{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:01:00Z","timestamp":1694149260992},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1038\/s41409-019-0595-0","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:02:31Z","timestamp":1566345751000},"page":"733-737","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Toward safer haploidnetical hematopoietic stem cell transplantation"],"prefix":"10.1038","volume":"54","author":[{"given":"Rakefet","family":"Sidlik-Muskatel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Reisner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"595_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/nrclinonc.2015.128","volume":"13","author":"CG Kanakry","year":"2016","unstructured":"Kanakry CG, Fuchs EJ, Luznik L. Modern approaches to HLA-haploidentical blood or marrow transplantation. Nat Rev Clin Oncol. 2016;13:10.","journal-title":"Nat Rev Clin Oncol"},{"key":"595_CR2","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/bjh.13868","volume":"172","author":"N Or\u2010Geva","year":"2016","unstructured":"Or\u2010Geva N, Reisner Y. The evolution of T\u2010cell depletion in haploidentical stem\u2010cell transplantation. Br J Haematol. 2016;172:667\u201384.","journal-title":"Br J Haematol"},{"key":"595_CR3","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1097\/01.TP.0000064211.23536.AD","volume":"75","author":"TR Spitzer","year":"2003","unstructured":"Spitzer TR, Mcafee SL, Dey BR, Colby C, Hope J, Grossberg H, et al. Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation. 2003;75:1748\u201351.","journal-title":"Transplantation"},{"key":"595_CR4","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1182\/bloodadvances.2017009423","volume":"1","author":"F Aversa","year":"2017","unstructured":"Aversa F, Bachar-Lustig E, Or-Geva N, Prezioso L, Bonomini S, Manfra I, et al. Immune tolerance induction by nonmyeloablative haploidentical HSCT combining T-cell depletion and posttransplant cyclophosphamide. Blood Adv. 2017;1:2166\u201375.","journal-title":"Blood Adv"},{"key":"595_CR5","doi-asserted-by":"publisher","first-page":"a015529","DOI":"10.1101\/cshperspect.a015529","volume":"4","author":"DH Sachs","year":"2014","unstructured":"Sachs DH, Kawai T, Sykes M. Induction of tolerance through mixed chimerism. Cold Spring Harb Perspect Med. 2014;4:a015529.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"595_CR6","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1365-2796.2007.01855.x","volume":"262","author":"M Sykes","year":"2007","unstructured":"Sykes M. Immune tolerance: mechanisms and application in clinical transplantation. J Intern Med. 2007;262:288\u2013310.","journal-title":"J Intern Med"},{"key":"595_CR7","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1097\/00007890-199805270-00017","volume":"65","author":"N Rachamim","year":"1998","unstructured":"Rachamim N, Gan J, Segall H, Krauthgamer R, Marcus H, Berrebi A, et al. Tolerance induction by \u201cmegadose\u201d hematopoietic transplants: donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture1. Transplantation. 1998;65:1386\u201393.","journal-title":"Transplantation"},{"key":"595_CR8","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/287544a0","volume":"287","author":"RG Miller","year":"1980","unstructured":"Miller RG. An immunological suppressor cell inactivating cytotoxic T-lymphocyte precursor cells recognizing it. Nature. 1980;287:544.","journal-title":"Nature"},{"key":"595_CR9","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1182\/blood-2012-02-410803","volume":"120","author":"L Zangi","year":"2012","unstructured":"Zangi L, Klionsky YZ, Yarimi L, Bachar-Lustig E, Eidelstein Y, Shezen E, et al. Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7. Blood. 2012;120:1647\u201357.","journal-title":"Blood"},{"key":"595_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1006\/cimm.2001.1771","volume":"208","author":"P Chrobak","year":"2001","unstructured":"Chrobak P, Gress RE. Veto activity of activated bone marrow does not require perforin and Fas ligand. Cell Immunol. 2001;208:80\u20137.","journal-title":"Cell Immunol"},{"key":"595_CR11","doi-asserted-by":"publisher","first-page":"6660","DOI":"10.4049\/jimmunol.173.11.6660","volume":"173","author":"S Reich-Zeliger","year":"2004","unstructured":"Reich-Zeliger S, Gan J, Bachar-Lustig E, Reisner Y. Tolerance induction by veto CTLs in the TCR transgenic 2C mouse model. II. Deletion of effector cells by Fas-Fas ligand apoptosis. J Immunol. 2004;173:6660\u20136.","journal-title":"J Immunol"},{"key":"595_CR12","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1182\/blood-2002-11-3463","volume":"105","author":"H Gur","year":"2005","unstructured":"Gur H, Krauthgamer R, Bachar-Lustig E, Katchman H, Arbel-Goren R, Berrebi A, et al. Immune regulatory activity of CD34\u2009+\u2009progenitor cells: evidence for a deletion-based mechanism mediated by TNF-alpha. Blood. 