{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:56:18Z","timestamp":1770836178609,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1038\/s41409-018-0259-5","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T07:42:11Z","timestamp":1528875731000},"page":"275-283","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hematopoietic stem cell transplantation for isolated extramedullary relapse of acute lymphoblastic leukemia in children"],"prefix":"10.1038","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-9895","authenticated-orcid":false,"given":"Maria","family":"Gabelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zecca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Messina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Carraro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Buldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attilio Maria","family":"Rovelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Fagioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Bertaina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Lanino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Favre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rabusin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arcangelo","family":"Prete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimmo","family":"Ripaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Barberi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Caniglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Santarone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Basso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"259_CR1","doi-asserted-by":"publisher","first-page":"e205","DOI":"10.1016\/S1470-2045(12)70580-6","volume":"14","author":"D Bhojwani","year":"2013","unstructured":"Bhojwani D, Pui CH. Relapsed childhood acute lymphoblastic leukemia. Lancet Oncol. 2013;14:e205\u201317.","journal-title":"Lancet Oncol"},{"key":"259_CR2","doi-asserted-by":"publisher","first-page":"5800","DOI":"10.1200\/JCO.2007.10.7508","volume":"25","author":"S Malempati","year":"2007","unstructured":"Malempati S, Gaynon PS, Sather H, La MK, Stork LC. Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children\u2019s Oncology Group study CCG-1952. J Clin Oncol. 2007;25:5800\u20137.","journal-title":"J Clin Oncol"},{"key":"259_CR3","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1200\/JCO.2009.25.1983","volume":"28","author":"G Tallen","year":"2010","unstructured":"Tallen G, Ratei R, Mann G, Kaspers G, Niggli F, Karachunsky A, et al. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. J Clin Oncol. 2010;28:2339\u201347.","journal-title":"J Clin Oncol"},{"key":"259_CR4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11899-010-0063-9","volume":"5","author":"JE Jacobs","year":"2010","unstructured":"Jacobs JE, Hastings C. Isolated extramedullary relapse in childhood acute lymphocytic leukemia. Curr Hematol Malig Rep. 2010;5:185\u201391.","journal-title":"Curr Hematol Malig Rep"},{"key":"259_CR5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/sj.leu.2405037","volume":"22","author":"M Eapen","year":"2008","unstructured":"Eapen M, Zhang MJ, Devidas M, Raetz E, Barredo JC, Ritchey AK, et al. Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children\u2019s Oncology Group and the Center for International Blood and Marrow Transplant Research. Leukemia. 2008;22:281\u20136.","journal-title":"Leukemia"},{"key":"259_CR6","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.bbmt.2008.03.011","volume":"14","author":"PD Harker-Murray","year":"2008","unstructured":"Harker-Murray PD, Thomas AJ, Wagner JE, Weisdorf D, Luo X, DeFor TE, et al. Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system. Biol Blood Marrow Transplant. 2008;14:685\u201392.","journal-title":"Biol Blood Marrow Transplant"},{"key":"259_CR7","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1016\/j.ejca.2008.08.007","volume":"4","author":"C Domenech","year":"2008","unstructured":"Domenech C, Mercier M, Plouvier E, Puraveau M, Bordigoni P, Michel G, et al. First isolated extramedullary relapse in children with B-cell precursor acute lymphoblastic leukaemia: results of the Cooprall-97 study. Eur J Cancer. 2008;4:2461\u20139.","journal-title":"Eur J Cancer"},{"key":"259_CR8","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/pbc.22946","volume":"57","author":"H Berg van den","year":"2011","unstructured":"van den Berg H,de Groot-Kruseman HA,Damen-Korbijn CM,de Bont ESJM,Schouten-van Meeteren AYN,Hoogerbrugge PM, Outcome after first relapse in children with acute lymphoblastic leukemia: a report based on the Dutch Childhood Oncology Group (DCOG) relapse ALL 98 protocol. Pediatr Blood Cancer. 2011;57:210\u20136.","journal-title":"Pediatr Blood Cancer"},{"key":"259_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.bmt.1701052","volume":"21","author":"C Messina","year":"1998","unstructured":"Messina C, Valsecchi MG, Aric\u00f2 A, Locatelli F, Rossetti F, Rondelli R, et al. