{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:18:56Z","timestamp":1793531936814,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1038\/s41409-019-0701-3","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T12:27:38Z","timestamp":1569846458000},"page":"603-612","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Changing epidemiology of bloodstream infection in a 25-years hematopoietic stem cell transplant program: current challenges and pitfalls on empiric antibiotic treatment impacting outcomes"],"prefix":"10.1038","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-0217","authenticated-orcid":false,"given":"Pedro","family":"Puerta-Alcalde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Su\u00e1rez-Lled\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Fern\u00e1ndez-Avil\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-8279","authenticated-orcid":false,"given":"Gonzalo","family":"Guti\u00e9rrez-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Chumbita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rosi\u00f1ol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Urbano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Garcia-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"701_CR1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/sj.bmt.1705690","volume":"40","author":"DD Poutsiaka","year":"2007","unstructured":"Poutsiaka DD, Price LL, Ucuzian A, Chan GW, Miller KB, Snydman DR. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transpl. 2007;40:63\u201370.","journal-title":"Bone Marrow Transpl"},{"key":"701_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bbmt.2008.10.024","volume":"15","author":"M Mikulska","year":"2009","unstructured":"Mikulska M, Del Bono V, Raiola AM, Bruno B, Gualandi F, Occhini D, et al. Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of Gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transpl. 2009;15:47\u201353.","journal-title":"Biol Blood Marrow Transpl"},{"key":"701_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.5045\/br.2016.51.2.102","volume":"51","author":"I Stoma","year":"2016","unstructured":"Stoma I, Karpov I, Milanovich N, Uss A, Iskrov I. Risk factors for mortality in patients with bloodstream infections during the pre-engraftment period after hematopoietic stem cell transplantation. Blood Res. 2016;51:102\u20136.","journal-title":"Blood Res"},{"key":"701_CR4","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.bmt.1705677","volume":"39","author":"AL Oliveira","year":"2007","unstructured":"Oliveira AL, de Souza M, Carvalho-Dias VMH, Ruiz MA, Silla L, Tanaka PY, et al. Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients. Bone Marrow Transpl. 2007;39:775\u201381.","journal-title":"Bone Marrow Transpl"},{"key":"701_CR5","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/bmt.2014.37","volume":"49","author":"C Gudiol","year":"2014","unstructured":"Gudiol C, Arnan M, Pati\u00f1o B, Duarte R, Carratal\u00e0 J, Garcia-Vidal C, et al. Etiology, clinical features and outcomes of pre-engraftment and post-engraftment bloodstream infection in hematopoietic SCT recipients. Bone Marrow Transpl. 2014;49:824\u201330.","journal-title":"Bone Marrow Transpl"},{"key":"701_CR6","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/bmt.2014.231","volume":"50","author":"C Girmenia","year":"2015","unstructured":"Girmenia C, Rossolini GM, Piciocchi A, Bertaina A, Pisapia G, Pastore D, et al. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy. Bone Marrow Transpl. 2015;50:282\u20138.","journal-title":"Bone Marrow Transpl"},{"key":"701_CR7","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1086\/322604","volume":"33","author":"BA Collin","year":"2001","unstructured":"Collin BA, Leather HL, Wingard JR, Ramphal R. Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis. 2001;33:947\u201353.","journal-title":"Clin Infect Dis"},{"key":"701_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1086\/599376","volume":"49","author":"LA Mermel","year":"2009","unstructured":"Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O\u2019Grady NP, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49:1\u201345.","journal-title":"Clin Infect Dis"},{"key":"701_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0199531","volume":"13","author":"C Garcia-Vidal","year":"2018","unstructured":"Garcia-Vidal C, Cardozo-Espinola C, Puerta-Alcalde P, Marco F, Tellez A, Ag\u00fc Ero D, et al. Risk factors for mortality in patients with acute leukemia and bloodstream infections in the era of multiresistance. PLoS One. 2018;13:1\u201312.","journal-title":"PLoS One"},{"key":"701_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10096-015-2566-8","volume":"35","author":"C De la Calle","year":"2016","unstructured":"De la Calle C, Morata L, Cobos-Trigueros N, Martinez JA, Cardozo C, Mensa J, et al. Staphylococcus aureus bacteremic pneumonia. Eur J Clin Microbiol Infect Dis. 2016;35:497\u2013502.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"701_CR11","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"A-P Magiorakos","year":"2012","unstructured":"Magiorakos A-P, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268\u201381.","journal-title":"Clin Microbiol Infect"},{"key":"701_CR12","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1086\/513764","volume":"25","author":"WT Hughes","year":"1997","unstructured":"Hughes WT, Armstrong D, Bodey GP, Brown AE, Edwards JE, Feld R, et al. 