2005;105:2585\u201393.","journal-title":"Blood"},{"key":"595_CR13","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S1074-7613(00)00050-9","volume":"13","author":"S Reich-Zeliger","year":"2000","unstructured":"Reich-Zeliger S, Zhao Y, Krauthgamer R, Bachar-Lustig E, Reisner Y. Anti-third party CD8 CTLs as potent veto cells: coexpression of CD8 and FasL is a prerequisite. Immunity. 2000;13:507\u201315.","journal-title":"Immunity"},{"key":"595_CR14","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1182\/blood-2010-05-283770","volume":"117","author":"O Milstein","year":"2011","unstructured":"Milstein O, Hagin D, Lask A, Reich-Zeliger S, Shezen E, Ophir E, et al. CTLs respond with activation and granule secretion when serving as targets for T-cell recognition. Blood. 2011;117:1042\u201352.","journal-title":"Blood"},{"key":"595_CR15","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.immuni.2015.08.015","volume":"43","author":"Y Zlotnikov-Klionsky","year":"2015","unstructured":"Zlotnikov-Klionsky Y, Nathansohn-Levi B, Shezen E, Rosen C, Kagan S, Bar-On L, et al. Perforin-positive dendritic cells exhibit an immuno-regulatory role in metabolic syndrome and autoimmunity. Immunity. 2015;43:776\u201387.","journal-title":"Immunity"},{"key":"595_CR16","doi-asserted-by":"publisher","first-page":"6389","DOI":"10.4049\/jimmunol.179.10.6389","volume":"179","author":"S Reich-Zeliger","year":"2007","unstructured":"Reich-Zeliger S, Bachar-Lustig E, Bar-Ilan A, Reisner Y. Tolerance induction in presensitized bone marrow recipients by veto CTLs: effective deletion of host anti-donor memory effector cells. J Immunol. 2007;179:6389\u201394.","journal-title":"J Immunol"},{"key":"595_CR17","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1182\/blood-2003-03-0759","volume":"102","author":"E Bachar-Lustig","year":"2003","unstructured":"Bachar-Lustig E, Reich-Zeliger S, Reisner Y. Anti-third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose. Blood. 2003;102:1943\u201350.","journal-title":"Blood"},{"key":"595_CR18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/01.tp.0000185302.38890.6b","volume":"81","author":"KM Anderson","year":"2006","unstructured":"Anderson KM, Zimring JC. Rapamycin prolongs susceptibility of responding T cells to tolerance induction by CD8 veto cells. Transplantation. 2006;81:88\u201394.","journal-title":"Transplantation"},{"key":"595_CR19","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1182\/blood-2009-10-248716","volume":"115","author":"E Ophir","year":"2010","unstructured":"Ophir E, Eidelstein Y, Afik R, Bachar-Lustig E, Reisner Y. Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells. Blood. 2010;115:2095\u2013104.","journal-title":"Blood"},{"key":"595_CR20","doi-asserted-by":"crossref","unstructured":"Or-Geva N, Gidron-Budovsky R, Sidlik-Muskatel R, Singh AK, Reisner Y. Next-generation CD8 memory veto T cells directed against memory antigens. Leukemia. 2019 Jun 12. [Epub ahead of print]","DOI":"10.1038\/s41375-019-0501-1"},{"key":"595_CR21","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1182\/blood-2012-07-441493","volume":"121","author":"E Ophir","year":"2013","unstructured":"Ophir E, Or-Geva N, Gurevich I, Tal O, Eidelstein Y, Shezen E, et al. Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells. Blood. 2013;121:1220\u20138.","journal-title":"Blood"},{"key":"595_CR22","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/leu.2017.332","volume":"32","author":"N Or-Geva","year":"2018","unstructured":"Or-Geva N, Gidron-Budovsky R, Radomir L, Edelstein Y, Singh AK, Sidlik-Muskatel R, et al. Towards \u2018off-the-shelf\u2019genetically modified T cells: prolonging functional engraftment in mice by CD8 veto T cells. Leukemia. 2018;32:1038.","journal-title":"Leukemia"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41409-019-0595-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41409-019-0595-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41409-019-0595-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:14:59Z","timestamp":1684617299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41409-019-0595-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":22,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["595"],"URL":"https:\/\/doi.org\/10.1038\/s41409-019-0595-0","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"20 August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"YR received grant funding, consulting fees and\u00a0owns equity in Cell Source Ltd. RS-M declare that she has no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}