244\u20137.","journal-title":"Leukemia"},{"key":"1405_CR10","doi-asserted-by":"publisher","first-page":"E2567","DOI":"10.1073\/pnas.1406974111","volume":"111","author":"Z Sabouri","year":"2014","unstructured":"Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, et al. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity. Proc Natl Acad Sci USA. 2014;111:E2567\u201375.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1405_CR11","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1086907","volume":"301","author":"H Wardemann","year":"2003","unstructured":"Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science. 2003;301:1374\u20137.","journal-title":"Science"},{"key":"1405_CR12","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1038\/s41591-021-01521-4","volume":"27","author":"A Niroula","year":"2021","unstructured":"Niroula A, Sekar A, Murakami MA, Trinder M, Agrawal M, Wong WJ, et al. Distinction of lymphoid and myeloid clonal hematopoiesis. Nat Med. 2021;27:1921\u20137.","journal-title":"Nat Med"},{"key":"1405_CR13","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1158\/2159-8290.CD-14-0104","volume":"4","author":"F Damm","year":"2014","unstructured":"Damm F, Mylonas E, Cosson A, Yoshida K, Della Valle V, Mouly E, et al. Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov. 2014;4:1088\u2013101.","journal-title":"Cancer Discov"},{"key":"1405_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15746","volume":"8","author":"C Minici","year":"2017","unstructured":"Minici C, Gounari M, Ubelhart R, Scarfo L, Duhren-von Minden M, Schneider D, et al. Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun. 2017;8:15746.","journal-title":"Nat Commun"},{"key":"1405_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36853-8","volume":"9","author":"C Schleiss","year":"2019","unstructured":"Schleiss C, Ilias W, Tahar O, Guler Y, Miguet L, Mayeur-Rousse C, et al. BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo. Sci Rep. 2019;9:701.","journal-title":"Sci Rep"}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41408-025-01405-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41408-025-01405-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41408-025-01405-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T22:28:23Z","timestamp":1762295303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41408-025-01405-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1405"],"URL":"https:\/\/doi.org\/10.1038\/s41408-025-01405-7","relation":{},"ISSN":["2044-5385"],"issn-type":[{"type":"electronic","value":"2044-5385"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"27 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. The study was approved by the medical ethics committee at the Amsterdam University Medical Center under the name B cell malignancies Biobank and number 2013_159. Written informed consent was obtained from all subjects in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"191"}}