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Infectious Diseases Society of America. Clin Infect Dis. 1997;25:551\u201373.","journal-title":"Clin Infect Dis"},{"key":"701_CR13","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1086\/339215","volume":"34","author":"WT Hughes","year":"2002","unstructured":"Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002;34:730\u201351.","journal-title":"Clin Infect Dis"},{"key":"701_CR14","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/cid\/ciq147","volume":"52","author":"AG Freifeld","year":"2011","unstructured":"Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, et al. Executive summary: clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2011;52:427\u201331.","journal-title":"Clin Infect Dis"},{"key":"701_CR15","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/j.ejca.2008.07.008","volume":"44","author":"F Meunier","year":"2008","unstructured":"Meunier F, Lukan C. The first european conference on infections in leukaemia \u2013 ECIL1: a current perspective. Eur J Cancer. 2008;44:2112\u20137.","journal-title":"Eur J Cancer"},{"key":"701_CR16","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.3324\/haematol.2013.091025","volume":"98","author":"D Averbuch","year":"2013","unstructured":"Averbuch D, Orasch C, Cordonnier C, Livermore DM, Mikulska M, Viscoli C, et al. European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia. Haematologica. 2013;98:1826\u201335.","journal-title":"Haematologica"},{"key":"701_CR17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1469-0691.2007.01846.x","volume":"14","author":"L Drieux","year":"2008","unstructured":"Drieux L, Brossier F, Sougakoff W, Jarlier V. Phenotypic detection of extended-spectrum beta-lactamase production in Enterobacteriaceae: review and bench guide. Clin Microbiol Infect. 2008;14:90\u2013103.","journal-title":"Clin Microbiol Infect"},{"key":"701_CR18","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1038\/bmt.2010.286","volume":"46","author":"C Liu","year":"2010","unstructured":"Liu C, Lai Y, Huang L-J, Yang Y-W, Chen T-L, Hsiao L-T, et al. Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients. Bone Marrow Transpl. 2010;46:1231\u20139.","journal-title":"Bone Marrow Transpl"},{"key":"701_CR19","doi-asserted-by":"publisher","first-page":"e1931","DOI":"10.1097\/MD.0000000000001931","volume":"94","author":"L Wang","year":"2015","unstructured":"Wang L, Wang Y, Fan X, Tang W, Hu J. Prevalence of resistant gram-negative bacilli in bloodstream infection in febrile neutropenia patients undergoing hematopoietic stem cell transplantation: a Single Center Retrospective Cohort Study. Medicine. 2015;94:e1931.","journal-title":"Medicine"},{"key":"701_CR20","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.cmi.2017.03.020","volume":"23","author":"M Weisser","year":"2017","unstructured":"Weisser M, Theilacker C, Tschudin Sutter S, Babikir R, Bertz H, G\u00f6tting T, et al. Secular trends of bloodstream infections during neutropenia in 15 181 haematopoietic stem cell transplants: 13-year results from a European multicentre surveillance study (ONKO-KISS). Clin Microbiol Infect. 2017;23:854\u20139.","journal-title":"Clin Microbiol Infect"},{"key":"701_CR21","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1093\/jac\/dkr231","volume":"66","author":"M Marcos","year":"2011","unstructured":"Marcos M, Soriano A, Inurrieta A, Martinez JA, Romero A, Cobos N, et al. Changing epidemiology of central venous catheter-related bloodstream infections: increasing prevalence of Gram-negative pathogens. J Antimicrob Chemother. 2011;66:2119\u201325.","journal-title":"J Antimicrob Chemother"},{"key":"701_CR22","doi-asserted-by":"publisher","first-page":"O627","DOI":"10.1111\/1469-0691.12565","volume":"20","author":"E Braun","year":"2014","unstructured":"Braun E, Hussein K, Geffen Y, Rabino G, Bar-Lavie Y, Paul M. Predominance of Gram-negative bacilli among patients with catheter-related bloodstream infections. Clin Microbiol Infect. 2014;20:O627\u2013O629.","journal-title":"Clin Microbiol Infect"},{"key":"701_CR23","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1093\/cid\/cix690","volume":"65","author":"C Girmenia","year":"2017","unstructured":"Girmenia C, Bertaina A, Piciocchi A, Perruccio K, Algarotti A, Busca A, et al. Incidence, risk factors and outcome of pre-engraftment gram-negative bacteremia after allogeneic and autologous hematopoietic stem cell transplantation: an Italian Prospective Multicenter Survey. Clin Infect Dis. 2017;65:1884\u201396.","journal-title":"Clin Infect Dis"},{"key":"701_CR24","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1093\/cid\/cix646","volume":"65","author":"D Averbuch","year":"2017","unstructured":"Averbuch D, Tridello G, Hoek J, Mikulska M, Akan H, Yanez San Segundo L, et al. Antimicrobial resistance in gram-negative rods causing bacteremia in hematopoietic stem cell transplant recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group. Clin Infect Dis. 2017;65:1819\u201328.","journal-title":"Clin Infect Dis"},{"key":"701_CR25","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1128\/JCM.00753-11","volume":"49","author":"M Garc\u00eda-Castillo","year":"2011","unstructured":"Garc\u00eda-Castillo M, Del Campo R, Morosini MI, Riera E, Cabot G, Willems R, et al. Wide dispersion of ST175 clone despite high genetic diversity of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical strains in 16 Spanish hospitals. J Clin Microbiol. 