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia. Bone Marrow Transplant. 1998;21:9\u201314.","journal-title":"Bone Marrow Transplant"},{"key":"259_CR10","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/sj.bmt.1701204","volume":"21","author":"C Messina","year":"1998","unstructured":"Messina C, Cesaro S, Rondelli R, Rossetti F, Locatelli F, Pession A, et al. Autologous bone marrow transplantation for childhood acute lymphoblastic leukaemia in Italy. AIEOP\/FONOP-TMO Group. Italian Association of Paediatric Haemato-Oncology. Bone Marrow Transplant. 1998;21:1015\u201321.","journal-title":"Bone Marrow Transplant"},{"key":"259_CR11","first-page":"1380","volume":"90","author":"JH Lee","year":"2005","unstructured":"Lee JH, Choi SJ, Lee JH, Seol M, Lee YS, Ryu SG, et al. Anti-leukemic effect of graft-versus-host disease on bone marrow and extramedullary relapses in acute leukemia. Haematologica. 2005;90:1380\u20138.","journal-title":"Haematologica"},{"key":"259_CR12","doi-asserted-by":"publisher","first-page":"3835","DOI":"10.1182\/blood.V101.10.3835","volume":"101","author":"A Borgmann","year":"2003","unstructured":"Borgmann A, von Stackelberg A, Hartmann R, Ebell W, Klingebiel T, Peters C, et al. Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis. Blood. 2003;101:3835\u20139.","journal-title":"Blood"},{"key":"259_CR13","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1182\/blood-2012-02-265884","volume":"120","author":"F Locatelli","year":"2012","unstructured":"Locatelli F, Schrappe M, Bernardo ME, Rutella S. How I treat relapsed childhood acute lymphoblastic leukemia. Blood. 2012;120:2807\u201316.","journal-title":"Blood"},{"key":"259_CR14","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1002\/pbc.23169","volume":"57","author":"A Balduzzi","year":"2011","unstructured":"Balduzzi A, Galimberti S, Valsecchi MG, Bonanomi S, Conter V, Barth A, et al. Autologous purified peripheral blood stem cell transplantation compare to chemotherapy in childhood acute lymphoblastic leukemia after low-risk relapse. Pediatr Blood Cancer. 2011;57:654\u20139.","journal-title":"Pediatr Blood Cancer"},{"key":"259_CR15","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1038\/leu.2008.251","volume":"22","author":"K Nguyen","year":"2008","unstructured":"Nguyen K, Devidas M, Cheng SC, La M, Raetz EA, Carroll WL, et al. Factors influencing survival after relapse from acute lymphoblastic leukemia. A Children's Oncology Group study. Leukemia. 2008;22:2142\u201350.","journal-title":"Leukemia"},{"key":"259_CR16","doi-asserted-by":"publisher","first-page":"3745","DOI":"10.1200\/JCO.1999.17.12.3745","volume":"17","author":"AK Ritchey","year":"1999","unstructured":"Ritchey AK, Pollock BH, Lauer SJ, Andejeski Y, Buchanan GR. Improved survival of children with isolated CNS relapse of acute lymphoblastic leukemia: a Pediatric Oncology Group study. J Clin Oncol. 1999;17:3745\u201352.","journal-title":"J Clin Oncol"},{"key":"259_CR17","doi-asserted-by":"publisher","first-page":"7942","DOI":"10.1200\/JCO.2005.01.1031","volume":"23","author":"HG Einsiedel","year":"2005","unstructured":"Einsiedel HG, von Stackelberg A, Hartmann R, Fengler R, Schrappe M, Janka-Schaub G, et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Munster Group 87. J Clin Oncol. 2005;23:7942\u201350.","journal-title":"J Clin Oncol"},{"key":"259_CR18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1365-2141.2005.05572.x","volume":"130","author":"A Roy","year":"2005","unstructured":"Roy A, Cargill A, Love S, Moorman AV, Stoneham S, Lim A, et al. Outcome after first relapse in childhood acute lymphoblastic leukaemia\u2014lessons from the United Kingdom R2 trial. Br J Haematol. 2005;130:67\u201375.","journal-title":"Br J Haematol"},{"key":"259_CR19","doi-asserted-by":"publisher","first-page":"5750","DOI":"10.1200\/JCO.2006.07.1225","volume":"24","author":"UM Saarinen-Pihkala","year":"2006","unstructured":"Saarinen-Pihkala UM, Heilmann C, Winiarski J, Glomstein A, Abrahamsson J, Arvidson J, et al. Pathways through relapses and deaths of children with acute lymphoblastic leukemia: role of allogeneic stem cell transplantation in Nordic data. J Clin Oncol. 2006;24:5750\u201362.","journal-title":"J Clin Oncol"},{"key":"259_CR20","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1200\/JCO.2005.03.3373","volume":"24","author":"JC Barredo","year":"2006","unstructured":"Barredo JC, Devidas M, Lauer SJ, Billett A, Marymont MA, Pullen J, et al. Isolated CNS relapse of acute lymphoblastic leukemia treated with intensive systemic chemotherapy and delayed CNS radiation: a Pediatric Oncology Group Study. J Clin Oncol. 