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Outcome measures included: Ocular Surface Disease Index (OSDI), tear osmolarity, Schirmer\u2019s test, Oxford corneal staining score, tear break-up time (TBUT), and tear and serum biomarkers (IFN-\u03b3, IL-10, MMP-9, IL-12, IL-13, IL-17\u03b1, IL-1\u03b2, IL-2, IL-4, IL-6, IL-8, CXCL10, MCP-1, MIP-1\u03b1, RANTES, TNF-\u03b1). At baseline the HSCT group had higher median Oxford corneal staining score (1.7 vs. 0.0; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), higher tear TNF-\u03b1 (20.0 vs. 11.2\u2009pg\/mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), lower tear RANTES (70.4 vs. 190.2\u2009pg\/mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), higher serum IL-8 (10.2 vs. 4.5\u2009pg\/mL; <jats:italic>P<\/jats:italic>\u2009=\u20090.0008), and higher serum TNF-\u03b1 (8.7 vs. 4.2\u2009pg\/mL; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The incidence of oGVHD was 62% and associated changes included increased Oxford corneal staining score (4.6 vs. 1.8, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001), decreased Schirmer\u2019s test (3.0 vs. 10.0; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and decreased TBUT (4.7 vs. 9.0\u2009s; <jats:italic>P<\/jats:italic>\u2009=\u20090.0004). Baseline differences in ocular surface indicators suggest a tendency toward ocular dryness in individuals with hematologic disorders preparing for HSCT. Individuals who developed oGVHD showed changes in corneal staining score, Schirmer\u2019s test, and TBUT.<\/jats:p>","DOI":"10.1038\/s41409-021-01254-5","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T14:03:43Z","timestamp":1615212223000},"page":"1850-1858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ocular surface indicators and biomarkers in chronic ocular graft-versus-host disease: a prospective cohort study"],"prefix":"10.1038","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-6261","authenticated-orcid":false,"given":"Alexandra A.","family":"Pietraszkiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Garced","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna C.","family":"Devarasetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya M.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sveti","family":"Ugarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-0211","authenticated-orcid":false,"given":"Filip","family":"Pirsl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sencer","family":"Goklemez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick L.","family":"Ferris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Battiwalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Childs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Z.","family":"Pavletic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,8]]},"reference":[{"key":"1254_CR1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/ACI.0b013e328357b4b9","volume":"12","author":"M Hessen","year":"2012","unstructured":"Hessen M, Akpek EK. 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