2011;49:2905\u201310.","journal-title":"J Clin Microbiol"},{"key":"701_CR26","doi-asserted-by":"publisher","first-page":"6349","DOI":"10.1128\/AAC.01388-12","volume":"56","author":"G Cabot","year":"2012","unstructured":"Cabot G, Ocampo-Sosa AA, Dom\u00ednguez MA, Gago JF, Juan C, Tubau F, et al. Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones. Antimicrob Agents Chemother. 2012;56:6349\u201357.","journal-title":"Antimicrob Agents Chemother"},{"key":"701_CR27","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1093\/cid\/ciq257","volume":"52","author":"K Gupta","year":"2011","unstructured":"Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52:e103\u201320.","journal-title":"Clin Infect Dis"},{"key":"701_CR28","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1093\/cid\/ciw353","volume":"63","author":"AC Kalil","year":"2016","unstructured":"Kalil AC, Metersky ML, Klompas M, Muscedere J, Sweeney DA, Palmer LB, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:e61\u2013e111.","journal-title":"Clin Infect Dis"},{"key":"701_CR29","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00277-012-1424-3","volume":"91","author":"C Cattaneo","year":"2012","unstructured":"Cattaneo C, Antoniazzi F, Casari S, Ravizzola G, Gelmi M, Pagani C, et al. P. aeruginosa bloodstream infections among hematological patients: an old or new question? Ann Hematol. 2012;91:1299\u2013304.","journal-title":"Ann Hematol"},{"key":"701_CR30","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1128\/AAC.00462-11","volume":"56","author":"P Retamar","year":"2012","unstructured":"Retamar P, Portillo MM, L\u00f3pez-Prieto MD, Rodr\u00edguez-L\u00f3pez F, de Cueto M, Garc\u00eda MV, et al. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis. Antimicrob Agents Chemother. 2012;56:472\u20138.","journal-title":"Antimicrob Agents Chemother"},{"key":"701_CR31","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3324\/haematol.2009.011809","volume":"95","author":"TH Terwey","year":"2010","unstructured":"Terwey TH, Hemmati PG, Martus P, Dietz E, Vuong LG, Massenkeil G, et al. A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia. Haematologica. 2010;95:810\u20138.","journal-title":"Haematologica"},{"key":"701_CR32","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/ajh.24489","volume":"91","author":"EM Trecarichi","year":"2016","unstructured":"Trecarichi EM, Pagano L, Martino B, Candoni A, Di Blasi R, Nadali G, et al. Bloodstream infections caused by Klebsiella pneumoniae in onco-hematological patients: clinical impact of carbapenem resistance in a multicentre prospective survey. Am J Hematol. 2016;91:1076\u201381.","journal-title":"Am J Hematol"},{"key":"701_CR33","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1111\/j.1600-6143.2007.01964.x","volume":"7","author":"A Moreno","year":"2007","unstructured":"Moreno A, Cervera C, Gavald J, Cisneros JM, Fort J, Gurgu M, et al. Bloodstream infections among transplant recipients: results of a Nationwide Surveillance in Spain 1. Am J Transpl. 2007;7:2579\u201386.","journal-title":"Am J Transpl"},{"key":"701_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s15010-011-0229-y","volume":"40","author":"M Mikulska","year":"2012","unstructured":"Mikulska M, Bono VDel, Bruzzi P, Raiola AM, Gualandi F, Lint MTVan, et al. Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients. Infection. 2012;40:271\u20138.","journal-title":"Infection"},{"key":"701_CR35","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1002\/cncr.22205","volume":"107","author":"L Leibovici","year":"2006","unstructured":"Leibovici L, Paul M, Cullen M, Bucaneve G, Gafter-Gvili A, Fraser A, et al. Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions. Cancer. 2006;107:1743\u201351.","journal-title":"Cancer"},{"key":"701_CR36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jinf.2014.02.013","volume":"69","author":"S Kimura","year":"2014","unstructured":"Kimura S, Akahoshi Y, Nakano H, Ugai T, Wada H, Yamasaki R, et al. Antibiotic prophylaxis in hematopoietic stem cell transplantation. A meta-analysis of randomized controlled trials. J Infect. 2014;69:13\u201325.","journal-title":"J Infect"},{"key":"701_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-356","volume":"13","author":"M Garnica","year":"2013","unstructured":"Garnica M, Nou\u00e9r SA, FLPC Pellegrino, Moreira BM, Maiolino A, Nucci M. Ciprofloxacin prophylaxis in high risk neutropenic patients: effects on outcomes, antimicrobial therapy and resistance. BMC Infect Dis. 2013;13:356.","journal-title":"BMC Infect Dis"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41409-019-0701-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41409-019-0701-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41409-019-0701-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:15:57Z","timestamp":1684617357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41409-019-0701-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["701"],"URL":"https:\/\/doi.org\/10.1038\/s41409-019-0701-3","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"4 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"CG-V has received honoraria for talks on behalf of Gilead Science, Merck Sharp and Dohme, Pfizer, Jannsen, Novartis, Lilly and a grant support from Gilead Science and Merck Sharp and Dohme. AS has received honoraria for talks on behalf of Merck Sharp and Dohme, Pfizer, Novartis, Angellini, and a grant support from Pfizer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}