2006;24:3142\u20139.","journal-title":"J Clin Oncol"},{"key":"259_CR21","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1046\/j.1365-2141.1998.00825.x","volume":"102","author":"P Bordigoni","year":"1998","unstructured":"Bordigoni P, Esperou H, Souillet G, Pico J, Michel G, Lacour B, et al. Total body irradiation-high-dose cytosine arabinoside and melphalan followed by allogeneic bone marrow transplantation from HLA-identical siblings in the treatment of children with acute lymphoblastic leukaemia after relapse while receiving chemotherapy: a Soci\u00e9t\u00e9 Fran\u00e7aise de Greffe de Moelle study. Br J Haematol. 1998;102:656\u201365.","journal-title":"Br J Haematol"},{"key":"259_CR22","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/sj.bmt.1704958","volume":"35","author":"Z Afify","year":"2005","unstructured":"Afify Z, Hunt L, Green A, Guttridge M, Cornish J, Oakhill A. Factors affecting the outcome of stem cell transplantation from unrelated donors for childhood acute lymphoblastic leukemia in third remission. Bone Marrow Transplant. 2005;35:1041\u20137.","journal-title":"Bone Marrow Transplant"},{"key":"259_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/sj.bmt.1705202","volume":"37","author":"T Yoshihara","year":"2006","unstructured":"Yoshihara T, Morimoto A, Kuroda H, Imamura T, Ishida H, Tsunamoto K, et al. Allogeneic stem cell transplantation in children with acute lymphoblastic leukemia after isolated central nervous system relapse: our experiences and review of the literature. Bone Marrow Transplant. 2006;37:25\u201331.","journal-title":"Bone Marrow Transplant"},{"key":"259_CR24","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.bbmt.2017.03.023","volume":"23","author":"N Shem-Tov","year":"2017","unstructured":"Shem-Tov N, Saraceni F, Danylesko I, Shouval R, Yerushalmi R, Nagler A, et al. Isolated extramedullary relapse of acute leukemia after allogeneic stem cell transplantation: different kinetics and better prognosis than systemic relapse. Biol Blood Marrow Transplant. 2017;23:1087\u201394.","journal-title":"Biol Blood Marrow Transplant"},{"key":"259_CR25","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/sj.bmt.1702488","volume":"26","author":"KH Lee","year":"2000","unstructured":"Lee K-H, Lee J-H, Kim S, Lee J-S, Kim S-H, Kim W-K. High frequency of extramedullary relapse of acute leukemia after allogeneic bone marrow transplantation. Bone Marrow Transplant. 2000;26:147\u201352.","journal-title":"Bone Marrow Transplant"},{"key":"259_CR26","first-page":"e20","volume":"91","author":"K Huck","year":"2006","unstructured":"Huck K, Laws H-J, Meisel R, Tr\u00f6ger A, Bernbeck B, Sch\u00f6nberger S, et al. Three cases of renal relapse after allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia. Haematologica. 2006;91:e20\u20135.","journal-title":"Haematologica"},{"key":"259_CR27","doi-asserted-by":"publisher","first-page":"745","DOI":"10.3892\/mco.2016.1052","volume":"5","author":"B Kantarcioglu","year":"2016","unstructured":"Kantarcioglu B, Bekoz HF, Ogret YD, Cakir A, Kivanc D, Oguz F, et al. Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: a case report. Mol Clin Oncol. 2016;5:745\u20139.","journal-title":"Mol Clin Oncol"},{"key":"259_CR28","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3109\/10428199909058408","volume":"32","author":"S Singhal","year":"1999","unstructured":"Singhal S, Powles R, Kulkarni S, Treleaven J, Saso R, Mehta J. Long-term follow-up of relapsed acute leukemia treated with immunotherapy after allogeneic transplantation: the inseparability of graft-versus-host disease and graft-versus-leukemia, and the problem of extramedullary relapse. Leuk Lymphoma. 1999;32:505\u201312.","journal-title":"Leuk Lymphoma"},{"key":"259_CR29","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s00277-011-1171-x","volume":"90","author":"M Neumann","year":"2011","unstructured":"Neumann M, Blau IW, Burmeister T, Tietze-Buerger C, Blau O, Gerbits A, et al. Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation. Ann Hematol. 2011;90:911\u20136.","journal-title":"Ann Hematol"},{"key":"259_CR30","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1056\/NEJMoa1709919","volume":"378","author":"JH Park","year":"2018","unstructured":"Park JH, Rivi\u00e8re I, Gonen M, Wang Y, Senechal B, Curran KJ, et al. Long-term follow-up of CD19 CAR therapy in acute lymphoblastic leukemia. N Engl J Med. 2018;378:449\u201359.","journal-title":"N Engl J Med"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41409-018-0259-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41409-018-0259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41409-018-0259-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:12:33Z","timestamp":1684617153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41409-018-0259-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["259"],"URL":"https:\/\/doi.org\/10.1038\/s41409-018-0259-5","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"assertion":[{"value":"14 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}